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Items: 1 to 50 of 88

1.

Blockade of nitric oxide signalling promotes resilience to the effects of social defeat stress on the conditioned rewarding properties of MDMA in mice.

García-Pardo MP, LLansola M, Felipo V, De la Rubia Ortí JE, Aguilar MA.

Nitric Oxide. 2020 May 1;98:29-32. doi: 10.1016/j.niox.2020.03.001. Epub 2020 Mar 3.

PMID:
32142901
2.

Sustained hyperammonemia induces TNF-a IN Purkinje neurons by activating the TNFR1-NF-κB pathway.

Balzano T, Arenas YM, Dadsetan S, Forteza J, Gil-Perotin S, Cubas-Nuñez L, Casanova B, Gracià F, Varela-Andrés N, Montoliu C, Llansola M, Felipo V.

J Neuroinflammation. 2020 Feb 22;17(1):70. doi: 10.1186/s12974-020-01746-z.

3.

Hyperammonemia alters the mismatch negativity in the auditory evoked potential by altering functional connectivity and neurotransmission.

García-García R, Guerrero JF, Lavilla-Miyasato M, Magdalena JR, Ordoño JF, Llansola M, Montoliu C, Teruel-Martí V, Felipo V.

J Neurochem. 2019 Dec 15:e14941. doi: 10.1111/jnc.14941. [Epub ahead of print]

PMID:
31840253
4.

A Multiomics Study To Unravel the Effects of Developmental Exposure to Endosulfan in Rats: Molecular Explanation for Sex-Dependent Effects.

Tarazona S, Bernabeu E, Carmona H, Gómez-Giménez B, García-Planells J, Leonards PEG, Jung S, Conesa A, Felipo V, Llansola M.

ACS Chem Neurosci. 2019 Oct 16;10(10):4264-4279. doi: 10.1021/acschemneuro.9b00304. Epub 2019 Sep 10.

PMID:
31464424
5.

Bicuculline Reduces Neuroinflammation in Hippocampus and Improves Spatial Learning and Anxiety in Hyperammonemic Rats. Role of Glutamate Receptors.

Malaguarnera M, Llansola M, Balzano T, Gómez-Giménez B, Antúnez-Muñoz C, Martínez-Alarcón N, Mahdinia R, Felipo V.

Front Pharmacol. 2019 Feb 25;10:132. doi: 10.3389/fphar.2019.00132. eCollection 2019.

6.

Peripheral inflammation induces neuroinflammation that alters neurotransmission and cognitive and motor function in hepatic encephalopathy: Underlying mechanisms and therapeutic implications.

Cabrera-Pastor A, Llansola M, Montoliu C, Malaguarnera M, Balzano T, Taoro-Gonzalez L, García-García R, Mangas-Losada A, Izquierdo-Altarejos P, Arenas YM, Leone P, Felipo V.

Acta Physiol (Oxf). 2019 Jun;226(2):e13270. doi: 10.1111/apha.13270. Epub 2019 Mar 22. Review.

PMID:
30830722
7.

Chronic hyperammonemia induces peripheral inflammation that leads to cognitive impairment in rats: reversal by anti-tnfa treatment.

Balzano T, Dadsetan S, Forteza J, Cabrera-Pastor A, Taoro-Gonzalez L, Malaguarnera M, Gil-Perotin S, Cubas-Nuñez L, Casanova B, Castro-Quintas A, Ponce-Mora A, Arenas YM, Leone P, Llansola M, Felipo V.

J Hepatol. 2019 Jan 14. pii: S0168-8278(19)30019-4. doi: 10.1016/j.jhep.2019.01.008. [Epub ahead of print]

PMID:
30654069
8.

Role of NMDA and AMPA glutamatergic receptors in the effects of social defeat on the rewarding properties of MDMA in mice.

García-Pardo MP, Miñarro J, Llansola M, Felipo V, Aguilar MA.

Eur J Neurosci. 2019 Aug;50(3):2623-2634. doi: 10.1111/ejn.14190. Epub 2018 Oct 24.

PMID:
30276890
9.

Increasing extracellular cGMP in cerebellum in vivo reduces neuroinflammation, GABAergic tone and motor in-coordination in hyperammonemic rats.

Cabrera-Pastor A, Balzano T, Hernández-Rabaza V, Malaguarnera M, Llansola M, Felipo V.

Brain Behav Immun. 2018 Mar;69:386-398. doi: 10.1016/j.bbi.2017.12.013. Epub 2017 Dec 27.

