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Items: 1 to 50 of 108

1.

Architecture of the mycobacterial type VII secretion system.

Famelis N, Rivera-Calzada A, Degliesposti G, Wingender M, Mietrach N, Skehel JM, Fernandez-Leiro R, Böttcher B, Schlosser A, Llorca O, Geibel S.

Nature. 2019 Oct 9. doi: 10.1038/s41586-019-1633-1. [Epub ahead of print]

PMID:
31597161
2.

Recurrent Germline DLST Mutations in Individuals with Multiple Pheochromocytomas and Paragangliomas.

Remacha L, Pirman D, Mahoney CE, Coloma J, Calsina B, Currás-Freixes M, Letón R, Torres-Pérez R, Richter S, Pita G, Herráez B, Cianchetta G, Honrado E, Maestre L, Urioste M, Aller J, García-Uriarte Ó, Gálvez MÁ, Luque RM, Lahera M, Moreno-Rengel C, Eisenhofer G, Montero-Conde C, Rodríguez-Antona C, Llorca Ó, Smolen GA, Robledo M, Cascón A.

Am J Hum Genet. 2019 May 2;104(5):1008-1010. doi: 10.1016/j.ajhg.2019.04.010. No abstract available.

3.

Structural mechanism for regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP co-chaperone revealed by cryo-EM.

Muñoz-Hernández H, Pal M, Rodríguez CF, Fernandez-Leiro R, Prodromou C, Pearl LH, Llorca O.

Sci Adv. 2019 May 1;5(5):eaaw1616. doi: 10.1126/sciadv.aaw1616. eCollection 2019 May.

4.

Recurrent Germline DLST Mutations in Individuals with Multiple Pheochromocytomas and Paragangliomas.

Remacha L, Pirman D, Mahoney CE, Coloma J, Calsina B, Currás-Freixes M, Letón R, Torres-Pérez R, Richter S, Pita G, Herráez B, Cianchetta G, Honrado E, Maestre L, Urioste M, Aller J, García-Uriarte Ó, Gálvez MÁ, Luque RM, Lahera M, Moreno-Rengel C, Eisenhofer G, Montero-Conde C, Rodríguez-Antona C, Llorca Ó, Smolen GA, Robledo M, Cascón A.

Am J Hum Genet. 2019 Apr 4;104(4):651-664. doi: 10.1016/j.ajhg.2019.02.017. Epub 2019 Mar 28. Erratum in: Am J Hum Genet. 2019 May 2;104(5):1008-1010.

5.

Advances on the Structure of the R2TP/Prefoldin-like Complex.

Muñoz-Hernández H, Pal M, Rodríguez CF, Prodromou C, Pearl LH, Llorca O.

Adv Exp Med Biol. 2018;1106:73-83. doi: 10.1007/978-3-030-00737-9_5.

PMID:
30484153
6.

Author Correction: RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex.

Martino F, Pal M, Muñoz-Hernández H, Rodríguez CF, Núñez-Ramírez R, Gil-Carton D, Degliesposti G, Skehel JM, Roe SM, Prodromou C, Pearl LH, Llorca O.

Nat Commun. 2018 Jul 31;9(1):3063. doi: 10.1038/s41467-018-05546-1.

7.

RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex.

Martino F, Pal M, Muñoz-Hernández H, Rodríguez CF, Núñez-Ramírez R, Gil-Carton D, Degliesposti G, Skehel JM, Roe SM, Prodromou C, Pearl LH, Llorca O.

Nat Commun. 2018 Apr 16;9(1):1501. doi: 10.1038/s41467-018-03942-1. Erratum in: Nat Commun. 2018 Jul 31;9(1):3063.

8.

Self-Organization of FtsZ Polymers in Solution Reveals Spacer Role of the Disordered C-Terminal Tail.

Huecas S, Ramírez-Aportela E, Vergoñós A, Núñez-Ramírez R, Llorca O, Díaz JF, Juan-Rodríguez D, Oliva MA, Castellen P, Andreu JM.

Biophys J. 2017 Oct 17;113(8):1831-1844. doi: 10.1016/j.bpj.2017.08.046.

9.

