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Items: 1 to 50 of 166


C-reactive protein point-of-care testing for safely reducing antibiotics for acute exacerbations of chronic obstructive pulmonary disease: the PACE RCT.

Francis NA, Gillespie D, White P, Bates J, Lowe R, Sewell B, Phillips R, Stanton H, Kirby N, Wootton M, Thomas-Jones E, Hood K, Llor C, Cals J, Melbye H, Naik G, Gal M, Fitzsimmons D, Alam MF, Riga E, Cochrane A, Butler CC.

Health Technol Assess. 2020 Mar;24(15):1-108. doi: 10.3310/hta24150.


Effectiveness and cost-effectiveness of Improving clinicians' diagnostic and communication Skills on Antibiotic prescribing Appropriateness in patients with acute Cough in primary care in CATalonia (the ISAAC-CAT study): study protocol for a cluster randomised controlled trial.

Ruiz R, Moragas A, Trapero-Bertran M, Sisó A, Berenguera A, Oliva G, Borràs-Santos A, García-Sangenís A, Puig-Junoy J, Cots JM, Morros R, Mora T, Lanau-Roig A, Monfà R, Troncoso A, Abellana RM, Gálvez P, Medina-Perucha L, Bjerrum L, Amo I, Barragán N, Llor C.

Trials. 2019 Dec 17;20(1):740. doi: 10.1186/s13063-019-3727-3.


Oseltamivir plus usual care versus usual care for influenza-like illness in primary care: an open-label, pragmatic, randomised controlled trial.

Butler CC, van der Velden AW, Bongard E, Saville BR, Holmes J, Coenen S, Cook J, Francis NA, Lewis RJ, Godycki-Cwirko M, Llor C, Chlabicz S, Lionis C, Seifert B, Sundvall PD, Colliers A, Aabenhus R, Bjerrum L, Jonassen Harbin N, Lindbæk M, Glinz D, Bucher HC, Kovács B, Radzeviciene Jurgute R, Touboul Lundgren P, Little P, Murphy AW, De Sutter A, Openshaw P, de Jong MD, Connor JT, Matheeussen V, Ieven M, Goossens H, Verheij TJ.

Lancet. 2020 Jan 4;395(10217):42-52. doi: 10.1016/S0140-6736(19)32982-4. Epub 2019 Dec 12.


Correlation between disease severity factors and EQ-5D utilities in chronic obstructive pulmonary disease.

Esquinas C, Ramon MA, Nuñez A, Molina J, Quintano JA, Roman-Rodríguez M, Naberan K, Llor C, Roncero C, Miravitlles M, Barrecheguren M.

Qual Life Res. 2020 Mar;29(3):607-617. doi: 10.1007/s11136-019-02340-4. Epub 2019 Oct 31.


Non-eosinophilic severe exacerbations of COPD: what about antibiotics?

Miravitlles M, Llor C.

Lancet Respir Med. 2019 Nov;7(11):e33. doi: 10.1016/S2213-2600(19)30347-9. No abstract available.


Is CRP-guided antibiotic treatment a safe way to reduce antibiotic use in severe hospitalised patients with exacerbations of COPD?

Miravitlles M, Llor C, Bjerrum L, Sethi S, Anzueto A.

Eur Respir J. 2019 Oct 17;54(4). pii: 1901405. doi: 10.1183/13993003.01405-2019. Print 2019 Oct. No abstract available.


Challenges in managing urinary tract infection and the potential of a point-of-care test guided care in primary care: an international qualitative study.

Brookes-Howell L, Thomas-Jones E, Bates J, Bekkers MJ, Brugman C, Coulman E, Francis N, Hashmi K, Hood K, Kirby N, Llor C, Little P, Moore M, Moragas A, Rumsby K, Verheij T, Butler C.

BJGP Open. 2019 Jul 23;3(2). pii: bjgpopen18X101630. doi: 10.3399/bjgpopen18X101630. Print 2019 Jul.


Antibiotic Prescribing for Respiratory Tract Infections and Encounter Length.