PMID:
29288802
10.

Chronic hyperammonemia alters in opposite ways membrane expression of GluA1 and GluA2 AMPA receptor subunits in cerebellum. Molecular mechanisms involved.

Cabrera-Pastor A, Taoro-González L, López-Merino E, Celma F, Llansola M, Felipo V.

Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):286-295. doi: 10.1016/j.bbadis.2017.10.031. Epub 2017 Oct 28.

11.

Endosulfan and Cypermethrin Pesticide Mixture Induces Synergistic or Antagonistic Effects on Developmental Exposed Rats Depending on the Analyzed Behavioral or Neurochemical End Points.

Gómez-Giménez B, Llansola M, Cabrera-Pastor A, Hernández-Rabaza V, Agustí A, Felipo V.

ACS Chem Neurosci. 2018 Feb 21;9(2):369-380. doi: 10.1021/acschemneuro.7b00364. Epub 2017 Nov 13.

PMID:
29094921
12.

Developmental Exposure to Pesticides Alters Motor Activity and Coordination in Rats: Sex Differences and Underlying Mechanisms.

Gómez-Giménez B, Felipo V, Cabrera-Pastor A, Agustí A, Hernández-Rabaza V, Llansola M.

Neurotox Res. 2018 Feb;33(2):247-258. doi: 10.1007/s12640-017-9823-9. Epub 2017 Oct 3.

PMID:
28975519
13.

Inhibition of γ-Secretase Leads to an Increase in Presenilin-1.

Sogorb-Esteve A, García-Ayllón MS, Llansola M, Felipo V, Blennow K, Sáez-Valero J.

Mol Neurobiol. 2018 Jun;55(6):5047-5058. doi: 10.1007/s12035-017-0705-1. Epub 2017 Aug 16.

14.

Determination of selected neurotoxic insecticides in small amounts of animal tissue utilizing a newly constructed mini-extractor.

Seifertová M, Čechová E, Llansola M, Felipo V, Vykoukalová M, Kočan A.

Anal Bioanal Chem. 2017 Oct;409(25):6015-6026. doi: 10.1007/s00216-017-0533-1. Epub 2017 Aug 10.

PMID:
28799107
15.

Sildenafil reduces neuroinflammation in cerebellum, restores GABAergic tone, and improves motor in-coordination in rats with hepatic encephalopathy.

Agusti A, Hernández-Rabaza V, Balzano T, Taoro-Gonzalez L, Ibañez-Grau A, Cabrera-Pastor A, Fustero S, Llansola M, Montoliu C, Felipo V.

CNS Neurosci Ther. 2017 May;23(5):386-394. doi: 10.1111/cns.12688. Epub 2017 Mar 11.

16.

Sex-dependent effects of developmental exposure to different pesticides on spatial learning. The role of induced neuroinflammation in the hippocampus.

Gómez-Giménez B, Llansola M, Hernández-Rabaza V, Cabrera-Pastor A, Malaguarnera M, Agusti A, Felipo V.

Food Chem Toxicol. 2017 Jan;99:135-148. doi: 10.1016/j.fct.2016.11.028. Epub 2016 Nov 29.

PMID:
27908700
17.

Reducing Peripheral Inflammation with Infliximab Reduces Neuroinflammation and Improves Cognition in Rats with Hepatic Encephalopathy.

Dadsetan S, Balzano T, Forteza J, Cabrera-Pastor A, Taoro-Gonzalez L, Hernandez-Rabaza V, Gil-Perotín S, Cubas-Núñez L, García-Verdugo JM, Agusti A, Llansola M, Felipo V.

Front Mol Neurosci. 2016 Nov 2;9:106. eCollection 2016.

18.
19.

Extracellular cGMP Modulates Learning Biphasically by Modulating Glycine Receptors, CaMKII and Glutamate-Nitric Oxide-cGMP Pathway.

Cabrera-Pastor A, Malaguarnera M, Taoro-Gonzalez L, Llansola M, Felipo V.

Sci Rep. 2016 Sep 16;6:33124. doi: 10.1038/srep33124.

20.

Infliximab reduces peripheral inflammation, neuroinflammation, and extracellular GABA in the cerebellum and improves learning and motor coordination in rats with hepatic encephalopathy.

Dadsetan S, Balzano T, Forteza J, Agusti A, Cabrera-Pastor A, Taoro-Gonzalez L, Hernandez-Rabaza V, Gomez-Gimenez B, ElMlili N, Llansola M, Felipo V.

