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Items: 14

1.

A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation.

Castroviejo-Bermejo M, Cruz C, Llop-Guevara A, Gutiérrez-Enríquez S, Ducy M, Ibrahim YH, Gris-Oliver A, Pellegrino B, Bruna A, Guzmán M, Rodríguez O, Grueso J, Bonache S, Moles-Fernández A, Villacampa G, Viaplana C, Gómez P, Vidal M, Peg V, Serres-Créixams X, Dellaire G, Simard J, Nuciforo P, Rubio IT, Dientsmann R, Barrett JC, Caldas C, Baselga J, Saura C, Cortés J, Déas O, Jonkers J, Masson JY, Cairo S, Judde JG, O'Connor MJ, Díez O, Balmaña J, Serra V.

EMBO Mol Med. 2018 Oct 30. pii: e9172. doi: 10.15252/emmm.201809172. [Epub ahead of print]

2.

Multicenter Phase II Study of Lurbinectedin in BRCA-Mutated and Unselected Metastatic Advanced Breast Cancer and Biomarker Assessment Substudy.

Cruz C, Llop-Guevara A, Garber JE, Arun BK, Pérez Fidalgo JA, Lluch A, Telli ML, Fernández C, Kahatt C, Galmarini CM, Soto-Matos A, Alfaro V, Pérez de la Haza A, Domchek SM, Antolin S, Vahdat L, Tung NM, Lopez R, Arribas J, Vivancos A, Baselga J, Serra V, Balmaña J, Isakoff SJ.

J Clin Oncol. 2018 Sep 21:JCO2018786558. doi: 10.1200/JCO.2018.78.6558. [Epub ahead of print] Erratum in: J Clin Oncol. 2018 Nov 20;36(33):3348.

3.

RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer.

Cruz C, Castroviejo-Bermejo M, Gutiérrez-Enríquez S, Llop-Guevara A, Ibrahim YH, Gris-Oliver A, Bonache S, Morancho B, Bruna A, Rueda OM, Lai Z, Polanska UM, Jones GN, Kristel P, de Bustos L, Guzman M, Rodríguez O, Grueso J, Montalban G, Caratú G, Mancuso F, Fasani R, Jiménez J, Howat WJ, Dougherty B, Vivancos A, Nuciforo P, Serres-Créixams X, Rubio IT, Oaknin A, Cadogan E, Barrett JC, Caldas C, Baselga J, Saura C, Cortés J, Arribas J, Jonkers J, Díez O, O'Connor MJ, Balmaña J, Serra V.

Ann Oncol. 2018 May 1;29(5):1203-1210. doi: 10.1093/annonc/mdy099.

4.

Activity of HSP90 Inhibiton in a Metastatic Lung Cancer Patient With a Germline BRCA1 Mutation.

Cedrés S, Felip E, Cruz C, Martinez de Castro A, Pardo N, Navarro A, Martinez-Marti A, Remon J, Zeron-Medina J, Balmaña J, Llop-Guevara A, Miquel JM, Sansano I, Nuciforo P, Mancuso F, Serra V, Vivancos A.

J Natl Cancer Inst. 2018 Aug 1;110(8):914-917. doi: 10.1093/jnci/djy012.

5.

Simultaneous inhibition of JAK and SYK kinases ameliorates chronic and destructive arthritis in mice.

Llop-Guevara A, Porras M, Cendón C, Di Ceglie I, Siracusa F, Madarena F, Rinotas V, Gómez L, van Lent PL, Douni E, Chang HD, Kamradt T, Román J.

Arthritis Res Ther. 2015 Dec 10;17:356. doi: 10.1186/s13075-015-0866-0.

6.

Therapeutic potential of anti-IL-6 therapies for granulocytic airway inflammation in asthma.

Chu DK, Al-Garawi A, Llop-Guevara A, Pillai RA, Radford K, Shen P, Walker TD, Goncharova S, Calhoun WJ, Nair P, Jordana M.