Llor C, Boël M, Cordoba G, Bjerrum L.

Ann Intern Med. 2019 Jul 16;171(2):149-150. doi: 10.7326/L19-0263. No abstract available.


C-Reactive Protein Testing to Guide Antibiotic Prescribing for COPD Exacerbations.

Butler CC, Gillespie D, White P, Bates J, Lowe R, Thomas-Jones E, Wootton M, Hood K, Phillips R, Melbye H, Llor C, Cals JWL, Naik G, Kirby N, Gal M, Riga E, Francis NA.

N Engl J Med. 2019 Jul 11;381(2):111-120. doi: 10.1056/NEJMoa1803185.


Making guidelines, research and scientific papers as simple as possible.

Llor C.

Eur J Gen Pract. 2019 Jul;25(3):99-100. doi: 10.1080/13814788.2019.1635368. Epub 2019 Jul 10. No abstract available.


Effectiveness of antitussives, anticholinergics or honey versus usual care in adults with uncomplicated acute bronchitis: a study protocol of an open randomised clinical trial in primary care.

Cots JM, Moragas A, García-Sangenís A, Morros R, Gomez-Lumbreras A, Ouchi D, Monfà R, Pera H, Pujol J, Bayona C, de la Poza-Abad M, Llor C.

BMJ Open. 2019 May 16;9(5):e028159. doi: 10.1136/bmjopen-2018-028159.


Use of point-of-care tests and antibiotic prescribing in sore throat and lower respiratory infections by general practitioners.

Llor C, Molero JM, Moragas A, Cordoba G, Bjerrum L.

Enferm Infecc Microbiol Clin. 2020 Jan;38(1):21-24. doi: 10.1016/j.eimc.2019.02.005. Epub 2019 Apr 10. English, Spanish.


General practitioners' opinions and perceptions about antibiotic use for respiratory tract infections in primary care.

Moragas A, Molero JM, Bjerrum L, Llor C.

Aten Primaria. 2019 Aug - Sep;51(7):460-461. doi: 10.1016/j.aprim.2019.01.011. Epub 2019 Mar 26. No abstract available.


Use of delayed antibiotic prescription in primary care: a cross-sectional study.

de la Poza Abad M, Mas Dalmau G, Gich Saladich I, Martínez García L, Llor C, Alonso-Coello P.

BMC Fam Pract. 2019 Mar 26;20(1):45. doi: 10.1186/s12875-019-0934-7.


Phase-contrast microscopy in the diagnosis of urinary tract infections in the outpatient setting: A diagnostic validity study.

Llor C, Moragas A, Alfaro A, Sierra N.

Aten Primaria. 2019 Aug - Sep;51(7):462-464. doi: 10.1016/j.aprim.2019.02.001. Epub 2019 Mar 16. No abstract available.


Antibiotic Prescribing for Acute Respiratory Tract Infections 12 Months After Communication and CRP Training: A Randomized Trial.

Little P, Stuart B, Francis N, Douglas E, Tonkin-Crine S, Anthierens S, Cals JWL, Melbye H, Santer M, Moore M, Coenen S, Butler CC, Hood K, Kelson M, Godycki-Cwirko M, Mierzecki A, Torres A, Llor C, Davies M, Mullee M, O'Reilly G, van der Velden A, Geraghty AWA, Goossens H, Verheij T, Yardley L; GRACE consortium.

Ann Fam Med. 2019 Mar;17(2):125-132. doi: 10.1370/afm.2356.


Overdiagnosis paradigm: not suitable for decreasing the overuse of antibiotics.

Cordoba G, Llor C.

BMJ Evid Based Med. 2019 Oct;24(5):174-176. doi: 10.1136/bmjebm-2018-111146. Epub 2019 Feb 11.


Reducing antibiotic prescribing for lower respiratory tract infections 6 years after a multifaceted intervention.

Molero JM, Moragas A, González López-Valcárcel B, Bjerrum L, Cots JM, Llor C.