How novel structures inform understanding of complement function.

de Jorge EG, Yebenes H, Serna M, Tortajada A, Llorca O, de Córdoba SR.

Semin Immunopathol. 2018 Jan;40(1):3-14. doi: 10.1007/s00281-017-0643-z. Epub 2017 Aug 14. Review.

PMID:
28808775
10.

The Structure of the R2TP Complex Defines a Platform for Recruiting Diverse Client Proteins to the HSP90 Molecular Chaperone System.

Rivera-Calzada A, Pal M, Muñoz-Hernández H, Luque-Ortega JR, Gil-Carton D, Degliesposti G, Skehel JM, Prodromou C, Pearl LH, Llorca O.

Structure. 2017 Jul 5;25(7):1145-1152.e4. doi: 10.1016/j.str.2017.05.016. Epub 2017 Jun 22.

11.

Ionic tethering contributes to the conformational stability and function of complement C3b.

López-Perrote A, Harrison RE, Subías M, Alcorlo M, Rodríguez de Córdoba S, Morikis D, Llorca O.

Mol Immunol. 2017 May;85:137-147. doi: 10.1016/j.molimm.2016.12.015. Epub 2017 Mar 8.

PMID:
28254726
12.

TubZ filament assembly dynamics requires the flexible C-terminal tail.

Fuentes-Pérez ME, Núñez-Ramírez R, Martín-González A, Juan-Rodríguez D, Llorca O, Moreno-Herrero F, Oliva MA.

Sci Rep. 2017 Feb 23;7:43342. doi: 10.1038/srep43342.

13.

Functional and structural characterization of four mouse monoclonal antibodies to complement C3 with potential therapeutic and diagnostic applications.

Subías Hidalgo M, Yébenes H, Rodríguez-Gallego C, Martín-Ambrosio A, Domínguez M, Tortajada A, Rodríguez de Córdoba S, Llorca O.

Eur J Immunol. 2017 Mar;47(3):504-515. doi: 10.1002/eji.201646758. Epub 2017 Feb 6.

14.

The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation.

Melero R, Hug N, López-Perrote A, Yamashita A, Cáceres JF, Llorca O.

Nat Commun. 2016 Feb 4;7:10585. doi: 10.1038/ncomms10585.

15.

Human nonsense-mediated mRNA decay factor UPF2 interacts directly with eRF3 and the SURF complex.

López-Perrote A, Castaño R, Melero R, Zamarro T, Kurosawa H, Ohnishi T, Uchiyama A, Aoyagi K, Buchwald G, Kataoka N, Yamashita A, Llorca O.

Nucleic Acids Res. 2016 Feb 29;44(4):1909-23. doi: 10.1093/nar/gkv1527. Epub 2016 Jan 5.

16.

Structural insights on complement activation.

Alcorlo M, López-Perrote A, Delgado S, Yébenes H, Subías M, Rodríguez-Gallego C, Rodríguez de Córdoba S, Llorca O.

FEBS J. 2015 Oct;282(20):3883-91. doi: 10.1111/febs.13399. Epub 2015 Aug 31. Review.

17.

The AAA+ proteins Pontin and Reptin enter adult age: from understanding their basic biology to the identification of selective inhibitors.

Matias PM, Baek SH, Bandeiras TM, Dutta A, Houry WA, Llorca O, Rosenbaum J.

Front Mol Biosci. 2015 May 5;2:17. doi: 10.3389/fmolb.2015.00017. eCollection 2015.

18.

The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome.

Martínez-Barricarte R, Heurich M, López-Perrote A, Tortajada A, Pinto S, López-Trascasa M, Sánchez-Corral P, Morgan BP, Llorca O, Harris CL, Rodríguez de Córdoba S.

Mol Immunol. 2015 Aug;66(2):263-73. doi: 10.1016/j.molimm.2015.03.248. Epub 2015 Apr 11.

19.

Modulation of the chaperone DnaK allosterism by the nucleotide exchange factor GrpE.

Melero R, Moro F, Pérez-Calvo MÁ, Perales-Calvo J, Quintana-Gallardo L, Llorca O, Muga A, Valpuesta JM.

