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Items: 1 to 50 of 140

1.

Multi-omics profiling reveals key signaling pathways in ovarian cancer controlled by STAT3.

Lu T, Bankhead A 3rd, Ljungman M, Neamati N.

Theranostics. 2019 Jul 28;9(19):5478-5496. doi: 10.7150/thno.33444. eCollection 2019.

2.

Further investigations of the IgE response to tetanus and diphtheria following covaccination with acellular rather than cellular Bordetella pertussis.

Aalberse RC, Grüber C, Ljungman M, Kakat S, Wahn U, Niggemann B, Nilsson LJ.

Pediatr Allergy Immunol. 2019 Aug 16. doi: 10.1111/pai.13113. [Epub ahead of print]

PMID:
31419322
3.

The role of H3K79 methylation in transcription and the DNA damage response.

Ljungman M, Parks L, Hulbatte R, Bedi K.

Mutat Res. 2019 Apr - Jun;780:48-54. doi: 10.1016/j.mrrev.2017.11.001. Epub 2017 Nov 16. Review.

PMID:
31395348
4.

Inhibition of protein disulfide isomerase in glioblastoma causes marked downregulation of DNA repair and DNA damage response genes.

Xu S, Liu Y, Yang K, Wang H, Shergalis A, Kyani A, Bankhead A 3rd, Tamura S, Yang S, Wang X, Wang CC, Rehemtulla A, Ljungman M, Neamati N.

Theranostics. 2019 Apr 12;9(8):2282-2298. doi: 10.7150/thno.30621. eCollection 2019.

5.

ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis.

Wang L, Yang H, Zamperone A, Diolaiti D, Palmbos PL, Abel EV, Purohit V, Dolgalev I, Rhim AD, Ljungman M, Hadju CH, Halbrook CJ, Bar-Sagi D, di Magliano MP, Crawford HC, Simeone DM.

Genes Dev. 2019 Jun 1;33(11-12):641-655. doi: 10.1101/gad.323303.118. Epub 2019 May 2.

PMID:
31048544
6.

Activation of the Unfolded Protein Response via Inhibition of Protein Disulfide Isomerase Decreases the Capacity for DNA Repair to Sensitize Glioblastoma to Radiotherapy.

Liu Y, Ji W, Shergalis A, Xu J, Delaney AM, Calcaterra A, Pal A, Ljungman M, Neamati N, Rehemtulla A.

Cancer Res. 2019 Jun 1;79(11):2923-2932. doi: 10.1158/0008-5472.CAN-18-2540. Epub 2019 Apr 17.

PMID:
30996048
7.

Genome-wide de novo L1 Retrotransposition Connects Endonuclease Activity with Replication.

Flasch DA, Macia Á, Sánchez L, Ljungman M, Heras SR, García-Pérez JL, Wilson TE, Moran JV.

Cell. 2019 May 2;177(4):837-851.e28. doi: 10.1016/j.cell.2019.02.050. Epub 2019 Apr 4.

PMID:
30955886
8.

Pertactin-deficient Bordetella pertussis isolates: evidence of increased circulation in Europe, 1998 to 2015.

Barkoff AM, Mertsola J, Pierard D, Dalby T, Hoegh SV, Guillot S, Stefanelli P, van Gent M, Berbers G, Vestrheim D, Greve-Isdahl M, Wehlin L, Ljungman M, Fry NK, Markey K, He Q.

Euro Surveill. 2019 Feb;24(7). doi: 10.2807/1560-7917.ES.2019.24.7.1700832.

9.

IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response.

Núñez FJ, Mendez FM, Kadiyala P, Alghamri MS, Savelieff MG, Garcia-Fabiani MB, Haase S, Koschmann C, Calinescu AA, Kamran N, Saxena M, Patel R, Carney S, Guo MZ, Edwards M, Ljungman M, Qin T, Sartor MA, Tagett R, Venneti S, Brosnan-Cashman J, Meeker A, Gorbunova V, Zhao L, Kremer DM, Zhang L, Lyssiotis CA, Jones L, Herting CJ, Ross JL, Hambardzumyan D, Hervey-Jumper S, Figueroa ME, Lowenstein PR, Castro MG.

