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Items: 43

1.

Predictors of recurrence, early treatment failure and death from Staphylococcus aureus bacteraemia: observational analyses within the ARREST trial.

Szubert A, Bailey SL, Cooke GS, Peto T, Llewelyn MJ, Edgeworth JD, Walker AS, Thwaites GE; United Kingdom Clinical Infection Research Group (UKCIRG).

J Infect. 2019 Aug 6. pii: S0163-4453(19)30240-3. doi: 10.1016/j.jinf.2019.08.001. [Epub ahead of print]

2.

Adaptation and implementation of the ARK (Antibiotic Review Kit) Intervention to safely and substantially reduce antibiotic use in hospitals: A feasibility study.

Cross ELA, Sivyer K, Islam J, Santillo M, Mowbray F, Peto TEA, Walker AS, Yardley L, Llewelyn MJ.

J Hosp Infect. 2019 Aug 5. pii: S0195-6701(19)30311-1. doi: 10.1016/j.jhin.2019.07.017. [Epub ahead of print]

PMID:
31394146
3.

Antibiotic Review Kit for Hospitals (ARK-Hospital): study protocol for a stepped-wedge cluster-randomised controlled trial.

Walker AS, Budgell E, Laskawiec-Szkonter M, Sivyer K, Wordsworth S, Quaddy J, Santillo M, Krusche A, Roope LSJ, Bright N, Mowbray F, Jones N, Hand K, Rahman N, Dobson M, Hedley E, Crook D, Sharland M, Roseveare C, Hobbs FDR, Butler C, Vaughan L, Hopkins S, Yardley L, Peto TEA, Llewelyn MJ; ARK trial team.

Trials. 2019 Jul 11;20(1):421. doi: 10.1186/s13063-019-3497-y.

4.

Duration of antibiotic treatment for common infections in English primary care: cross sectional analysis and comparison with guidelines.

Pouwels KB, Hopkins S, Llewelyn MJ, Walker AS, McNulty CA, Robotham JV.

BMJ. 2019 Feb 27;364:l440. doi: 10.1136/bmj.l440.

5.

The quality of studies evaluating antimicrobial stewardship interventions: a systematic review.

Schweitzer VA, van Heijl I, van Werkhoven CH, Islam J, Hendriks-Spoor KD, Bielicki J, Bonten MJM, Walker AS, Llewelyn MJ; Consensus on Antimicrobial Stewardship Evaluations (CASE) study group.

Clin Microbiol Infect. 2019 May;25(5):555-561. doi: 10.1016/j.cmi.2018.11.002. Epub 2018 Nov 23.

PMID:
30472426
6.

Adjunctive rifampicin to reduce early mortality from Staphylococcus aureus bacteraemia: the ARREST RCT.

Thwaites GE, Scarborough M, Szubert A, Saramago Goncalves P, Soares M, Bostock J, Nsutebu E, Tilley R, Cunningham R, Greig J, Wyllie SA, Wilson P, Auckland C, Cairns J, Ward D, Lal P, Guleri A, Jenkins N, Sutton J, Wiselka M, Armando GR, Graham C, Chadwick PR, Barlow G, Gordon NC, Young B, Meisner S, McWhinney P, Price DA, Harvey D, Nayar D, Jeyaratnam D, Planche T, Minton J, Hudson F, Hopkins S, Williams J, Török ME, Llewelyn MJ, Edgeworth JD, Walker AS.

Health Technol Assess. 2018 Oct;22(59):1-148. doi: 10.3310/hta22590.

7.

Survival following Staphylococcus aureus bloodstream infection: A prospective multinational cohort study assessing the impact of place of care.

Nambiar K, Seifert H, Rieg S, Kern WV, Scarborough M, Gordon NC, Kim HB, Song KH, Tilley R, Gott H, Liao CH, Edgeworth J, Nsutebu E, López-Cortés LE, Morata L, Walker AS, Thwaites G, Llewelyn MJ, Kaasch AJ; International Staphylococcus aureus collaboration (ISAC) study group (with linked authorship to members in the Acknowledgements) and the ESCMID Study Group for Bloodstream Infections and Sepsis (ESGBIS).

