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Best matches for Llinás M[au]:

Nutrient sensing modulates malaria parasite virulence. Mancio-Silva L et al. Nature. (2017)

Regulation of Sexual Commitment and Gametocytogenesis in Malaria Parasites. Josling GA et al. Annu Rev Microbiol. (2018)

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials. Antonova-Koch Y et al. Science. (2018)

Search results

Items: 1 to 50 of 271

1.

Hierarchical transcriptional control regulates Plasmodium falciparum sexual differentiation.

van Biljon R, van Wyk R, Painter HJ, Orchard L, Reader J, Niemand J, Llinás M, Birkholtz LM.

BMC Genomics. 2019 Dec 3;20(1):920. doi: 10.1186/s12864-019-6322-9.

2.

Trophoblast-induced spiral artery remodelling and uteroplacental haemodynamics in pregnant rats with increased blood pressure induced by heme oxygenase inhibition.

Oltra L, Reverte V, Garcés B, Li Volti G, Moreno JM, Salazar FJ, Llinás MT.

Placenta. 2019 Nov 21;89:91-98. doi: 10.1016/j.placenta.2019.11.002. [Epub ahead of print]

PMID:
31778922
3.

A novel antiparasitic compound kills ring-stage Plasmodium falciparum and retains activity against artemisinin-resistant parasites.

Clements RL, Streva V, Dumoulin P, Huang W, Owens E, Raj DK, Burleigh B, Llinás M, Winzeler EA, Zhang Q, Dvorin JD.

J Infect Dis. 2019 Oct 16. pii: jiz534. doi: 10.1093/infdis/jiz534. [Epub ahead of print]

PMID:
31616928
4.

The G9a Histone Methyltransferase Inhibitor BIX-01294 Modulates Gene Expression during Plasmodium falciparum Gametocyte Development and Transmission.

Ngwa CJ, Kiesow MJ, Orchard LM, Farrukh A, Llinás M, Pradel G.

Int J Mol Sci. 2019 Oct 14;20(20). pii: E5087. doi: 10.3390/ijms20205087.

5.

First-in-human trial of blood-brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound.

Abrahao A, Meng Y, Llinas M, Huang Y, Hamani C, Mainprize T, Aubert I, Heyn C, Black SE, Hynynen K, Lipsman N, Zinman L.

Nat Commun. 2019 Sep 26;10(1):4373. doi: 10.1038/s41467-019-12426-9.

6.

Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum.

Schalkwijk J, Allman EL, Jansen PAM, de Vries LE, Verhoef JMJ, Jackowski S, Botman PNM, Beuckens-Schortinghuis CA, Koolen KMJ, Bolscher JM, Vos MW, Miller K, Reeves SA, Pett H, Trevitt G, Wittlin S, Scheurer C, Sax S, Fischli C, Angulo-Barturen I, Jiménez-Diaz MB, Josling G, Kooij TWA, Bonnert R, Campo B, Blaauw RH, Rutjes FPJT, Sauerwein RW, Llinás M, Hermkens PHH, Dechering KJ.

Sci Transl Med. 2019 Sep 18;11(510). pii: eaas9917. doi: 10.1126/scitranslmed.aas9917.

PMID:
31534021
7.

Isothiocyanate-Functionalized Mesoporous Silica Nanoparticles as Building Blocks for the Design of Nanovehicles with Optimized Drug Release Profile.

Martínez-Edo G, Llinàs MC, Borrós S, Sánchez-García D.

Nanomaterials (Basel). 2019 Aug 29;9(9). pii: E1219. doi: 10.3390/nano9091219.

8.

Cutting back malaria: CRISPR/Cas9 genome editing of Plasmodium.

Lee MCS, Lindner SE, Lopez-Rubio JJ, Llinás M.

Brief Funct Genomics. 2019 Sep 24;18(5):281-289. doi: 10.1093/bfgp/elz012.

9.

Commitment Isn't for Everyone.

Josling GA, Llinás M.