J Neuroinflammation. 2016 Sep 13;13(1):245. doi: 10.1186/s12974-016-0710-8.

21.

Sildenafil Treatment Eliminates Pruritogenesis and Thermal Hyperalgesia in Rats with Portacaval Shunts.

Belghiti M, Agusti A, Hernandez-Rabaza V, Cabrera-Pastor A, Llansola M, Felipo V.

Neurochem Res. 2017 Mar;42(3):788-794. doi: 10.1007/s11064-016-1980-3. Epub 2016 Jun 20.

PMID:
27321307
22.

In vivo administration of extracellular cGMP normalizes TNF-α and membrane expression of AMPA receptors in hippocampus and spatial reference memory but not IL-1β, NMDA receptors in membrane and working memory in hyperammonemic rats.

Cabrera-Pastor A, Hernandez-Rabaza V, Taoro-Gonzalez L, Balzano T, Llansola M, Felipo V.

Brain Behav Immun. 2016 Oct;57:360-370. doi: 10.1016/j.bbi.2016.05.011. Epub 2016 May 14.

PMID:
27189036
23.

Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia.

Hernandez-Rabaza V, Cabrera-Pastor A, Taoro-Gonzalez L, Gonzalez-Usano A, Agusti A, Balzano T, Llansola M, Felipo V.

J Neuroinflammation. 2016 Apr 18;13(1):83. doi: 10.1186/s12974-016-0549-z.

24.

Hyperammonemia induces glial activation, neuroinflammation and alters neurotransmitter receptors in hippocampus, impairing spatial learning: reversal by sulforaphane.

Hernández-Rabaza V, Cabrera-Pastor A, Taoro-González L, Malaguarnera M, Agustí A, Llansola M, Felipo V.

J Neuroinflammation. 2016 Feb 16;13:41. doi: 10.1186/s12974-016-0505-y.

25.

Sildenafil reduces neuroinflammation and restores spatial learning in rats with hepatic encephalopathy: underlying mechanisms.

Hernandez-Rabaza V, Agusti A, Cabrera-Pastor A, Fustero S, Delgado O, Taoro-Gonzalez L, Montoliu C, Llansola M, Felipo V.

J Neuroinflammation. 2015 Oct 29;12:195. doi: 10.1186/s12974-015-0420-7.

26.

Roles of the NMDA Receptor and EAAC1 Transporter in the Modulation of Extracellular Glutamate by Low and High Affinity AMPA Receptors in the Cerebellum in Vivo: Differential Alteration in Chronic Hyperammonemia.

Cabrera-Pastor A, Taoro L, Llansola M, Felipo V.

ACS Chem Neurosci. 2015 Dec 16;6(12):1913-21. doi: 10.1021/acschemneuro.5b00212. Epub 2015 Oct 13.

PMID:
26428532
27.

Modulation of GABAA receptors by neurosteroids. A new concept to improve cognitive and motor alterations in hepatic encephalopathy.

Agusti A, Llansola M, Hernández-Rabaza V, Cabrera-Pastor A, Montoliu C, Felipo V.

J Steroid Biochem Mol Biol. 2016 Jun;160:88-93. doi: 10.1016/j.jsbmb.2015.08.020. Epub 2015 Aug 22. Review.

PMID:
26307490
28.

Rats with minimal hepatic encephalopathy show reduced cGMP-dependent protein kinase activity in hypothalamus correlating with circadian rhythms alterations.

Felipo V, Piedrafita B, Barios JA, Agustí A, Ahabrach H, Romero-Vives M, Barrio LC, Rey B, Gaztelu JM, Llansola M.

Chronobiol Int. 2015;32(7):966-79. doi: 10.3109/07420528.2015.1057640.

PMID:
26203935
29.

GR3027 antagonizes GABAA receptor-potentiating neurosteroids and restores spatial learning and motor coordination in rats with chronic hyperammonemia and hepatic encephalopathy.

Johansson M, Agusti A, Llansola M, Montoliu C, Strömberg J, Malinina E, Ragagnin G, Doverskog M, Bäckström T, Felipo V.

Am J Physiol Gastrointest Liver Physiol. 2015 Sep 1;309(5):G400-9. doi: 10.1152/ajpgi.00073.2015. Epub 2015 Jul 2.

30.

Gender differences in spatial learning, synaptic activity, and long-term potentiation in the hippocampus in rats: molecular mechanisms.

