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Items: 25


Intrinsic Instability of BOK Enables Membrane Permeabilization in Apoptosis.

Zheng JH, Grace CR, Guibao CD, McNamara DE, Llambi F, Wang YM, Chen T, Moldoveanu T.

Cell Rep. 2018 May 15;23(7):2083-2094.e6. doi: 10.1016/j.celrep.2018.04.060.


Regulation of apoptosis by an intrinsically disordered region of Bcl-xL.

Follis AV, Llambi F, Kalkavan H, Yao Y, Phillips AH, Park CG, Marassi FM, Green DR, Kriwacki RW.

Nat Chem Biol. 2018 May;14(5):458-465. doi: 10.1038/s41589-018-0011-x. Epub 2018 Mar 5.


BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation.

Llambi F, Wang YM, Victor B, Yang M, Schneider DM, Gingras S, Parsons MJ, Zheng JH, Brown SA, Pelletier S, Moldoveanu T, Chen T, Green DR.

Cell. 2016 Apr 7;165(2):421-33. doi: 10.1016/j.cell.2016.02.026. Epub 2016 Mar 3.


Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis.

Quarato G, Guy CS, Grace CR, Llambi F, Nourse A, Rodriguez DA, Wakefield R, Frase S, Moldoveanu T, Green DR.

Mol Cell. 2016 Feb 18;61(4):589-601. doi: 10.1016/j.molcel.2016.01.011. Epub 2016 Feb 4.


Cell Death Signaling.

Green DR, Llambi F.

Cold Spring Harb Perspect Biol. 2015 Dec 1;7(12). pii: a006080. doi: 10.1101/cshperspect.a006080. Review.


Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis.

Follis AV, Llambi F, Merritt P, Chipuk JE, Green DR, Kriwacki RW.

Mol Cell. 2015 Aug 20;59(4):677-84. doi: 10.1016/j.molcel.2015.06.029. Epub 2015 Jul 30.


Novel combination of mitochondrial division inhibitor 1 (mdivi-1) and platinum agents produces synergistic pro-apoptotic effect in drug resistant tumor cells.

Qian W, Wang J, Roginskaya V, McDermott LA, Edwards RP, Stolz DB, Llambi F, Green DR, Van Houten B.

Oncotarget. 2014 Jun 30;5(12):4180-94.


The DNA-binding domain mediates both nuclear and cytosolic functions of p53.

Follis AV, Llambi F, Ou L, Baran K, Green DR, Kriwacki RW.

Nat Struct Mol Biol. 2014 Jun;21(6):535-43. doi: 10.1038/nsmb.2829. Epub 2014 May 11.


RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3.

Dillon CP, Weinlich R, Rodriguez DA, Cripps JG, Quarato G, Gurung P, Verbist KC, Brewer TL, Llambi F, Gong YN, Janke LJ, Kelliher MA, Kanneganti TD, Green DR.

Cell. 2014 May 22;157(5):1189-202. doi: 10.1016/j.cell.2014.04.018. Epub 2014 May 8.


The dependence receptor TrkC triggers mitochondria-dependent apoptosis upon Cobra-1 recruitment.

Ichim G, Genevois AL, Ménard M, Yu LY, Coelho-Aguiar JM, Llambi F, Jarrosson-Wuilleme L, Lefebvre J, Tulasne D, Dupin E, Le Douarin N, Arumäe U, Tauszig-Delamasure S, Mehlen P.

Mol Cell. 2013 Sep 12;51(5):632-46. doi: 10.1016/j.molcel.2013.08.021.


BID-induced structural changes in BAK promote apoptosis.

Moldoveanu T, Grace CR, Llambi F, Nourse A, Fitzgerald P, Gehring K, Kriwacki RW, Green DR.

Nat Struct Mol Biol. 2013 May;20(5):589-97. doi: 10.1038/nsmb.2563. Epub 2013 Apr 21.


Systems analysis of BCL2 protein family interactions establishes a model to predict responses to chemotherapy.