Trends Parasitol. 2019 Jun;35(6):381-383. doi: 10.1016/j.pt.2019.03.012. Epub 2019 Apr 30.

PMID:
31053335
10.

Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis.

Istvan ES, Das S, Bhatnagar S, Beck JR, Owen E, Llinas M, Ganesan SM, Niles JC, Winzeler E, Vaidya AB, Goldberg DE.

Elife. 2019 Mar 19;8. pii: e40529. doi: 10.7554/eLife.40529.

11.

Successful spinal cord stimulation for severe medication-refractory restless legs syndrome.

De Vloo P, Reddy GD, Rowland N, Sammartino F, Llinas M, Paul D, Murray BJ, Lang AE, Fasano A, Munhoz RP, Kalia SK.

Mov Disord. 2019 Apr;34(4):585-586. doi: 10.1002/mds.27644. Epub 2019 Feb 15. No abstract available.

PMID:
30768799
12.

Identifying the Components of Acidosis in Patients With Severe Plasmodium falciparum Malaria Using Metabolomics.

Leopold SJ, Ghose A, Allman EL, Kingston HWF, Hossain A, Dutta AK, Plewes K, Chotivanich K, Day NPJ, Tarning J, Winterberg M, White NJ, Llinás M, Dondorp AM.

J Infect Dis. 2019 May 5;219(11):1766-1776. doi: 10.1093/infdis/jiy727.

13.

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.

Antonova-Koch Y, Meister S, Abraham M, Luth MR, Ottilie S, Lukens AK, Sakata-Kato T, Vanaerschot M, Owen E, Jado JC, Maher SP, Calla J, Plouffe D, Zhong Y, Chen K, Chaumeau V, Conway AJ, McNamara CW, Ibanez M, Gagaring K, Serrano FN, Eribez K, Taggard CM, Cheung AL, Lincoln C, Ambachew B, Rouillier M, Siegel D, Nosten F, Kyle DE, Gamo FJ, Zhou Y, Llinás M, Fidock DA, Wirth DF, Burrows J, Campo B, Winzeler EA.

Science. 2018 Dec 7;362(6419). pii: eaat9446. doi: 10.1126/science.aat9446.

14.

Sex-dependent differences in the adverse renal changes induced by an early in life exposure to a high-fat diet.

Moreno JM, Tapia A, Martinez CM, Reverte V, Oltra L, Llinas MT, Salazar FJ.

Am J Physiol Renal Physiol. 2019 Feb 1;316(2):F332-F340. doi: 10.1152/ajprenal.00394.2018. Epub 2018 Dec 5.

PMID:
30516421
15.

Focused ultrasound thalamotomy location determines clinical benefits in patients with essential tremor.

Boutet A, Ranjan M, Zhong J, Germann J, Xu D, Schwartz ML, Lipsman N, Hynynen K, Devenyi GA, Chakravarty M, Hlasny E, Llinas M, Lozano CS, Elias GJB, Chan J, Coblentz A, Fasano A, Kucharczyk W, Hodaie M, Lozano AM.

Brain. 2018 Dec 1;141(12):3405-3414. doi: 10.1093/brain/awy278.

PMID:
30452554
16.

Inducing controlled cell cycle arrest and re-entry during asexual proliferation of Plasmodium falciparum malaria parasites.

van Biljon R, Niemand J, van Wyk R, Clark K, Verlinden B, Abrie C, von Grüning H, Smidt W, Smit A, Reader J, Painter H, Llinás M, Doerig C, Birkholtz LM.

Sci Rep. 2018 Nov 8;8(1):16581. doi: 10.1038/s41598-018-34964-w.

17.

Magnetic resonance-guided focused ultrasound thalamotomy for treatment of essential tremor: A 2-year outcome study.

Meng Y, Solomon B, Boutet A, Llinas M, Scantlebury N, Huang Y, Hynynen K, Hamani C, Fasano A, Lozano AM, Lipsman N, Schwartz ML.