Sci Transl Med. 2019 Feb 13;11(479). pii: eaaq1427. doi: 10.1126/scitranslmed.aaq1427.

10.

Design, Synthesis, and Biological Evaluation of Novel Allosteric Protein Disulfide Isomerase Inhibitors.

Yang S, Shergalis A, Lu D, Kyani A, Liu Z, Ljungman M, Neamati N.

J Med Chem. 2019 Apr 11;62(7):3447-3474. doi: 10.1021/acs.jmedchem.8b01951. Epub 2019 Apr 2.

PMID:
30759340
11.

ATDC mediates a TP63-regulated basal cancer invasive program.

Palmbos PL, Wang Y, Bankhead Iii A, Kelleher AJ, Wang L, Yang H, Ahmet ML, Gumkowski ER, Welling SD, Magnuson B, Leflein J, Lorenzatti Hiles G, Abel EV, Dziubinski ML, Urs S, Day ML, Ljungman ME, Simeone DM.

Oncogene. 2019 May;38(18):3340-3354. doi: 10.1038/s41388-018-0646-9. Epub 2019 Jan 14.

12.

Identifying cis Elements for Spatiotemporal Control of Mammalian DNA Replication.

Sima J, Chakraborty A, Dileep V, Michalski M, Klein KN, Holcomb NP, Turner JL, Paulsen MT, Rivera-Mulia JC, Trevilla-Garcia C, Bartlett DA, Zhao PA, Washburn BK, Nora EP, Kraft K, Mundlos S, Bruneau BG, Ljungman M, Fraser P, Ay F, Gilbert DM.

Cell. 2019 Feb 7;176(4):816-830.e18. doi: 10.1016/j.cell.2018.11.036. Epub 2018 Dec 27.

PMID:
30595451
13.

Synthesis and mechanistic studies of quinolin-chlorobenzothioate derivatives with proteasome inhibitory activity in pancreatic cancer cell lines.

Hu S, Jin Y, Liu Y, Ljungman M, Neamati N.

Eur J Med Chem. 2018 Oct 5;158:884-895. doi: 10.1016/j.ejmech.2018.09.037. Epub 2018 Sep 15.

14.

HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties.

Abel EV, Goto M, Magnuson B, Abraham S, Ramanathan N, Hotaling E, Alaniz AA, Kumar-Sinha C, Dziubinski ML, Urs S, Wang L, Shi J, Waghray M, Ljungman M, Crawford HC, Simeone DM.

Elife. 2018 Aug 3;7. pii: e33947. doi: 10.7554/eLife.33947.

15.

Abnormal RNA stability in amyotrophic lateral sclerosis.

Tank EM, Figueroa-Romero C, Hinder LM, Bedi K, Archbold HC, Li X, Weskamp K, Safren N, Paez-Colasante X, Pacut C, Thumma S, Paulsen MT, Guo K, Hur J, Ljungman M, Feldman EL, Barmada SJ.

Nat Commun. 2018 Jul 20;9(1):2845. doi: 10.1038/s41467-018-05049-z.

16.

Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression.

Zhang Y, Pitchiaya S, Cieślik M, Niknafs YS, Tien JC, Hosono Y, Iyer MK, Yazdani S, Subramaniam S, Shukla SK, Jiang X, Wang L, Liu TY, Uhl M, Gawronski AR, Qiao Y, Xiao L, Dhanasekaran SM, Juckette KM, Kunju LP, Cao X, Patel U, Batish M, Shukla GC, Paulsen MT, Ljungman M, Jiang H, Mehra R, Backofen R, Sahinalp CS, Freier SM, Watt AT, Guo S, Wei JT, Feng FY, Malik R, Chinnaiyan AM.

Nat Genet. 2018 Jun;50(6):814-824. doi: 10.1038/s41588-018-0120-1. Epub 2018 May 28.

