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Items: 1 to 50 of 106

1.

A Multinational European Study of Patient Preferences for Novel Diagnostics to Manage Antimicrobial Resistance.

Mott DJ, Hampson G, Llewelyn MJ, Mestre-Ferrandiz J, Hopkins MM.

Appl Health Econ Health Policy. 2019 Sep 20. doi: 10.1007/s40258-019-00516-0. [Epub ahead of print]

PMID:
31541361
2.

Optimizing design of research to evaluate antibiotic stewardship interventions: consensus recommendations of a multinational working group.

Schweitzer VA, van Werkhoven CH, Rodríguez Baño J, Bielicki J, Harbarth S, Hulscher M, Huttner B, Islam J, Little P, Pulcini C, Savoldi A, Tacconelli E, Timsit JF, van Smeden M, Wolkewitz M, Bonten MJM, Walker AS, Llewelyn MJ; Joint Programming Initiative on Antimicrobial Resistance (JPIAMR) Working Group on Design of Antimicrobial Stewardship Evaluations.

Clin Microbiol Infect. 2019 Sep 4. pii: S1198-743X(19)30477-X. doi: 10.1016/j.cmi.2019.08.017. [Epub ahead of print]

3.

Intervention planning for Antibiotic Review Kit (ARK): a digital and behavioural intervention to safely review and reduce antibiotic prescriptions in acute and general medicine.

Santillo M, Sivyer K, Krusche A, Mowbray F, Jones N, Peto TEA, Walker AS, Llewelyn MJ, Yardley L; ARK-Hospital .

J Antimicrob Chemother. 2019 Nov 1;74(11):3362-3370. doi: 10.1093/jac/dkz333.

PMID:
31430366
4.

Predictors of recurrence, early treatment failure and death from Staphylococcus aureus bacteraemia: Observational analyses within the ARREST trial.

Szubert A, Bailey SL, Cooke GS, Peto T, Llewelyn MJ, Edgeworth JD, Walker AS, Thwaites GE; United Kingdom Clinical Infection Research Group (UKCIRG).

J Infect. 2019 Oct;79(4):332-340. doi: 10.1016/j.jinf.2019.08.001. Epub 2019 Aug 6.

5.

Adaptation and implementation of the ARK (Antibiotic Review Kit) intervention to safely and substantially reduce antibiotic use in hospitals: a feasibility study.

Cross ELA, Sivyer K, Islam J, Santillo M, Mowbray F, Peto TEA, Walker AS, Yardley L, Llewelyn MJ.

J Hosp Infect. 2019 Aug 5. pii: S0195-6701(19)30311-1. doi: 10.1016/j.jhin.2019.07.017. [Epub ahead of print]

PMID:
31394146
6.

Antibiotic Review Kit for Hospitals (ARK-Hospital): study protocol for a stepped-wedge cluster-randomised controlled trial.

Walker AS, Budgell E, Laskawiec-Szkonter M, Sivyer K, Wordsworth S, Quaddy J, Santillo M, Krusche A, Roope LSJ, Bright N, Mowbray F, Jones N, Hand K, Rahman N, Dobson M, Hedley E, Crook D, Sharland M, Roseveare C, Hobbs FDR, Butler C, Vaughan L, Hopkins S, Yardley L, Peto TEA, Llewelyn MJ; ARK trial team.

Trials. 2019 Jul 11;20(1):421. doi: 10.1186/s13063-019-3497-y.

7.

Draft Genome Sequences of 64 Type Strains of 50 Species and 25 Subspecies of the Genus Staphylococcus Rosenbach 1884.

Cole K, Foster D, Russell JE, Golubchik T, Llewelyn M, Wilson DJ, Crook D, Paul J; Modernising Medical Microbiology Consortium.

Microbiol Resour Announc. 2019 Apr 25;8(17). pii: e00062-19. doi: 10.1128/MRA.00062-19.

8.

Duration of antibiotic treatment for common infections in English primary care: cross sectional analysis and comparison with guidelines.

Pouwels KB, Hopkins S, Llewelyn MJ, Walker AS, McNulty CA, Robotham JV.