Int J Clin Pract. 2019 May;73(5):e13312. doi: 10.1111/ijcp.13312. Epub 2019 Feb 6.


[Utilisation of first-line antibiotics six years after a multifaceted intervention].

Molero JM, Gómez M, Guerra G, Alcántara JD, Ortega J, García G, Pineda V, Munuera S, Cid M, Monedero MJ, Ribas JM, Cots JM, Moragas A, Bjerrum L, Llor C; Grupo de Trabajo HAPPY AUDIT 3.

Rev Esp Quimioter. 2018 Dec;31(6):520-527. Epub 2018 Nov 5. Spanish.


[Twenty-five myths in infectious diseases in primary care associated with overdiagnosis and overtreatment].

Llor C, Moragas A, Cordoba G.

Aten Primaria. 2018 Nov;50 Suppl 2:57-64. doi: 10.1016/j.aprim.2018.09.005. Epub 2018 Sep 27. Review. Spanish.


Long-term effect of a practice-based intervention (HAPPY AUDIT) aimed at reducing antibiotic prescribing in patients with respiratory tract infections.

Llor C, Bjerrum L, Molero JM, Moragas A, González López-Valcárcel B, Monedero MJ, Gómez M, Cid M, Alcántara JD, Cots JM, Ribas JM, García G, Ortega J, Pineda V, Guerra G, Munuera S; HAPPY AUDIT 3 Study Team.

J Antimicrob Chemother. 2018 Aug 1;73(8):2215-2222. doi: 10.1093/jac/dky137.


Previous antibiotic exposure and antibiotic resistance of commensal Staphylococcus aureus in Spanish primary care.

Boada A, Pons-Vigués M, Real J, Grezner E, Bolíbar B, Llor C.

Eur J Gen Pract. 2018 Dec;24(1):125-130. doi: 10.1080/13814788.2018.1444748.


Point-of-care urine culture for managing urinary tract infection in primary care: a randomised controlled trial of clinical and cost-effectiveness.

Butler CC, Francis NA, Thomas-Jones E, Longo M, Wootton M, Llor C, Little P, Moore M, Bates J, Pickles T, Kirby N, Gillespie D, Rumsby K, Brugman C, Gal M, Hood K, Verheij T.

Br J Gen Pract. 2018 Apr;68(669):e268-e278. doi: 10.3399/bjgp18X695285. Epub 2018 Feb 26.


Respuesta de los autores.

Llor C, Moragas A.

Aten Primaria. 2018 Mar;50(3):198-199. doi: 10.1016/j.aprim.2017.09.004. Epub 2018 Jan 17. No abstract available.


Respuesta de los autores.

Llor C.

Aten Primaria. 2018 Mar;50(3):200-201. doi: 10.1016/j.aprim.2017.09.008. Epub 2017 Dec 20. No abstract available.


Short courses of penicillin for streptococcal pharyngitis are not supported by the evidence.

Llor C, Bjerrum L.

Fam Pract. 2018 Mar 27;35(2):228-229. doi: 10.1093/fampra/cmx126. Review. No abstract available.


Variations in presentation, management, and patient outcomes of urinary tract infection: a prospective four-country primary care observational cohort study.

Butler CC, Francis N, Thomas-Jones E, Llor C, Bongard E, Moore M, Little P, Bates J, Lau M, Pickles T, Gal M, Wootton M, Kirby N, Gillespie D, Rumbsy K, Brugman C, Hood K, Verheij T.

Br J Gen Pract. 2017 Dec;67(665):e830-e841. doi: 10.3399/bjgp17X693641.


Efficacy of high doses of penicillin versus amoxicillin in the treatment of uncomplicated community acquired pneumonia in adults. A non-inferiority controlled clinical trial.

Llor C, Pérez A, Carandell E, García-Sangenís A, Rezola J, Llorente M, Gestoso S, Bobé F, Román-Rodríguez M, Cots JM, Hernández S, Cortés J, Miravitlles M, Morros R.

Aten Primaria. 2019 Jan;51(1):32-39. doi: 10.1016/j.aprim.2017.08.003. Epub 2017 Oct 20.