Mov Disord. 2018 Oct;33(10):1647-1650. doi: 10.1002/mds.99. Epub 2018 Oct 4.

PMID:
30288794
18.

Lipopeptisomes: Anticancer peptide-assembled particles for fusolytic oncotherapy.

Aronson MR, Simonson AW, Orchard LM, Llinás M, Medina SH.

Acta Biomater. 2018 Oct 15;80:269-277. doi: 10.1016/j.actbio.2018.09.025. Epub 2018 Sep 19.

PMID:
30240951
19.

NLCs as a potential carrier system for transdermal delivery of forskolin.

Lasoń E, Sikora E, Miastkowska M, Escribano E, Garcia-Celma MJ, Solans C, Llinas M, Ogonowski J.

Acta Biochim Pol. 2018;65(3):437-442. doi: 10.18388/abp.2018_2554. Epub 2018 Sep 15.

20.

Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter.

Lee AH, Dhingra SK, Lewis IA, Singh MK, Siriwardana A, Dalal S, Rubiano K, Klein MS, Baska KS, Krishna S, Klemba M, Roepe PD, Llinás M, Garcia CRS, Fidock DA.

Sci Rep. 2018 Sep 11;8(1):13578. doi: 10.1038/s41598-018-31715-9.

21.

Glycolysis is important for optimal asexual growth and formation of mature tissue cysts by Toxoplasma gondii.

Shukla A, Olszewski KL, Llinás M, Rommereim LM, Fox BA, Bzik DJ, Xia D, Wastling J, Beiting D, Roos DS, Shanmugam D.

Int J Parasitol. 2018 Oct;48(12):955-968. doi: 10.1016/j.ijpara.2018.05.013. Epub 2018 Aug 31.

PMID:
30176233
22.

A seven-helix protein constitutes stress granules crucial for regulating translation during human-to-mosquito transmission of Plasmodium falciparum.

Bennink S, von Bohl A, Ngwa CJ, Henschel L, Kuehn A, Pilch N, Weißbach T, Rosinski AN, Scheuermayer M, Repnik U, Przyborski JM, Minns AM, Orchard LM, Griffiths G, Lindner SE, Llinás M, Pradel G.

PLoS Pathog. 2018 Aug 22;14(8):e1007249. doi: 10.1371/journal.ppat.1007249. eCollection 2018 Aug.

23.

Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development.

Painter HJ, Chung NC, Sebastian A, Albert I, Storey JD, Llinás M.

Nat Commun. 2018 Jul 9;9(1):2656. doi: 10.1038/s41467-018-04966-3.

24.

Regulation of Sexual Commitment and Gametocytogenesis in Malaria Parasites.

Josling GA, Williamson KC, Llinás M.

Annu Rev Microbiol. 2018 Sep 8;72:501-519. doi: 10.1146/annurev-micro-090817-062712. Epub 2018 Jul 5. Review.

PMID:
29975590
25.

Preparation of a mesoporous silica-based nano-vehicle for dual DOX/CPT pH-triggered delivery.

Llinàs MC, Martínez-Edo G, Cascante A, Porcar I, Borrós S, Sánchez-García D.

Drug Deliv. 2018 Nov;25(1):1137-1146. doi: 10.1080/10717544.2018.1472678.

26.

Magnetic Resonance Imaging-Guided Focused Ultrasound Thalamotomy in Parkinson Tremor: Reoperation After Benefit Decay.

Fasano A, De Vloo P, Llinas M, Hlasny E, Kucharczyk W, Hamani C, Lozano AM.

Mov Disord. 2018 May;33(5):848-849. doi: 10.1002/mds.27348. Epub 2018 Mar 23. No abstract available.

PMID:
29570865
27.

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics.