BMJ. 2019 Feb 27;364:l440. doi: 10.1136/bmj.l440.

9.

The quality of studies evaluating antimicrobial stewardship interventions: a systematic review.

Schweitzer VA, van Heijl I, van Werkhoven CH, Islam J, Hendriks-Spoor KD, Bielicki J, Bonten MJM, Walker AS, Llewelyn MJ; Consensus on Antimicrobial Stewardship Evaluations (CASE) study group.

Clin Microbiol Infect. 2019 May;25(5):555-561. doi: 10.1016/j.cmi.2018.11.002. Epub 2018 Nov 23.

PMID:
30472426
10.

Adjunctive rifampicin to reduce early mortality from Staphylococcus aureus bacteraemia: the ARREST RCT.

Thwaites GE, Scarborough M, Szubert A, Saramago Goncalves P, Soares M, Bostock J, Nsutebu E, Tilley R, Cunningham R, Greig J, Wyllie SA, Wilson P, Auckland C, Cairns J, Ward D, Lal P, Guleri A, Jenkins N, Sutton J, Wiselka M, Armando GR, Graham C, Chadwick PR, Barlow G, Gordon NC, Young B, Meisner S, McWhinney P, Price DA, Harvey D, Nayar D, Jeyaratnam D, Planche T, Minton J, Hudson F, Hopkins S, Williams J, Török ME, Llewelyn MJ, Edgeworth JD, Walker AS.

Health Technol Assess. 2018 Oct;22(59):1-148. doi: 10.3310/hta22590.

11.

Survival following Staphylococcus aureus bloodstream infection: A prospective multinational cohort study assessing the impact of place of care.

Nambiar K, Seifert H, Rieg S, Kern WV, Scarborough M, Gordon NC, Kim HB, Song KH, Tilley R, Gott H, Liao CH, Edgeworth J, Nsutebu E, López-Cortés LE, Morata L, Walker AS, Thwaites G, Llewelyn MJ, Kaasch AJ; International Staphylococcus aureus collaboration (ISAC) study group (with linked authorship to members in the Acknowledgements) and the ESCMID Study Group for Bloodstream Infections and Sepsis (ESGBIS).

J Infect. 2018 Dec;77(6):516-525. doi: 10.1016/j.jinf.2018.08.015. Epub 2018 Sep 1.

PMID:
30179645
12.

Trends over time in Escherichia coli bloodstream infections, urinary tract infections, and antibiotic susceptibilities in Oxfordshire, UK, 1998-2016: a study of electronic health records.

Vihta KD, Stoesser N, Llewelyn MJ, Quan TP, Davies T, Fawcett NJ, Dunn L, Jeffery K, Butler CC, Hayward G, Andersson M, Morgan M, Oakley S, Mason A, Hopkins S, Wyllie DH, Crook DW, Wilcox MH, Johnson AP, Peto TEA, Walker AS.

Lancet Infect Dis. 2018 Oct;18(10):1138-1149. doi: 10.1016/S1473-3099(18)30353-0. Epub 2018 Aug 17.

13.

Mycobacterium chimaera infection following cardiac surgery in the United Kingdom: clinical features and outcome of the first 30 cases.

Scriven JE, Scobie A, Verlander NQ, Houston A, Collyns T, Cajic V, Kon OM, Mitchell T, Rahama O, Robinson A, Withama S, Wilson P, Maxwell D, Agranoff D, Davies E, Llewelyn M, Soo SS, Sahota A, Cooper MA, Hunter M, Tomlins J, Tiberi S, Kendall S, Dedicoat M, Alexander E, Fenech T, Zambon M, Lamagni T, Smith EG, Chand M.

Clin Microbiol Infect. 2018 Nov;24(11):1164-1170. doi: 10.1016/j.cmi.2018.04.027. Epub 2018 May 25.

14.

Overview of systematic reviews assessing the evidence for shorter versus longer duration antibiotic treatment for bacterial infections in secondary care.

Onakpoya IJ, Walker AS, Tan PS, Spencer EA, Gbinigie OA, Cook J, Llewelyn MJ, Butler CC.