J Infect. 2018 Dec;77(6):516-525. doi: 10.1016/j.jinf.2018.08.015. Epub 2018 Sep 1.

PMID:
30179645
8.

Trends over time in Escherichia coli bloodstream infections, urinary tract infections, and antibiotic susceptibilities in Oxfordshire, UK, 1998-2016: a study of electronic health records.

Vihta KD, Stoesser N, Llewelyn MJ, Quan TP, Davies T, Fawcett NJ, Dunn L, Jeffery K, Butler CC, Hayward G, Andersson M, Morgan M, Oakley S, Mason A, Hopkins S, Wyllie DH, Crook DW, Wilcox MH, Johnson AP, Peto TEA, Walker AS.

Lancet Infect Dis. 2018 Oct;18(10):1138-1149. doi: 10.1016/S1473-3099(18)30353-0. Epub 2018 Aug 17.

9.

Overview of systematic reviews assessing the evidence for shorter versus longer duration antibiotic treatment for bacterial infections in secondary care.

Onakpoya IJ, Walker AS, Tan PS, Spencer EA, Gbinigie OA, Cook J, Llewelyn MJ, Butler CC.

PLoS One. 2018 Mar 28;13(3):e0194858. doi: 10.1371/journal.pone.0194858. eCollection 2018. Review.

10.

A national quality incentive scheme to reduce antibiotic overuse in hospitals: evaluation of perceptions and impact.

Islam J, Ashiru-Oredope D, Budd E, Howard P, Walker AS, Hopkins S, Llewelyn MJ.

J Antimicrob Chemother. 2018 Jun 1;73(6):1708-1713. doi: 10.1093/jac/dky041.

PMID:
29506043
11.

Severity of Systemic Inflammatory Response Syndrome Affects the Blood Levels of Circulating Inflammatory-Relevant MicroRNAs.

Caserta S, Mengozzi M, Kern F, Newbury SF, Ghezzi P, Llewelyn MJ.

Front Immunol. 2018 Feb 5;8:1977. doi: 10.3389/fimmu.2017.01977. eCollection 2017.

12.

Robust Prediction of Resistance to Trimethoprim in Staphylococcus aureus.

Fowler PW, Cole K, Gordon NC, Kearns AM, Llewelyn MJ, Peto TEA, Crook DW, Walker AS.

Cell Chem Biol. 2018 Mar 15;25(3):339-349.e4. doi: 10.1016/j.chembiol.2017.12.009. Epub 2018 Jan 4.

13.

Severe infections emerge from commensal bacteria by adaptive evolution.

Young BC, Wu CH, Gordon NC, Cole K, Price JR, Liu E, Sheppard AE, Perera S, Charlesworth J, Golubchik T, Iqbal Z, Bowden R, Massey RC, Paul J, Crook DW, Peto TE, Walker AS, Llewelyn MJ, Wyllie DH, Wilson DJ.

Elife. 2017 Dec 19;6. pii: e30637. doi: 10.7554/eLife.30637.

14.

Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial.

Thwaites GE, Scarborough M, Szubert A, Nsutebu E, Tilley R, Greig J, Wyllie SA, Wilson P, Auckland C, Cairns J, Ward D, Lal P, Guleri A, Jenkins N, Sutton J, Wiselka M, Armando GR, Graham C, Chadwick PR, Barlow G, Gordon NC, Young B, Meisner S, McWhinney P, Price DA, Harvey D, Nayar D, Jeyaratnam D, Planche T, Minton J, Hudson F, Hopkins S, Williams J, Török ME, Llewelyn MJ, Edgeworth JD, Walker AS; United Kingdom Clinical Infection Research Group (UKCIRG).

Lancet. 2018 Feb 17;391(10121):668-678. doi: 10.1016/S0140-6736(17)32456-X. Epub 2017 Dec 14.

15.

The antibiotic course has had its day.

Llewelyn MJ, Fitzpatrick JM, Darwin E, SarahTonkin-Crine, Gorton C, Paul J, Peto TEA, Yardley L, Hopkins S, Walker AS.