General practitioner use of a C-reactive protein point-of-care test to help target antibiotic prescribing in patients with acute exacerbations of chronic obstructive pulmonary disease (the PACE study): study protocol for a randomised controlled trial.

Bates J, Francis NA, White P, Gillespie D, Thomas-Jones E, Breen R, Kirby N, Hood K, Gal M, Phillips R, Naik G, Cals J, Llor C, Melbye H, Wootton M, Riga E, Cochrane A, Howe R, Fitzsimmons D, Sewell B, Alam MF, Butler CC.

Trials. 2017 Sep 29;18(1):442. doi: 10.1186/s13063-017-2144-8.


Reducing overdiagnosis in primary care is needed.

Llor C.

Eur J Gen Pract. 2017 Dec;23(1):215-216. doi: 10.1080/13814788.2017.1365836. No abstract available.


[Recommendations for the use of rapid diagnosis techniques in respiratory infections in primary care].

Llor C, Alkorta Gurrutxaga M, de la Flor I Bru J, Bernárdez Carracedo S, Cañada Merino JL, Bárcena Caamaño M, Serrano Martino C, Cots Yago JM.

Aten Primaria. 2017 Aug - Sep;49(7):426-437. doi: 10.1016/j.aprim.2017.03.010. Epub 2017 Jun 13. Spanish.


The STOP-AB trial protocol: efficacy and safety of discontinuing patient antibiotic treatment when physicians no longer consider it necessary.

Llor C, Moragas A, Bayona C, Cots JM, Molero JM, Ribas J, Fóthy JF, Gutiérrez I, Sánchez C, Ortega J, Arranz J, Botanes J, Robles P.

BMJ Open. 2017 Jun 6;7(5):e015814. doi: 10.1136/bmjopen-2016-015814.


Self-reported daily walking time in COPD: relationship with relevant clinical and functional characteristics.

Ramon MA, Esquinas C, Barrecheguren M, Pleguezuelos E, Molina J, Quintano JA, Roman-Rodríguez M, Naberan K, Llor C, Roncero C, Miravitlles M.

Int J Chron Obstruct Pulmon Dis. 2017 Apr 13;12:1173-1181. doi: 10.2147/COPD.S128234. eCollection 2017.


[Antibiotic susceptibility of Staphylococcus aureus and Streptococcus pneumoniae in healthy carrier individuals in primary care in Barcelona area].

Llor C, Boada A, Pons-Vigués M, Grenzner E, Juvé R, Almeda J.

Aten Primaria. 2018 Jan;50(1):44-52. doi: 10.1016/j.aprim.2016.12.008. Epub 2017 Apr 14. Spanish.


Clinicians' interpretations of point of care urine culture versus laboratory culture results: analysis from the four-country POETIC trial of diagnosis of uncomplicated urinary tract infection in primary care.

Hullegie S, Wootton M, Verheij TJM, Thomas-Jones E, Bates J, Hood K, Gal M, Francis NA, Little P, Moore M, Llor C, Pickles T, Gillespie D, Kirby N, Brugman C, Butler CC.

Fam Pract. 2017 Aug 1;34(4):392-399. doi: 10.1093/fampra/cmx009.


Debunking myths: The utilisation of antibiotics in primary care in Spain.

Llor C.

Aten Primaria. 2017 Mar;49(3):129-130. doi: 10.1016/j.aprim.2017.02.001. No abstract available.


Reducing antimicrobial resistance through population empowerment.

Llor C.

Eur J Gen Pract. 2017 Dec;23(1):51-52. doi: 10.1080/13814788.2016.1276166. No abstract available.


Survey of Spanish general practitioners' attitudes toward management of sore throat: an internet-based questionnaire study.

Llor C, Vilaseca I, Lehrer-Coriat E, Boleda X, Cañada JL, Moragas A, Cots JM.

BMC Fam Pract. 2017 Feb 14;18(1):21. doi: 10.1186/s12875-017-0597-1.