PLoS One. 2018 Mar 28;13(3):e0194858. doi: 10.1371/journal.pone.0194858. eCollection 2018. Review.

15.

A national quality incentive scheme to reduce antibiotic overuse in hospitals: evaluation of perceptions and impact.

Islam J, Ashiru-Oredope D, Budd E, Howard P, Walker AS, Hopkins S, Llewelyn MJ.

J Antimicrob Chemother. 2018 Jun 1;73(6):1708-1713. doi: 10.1093/jac/dky041.

PMID:
29506043
16.

Severity of Systemic Inflammatory Response Syndrome Affects the Blood Levels of Circulating Inflammatory-Relevant MicroRNAs.

Caserta S, Mengozzi M, Kern F, Newbury SF, Ghezzi P, Llewelyn MJ.

Front Immunol. 2018 Feb 5;8:1977. doi: 10.3389/fimmu.2017.01977. eCollection 2017.

17.

Robust Prediction of Resistance to Trimethoprim in Staphylococcus aureus.

Fowler PW, Cole K, Gordon NC, Kearns AM, Llewelyn MJ, Peto TEA, Crook DW, Walker AS.

Cell Chem Biol. 2018 Mar 15;25(3):339-349.e4. doi: 10.1016/j.chembiol.2017.12.009. Epub 2018 Jan 4.

18.

Severe infections emerge from commensal bacteria by adaptive evolution.

Young BC, Wu CH, Gordon NC, Cole K, Price JR, Liu E, Sheppard AE, Perera S, Charlesworth J, Golubchik T, Iqbal Z, Bowden R, Massey RC, Paul J, Crook DW, Peto TE, Walker AS, Llewelyn MJ, Wyllie DH, Wilson DJ.

Elife. 2017 Dec 19;6. pii: e30637. doi: 10.7554/eLife.30637.

19.

Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial.

Thwaites GE, Scarborough M, Szubert A, Nsutebu E, Tilley R, Greig J, Wyllie SA, Wilson P, Auckland C, Cairns J, Ward D, Lal P, Guleri A, Jenkins N, Sutton J, Wiselka M, Armando GR, Graham C, Chadwick PR, Barlow G, Gordon NC, Young B, Meisner S, McWhinney P, Price DA, Harvey D, Nayar D, Jeyaratnam D, Planche T, Minton J, Hudson F, Hopkins S, Williams J, Török ME, Llewelyn MJ, Edgeworth JD, Walker AS; United Kingdom Clinical Infection Research Group (UKCIRG).

Lancet. 2018 Feb 17;391(10121):668-678. doi: 10.1016/S0140-6736(17)32456-X. Epub 2017 Dec 14.

20.

Severity of illness and the weekend effect - Authors' reply.

Walker AS, Watkinson P, Llewelyn M, Stoesser N, Peto T.

Lancet. 2017 Oct 14;390(10104):1735. doi: 10.1016/S0140-6736(17)32425-X. Epub 2017 Oct 12. No abstract available.

PMID:
29047441
21.

The antibiotic course has had its day.

Llewelyn MJ, Fitzpatrick JM, Darwin E, SarahTonkin-Crine, Gorton C, Paul J, Peto TEA, Yardley L, Hopkins S, Walker AS.

BMJ. 2017 Jul 26;358:j3418. doi: 10.1136/bmj.j3418. No abstract available.

PMID:
28747365
22.

Re-irradiation of cervical and endometrial cancer.

Llewelyn M, Taylor A.

Curr Opin Oncol. 2017 Sep;29(5):343-350. doi: 10.1097/CCO.0000000000000392. Review.

PMID:
28697002
23.

Impact of recurrent Clostridium difficile infection: hospitalization and patient quality of life.

Wilcox MH, Ahir H, Coia JE, Dodgson A, Hopkins S, Llewelyn MJ, Settle C, Mclain-Smith S, Marcella SW.

J Antimicrob Chemother. 2017 Sep 1;72(9):2647-2656. doi: 10.1093/jac/dkx174.

