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Items: 32

1.

The Reaction Mechanism of Metallo-β-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop.

Palacios AR, Mojica MF, Giannini E, Taracila MA, Bethel CR, Alzari PM, Otero LH, Klinke S, Llarrull LI, Bonomo RA, Vila AJ.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01754-18. doi: 10.1128/AAC.01754-18. Print 2019 Jan.

2.

A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamases.

Lisa MN, Palacios AR, Aitha M, González MM, Moreno DM, Crowder MW, Bonomo RA, Spencer J, Tierney DL, Llarrull LI, Vila AJ.

Nat Commun. 2017 Sep 14;8(1):538. doi: 10.1038/s41467-017-00601-9.

3.

Bisthiazolidines: A Substrate-Mimicking Scaffold as an Inhibitor of the NDM-1 Carbapenemase.

González MM, Kosmopoulou M, Mojica MF, Castillo V, Hinchliffe P, Pettinati I, Brem J, Schofield CJ, Mahler G, Bonomo RA, Llarrull LI, Spencer J, Vila AJ.

ACS Infect Dis. 2015 Nov 13;1(11):544-54. doi: 10.1021/acsinfecdis.5b00046. Epub 2015 Jul 20.

4.

Phosphorylation of BlaR1 in Manifestation of Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus and Its Abrogation by Small Molecules.

Boudreau MA, Fishovitz J, Llarrull LI, Xiao Q, Mobashery S.

ACS Infect Dis. 2015 Oct 9;1(10):454-9. doi: 10.1021/acsinfecdis.5b00086. Epub 2015 Aug 24.

5.

Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes.

Hinchliffe P, González MM, Mojica MF, González JM, Castillo V, Saiz C, Kosmopoulou M, Tooke CL, Llarrull LI, Mahler G, Bonomo RA, Vila AJ, Spencer J.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3745-54. doi: 10.1073/pnas.1601368113. Epub 2016 Jun 14.

6.

Overcoming differences: The catalytic mechanism of metallo-β-lactamases.

Meini MR, Llarrull LI, Vila AJ.

FEBS Lett. 2015 Nov 14;589(22):3419-32. doi: 10.1016/j.febslet.2015.08.015. Epub 2015 Aug 20. Review.

7.

Exploring the Role of Residue 228 in Substrate and Inhibitor Recognition by VIM Metallo-β-lactamases.

Mojica MF, Mahler SG, Bethel CR, Taracila MA, Kosmopoulou M, Papp-Wallace KM, Llarrull LI, Wilson BM, Marshall SH, Wallace CJ, Villegas MV, Harris ME, Vila AJ, Spencer J, Bonomo RA.

Biochemistry. 2015 May 26;54(20):3183-96. doi: 10.1021/acs.biochem.5b00106. Epub 2015 May 12.

8.

Evolution of Metallo-β-lactamases: Trends Revealed by Natural Diversity and in vitro Evolution.

Meini MR, Llarrull LI, Vila AJ.

Antibiotics (Basel). 2014 Jul 1;3(3):285-316.

9.

Regulation of the expression of the β-lactam antibiotic-resistance determinants in methicillin-resistant Staphylococcus aureus (MRSA).

Blázquez B, Llarrull LI, Luque-Ortega JR, Alfonso C, Boggess B, Mobashery S.

Biochemistry. 2014 Mar 18;53(10):1548-50. doi: 10.1021/bi500074w. Epub 2014 Mar 3.

10.

Discovery of a new class of non-β-lactam inhibitors of penicillin-binding proteins with Gram-positive antibacterial activity.

O'Daniel PI, Peng Z, Pi H, Testero SA, Ding D, Spink E, Leemans E, Boudreau MA, Yamaguchi T, Schroeder VA, Wolter WR, Llarrull LI, Song W, Lastochkin E, Kumarasiri M, Antunes NT, Espahbodi M, Lichtenwalter K, Suckow MA, Vakulenko S, Mobashery S, Chang M.