J Biol Chem. 2015 Apr 17;290(16):10083-92. doi: 10.1074/jbc.M114.623371. Epub 2015 Mar 4.

20.

Amyloidogenesis of bacterial prionoid RepA-WH1 recapitulates dimer to monomer transitions of RepA in DNA replication initiation.

Torreira E, Moreno-Del Álamo M, Fuentes-Perez ME, Fernández C, Martín-Benito J, Moreno-Herrero F, Giraldo R, Llorca O.

Structure. 2015 Jan 6;23(1):183-189. doi: 10.1016/j.str.2014.11.007. Epub 2014 Dec 24.

21.

A novel antibody against human factor B that blocks formation of the C3bB proconvertase and inhibits complement activation in disease models.

Subías M, Tortajada A, Gastoldi S, Galbusera M, López-Perrote A, Lopez Lde J, González-Fernández FA, Villegas-Martínez A, Dominguez M, Llorca O, Noris M, Morgan BP, Rodríguez de Córdoba S.

J Immunol. 2014 Dec 1;193(11):5567-75. doi: 10.4049/jimmunol.1402013. Epub 2014 Oct 29.

22.

Structures of SMG1-UPFs complexes: SMG1 contributes to regulate UPF2-dependent activation of UPF1 in NMD.

Melero R, Uchiyama A, Castaño R, Kataoka N, Kurosawa H, Ohno S, Yamashita A, Llorca O.

Structure. 2014 Aug 5;22(8):1105-1119. doi: 10.1016/j.str.2014.05.015. Epub 2014 Jul 4.

23.

Structure of Yin Yang 1 oligomers that cooperate with RuvBL1-RuvBL2 ATPases.

López-Perrote A, Alatwi HE, Torreira E, Ismail A, Ayora S, Downs JA, Llorca O.

J Biol Chem. 2014 Aug 15;289(33):22614-29. doi: 10.1074/jbc.M114.567040. Epub 2014 Jul 2.

24.

The C-terminal SH3 domain contributes to the intramolecular inhibition of Vav family proteins.

Barreira M, Fabbiano S, Couceiro JR, Torreira E, Martínez-Torrecuadrada JL, Montoya G, Llorca O, Bustelo XR.

Sci Signal. 2014 Apr 15;7(321):ra35. doi: 10.1126/scisignal.2004993.

PMID:
24736456
25.

A humanized antibody that regulates the alternative pathway convertase: potential for therapy of renal disease associated with nephritic factors.

Paixão-Cavalcante D, Torreira E, Lindorfer MA, Rodriguez de Cordoba S, Morgan BP, Taylor RP, Llorca O, Harris CL.

J Immunol. 2014 May 15;192(10):4844-51. doi: 10.4049/jimmunol.1303131. Epub 2014 Apr 11.

26.

The structures of cytosolic and plastid-located glutamine synthetases from Medicago truncatula reveal a common and dynamic architecture.

Torreira E, Seabra AR, Marriott H, Zhou M, Llorca Ó, Robinson CV, Carvalho HG, Fernández-Tornero C, Pereira PJ.

Acta Crystallogr D Biol Crystallogr. 2014 Apr;70(Pt 4):981-93. doi: 10.1107/S1399004713034718. Epub 2014 Mar 19.

27.

Iterative elastic 3D-to-2D alignment method using normal modes for studying structural dynamics of large macromolecular complexes.

Jin Q, Sorzano CO, de la Rosa-Trevín JM, Bilbao-Castro JR, Núñez-Ramírez R, Llorca O, Tama F, Jonić S.

Structure. 2014 Mar 4;22(3):496-506. doi: 10.1016/j.str.2014.01.004. Epub 2014 Feb 6.

28.

Structural basis for the stabilization of the complement alternative pathway C3 convertase by properdin.

Alcorlo M, Tortajada A, Rodríguez de Córdoba S, Llorca O.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13504-9. doi: 10.1073/pnas.1309618110. Epub 2013 Jul 30.

29.

C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation.

Tortajada A, Yébenes H, Abarrategui-Garrido C, Anter J, García-Fernández JM, Martínez-Barricarte R, Alba-Domínguez M, Malik TH, Bedoya R, Cabrera Pérez R, López Trascasa M, Pickering MC, Harris CL, Sánchez-Corral P, Llorca O, Rodríguez de Córdoba S.