24.

Staphylococcus aureus in critical care - Authors' reply.

Price JR, Crook DW, Walker AS, Peto TEA, Llewelyn MJ, Paul J.

Lancet Infect Dis. 2017 Jun;17(6):580-581. doi: 10.1016/S1473-3099(17)30269-4. No abstract available.

PMID:
28555579
25.

Mortality risks associated with emergency admissions during weekends and public holidays: an analysis of electronic health records.

Walker AS, Mason A, Quan TP, Fawcett NJ, Watkinson P, Llewelyn M, Stoesser N, Finney J, Davies J, Wyllie DH, Crook DW, Peto TEA.

Lancet. 2017 Jul 1;390(10089):62-72. doi: 10.1016/S0140-6736(17)30782-1. Epub 2017 May 9.

26.

Whole-Genome Sequencing Reveals the Contribution of Long-Term Carriers in Staphylococcus aureus Outbreak Investigation.

Gordon NC, Pichon B, Golubchik T, Wilson DJ, Paul J, Blanc DS, Cole K, Collins J, Cortes N, Cubbon M, Gould FK, Jenks PJ, Llewelyn M, Nash JQ, Orendi JM, Paranthaman K, Price JR, Senn L, Thomas HL, Wyllie S, Crook DW, Peto TEA, Walker AS, Kearns AM.

J Clin Microbiol. 2017 Jul;55(7):2188-2197. doi: 10.1128/JCM.00363-17. Epub 2017 May 3.

27.

Toxigenic Clostridium difficile colonization among hospitalised adults; risk factors and impact on survival.

Behar L, Chadwick D, Dunne A, Jones CI, Proctor C, Rajkumar C, Sharratt P, Stanley P, Whiley A, Wilks M, Llewelyn MJ.

J Infect. 2017 Jul;75(1):20-25. doi: 10.1016/j.jinf.2017.04.006. Epub 2017 Apr 21.

28.

Re-emergence of methicillin susceptibility in a resistant lineage of Staphylococcus aureus.

Ledda A, Price JR, Cole K, Llewelyn MJ, Kearns AM, Crook DW, Paul J, Didelot X.

J Antimicrob Chemother. 2017 May 1;72(5):1285-1288. doi: 10.1093/jac/dkw570.

29.

Transmission of Staphylococcus aureus between health-care workers, the environment, and patients in an intensive care unit: a longitudinal cohort study based on whole-genome sequencing.

Price JR, Cole K, Bexley A, Kostiou V, Eyre DW, Golubchik T, Wilson DJ, Crook DW, Walker AS, Peto TEA, Llewelyn MJ, Paul J; Modernising Medical Microbiology informatics group.

Lancet Infect Dis. 2017 Feb;17(2):207-214. doi: 10.1016/S1473-3099(16)30413-3. Epub 2016 Nov 16.

30.

Proposed primary endpoints for use in clinical trials that compare treatment options for bloodstream infection in adults: a consensus definition.

Harris PNA, McNamara JF, Lye DC, Davis JS, Bernard L, Cheng AC, Doi Y, Fowler VG Jr, Kaye KS, Leibovici L, Lipman J, Llewelyn MJ, Munoz-Price S, Paul M, Peleg AY, Rodríguez-Baño J, Rogers BA, Seifert H, Thamlikitkul V, Thwaites G, Tong SYC, Turnidge J, Utili R, Webb SAR, Paterson DL.

Clin Microbiol Infect. 2017 Aug;23(8):533-541. doi: 10.1016/j.cmi.2016.10.023. Epub 2016 Nov 1. Review.

31.

Identifying lineage effects when controlling for population structure improves power in bacterial association studies.

Earle SG, Wu CH, Charlesworth J, Stoesser N, Gordon NC, Walker TM, Spencer CCA, Iqbal Z, Clifton DA, Hopkins KL, Woodford N, Smith EG, Ismail N, Llewelyn MJ, Peto TE, Crook DW, McVean G, Walker AS, Wilson DJ.

Nat Microbiol. 2016 Apr 4;1:16041. doi: 10.1038/nmicrobiol.2016.41.