Lindner AU, Concannon CG, Boukes GJ, Cannon MD, Llambi F, Ryan D, Boland K, Kehoe J, McNamara DA, Murray F, Kay EW, Hector S, Green DR, Huber HJ, Prehn JH.

Cancer Res. 2013 Jan 15;73(2):519-28. doi: 10.1158/0008-5472.CAN-12-2269.


Nail psoriasis: treatment with tazarotene 0.1% hydrophilic ointment.

Fischer-Levancini C, Sánchez-Regaña M, Llambí F, Collgros H, Expósito-Serrano V, Umbert-Millet P.

Actas Dermosifiliogr. 2012 Oct;103(8):725-8. Epub 2012 Jul 19. English, Spanish.


Mitochondrial pathway of apoptosis is ancestral in metazoans.

Bender CE, Fitzgerald P, Tait SW, Llambi F, McStay GP, Tupper DO, Pellettieri J, Sánchez Alvarado A, Salvesen GS, Green DR.

Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4904-9. doi: 10.1073/pnas.1120680109. Epub 2012 Mar 13.


A unified model of mammalian BCL-2 protein family interactions at the mitochondria.

Llambi F, Moldoveanu T, Tait SW, Bouchier-Hayes L, Temirov J, McCormick LL, Dillon CP, Green DR.

Mol Cell. 2011 Nov 18;44(4):517-31. doi: 10.1016/j.molcel.2011.10.001. Epub 2011 Oct 27.


Apoptosis and oncogenesis: give and take in the BCL-2 family.

Llambi F, Green DR.

Curr Opin Genet Dev. 2011 Feb;21(1):12-20. doi: 10.1016/j.gde.2010.12.001. Epub 2011 Jan 13. Review.


Resistance to caspase-independent cell death requires persistence of intact mitochondria.

Tait SW, Parsons MJ, Llambi F, Bouchier-Hayes L, Connell S, Muñoz-Pinedo C, Green DR.

Dev Cell. 2010 May 18;18(5):802-13. doi: 10.1016/j.devcel.2010.03.014.


The BCL-2 family reunion.

Chipuk JE, Moldoveanu T, Llambi F, Parsons MJ, Green DR.

Mol Cell. 2010 Feb 12;37(3):299-310. doi: 10.1016/j.molcel.2010.01.025. Review.


Interfering with multimerization of netrin-1 receptors triggers tumor cell death.

Mille F, Llambi F, Guix C, Delloye-Bourgeois C, Guenebeaud C, Castro-Obregon S, Bredesen DE, Thibert C, Mehlen P.

Cell Death Differ. 2009 Oct;16(10):1344-51. doi: 10.1038/cdd.2009.75. Epub 2009 Jun 19.


Netrin-1 interacts with amyloid precursor protein and regulates amyloid-beta production.

Lourenço FC, Galvan V, Fombonne J, Corset V, Llambi F, Müller U, Bredesen DE, Mehlen P.

Cell Death Differ. 2009 May;16(5):655-63. doi: 10.1038/cdd.2008.191. Epub 2009 Jan 16.


Role of netrin-1 and netrin-1 dependence receptors in colorectal cancers.

Mehlen P, Llambi F.

Br J Cancer. 2005 Jul 11;93(1):1-6. Review.


The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase.

Llambi F, Lourenço FC, Gozuacik D, Guix C, Pays L, Del Rio G, Kimchi A, Mehlen P.

EMBO J. 2005 Mar 23;24(6):1192-201. Epub 2005 Feb 24.


The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment.

Thiebault K, Mazelin L, Pays L, Llambi F, Joly MO, Scoazec JY, Saurin JC, Romeo G, Mehlen P.

Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4173-8. Epub 2003 Mar 24.


Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation.

Forcet C, Stein E, Pays L, Corset V, Llambi F, Tessier-Lavigne M, Mehlen P.

Nature. 2002 May 23;417(6887):443-7. Epub 2002 May 1.


Netrin-1 acts as a survival factor via its receptors UNC5H and DCC.

Llambi F, Causeret F, Bloch-Gallego E, Mehlen P.

EMBO J. 2001 Jun 1;20(11):2715-22.

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