Cowell AN, Istvan ES, Lukens AK, Gomez-Lorenzo MG, Vanaerschot M, Sakata-Kato T, Flannery EL, Magistrado P, Owen E, Abraham M, LaMonte G, Painter HJ, Williams RM, Franco V, Linares M, Arriaga I, Bopp S, Corey VC, Gnädig NF, Coburn-Flynn O, Reimer C, Gupta P, Murithi JM, Moura PA, Fuchs O, Sasaki E, Kim SW, Teng CH, Wang LT, Akidil A, Adjalley S, Willis PA, Siegel D, Tanaseichuk O, Zhong Y, Zhou Y, Llinás M, Ottilie S, Gamo FJ, Lee MCS, Goldberg DE, Fidock DA, Wirth DF, Winzeler EA.

Science. 2018 Jan 12;359(6372):191-199. doi: 10.1126/science.aan4472.

28.

Specific Inhibition of the Bifunctional Farnesyl/Geranylgeranyl Diphosphate Synthase in Malaria Parasites via a New Small-Molecule Binding Site.

Gisselberg JE, Herrera Z, Orchard LM, Llinás M, Yeh E.

Cell Chem Biol. 2018 Feb 15;25(2):185-193.e5. doi: 10.1016/j.chembiol.2017.11.010. Epub 2017 Dec 21.

29.

Less Lipid, More Commitment.

Llinás M.

Cell. 2017 Dec 14;171(7):1474-1476. doi: 10.1016/j.cell.2017.11.044.

30.

Nano-emulsions as vehicles for topical delivery of forskolin.

Miastkowska M, Sikora E, Lasoń E, Garcia-Celma MJ, Escribano-Ferrer E, Solans C, Llinas M.

Acta Biochim Pol. 2017;64(4):713-718. doi: 10.18388/abp.2017_2334. Epub 2017 Dec 13.

31.

Simultaneous genome-wide gene expression and transcript isoform profiling in the human malaria parasite.

Turnbull LB, Siwo GH, Button-Simons KA, Tan A, Checkley LA, Painter HJ, Llinás M, Ferdig MT.

PLoS One. 2017 Nov 7;12(11):e0187595. doi: 10.1371/journal.pone.0187595. eCollection 2017.

32.

Transcriptional Profiling Defines Histone Acetylation as a Regulator of Gene Expression during Human-to-Mosquito Transmission of the Malaria Parasite Plasmodium falciparum.

Ngwa CJ, Kiesow MJ, Papst O, Orchard LM, Filarsky M, Rosinski AN, Voss TS, Llinás M, Pradel G.

Front Cell Infect Microbiol. 2017 Jul 24;7:320. doi: 10.3389/fcimb.2017.00320. eCollection 2017.

33.

MRI-guided focused ultrasound thalamotomy in non-ET tremor syndromes.

Fasano A, Llinas M, Munhoz RP, Hlasny E, Kucharczyk W, Lozano AM.

Neurology. 2017 Aug 22;89(8):771-775. doi: 10.1212/WNL.0000000000004268. Epub 2017 Jul 26.

PMID:
28747452
34.

Nutrient sensing modulates malaria parasite virulence.

Mancio-Silva L, Slavic K, Grilo Ruivo MT, Grosso AR, Modrzynska KK, Vera IM, Sales-Dias J, Gomes AR, MacPherson CR, Crozet P, Adamo M, Baena-Gonzalez E, Tewari R, Llinás M, Billker O, Mota MM.

Nature. 2017 Jul 13;547(7662):213-216. doi: 10.1038/nature23009. Epub 2017 Jul 5.

35.

Red Blood Cell Invasion by the Malaria Parasite Is Coordinated by the PfAP2-I Transcription Factor.

Santos JM, Josling G, Ross P, Joshi P, Orchard L, Campbell T, Schieler A, Cristea IM, Llinás M.

Cell Host Microbe. 2017 Jun 14;21(6):731-741.e10. doi: 10.1016/j.chom.2017.05.006.

36.

Capturing in vivo RNA transcriptional dynamics from the malaria parasite Plasmodium falciparum.

Painter HJ, Carrasquilla M, Llinás M.