32.

Circulating Plasma microRNAs can differentiate Human Sepsis and Systemic Inflammatory Response Syndrome (SIRS).

Caserta S, Kern F, Cohen J, Drage S, Newbury SF, Llewelyn MJ.

Sci Rep. 2016 Jun 20;6:28006. doi: 10.1038/srep28006.

33.

An ageing population and changing UK bacteraemia profile may affect the characteristics and microbiology of infective spondylodiscitis.

Donovan J, Skittrall JP, Moore T, Sargent C, Agranoff D, Llewelyn M.

J Infect. 2016 Jul;73(1):91-3. doi: 10.1016/j.jinf.2016.04.005. Epub 2016 Apr 9. No abstract available.

PMID:
27066877
34.

Induction of Human Regulatory T Cells with Bacterial Superantigens.

Caserta S, Taylor AL, Terrazzini N, Llewelyn MJ.

Methods Mol Biol. 2016;1396:181-206. doi: 10.1007/978-1-4939-3344-0_16.

PMID:
26676048
35.

Gram-negative bacteraemia; a multi-centre prospective evaluation of empiric antibiotic therapy and outcome in English acute hospitals.

Fitzpatrick JM, Biswas JS, Edgeworth JD, Islam J, Jenkins N, Judge R, Lavery AJ, Melzer M, Morris-Jones S, Nsutebu EF, Peters J, Pillay DG, Pink F, Price JR, Scarborough M, Thwaites GE, Tilley R, Walker AS, Llewelyn MJ; United Kingdom Clinical Infection Research Group.

Clin Microbiol Infect. 2016 Mar;22(3):244-51. doi: 10.1016/j.cmi.2015.10.034. Epub 2015 Nov 11.

36.

Antibiotic policies in acute English NHS trusts: implementation of 'Start Smart-Then Focus' and relationship with Clostridium difficile infection rates.

Llewelyn MJ, Hand K, Hopkins S, Walker AS.

J Antimicrob Chemother. 2015 Apr;70(4):1230-5. doi: 10.1093/jac/dku515. Epub 2014 Dec 23.

PMID:
25538165
37.

Contraindicated BCG vaccination in "at risk" infants.

Rees P, Evans H, Panesar S, Llewelyn M, Edwards A, Carson-Stevens A.

BMJ. 2014 Sep 9;349:g5388. doi: 10.1136/bmj.g5388. No abstract available.

PMID:
25208721
38.

Reply to Mills and Linkin.

Price JR, Golubchik T, Wilson DJ, Crook DW, Walker AS, Peto TE, Paul J, Llewelyn MJ.

Clin Infect Dis. 2014 Sep 1;59(5):752-3. doi: 10.1093/cid/ciu370. Epub 2014 May 20. No abstract available.

39.

The role of the humoral immune response to Clostridium difficile toxins A and B in susceptibility to C. difficile infection: a case-control study.

Islam J, Taylor AL, Rao K, Huffnagle G, Young VB, Rajkumar C, Cohen J, Papatheodorou P, Aronoff DM, Llewelyn MJ.

Anaerobe. 2014 Jun;27:82-6. doi: 10.1016/j.anaerobe.2014.03.011. Epub 2014 Apr 5.

40.

Prediction of Staphylococcus aureus antimicrobial resistance by whole-genome sequencing.

Gordon NC, Price JR, Cole K, Everitt R, Morgan M, Finney J, Kearns AM, Pichon B, Young B, Wilson DJ, Llewelyn MJ, Paul J, Peto TE, Crook DW, Walker AS, Golubchik T.

J Clin Microbiol. 2014 Apr;52(4):1182-91. doi: 10.1128/JCM.03117-13. Epub 2014 Feb 5.

41.

Healthcare-associated outbreak of meticillin-resistant Staphylococcus aureus bacteraemia: role of a cryptic variant of an epidemic clone.

Miller RM, Price JR, Batty EM, Didelot X, Wyllie D, Golubchik T, Crook DW, Paul J, Peto TE, Wilson DJ, Cule M, Ip CL, Day NP, Moore CE, Bowden R, Llewelyn MJ.