BMJ. 2017 Jul 26;358:j3418. doi: 10.1136/bmj.j3418. No abstract available.

PMID:
28747365
16.

Impact of recurrent Clostridium difficile infection: hospitalization and patient quality of life.

Wilcox MH, Ahir H, Coia JE, Dodgson A, Hopkins S, Llewelyn MJ, Settle C, Mclain-Smith S, Marcella SW.

J Antimicrob Chemother. 2017 Sep 1;72(9):2647-2656. doi: 10.1093/jac/dkx174.

17.

Staphylococcus aureus in critical care - Authors' reply.

Price JR, Crook DW, Walker AS, Peto TEA, Llewelyn MJ, Paul J.

Lancet Infect Dis. 2017 Jun;17(6):580-581. doi: 10.1016/S1473-3099(17)30269-4. No abstract available.

PMID:
28555579
18.

Toxigenic Clostridium difficile colonization among hospitalised adults; risk factors and impact on survival.

Behar L, Chadwick D, Dunne A, Jones CI, Proctor C, Rajkumar C, Sharratt P, Stanley P, Whiley A, Wilks M, Llewelyn MJ.

J Infect. 2017 Jul;75(1):20-25. doi: 10.1016/j.jinf.2017.04.006. Epub 2017 Apr 21.

19.

Re-emergence of methicillin susceptibility in a resistant lineage of Staphylococcus aureus.

Ledda A, Price JR, Cole K, Llewelyn MJ, Kearns AM, Crook DW, Paul J, Didelot X.

J Antimicrob Chemother. 2017 May 1;72(5):1285-1288. doi: 10.1093/jac/dkw570.

20.

Transmission of Staphylococcus aureus between health-care workers, the environment, and patients in an intensive care unit: a longitudinal cohort study based on whole-genome sequencing.

Price JR, Cole K, Bexley A, Kostiou V, Eyre DW, Golubchik T, Wilson DJ, Crook DW, Walker AS, Peto TEA, Llewelyn MJ, Paul J; Modernising Medical Microbiology informatics group.

Lancet Infect Dis. 2017 Feb;17(2):207-214. doi: 10.1016/S1473-3099(16)30413-3. Epub 2016 Nov 16.

21.

Proposed primary endpoints for use in clinical trials that compare treatment options for bloodstream infection in adults: a consensus definition.

Harris PNA, McNamara JF, Lye DC, Davis JS, Bernard L, Cheng AC, Doi Y, Fowler VG Jr, Kaye KS, Leibovici L, Lipman J, Llewelyn MJ, Munoz-Price S, Paul M, Peleg AY, Rodríguez-Baño J, Rogers BA, Seifert H, Thamlikitkul V, Thwaites G, Tong SYC, Turnidge J, Utili R, Webb SAR, Paterson DL.

Clin Microbiol Infect. 2017 Aug;23(8):533-541. doi: 10.1016/j.cmi.2016.10.023. Epub 2016 Nov 1. Review.

22.

Identifying lineage effects when controlling for population structure improves power in bacterial association studies.

Earle SG, Wu CH, Charlesworth J, Stoesser N, Gordon NC, Walker TM, Spencer CCA, Iqbal Z, Clifton DA, Hopkins KL, Woodford N, Smith EG, Ismail N, Llewelyn MJ, Peto TE, Crook DW, McVean G, Walker AS, Wilson DJ.

Nat Microbiol. 2016 Apr 4;1:16041. doi: 10.1038/nmicrobiol.2016.41.

23.

Circulating Plasma microRNAs can differentiate Human Sepsis and Systemic Inflammatory Response Syndrome (SIRS).

Caserta S, Kern F, Cohen J, Drage S, Newbury SF, Llewelyn MJ.

Sci Rep. 2016 Jun 20;6:28006. doi: 10.1038/srep28006.

24.

Induction of Human Regulatory T Cells with Bacterial Superantigens.

Caserta S, Taylor AL, Terrazzini N, Llewelyn MJ.