Allergy Asthma Clin Immunol. 2015 Apr 12;11(1):14. doi: 10.1186/s13223-015-0081-1. eCollection 2015.

7.

Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo.

Chu DK, Jimenez-Saiz R, Verschoor CP, Walker TD, Goncharova S, Llop-Guevara A, Shen P, Gordon ME, Barra NG, Bassett JD, Kong J, Fattouh R, McCoy KD, Bowdish DM, Erjefält JS, Pabst O, Humbles AA, Kolbeck R, Waserman S, Jordana M.

J Exp Med. 2014 Jul 28;211(8):1657-72. doi: 10.1084/jem.20131800.

8.

T helper cell IL-4 drives intestinal Th2 priming to oral peanut antigen, under the control of OX40L and independent of innate-like lymphocytes.

Chu DK, Mohammed-Ali Z, Jiménez-Saiz R, Walker TD, Goncharova S, Llop-Guevara A, Kong J, Gordon ME, Barra NG, Gillgrass AE, Van Seggelen H, Khan WI, Ashkar AA, Bramson JL, Humbles AA, Kolbeck R, Waserman S, Jordana M.

Mucosal Immunol. 2014 Nov;7(6):1395-404. doi: 10.1038/mi.2014.29. Epub 2014 Apr 30.

PMID:
24781052
9.

A GM-CSF/IL-33 pathway facilitates allergic airway responses to sub-threshold house dust mite exposure.

Llop-Guevara A, Chu DK, Walker TD, Goncharova S, Fattouh R, Silver JS, Moore CL, Xie JL, O'Byrne PM, Coyle AJ, Kolbeck R, Humbles AA, Stämpfli MR, Jordana M.

PLoS One. 2014 Feb 14;9(2):e88714. doi: 10.1371/journal.pone.0088714. eCollection 2014.

10.

IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization.

Chu DK, Llop-Guevara A, Walker TD, Flader K, Goncharova S, Boudreau JE, Moore CL, Seunghyun In T, Waserman S, Coyle AJ, Kolbeck R, Humbles AA, Jordana M.

J Allergy Clin Immunol. 2013 Jan;131(1):187-200.e1-8. doi: 10.1016/j.jaci.2012.08.002. Epub 2012 Sep 21.

PMID:
23006545
11.

Cigarette smoke differentially affects eosinophilia and remodeling in a model of house dust mite asthma.

Botelho FM, Llop-Guevara A, Trimble NJ, Nikota JK, Bauer CM, Lambert KN, Kianpour S, Jordana M, Stämpfli MR.

Am J Respir Cell Mol Biol. 2011 Oct;45(4):753-60. doi: 10.1165/rcmb.2010-0404OC. Epub 2011 Feb 11.

PMID:
21317378
12.

A mouse model of airway disease: oncostatin M-induced pulmonary eosinophilia, goblet cell hyperplasia, and airway hyperresponsiveness are STAT6 dependent, and interstitial pulmonary fibrosis is STAT6 independent.

Fritz DK, Kerr C, Fattouh R, Llop-Guevara A, Khan WI, Jordana M, Richards CD.

J Immunol. 2011 Jan 15;186(2):1107-18. doi: 10.4049/jimmunol.0903476. Epub 2010 Dec 15.

13.

In vivo-to-in silico iterations to investigate aeroallergen-host interactions.

Llop-Guevara A, Colangelo M, Chu DK, Moore CL, Stieber NA, Walker TD, Goncharova S, Coyle AJ, Lundblad LK, O'Byrne PM, Lovric M, Jordana M.

PLoS One. 2008 Jun 11;3(6):e2426. doi: 10.1371/journal.pone.0002426.

14.

Modeling responses to respiratory house dust mite exposure.

Cates EC, Fattouh R, Johnson JR, Llop-Guevara A, Jordana M.

Contrib Microbiol. 2007;14:42-67. Review.

PMID:
17684332

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