J Hosp Infect. 2014 Feb;86(2):83-9. doi: 10.1016/j.jhin.2013.11.007. Epub 2013 Dec 21.

42.

Whole-genome sequencing shows that patient-to-patient transmission rarely accounts for acquisition of Staphylococcus aureus in an intensive care unit.

Price JR, Golubchik T, Cole K, Wilson DJ, Crook DW, Thwaites GE, Bowden R, Walker AS, Peto TE, Paul J, Llewelyn MJ.

Clin Infect Dis. 2014 Mar;58(5):609-18. doi: 10.1093/cid/cit807. Epub 2013 Dec 12.

43.

Staphylococcus aureus bloodstream infection: a pooled analysis of five prospective, observational studies.

Kaasch AJ, Barlow G, Edgeworth JD, Fowler VG Jr, Hellmich M, Hopkins S, Kern WV, Llewelyn MJ, Rieg S, Rodriguez-Baño J, Scarborough M, Seifert H, Soriano A, Tilley R, Tőrők ME, Weiß V, Wilson AP, Thwaites GE; ISAC, INSTINCT, SABG, UKCIRG, and Colleagues.

J Infect. 2014 Mar;68(3):242-51. doi: 10.1016/j.jinf.2013.10.015. Epub 2013 Nov 16. Erratum in: J Infect. 2014 Sep;69(3):306-7.

44.

Influence of cohorting patients with Clostridium difficile infection on risk of symptomatic recurrence.

Islam J, Cheek E, Navani V, Rajkumar C, Cohen J, Llewelyn MJ.

J Hosp Infect. 2013 Sep;85(1):17-21. doi: 10.1016/j.jhin.2013.06.009. Epub 2013 Aug 1.

PMID:
23910403
45.

Acalculous cholecystitis occurring in the context of Plasmodium malariae infection: a case report.

Harris EF, Younger E, Llewelyn MB.

J Med Case Rep. 2013 Jul 26;7:197. doi: 10.1186/1752-1947-7-197.

46.

Sepsis biomarkers in unselected patients on admission to intensive or high-dependency care.

Llewelyn MJ, Berger M, Gregory M, Ramaiah R, Taylor AL, Curdt I, Lajaunias F, Graf R, Blincko SJ, Drage S, Cohen J.

Crit Care. 2013 Mar 26;17(2):R60. doi: 10.1186/cc12588.

47.

Antibiotic resistance and transrectal prostate biopsies.

Davies RJ, Stephenson BM, Llewelyn M, Carter AC, Kubiak E.

BMJ. 2013 Feb 26;346:f1171. doi: 10.1136/bmj.f1171. No abstract available.

PMID:
23444435
48.

The usefulness of whole genome sequencing in the management of Staphylococcus aureus infections.

Price J, Gordon NC, Crook D, Llewelyn M, Paul J.

Clin Microbiol Infect. 2013 Sep;19(9):784-9. doi: 10.1111/1469-0691.12109. Epub 2013 Jan 18. Review.

49.

Adjunctive rifampicin to reduce early mortality from Staphylococcus aureus bacteraemia (ARREST): study protocol for a randomised controlled trial.

Thwaites G, Auckland C, Barlow G, Cunningham R, Davies G, Edgeworth J, Greig J, Hopkins S, Jeyaratnam D, Jenkins N, Llewelyn M, Meisner S, Nsutebu E, Planche T, Read RC, Scarborough M, Soares M, Tilley R, Török ME, Williams J, Wilson P, Wyllie S, Walker AS; United Kingdom Clinical Infection Research Group.

Trials. 2012 Dec 18;13:241. doi: 10.1186/1745-6215-13-241.

50.

Whole genome sequencing in the prevention and control of Staphylococcus aureus infection.

Price JR, Didelot X, Crook DW, Llewelyn MJ, Paul J.

J Hosp Infect. 2013 Jan;83(1):14-21. doi: 10.1016/j.jhin.2012.10.003. Epub 2012 Nov 16. Review.

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