J Am Chem Soc. 2014 Mar 5;136(9):3664-72. doi: 10.1021/ja500053x. Epub 2014 Feb 21.

11.

How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function.

Otero LH, Rojas-Altuve A, Llarrull LI, Carrasco-López C, Kumarasiri M, Lastochkin E, Fishovitz J, Dawley M, Hesek D, Lee M, Johnson JW, Fisher JF, Chang M, Mobashery S, Hermoso JA.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16808-13. doi: 10.1073/pnas.1300118110. Epub 2013 Oct 1.

12.

Reactions of all Escherichia coli lytic transglycosylases with bacterial cell wall.

Lee M, Hesek D, Llarrull LI, Lastochkin E, Pi H, Boggess B, Mobashery S.

J Am Chem Soc. 2013 Mar 6;135(9):3311-4. doi: 10.1021/ja309036q. Epub 2013 Feb 21.

13.

Inhibitors for Bacterial Cell-Wall Recycling.

Yamaguchi T, Blázquez B, Hesek D, Lee M, Llarrull LI, Boggess B, Oliver AG, Fisher JF, Mobashery S.

ACS Med Chem Lett. 2012 Mar 8;3(3):238-242. Epub 2012 Jan 19.

14.

Dissection of events in the resistance to β-lactam antibiotics mediated by the protein BlaR1 from Staphylococcus aureus.

Llarrull LI, Mobashery S.

Biochemistry. 2012 Jun 12;51(23):4642-9. doi: 10.1021/bi300429p. Epub 2012 May 29.

15.

X-ray absorption spectroscopy of metal site speciation in the metallo-β-lactamase BcII from Bacillus cereus.

Breece RM, Llarrull LI, Tioni MF, Vila AJ, Tierney DL.

J Inorg Biochem. 2012 Jun;111:182-6. doi: 10.1016/j.jinorgbio.2011.12.013. Epub 2012 Jan 31.

16.

An amino acid position at crossroads of evolution of protein function: antibiotic sensor domain of BlaR1 protein from Staphylococcus aureus versus clasS D β-lactamases.

Kumarasiri M, Llarrull LI, Borbulevych O, Fishovitz J, Lastochkin E, Baker BM, Mobashery S.

J Biol Chem. 2012 Mar 9;287(11):8232-41. doi: 10.1074/jbc.M111.333179. Epub 2012 Jan 18.

17.

Activation of BlaR1 protein of methicillin-resistant Staphylococcus aureus, its proteolytic processing, and recovery from induction of resistance.

Llarrull LI, Toth M, Champion MM, Mobashery S.

J Biol Chem. 2011 Nov 4;286(44):38148-58. doi: 10.1074/jbc.M111.288985. Epub 2011 Sep 6.

18.

Lysine Nzeta-decarboxylation switch and activation of the beta-lactam sensor domain of BlaR1 protein of methicillin-resistant Staphylococcus aureus.

Borbulevych O, Kumarasiri M, Wilson B, Llarrull LI, Lee M, Hesek D, Shi Q, Peng J, Baker BM, Mobashery S.

J Biol Chem. 2011 Sep 9;286(36):31466-72. doi: 10.1074/jbc.M111.252189. Epub 2011 Jul 20.

19.

High-resolution crystal structure of MltE, an outer membrane-anchored endolytic peptidoglycan lytic transglycosylase from Escherichia coli.

Artola-Recolons C, Carrasco-López C, Llarrull LI, Kumarasiri M, Lastochkin E, Martínez de Ilarduya I, Meindl K, Usón I, Mobashery S, Hermoso JA.

Biochemistry. 2011 Apr 5;50(13):2384-6. doi: 10.1021/bi200085y. Epub 2011 Mar 8.

20.

Sulfonate-containing thiiranes as selective gelatinase inhibitors.

Testero SA, Lee M, Staran RT, Espahbodi M, Llarrull LI, Toth M, Mobashery S, Chang M.

