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Essays Biochem. 2019 Jul 26. pii: EBC20190014. doi: 10.1042/EBC20190014. [Epub ahead of print]

Membrane dynamics in cell migration.

Author information

1
Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield, S102TN, U.K.
2
Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield, S102TN, U.K. e.rainero@sheffield.ac.uk.

Abstract

Migration of cells is required in multiple tissue-level processes, such as in inflammation or cancer metastasis. Endocytosis is an extremely regulated cellular process by which cells uptake extracellular molecules or internalise cell surface receptors. While the role of endocytosis of focal adhesions (FA) and plasma membrane (PM) turnover at the leading edge of migratory cells is wide known, the contribution of endocytic proteins per se in migration has been frequently disregarded. In this review, we describe the novel functions of the most well-known endocytic proteins in cancer cell migration, focusing on clathrin, caveolin, flotillins and GRAF1. In addition, we highlight the relevance of the macropinocytic pathway in amoeboid-like cell migration.

KEYWORDS:

caveolins; cell migration; clathrin; endocytosis; macropinocytosis

PMID:
31350382
DOI:
10.1042/EBC20190014

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