17.

Menin regulates the serine biosynthetic pathway in Ewing sarcoma.

Svoboda LK, Teh SSK, Sud S, Kerk S, Zebolsky A, Treichel S, Thomas D, Halbrook CJ, Lee HJ, Kremer D, Zhang L, Klossowski S, Bankhead AR, Magnuson B, Ljungman M, Cierpicki T, Grembecka J, Lyssiotis CA, Lawlor ER.

J Pathol. 2018 Jul;245(3):324-336. doi: 10.1002/path.5085. Epub 2018 May 28.

18.

Surveillance of Circulating Bordetella pertussis Strains in Europe during 1998 to 2015.

Barkoff AM, Mertsola J, Pierard D, Dalby T, Hoegh SV, Guillot S, Stefanelli P, van Gent M, Berbers G, Vestrheim DF, Greve-Isdahl M, Wehlin L, Ljungman M, Fry NK, Markey K, Auranen K, He Q.

J Clin Microbiol. 2018 Apr 25;56(5). pii: e01998-17. doi: 10.1128/JCM.01998-17. Print 2018 May.

19.

Apropå! Immunitet mot mässling.

Hallander HO, Ljungman M.

Lakartidningen. 2018 Feb 2;115. pii: EZSZ. Swedish. No abstract available.

20.

Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma.

Schofield HK, Zeller J, Espinoza C, Halbrook CJ, Del Vecchio A, Magnuson B, Fabo T, Daylan AEC, Kovalenko I, Lee HJ, Yan W, Feng Y, Karim SA, Kremer DM, Kumar-Sinha C, Lyssiotis CA, Ljungman M, Morton JP, Galbán S, Fearon ER, Pasca di Magliano M.

JCI Insight. 2018 Jan 25;3(2). pii: 97422. doi: 10.1172/jci.insight.97422. eCollection 2018 Jan 25.

21.

Design and Synthesis of Novel Reactive Oxygen Species Inducers for the Treatment of Pancreatic Ductal Adenocarcinoma.

Kuang Y, Sechi M, Nurra S, Ljungman M, Neamati N.

J Med Chem. 2018 Feb 22;61(4):1576-1594. doi: 10.1021/acs.jmedchem.7b01463. Epub 2018 Feb 2.

22.

Discovery and Mechanistic Elucidation of a Class of Protein Disulfide Isomerase Inhibitors for the Treatment of Glioblastoma.

Kyani A, Tamura S, Yang S, Shergalis A, Samanta S, Kuang Y, Ljungman M, Neamati N.

ChemMedChem. 2018 Jan 22;13(2):164-177. doi: 10.1002/cmdc.201700629. Epub 2018 Jan 4.

23.

A Bifunctional MAPK/PI3K Antagonist for Inhibition of Tumor Growth and Metastasis.

Galbán S, Apfelbaum AA, Espinoza C, Heist K, Haley H, Bedi K, Ljungman M, Galbán CJ, Luker GD, Dort MV, Ross BD.

Mol Cancer Ther. 2017 Nov;16(11):2340-2350. doi: 10.1158/1535-7163.MCT-17-0207. Epub 2017 Aug 3.

24.

A damaged genome's transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks.

Iannelli F, Galbiati A, Capozzo I, Nguyen Q, Magnuson B, Michelini F, D'Alessandro G, Cabrini M, Roncador M, Francia S, Crosetto N, Ljungman M, Carninci P, d'Adda di Fagagna F.

Nat Commun. 2017 May 31;8:15656. doi: 10.1038/ncomms15656.

25.

Human prostate luminal cell differentiation requires NOTCH3 induction by p38-MAPK and MYC.

Frank SB, Berger PL, Ljungman M, Miranti CK.

J Cell Sci. 2017 Jun 1;130(11):1952-1964. doi: 10.1242/jcs.197152. Epub 2017 Apr 26.

26.