J Clin Invest. 2013 Jun;123(6):2434-46.

30.

Structural insights into nonsense-mediated mRNA decay (NMD) by electron microscopy.

Llorca O.

Curr Opin Struct Biol. 2013 Feb;23(1):161-7. doi: 10.1016/j.sbi.2012.10.004. Epub 2012 Oct 23. Review. No abstract available.

31.

Conformational transitions regulate the exposure of a DNA-binding domain in the RuvBL1-RuvBL2 complex.

López-Perrote A, Muñoz-Hernández H, Gil D, Llorca O.

Nucleic Acids Res. 2012 Nov;40(21):11086-99. doi: 10.1093/nar/gks871. Epub 2012 Sep 21.

32.

Reconstitution of the Escherichia coli cell division ZipA-FtsZ complexes in nanodiscs as revealed by electron microscopy.

Hernández-Rocamora VM, García-Montañés C, Rivas G, Llorca O.

J Struct Biol. 2012 Dec;180(3):531-8. doi: 10.1016/j.jsb.2012.08.013. Epub 2012 Sep 19.

PMID:
23000704
33.

Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9.

Hadders MA, Bubeck D, Roversi P, Hakobyan S, Forneris F, Morgan BP, Pangburn MK, Llorca O, Lea SM, Gros P.

Cell Rep. 2012 Mar 29;1(3):200-7. doi: 10.1016/j.celrep.2012.02.003. Epub 2012 Feb 23.

34.

The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end.

Melero R, Buchwald G, Castaño R, Raabe M, Gil D, Lázaro M, Urlaub H, Conti E, Llorca O.

Nat Struct Mol Biol. 2012 Apr 22;19(5):498-505, S1-2. doi: 10.1038/nsmb.2287.

PMID:
22522823
35.

Caveolar domain organization and trafficking is regulated by Abl kinases and mDia1.

Echarri A, Muriel O, Pavón DM, Azegrouz H, Escolar F, Terrón MC, Sanchez-Cabo F, Martínez F, Montoya MC, Llorca O, Del Pozo MA.

J Cell Sci. 2012 Jul 1;125(Pt 13):3097-113. doi: 10.1242/jcs.090134. Epub 2012 Mar 27. Erratum in: J Cell Sci. 2012 Sep 15;125(Pt 18):4413.

36.

Structural and functional studies of LRP6 ectodomain reveal a platform for Wnt signaling.

Chen S, Bubeck D, MacDonald BT, Liang WX, Mao JH, Malinauskas T, Llorca O, Aricescu AR, Siebold C, He X, Jones EY.

Dev Cell. 2011 Nov 15;21(5):848-61. doi: 10.1016/j.devcel.2011.09.007. Epub 2011 Oct 13.

37.

Unique structure of iC3b resolved at a resolution of 24 Å by 3D-electron microscopy.

Alcorlo M, Martínez-Barricarte R, Fernández FJ, Rodríguez-Gallego C, Round A, Vega MC, Harris CL, de Cordoba SR, Llorca O.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13236-40. doi: 10.1073/pnas.1106746108. Epub 2011 Jul 25. Erratum in: Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16481.

38.

Flexible tethering of primase and DNA Pol α in the eukaryotic primosome.

Núñez-Ramírez R, Klinge S, Sauguet L, Melero R, Recuero-Checa MA, Kilkenny M, Perera RL, García-Alvarez B, Hall RJ, Nogales E, Pellegrini L, Llorca O.

Nucleic Acids Res. 2011 Oct;39(18):8187-99. doi: 10.1093/nar/gkr534. Epub 2011 Jun 28. Erratum in: Nucleic Acids Res. 2012 May;40(10):4726.

39.

Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies.

Morris EP, Rivera-Calzada A, da Fonseca PC, Llorca O, Pearl LH, Spagnolo L.

Nucleic Acids Res. 2011 Jul;39(13):5757-67. doi: 10.1093/nar/gkr146. Epub 2011 Mar 30.

40.

Molecular architecture and structural transitions of a Clostridium thermocellum mini-cellulosome.