Methods Mol Biol. 2016;1396:181-206. doi: 10.1007/978-1-4939-3344-0_16.

PMID:
26676048
25.

Gram-negative bacteraemia; a multi-centre prospective evaluation of empiric antibiotic therapy and outcome in English acute hospitals.

Fitzpatrick JM, Biswas JS, Edgeworth JD, Islam J, Jenkins N, Judge R, Lavery AJ, Melzer M, Morris-Jones S, Nsutebu EF, Peters J, Pillay DG, Pink F, Price JR, Scarborough M, Thwaites GE, Tilley R, Walker AS, Llewelyn MJ; United Kingdom Clinical Infection Research Group.

Clin Microbiol Infect. 2016 Mar;22(3):244-51. doi: 10.1016/j.cmi.2015.10.034. Epub 2015 Nov 11.

26.

Antibiotic policies in acute English NHS trusts: implementation of 'Start Smart-Then Focus' and relationship with Clostridium difficile infection rates.

Llewelyn MJ, Hand K, Hopkins S, Walker AS.

J Antimicrob Chemother. 2015 Apr;70(4):1230-5. doi: 10.1093/jac/dku515. Epub 2014 Dec 23.

PMID:
25538165
27.

Reply to Mills and Linkin.

Price JR, Golubchik T, Wilson DJ, Crook DW, Walker AS, Peto TE, Paul J, Llewelyn MJ.

Clin Infect Dis. 2014 Sep 1;59(5):752-3. doi: 10.1093/cid/ciu370. Epub 2014 May 20. No abstract available.

28.

The role of the humoral immune response to Clostridium difficile toxins A and B in susceptibility to C. difficile infection: a case-control study.

Islam J, Taylor AL, Rao K, Huffnagle G, Young VB, Rajkumar C, Cohen J, Papatheodorou P, Aronoff DM, Llewelyn MJ.

Anaerobe. 2014 Jun;27:82-6. doi: 10.1016/j.anaerobe.2014.03.011. Epub 2014 Apr 5.

29.

Prediction of Staphylococcus aureus antimicrobial resistance by whole-genome sequencing.

Gordon NC, Price JR, Cole K, Everitt R, Morgan M, Finney J, Kearns AM, Pichon B, Young B, Wilson DJ, Llewelyn MJ, Paul J, Peto TE, Crook DW, Walker AS, Golubchik T.

J Clin Microbiol. 2014 Apr;52(4):1182-91. doi: 10.1128/JCM.03117-13. Epub 2014 Feb 5.

30.

Healthcare-associated outbreak of meticillin-resistant Staphylococcus aureus bacteraemia: role of a cryptic variant of an epidemic clone.

Miller RM, Price JR, Batty EM, Didelot X, Wyllie D, Golubchik T, Crook DW, Paul J, Peto TE, Wilson DJ, Cule M, Ip CL, Day NP, Moore CE, Bowden R, Llewelyn MJ.

J Hosp Infect. 2014 Feb;86(2):83-9. doi: 10.1016/j.jhin.2013.11.007. Epub 2013 Dec 21.

31.

Whole-genome sequencing shows that patient-to-patient transmission rarely accounts for acquisition of Staphylococcus aureus in an intensive care unit.

Price JR, Golubchik T, Cole K, Wilson DJ, Crook DW, Thwaites GE, Bowden R, Walker AS, Peto TE, Paul J, Llewelyn MJ.

Clin Infect Dis. 2014 Mar;58(5):609-18. doi: 10.1093/cid/cit807. Epub 2013 Dec 12.

32.

Staphylococcus aureus bloodstream infection: a pooled analysis of five prospective, observational studies.

Kaasch AJ, Barlow G, Edgeworth JD, Fowler VG Jr, Hellmich M, Hopkins S, Kern WV, Llewelyn MJ, Rieg S, Rodriguez-Baño J, Scarborough M, Seifert H, Soriano A, Tilley R, Tőrők ME, Weiß V, Wilson AP, Thwaites GE; ISAC, INSTINCT, SABG, UKCIRG, and Colleagues.