ACS Med Chem Lett. 2010 Dec 13;2(2):177-81. doi: 10.1021/ml100254e. eCollection 2011 Feb 10.

21.

Crystallization and preliminary X-ray diffraction analysis of the lytic transglycosylase MltE from Escherichia coli.

Artola-Recolons C, Llarrull LI, Lastochkin E, Mobashery S, Hermoso JA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jan 1;67(Pt 1):161-3. doi: 10.1107/S1744309110049171. Epub 2010 Dec 24.

22.

The future of the β-lactams.

Llarrull LI, Testero SA, Fisher JF, Mobashery S.

Curr Opin Microbiol. 2010 Oct;13(5):551-7. doi: 10.1016/j.mib.2010.09.008. Epub 2010 Sep 29. Review.

PMID:
20888287
23.

Binding of the gene repressor BlaI to the bla operon in methicillin-resistant Staphylococcus aureus.

Llarrull LI, Prorok M, Mobashery S.

Biochemistry. 2010 Sep 21;49(37):7975-7. doi: 10.1021/bi101177a.

24.

Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases.

Forbes C, Shi Q, Fisher JF, Lee M, Hesek D, Llarrull LI, Toth M, Gossing M, Fridman R, Mobashery S.

Chem Biol Drug Des. 2009 Dec;74(6):527-34. doi: 10.1111/j.1747-0285.2009.00881.x. Epub 2009 Oct 6.

25.

Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge.

Llarrull LI, Fisher JF, Mobashery S.

Antimicrob Agents Chemother. 2009 Oct;53(10):4051-63. doi: 10.1128/AAC.00084-09. Epub 2009 May 26. Review. No abstract available.

26.

Trapping and characterization of a reaction intermediate in carbapenem hydrolysis by B. cereus metallo-beta-lactamase.

Tioni MF, Llarrull LI, Poeylaut-Palena AA, Martí MA, Saggu M, Periyannan GR, Mata EG, Bennett B, Murgida DH, Vila AJ.

J Am Chem Soc. 2008 Nov 26;130(47):15852-63. doi: 10.1021/ja801169j.

27.

Metal content and localization during turnover in B. cereus metallo-beta-lactamase.

Llarrull LI, Tioni MF, Vila AJ.

J Am Chem Soc. 2008 Nov 26;130(47):15842-51. doi: 10.1021/ja801168r.

PMID:
18980306
28.

Engineered mononuclear variants in Bacillus cereus metallo-beta-lactamase BcII are inactive.

Abriata LA, González LJ, Llarrull LI, Tomatis PE, Myers WK, Costello AL, Tierney DL, Vila AJ.

Biochemistry. 2008 Aug 19;47(33):8590-9. doi: 10.1021/bi8006912. Epub 2008 Jul 25.

29.

Evidence for a dinuclear active site in the metallo-beta-lactamase BcII with substoichiometric Co(II). A new model for metal uptake.

Llarrull LI, Tioni MF, Kowalski J, Bennett B, Vila AJ.

J Biol Chem. 2007 Oct 19;282(42):30586-95. Epub 2007 Aug 22.

30.

Asp-120 locates Zn2 for optimal metallo-beta-lactamase activity.

Llarrull LI, Fabiane SM, Kowalski JM, Bennett B, Sutton BJ, Vila AJ.

J Biol Chem. 2007 Jun 22;282(25):18276-85. Epub 2007 Apr 10.

31.

Structural basis of lipid biosynthesis regulation in Gram-positive bacteria.

Schujman GE, Guerin M, Buschiazzo A, Schaeffer F, Llarrull LI, Reh G, Vila AJ, Alzari PM, de Mendoza D.

EMBO J. 2006 Sep 6;25(17):4074-83. Epub 2006 Aug 24.

32.

Water-assisted reaction mechanism of monozinc beta-lactamases.

Dal Peraro M, Llarrull LI, Rothlisberger U, Vila AJ, Carloni P.

J Am Chem Soc. 2004 Oct 6;126(39):12661-8.

PMID:
15453800

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