Genome Res. 2017 Jun;27(6):1074-1086. doi: 10.1101/gr.217356.116. Epub 2017 Apr 17.

37.

Quantitative chromatin proteomics reveals a dynamic histone post-translational modification landscape that defines asexual and sexual Plasmodium falciparum parasites.

Coetzee N, Sidoli S, van Biljon R, Painter H, Llinás M, Garcia BA, Birkholtz LM.

Sci Rep. 2017 Apr 4;7(1):607. doi: 10.1038/s41598-017-00687-7.

38.

Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology.

Gabryszewski SJ, Dhingra SK, Combrinck JM, Lewis IA, Callaghan PS, Hassett MR, Siriwardana A, Henrich PP, Lee AH, Gnädig NF, Musset L, Llinás M, Egan TJ, Roepe PD, Fidock DA.

PLoS Pathog. 2016 Nov 10;12(11):e1005976. doi: 10.1371/journal.ppat.1005976. eCollection 2016 Nov.

39.

Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways.

Allman EL, Painter HJ, Samra J, Carrasquilla M, Llinás M.

Antimicrob Agents Chemother. 2016 Oct 21;60(11):6635-6649. doi: 10.1128/AAC.01224-16. Print 2016 Nov.

40.

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, Baker S, Ben Mamoun C, Bhatia S, Bickle Q, Bounaadja L, Bowling T, Bosch J, Boucher LE, Boyom FF, Brea J, Brennan M, Burton A, Caffrey CR, Camarda G, Carrasquilla M, Carter D, Belen Cassera M, Chih-Chien Cheng K, Chindaudomsate W, Chubb A, Colon BL, Colón-López DD, Corbett Y, Crowther GJ, Cowan N, D'Alessandro S, Le Dang N, Delves M, DeRisi JL, Du AY, Duffy S, Abd El-Salam El-Sayed S, Ferdig MT, Fernández Robledo JA, Fidock DA, Florent I, Fokou PV, Galstian A, Gamo FJ, Gokool S, Gold B, Golub T, Goldgof GM, Guha R, Guiguemde WA, Gural N, Guy RK, Hansen MA, Hanson KK, Hemphill A, Hooft van Huijsduijnen R, Horii T, Horrocks P, Hughes TB, Huston C, Igarashi I, Ingram-Sieber K, Itoe MA, Jadhav A, Naranuntarat Jensen A, Jensen LT, Jiang RH, Kaiser A, Keiser J, Ketas T, Kicka S, Kim S, Kirk K, Kumar VP, Kyle DE, Lafuente MJ, Landfear S, Lee N, Lee S, Lehane AM, Li F, Little D, Liu L, Llinás M, Loza MI, Lubar A, Lucantoni L, Lucet I, Maes L, Mancama D, Mansour NR, March S, McGowan S, Medina Vera I, Meister S, Mercer L, Mestres J, Mfopa AN, Misra RN, Moon S, Moore JP, Morais Rodrigues da Costa F, Müller J, Muriana A, Nakazawa Hewitt S, Nare B, Nathan C, Narraidoo N, Nawaratna S, Ojo KK, Ortiz D, Panic G, Papadatos G, Parapini S, Patra K, Pham N, Prats S, Plouffe DM, Poulsen SA, Pradhan A, Quevedo C, Quinn RJ, Rice CA, Abdo Rizk M, Ruecker A, St Onge R, Salgado Ferreira R, Samra J, Robinett NG, Schlecht U, Schmitt M, Silva Villela F, Silvestrini F, Sinden R, Smith DA, Soldati T, Spitzmüller A, Stamm SM, Sullivan DJ, Sullivan W, Suresh S, Suzuki BM, Suzuki Y, Swamidass SJ, Taramelli D, Tchokouaha LR, Theron A, Thomas D, Tonissen KF, Townson S, Tripathi AK, Trofimov V, Udenze KO, Ullah I, Vallieres C, Vigil E, Vinetz JM, Voong Vinh P, Vu H, Watanabe NA, Weatherby K, White PM, Wilks AF, Winzeler EA, Wojcik E, Wree M, Wu W, Yokoyama N, Zollo PH, Abla N, Blasco B, Burrows J, Laleu B, Leroy D, Spangenberg T, Wells T, Willis PA.