Monfort P, Gomez-Gimenez B, Llansola M, Felipo V.

ACS Chem Neurosci. 2015 Aug 19;6(8):1420-7. doi: 10.1021/acschemneuro.5b00096. Epub 2015 Jul 2.

PMID:
26098845
31.

Interplay between glutamatergic and GABAergic neurotransmission alterations in cognitive and motor impairment in minimal hepatic encephalopathy.

Llansola M, Montoliu C, Agusti A, Hernandez-Rabaza V, Cabrera-Pastor A, Gomez-Gimenez B, Malaguarnera M, Dadsetan S, Belghiti M, Garcia-Garcia R, Balzano T, Taoro L, Felipo V.

Neurochem Int. 2015 Sep;88:15-9. doi: 10.1016/j.neuint.2014.10.011. Epub 2014 Nov 20. Review.

PMID:
25447766
32.

Presence of diadenosine polyphosphates in microdialysis samples from rat cerebellum in vivo: effect of mild hyperammonemia on their receptors.

Gualix J, Gómez-Villafuertes R, Pintor J, Llansola M, Felipo V, Miras-Portugal MT.

Purinergic Signal. 2014;10(2):349-56. doi: 10.1007/s11302-013-9382-3. Epub 2013 Aug 13.

33.

Cerebral oedema is not responsible for motor or cognitive deficits in rats with hepatic encephalopathy.

Cauli O, Llansola M, Agustí A, Rodrigo R, Hernández-Rabaza V, Rodrigues TB, López-Larrubia P, Cerdán S, Felipo V.

Liver Int. 2014 Mar;34(3):379-87. doi: 10.1111/liv.12258. Epub 2013 Jul 21.

PMID:
23869990
34.

Impaired release of corticosterone from adrenals contributes to impairment of circadian rhythms of activity in hyperammonemic rats.

Llansola M, Ahabrach H, Errami M, Cabrera-Pastor A, Addaoudi K, Felipo V.

Arch Biochem Biophys. 2013 Aug 15;536(2):164-70. doi: 10.1016/j.abb.2013.01.009. Epub 2013 Feb 1.

PMID:
23376587
35.

Gender differential effects of developmental exposure to methyl-mercury, polychlorinated biphenyls 126 or 153, or its combinations on motor activity and coordination.

Cauli O, Piedrafita B, Llansola M, Felipo V.

Toxicology. 2013 Sep 6;311(1-2):61-8. doi: 10.1016/j.tox.2012.11.016. Epub 2012 Dec 5.

PMID:
23220684
36.

Chronic hyperammonemia, glutamatergic neurotransmission and neurological alterations.

Llansola M, Montoliu C, Cauli O, Hernández-Rabaza V, Agustí A, Cabrera-Pastor A, Giménez-Garzó C, González-Usano A, Felipo V.

Metab Brain Dis. 2013 Jun;28(2):151-4. doi: 10.1007/s11011-012-9337-3. Epub 2012 Sep 26. Review.

PMID:
23010935
37.

Differential effects of chronic hyperammonemia on modulation of the glutamate-nitric oxide-cGMP pathway by metabotropic glutamate receptor 5 and low and high affinity AMPA receptors in cerebellum in vivo.

Cabrera-Pastor A, Llansola M, Reznikov V, Boix J, Felipo V.

Neurochem Int. 2012 Jul;61(1):63-71. doi: 10.1016/j.neuint.2012.04.006. Epub 2012 Apr 11.

PMID:
22521775
38.

Insight into the neuroproteomics effects of the food-contaminant non-dioxin like polychlorinated biphenyls.

Brunelli L, Llansola M, Felipo V, Campagna R, Airoldi L, De Paola M, Fanelli R, Mariani A, Mazzoletti M, Pastorelli R.

J Proteomics. 2012 Apr 18;75(8):2417-30. doi: 10.1016/j.jprot.2012.02.023. Epub 2012 Feb 24.

PMID:
22387315
39.

Progressive reduction of sleep time and quality in rats with hepatic encephalopathy caused by portacaval shunts.

Llansola M, Cantero JL, Hita-Yañez E, Mirones-Maldonado MJ, Piedrafita B, Ahabrach H, Errami M, Agusti A, Felipo V.

Neuroscience. 2012 Jan 10;201:199-208. doi: 10.1016/j.neuroscience.2011.11.009. Epub 2011 Nov 12.

PMID:
22108612
40.

Exploratory investigation on nitro- and phospho-proteome cerebellum changes in hyperammonemia and hepatic encephalopathy rat models.