J Infect. 2014 Mar;68(3):242-51. doi: 10.1016/j.jinf.2013.10.015. Epub 2013 Nov 16. Erratum in: J Infect. 2014 Sep;69(3):306-7.

33.

Influence of cohorting patients with Clostridium difficile infection on risk of symptomatic recurrence.

Islam J, Cheek E, Navani V, Rajkumar C, Cohen J, Llewelyn MJ.

J Hosp Infect. 2013 Sep;85(1):17-21. doi: 10.1016/j.jhin.2013.06.009. Epub 2013 Aug 1.

PMID:
23910403
34.

Sepsis biomarkers in unselected patients on admission to intensive or high-dependency care.

Llewelyn MJ, Berger M, Gregory M, Ramaiah R, Taylor AL, Curdt I, Lajaunias F, Graf R, Blincko SJ, Drage S, Cohen J.

Crit Care. 2013 Mar 26;17(2):R60. doi: 10.1186/cc12588.

35.

Whole genome sequencing in the prevention and control of Staphylococcus aureus infection.

Price JR, Didelot X, Crook DW, Llewelyn MJ, Paul J.

J Hosp Infect. 2013 Jan;83(1):14-21. doi: 10.1016/j.jhin.2012.10.003. Epub 2012 Nov 16. Review.

36.

Probiotics for the prevention and treatment of Clostridium difficile in older patients.

Islam J, Cohen J, Rajkumar C, Llewelyn MJ.

Age Ageing. 2012 Nov;41(6):706-11. doi: 10.1093/ageing/afs077. Epub 2012 Jun 19. Review.

PMID:
22718155
37.

Induction of contact-dependent CD8(+) regulatory T cells through stimulation with staphylococcal and streptococcal superantigens.

Taylor AL, Cross EL, Llewelyn MJ.

Immunology. 2012 Feb;135(2):158-67. doi: 10.1111/j.1365-2567.2011.03529.x.

38.

Clinical management of Staphylococcus aureus bacteraemia.

Thwaites GE, Edgeworth JD, Gkrania-Klotsas E, Kirby A, Tilley R, Török ME, Walker S, Wertheim HF, Wilson P, Llewelyn MJ; UK Clinical Infection Research Group.

Lancet Infect Dis. 2011 Mar;11(3):208-22. doi: 10.1016/S1473-3099(10)70285-1. Review.

PMID:
21371655
39.

Superantigen-induced proliferation of human CD4+CD25- T cells is followed by a switch to a functional regulatory phenotype.

Taylor AL, Llewelyn MJ.

J Immunol. 2010 Dec 1;185(11):6591-8. doi: 10.4049/jimmunol.1002416. Epub 2010 Nov 3.

40.

How is diarrhoea managed in UK care homes? A survey with implications for recognition and control of Clostridium difficile infection.

Henderson HJ, Maddock L, Andrews S, Trail P, Loades N, Purcell B, Iversen A, Llewelyn MJ, Cassell JA.

J Public Health (Oxf). 2010 Dec;32(4):472-8. doi: 10.1093/pubmed/fdq036. Epub 2010 May 20.

PMID:
20488944
41.

Predictors of death after Clostridium difficile infection: a report on 128 strain-typed cases from a teaching hospital in the United Kingdom.

Wilson V, Cheek L, Satta G, Walker-Bone K, Cubbon M, Citron D, Gerding DN, Llewelyn MJ.

Clin Infect Dis. 2010 Jun 15;50(12):e77-81. doi: 10.1086/653012.

PMID:
20450417
42.

Tracking the microbes in sepsis: advancements in treatment bring challenges for microbial epidemiology.

Llewelyn MJ, Cohen J.

Clin Infect Dis. 2007 May 15;44(10):1343-8. Epub 2007 Apr 2. Review.

PMID:
17443473
43.

Diagnostic utility of bone marrow sampling in HIV-infected patients since the advent of highly active antiretroviral therapy.

Llewelyn MJ, Noursedeghi M, Dogan A, Edwards SG, Miller RF.

Int J STD AIDS. 2005 Oct;16(10):686-90.

PMID:
16212717

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