Estimated saving of antibiotics in pharyngitis and lower respiratory tract infections if general practitioners used rapid tests and followed guidelines.

Llor C, Moragas A, Cots JM, López-Valcárcel BG; Happy Audit Study Group.

Aten Primaria. 2017 Jun - Jul;49(6):319-325. doi: 10.1016/j.aprim.2016.07.002. Epub 2016 Nov 22.


Selling antimicrobials without prescription - Far beyond an administrative problem.

Guinovart MC, Figueras A, Llor C.

Enferm Infecc Microbiol Clin. 2018 May;36(5):290-292. doi: 10.1016/j.eimc.2016.10.006. Epub 2016 Nov 17. English, Spanish.


[Recommendations for management of acute pharyngitis in adults].

Cots JM, Alós JI, Bárcena M, Boleda X, Cañada JL, Gómez N, Mendoza A, Vilaseca I, Llor C.

Enferm Infecc Microbiol Clin. 2016 Nov;34(9):585-594. doi: 10.1016/j.eimc.2015.02.010. Epub 2015 Apr 11. Review. Spanish.


Diagnosis of alpha-1 antitrypsin deficiency: a population-based study.

Barrecheguren M, Monteagudo M, Simonet P, Llor C, Rodriguez E, Ferrer J, Esquinas C, Miravitlles M.

Int J Chron Obstruct Pulmon Dis. 2016 May 10;11:999-1004. doi: 10.2147/COPD.S108505. eCollection 2016.


Antibiotic prescribing for acute bronchitis.

Llor C, Bjerrum L.

Expert Rev Anti Infect Ther. 2016 Jul;14(7):633-42. doi: 10.1080/14787210.2016.1193435. Epub 2016 Jun 8. Review.


Discrepancies between qualitative and quantitative evaluation of randomised controlled trial results: achieving clarity through mixed methods triangulation.

Tonkin-Crine S, Anthierens S, Hood K, Yardley L, Cals JW, Francis NA, Coenen S, van der Velden AW, Godycki-Cwirko M, Llor C, Butler CC, Verheij TJ, Goossens H, Little P; GRACE INTRO/CHAMP consortium.

Implement Sci. 2016 May 12;11:66. doi: 10.1186/s13012-016-0436-0.


Mixed Diagnoses and Mixed Messages-Reply.

Alonso-Coello P, Llor C, de la Poza Abad M.

JAMA Intern Med. 2016 May 1;176(5):719. doi: 10.1001/jamainternmed.2016.1287. No abstract available.


Treatment patterns in COPD patients newly diagnosed in primary care. A population-based study.

Barrecheguren M, Monteagudo M, Ferrer J, Borrell E, Llor C, Esquinas C, Miravitlles M.

Respir Med. 2016 Feb;111:47-53. doi: 10.1016/j.rmed.2015.12.004. Epub 2015 Dec 23.


Prescription Strategies in Acute Uncomplicated Respiratory Infections: A Randomized Clinical Trial.

de la Poza Abad M, Mas Dalmau G, Moreno Bakedano M, González González AI, Canellas Criado Y, Hernández Anadón S, Rotaeche del Campo R, Torán Monserrat P, Negrete Palma A, Muñoz Ortiz L, Borrell Thió E, Llor C, Little P, Alonso-Coello P; Delayed Antibiotic Prescription (DAP) Group.

JAMA Intern Med. 2016 Jan;176(1):21-9. doi: 10.1001/jamainternmed.2015.7088.


Antibiotics without prescription: more cons than pros.

Llor C.

BMJ. 2015 Aug 11;351:h4202. doi: 10.1136/bmj.h4202. No abstract available.


[Recommendations for management of acute pharyngitis in adults].

Cots JM, Alós JI, Bárcena M, Boleda X, Cañada JL, Gómez N, Mendoza A, Vilaseca I, Llor C.

Aten Primaria. 2015 Oct;47(8):532-43. doi: 10.1016/j.aprim.2015.02.002. Epub 2015 May 27. Spanish.

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