Transcriptional and post-transcriptional regulation of the ionizing radiation response by ATM and p53.

Venkata Narayanan I, Paulsen MT, Bedi K, Berg N, Ljungman EA, Francia S, Veloso A, Magnuson B, di Fagagna FD, Wilson TE, Ljungman M.

Sci Rep. 2017 Mar 3;7:43598. doi: 10.1038/srep43598.

27.

RPA Interacts with HIRA and Regulates H3.3 Deposition at Gene Regulatory Elements in Mammalian Cells.

Zhang H, Gan H, Wang Z, Lee JH, Zhou H, Ordog T, Wold MS, Ljungman M, Zhang Z.

Mol Cell. 2017 Jan 19;65(2):272-284. doi: 10.1016/j.molcel.2016.11.030.

28.

PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance.

Roy N, Takeuchi KK, Ruggeri JM, Bailey P, Chang D, Li J, Leonhardt L, Puri S, Hoffman MT, Gao S, Halbrook CJ, Song Y, Ljungman M, Malik S, Wright CV, Dawson DW, Biankin AV, Hebrok M, Crawford HC.

Genes Dev. 2016 Dec 15;30(24):2669-2683. doi: 10.1101/gad.291021.116.

29.

Gene length as a biological timer to establish temporal transcriptional regulation.

Kirkconnell KS, Magnuson B, Paulsen MT, Lu B, Bedi K, Ljungman M.

Cell Cycle. 2017 Feb;16(3):259-270. doi: 10.1080/15384101.2016.1234550. Epub 2017 Jan 5.

30.

Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor.

Ramkumar K, Samanta S, Kyani A, Yang S, Tamura S, Ziemke E, Stuckey JA, Li S, Chinnaswamy K, Otake H, Debnath B, Yarovenko V, Sebolt-Leopold JS, Ljungman M, Neamati N.

Nat Commun. 2016 Oct 5;7:13084. doi: 10.1038/ncomms13084.

31.

Genome stability versus transcript diversity.

Magnuson B, Bedi K, Ljungman M.

DNA Repair (Amst). 2016 Aug;44:81-86. doi: 10.1016/j.dnarep.2016.05.010. Epub 2016 May 16. Review.

32.

Capturing the dynamic nascent transcriptome during acute cellular responses: The serum response.

Kirkconnell KS, Paulsen MT, Magnuson B, Bedi K, Ljungman M.

Biol Open. 2016 Jun 15;5(6):837-47. doi: 10.1242/bio.019323.

33.

Identifying transcription start sites and active enhancer elements using BruUV-seq.

Magnuson B, Veloso A, Kirkconnell KS, de Andrade Lima LC, Paulsen MT, Ljungman EA, Bedi K, Prasad J, Wilson TE, Ljungman M.

Sci Rep. 2015 Dec 11;5:17978. doi: 10.1038/srep17978.

34.

ATDC/TRIM29 Drives Invasive Bladder Cancer Formation through miRNA-Mediated and Epigenetic Mechanisms.

Palmbos PL, Wang L, Yang H, Wang Y, Leflein J, Ahmet ML, Wilkinson JE, Kumar-Sinha C, Ney GM, Tomlins SA, Daignault S, Kunju LP, Wu XR, Lotan Y, Liebert M, Ljungman ME, Simeone DM.

Cancer Res. 2015 Dec 1;75(23):5155-66. doi: 10.1158/0008-5472.CAN-15-0603. Epub 2015 Oct 15.

35.

Arsenic Disruption of DNA Damage Responses-Potential Role in Carcinogenesis and Chemotherapy.

Muenyi CS, Ljungman M, States JC.

Biomolecules. 2015 Sep 24;5(4):2184-93. doi: 10.3390/biom5042184. Review.

36.

ATDC (Ataxia Telangiectasia Group D Complementing) Promotes Radioresistance through an Interaction with the RNF8 Ubiquitin Ligase.

Yang H, Palmbos PL, Wang L, Kim EH, Ney GM, Liu C, Prasad J, Misek DE, Yu X, Ljungman M, Simeone DM.