García-Alvarez B, Melero R, Dias FM, Prates JA, Fontes CM, Smith SP, Romão MJ, Carvalho AL, Llorca O.

J Mol Biol. 2011 Apr 8;407(4):571-80. doi: 10.1016/j.jmb.2011.01.060. Epub 2011 Feb 15.

PMID:
21315080
41.

The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8.

Arias-Palomo E, Yamashita A, Fernández IS, Núñez-Ramírez R, Bamba Y, Izumi N, Ohno S, Llorca O.

Genes Dev. 2011 Jan 15;25(2):153-64. doi: 10.1101/gad.606911.

42.

Structure of human complement C8, a precursor to membrane attack.

Bubeck D, Roversi P, Donev R, Morgan BP, Llorca O, Lea SM.

J Mol Biol. 2011 Jan 14;405(2):325-30. doi: 10.1016/j.jmb.2010.10.031. Epub 2010 Nov 10.

43.

Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation.

Martínez-Barricarte R, Heurich M, Valdes-Cañedo F, Vazquez-Martul E, Torreira E, Montes T, Tortajada A, Pinto S, Lopez-Trascasa M, Morgan BP, Llorca O, Harris CL, Rodríguez de Córdoba S.

J Clin Invest. 2010 Oct;120(10):3702-12. doi: 10.1172/JCI43343. Epub 2010 Sep 13.

44.

Lessons from functional and structural analyses of disease-associated genetic variants in the complement alternative pathway.

Rodríguez de Córdoba S, Harris CL, Morgan BP, Llorca O.

Biochim Biophys Acta. 2011 Jan;1812(1):12-22. doi: 10.1016/j.bbadis.2010.09.002. Epub 2010 Sep 16.

45.

Biochemical characterization of the transcriptional regulator BzdR from Azoarcus sp. CIB.

Durante-Rodríguez G, Valderrama JA, Mancheño JM, Rivas G, Alfonso C, Arias-Palomo E, Llorca O, García JL, Díaz E, Carmona M.

J Biol Chem. 2010 Nov 12;285(46):35694-705. doi: 10.1074/jbc.M110.143503. Epub 2010 Sep 8.

46.

Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex.

Fernández IS, Yamashita A, Arias-Palomo E, Bamba Y, Bartolomé RA, Canales MA, Teixidó J, Ohno S, Llorca O.

Nucleic Acids Res. 2011 Jan;39(1):347-58. doi: 10.1093/nar/gkq749. Epub 2010 Sep 3.

47.

Structural and functional characterization of an influenza virus RNA polymerase-genomic RNA complex.

Resa-Infante P, Recuero-Checa MA, Zamarreño N, Llorca O, Ortín J.

J Virol. 2010 Oct;84(20):10477-87. doi: 10.1128/JVI.01115-10. Epub 2010 Aug 11.

48.

Cyclopentenone prostaglandins with dienone structure promote cross-linking of the chemoresistance-inducing enzyme glutathione transferase P1-1.

Sánchez-Gómez FJ, Díez-Dacal B, Pajares MA, Llorca O, Pérez-Sala D.

Mol Pharmacol. 2010 Oct;78(4):723-33. doi: 10.1124/mol.110.065391. Epub 2010 Jul 14.

PMID:
20631055
49.

The antibacterial cell division inhibitor PC190723 is an FtsZ polymer-stabilizing agent that induces filament assembly and condensation.

Andreu JM, Schaffner-Barbero C, Huecas S, Alonso D, Lopez-Rodriguez ML, Ruiz-Avila LB, Núñez-Ramírez R, Llorca O, Martín-Galiano AJ.

J Biol Chem. 2010 May 7;285(19):14239-46. doi: 10.1074/jbc.M109.094722. Epub 2010 Mar 8.

50.

Coexistence of closed and open conformations of complement factor B in the alternative pathway C3bB(Mg2+) proconvertase.

Torreira E, Tortajada A, Montes T, Rodríguez de Córdoba S, Llorca O.

J Immunol. 2009 Dec 1;183(11):7347-51. doi: 10.4049/jimmunol.0902310. Epub 2009 Nov 4.

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