Brunelli L, Campagna R, Airoldi L, Cauli O, Llansola M, Boix J, Felipo V, Pastorelli R.

Metab Brain Dis. 2012 Mar;27(1):37-49. doi: 10.1007/s11011-011-9268-4. Epub 2011 Nov 15.

PMID:
22083566
41.

Cerebellum proteomics addressing the cognitive deficit of rats perinatally exposed to the food-relevant polychlorinated biphenyl 138.

Campagna R, Brunelli L, Airoldi L, Fanelli R, Hakansson H, Heimeier RA, De Boever P, Boix J, Llansola M, Felipo V, Pastorelli R.

Toxicol Sci. 2011 Sep;123(1):170-9. doi: 10.1093/toxsci/kfr156. Epub 2011 Jun 14.

PMID:
21673325
42.

p38 MAP kinase is a therapeutic target for hepatic encephalopathy in rats with portacaval shunts.

Agusti A, Cauli O, Rodrigo R, Llansola M, Hernández-Rabaza V, Felipo V.

Gut. 2011 Nov;60(11):1572-9. doi: 10.1136/gut.2010.236083. Epub 2011 Jun 2.

PMID:
21636647
43.

Metabotropic glutamate receptor 5 modulates the nitric oxide-cGMP pathway in cerebellum in vivo through activation of AMPA receptors.

Boix J, Llansola M, Cabrera-Pastor A, Felipo V.

Neurochem Int. 2011 Apr;58(5):599-604. doi: 10.1016/j.neuint.2011.01.025. Epub 2011 Feb 12.

PMID:
21300123
44.

Polychlorinated biphenyls PCB 52, PCB 180, and PCB 138 impair the glutamate-nitric oxide-cGMP pathway in cerebellar neurons in culture by different mechanisms.

Llansola M, Montoliu C, Boix J, Felipo V.

Chem Res Toxicol. 2010 Apr 19;23(4):813-20. doi: 10.1021/tx900440q.

PMID:
20297801
45.

Cyclic GMP pathways in hepatic encephalopathy. Neurological and therapeutic implications.

Montoliu C, Rodrigo R, Monfort P, Llansola M, Cauli O, Boix J, Elmlili N, Agusti A, Felipo V.

Metab Brain Dis. 2010 Mar;25(1):39-48. doi: 10.1007/s11011-010-9184-z. Epub 2010 Mar 2. Review.

PMID:
20195723
46.

Metabotropic glutamate receptor 5, but not 1, modulates NMDA receptor-mediated activation of neuronal nitric oxide synthase.

Llansola M, Felipo V.

Neurochem Int. 2010 Mar;56(4):535-45. doi: 10.1016/j.neuint.2009.12.016. Epub 2010 Jan 4.

PMID:
20043967
47.

Chronic hyperammonemia alters the circadian rhythms of corticosteroid hormone levels and of motor activity in rats.

Ahabrach H, Piedrafita B, Ayad A, El Mlili N, Errami M, Felipo V, Llansola M.

J Neurosci Res. 2010 May 15;88(7):1605-14. doi: 10.1002/jnr.22311.

PMID:
19998493
48.

Polychlorinated biphenyls PCB 153 and PCB 126 impair the glutamate-nitric oxide-cGMP pathway in cerebellar neurons in culture by different mechanisms.

Llansola M, Piedrafita B, Rodrigo R, Montoliu C, Felipo V.

Neurotox Res. 2009 Aug;16(2):97-105. doi: 10.1007/s12640-009-9055-8. Epub 2009 Apr 29.

PMID:
19526286
49.

Mechanisms of cognitive alterations in hyperammonemia and hepatic encephalopathy: therapeutical implications.

Monfort P, Cauli O, Montoliu C, Rodrigo R, Llansola M, Piedrafita B, El Mlili N, Boix J, Agustí A, Felipo V.

Neurochem Int. 2009 Jul-Aug;55(1-3):106-12. doi: 10.1016/j.neuint.2009.01.021. Epub 2009 Feb 6.

PMID:
19428813
50.

Increasing the function of the glutamate-nitric oxide-cyclic guanosine monophosphate pathway increases the ability to learn a Y-maze task.

Llansola M, Hernandez-Viadel M, Erceg S, Montoliu C, Felipo V.

J Neurosci Res. 2009 Aug 1;87(10):2351-5. doi: 10.1002/jnr.22064.

PMID:
19326454

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