PLoS Pathog. 2016 Jul 28;12(7):e1005763. doi: 10.1371/journal.ppat.1005763. eCollection 2016 Jul.

41.

MRI-guided focused ultrasound thalamotomy in fragile X-associated tremor/ataxia syndrome.

Fasano A, Sammartino F, Llinas M, Lozano AM.

Neurology. 2016 Aug 16;87(7):736-8. doi: 10.1212/WNL.0000000000002982. Epub 2016 Jul 20. No abstract available.

PMID:
27440151
42.

Studies on the formation of polymeric nano-emulsions obtained via low-energy emulsification and their use as templates for drug delivery nanoparticle dispersions.

Calderó G, Montes R, Llinàs M, García-Celma MJ, Porras M, Solans C.

Colloids Surf B Biointerfaces. 2016 Sep 1;145:922-931. doi: 10.1016/j.colsurfb.2016.06.013. Epub 2016 Jun 8.

PMID:
27341306
43.

Characterization of the Plasmodium falciparum and P. berghei glycerol 3-phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite apicoplast.

Shears MJ, MacRae JI, Mollard V, Goodman CD, Sturm A, Orchard LM, Llinás M, McConville MJ, Botté CY, McFadden GI.

Cell Microbiol. 2017 Jan;19(1). doi: 10.1111/cmi.12633. Epub 2016 Aug 1.

44.

Proteome-wide analysis reveals widespread lysine acetylation of major protein complexes in the malaria parasite.

Cobbold SA, Santos JM, Ochoa A, Perlman DH, Llinás M.

Sci Rep. 2016 Jan 27;6:19722. doi: 10.1038/srep19722.

45.

Genome-wide transcriptome profiling reveals functional networks involving the Plasmodium falciparum drug resistance transporters PfCRT and PfMDR1.

Adjalley SH, Scanfeld D, Kozlowski E, Llinás M, Fidock DA.

BMC Genomics. 2015 Dec 21;16:1090. doi: 10.1186/s12864-015-2320-8.

46.

Sequestration and metabolism of host cell arginine by the intraerythrocytic malaria parasite Plasmodium falciparum.

Cobbold SA, Llinás M, Kirk K.

Cell Microbiol. 2016 Jun;18(6):820-30. doi: 10.1111/cmi.12552. Epub 2016 Jan 6.

PMID:
26633083
47.

Nitric oxide, prostaglandins and angiotensin II in the regulation of renal medullary blood flow during volume expansion.

Moreno C, Llinás MT, Rodriguez F, Moreno JM, Salazar FJ.

J Physiol Biochem. 2016 Mar;72(1):1-8. doi: 10.1007/s13105-015-0450-8. Epub 2015 Nov 26.

PMID:
26611113
48.

Beyond the E-Value: Stratified Statistics for Protein Domain Prediction.

Ochoa A, Storey JD, Llinás M, Singh M.

PLoS Comput Biol. 2015 Nov 17;11(11):e1004509. doi: 10.1371/journal.pcbi.1004509. eCollection 2015 Nov.

49.

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities.

Pulcini S, Staines HM, Lee AH, Shafik SH, Bouyer G, Moore CM, Daley DA, Hoke MJ, Altenhofen LM, Painter HJ, Mu J, Ferguson DJ, Llinás M, Martin RE, Fidock DA, Cooper RA, Krishna S.

Sci Rep. 2015 Sep 30;5:14552. doi: 10.1038/srep14552.

50.

Sexual development in Plasmodium parasites: knowing when it's time to commit.

Josling GA, Llinás M.

Nat Rev Microbiol. 2015 Sep;13(9):573-87. doi: 10.1038/nrmicro3519. Review.

PMID:
26272409

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