J Biol Chem. 2015 Nov 6;290(45):27146-57. doi: 10.1074/jbc.M115.665489. Epub 2015 Sep 17.

37.

Transcriptional and post-transcriptional regulation of nucleotide excision repair genes in human cells.

Lefkofsky HB, Veloso A, Ljungman M.

Mutat Res. 2015 Jun;776:9-15. doi: 10.1016/j.mrfmmm.2014.11.008. Epub 2014 Dec 3.

38.

Transcription Blockage Leads to New Beginnings.

Andrade-Lima LC, Veloso A, Ljungman M.

Biomolecules. 2015 Jul 21;5(3):1600-17. doi: 10.3390/biom5031600. Review.

39.

Guadecitabine (SGI-110) priming sensitizes hepatocellular carcinoma cells to oxaliplatin.

Kuang Y, El-Khoueiry A, Taverna P, Ljungman M, Neamati N.

Mol Oncol. 2015 Nov;9(9):1799-814. doi: 10.1016/j.molonc.2015.06.002. Epub 2015 Jun 16.

40.

Functional organization of the human 4D Nucleome.

Chen H, Chen J, Muir LA, Ronquist S, Meixner W, Ljungman M, Ried T, Smale S, Rajapakse I.

Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):8002-7. doi: 10.1073/pnas.1505822112. Epub 2015 Jun 15.

41.

Two consecutive randomized controlled pertussis booster trials in children initially vaccinated in infancy with an acellular vaccine: The first with a five-component Tdap vaccine to 5-year olds and the second with five- or monocomponent Tdap vaccines at age 14-15 years.

Carlsson RM, Gustafsson L, Hallander HO, Ljungman M, Olin P, Gothefors L, Nilsson L, Netterlid E.

Vaccine. 2015 Jul 17;33(31):3717-25. doi: 10.1016/j.vaccine.2015.05.079. Epub 2015 Jun 7.

PMID:
26057135
42.

Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing.

Selvanathan SP, Graham GT, Erkizan HV, Dirksen U, Natarajan TG, Dakic A, Yu S, Liu X, Paulsen MT, Ljungman ME, Wu CH, Lawlor ER, Üren A, Toretsky JA.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1307-16. doi: 10.1073/pnas.1500536112. Epub 2015 Mar 3.

43.

DNA repair and recovery of RNA synthesis following exposure to ultraviolet light are delayed in long genes.

Andrade-Lima LC, Veloso A, Paulsen MT, Menck CF, Ljungman M.

Nucleic Acids Res. 2015 Mar 11;43(5):2744-56. doi: 10.1093/nar/gkv148. Epub 2015 Feb 26.

44.

Effects of physiological and synthetic IAP antagonism on c-IAP-dependent signaling.

Kocab AJ, Veloso A, Paulsen MT, Ljungman M, Duckett CS.

Oncogene. 2015 Oct;34(43):5472-81. doi: 10.1038/onc.2015.3. Epub 2015 Feb 9.

45.

Overexpression of HOX genes is prevalent in Ewing sarcoma and is associated with altered epigenetic regulation of developmental transcription programs.

Svoboda LK, Harris A, Bailey NJ, Schwentner R, Tomazou E, von Levetzow C, Magnuson B, Ljungman M, Kovar H, Lawlor ER.

Epigenetics. 2014 Dec;9(12):1613-25. doi: 10.4161/15592294.2014.988048.

46.

Zinc finger protein 407 (ZFP407) regulates insulin-stimulated glucose uptake and glucose transporter 4 (Glut4) mRNA.

Buchner DA, Charrier A, Srinivasan E, Wang L, Paulsen MT, Ljungman M, Bridges D, Saltiel AR.

J Biol Chem. 2015 Mar 6;290(10):6376-86. doi: 10.1074/jbc.M114.623736. Epub 2015 Jan 16.

47.

ATDC induces an invasive switch in KRAS-induced pancreatic tumorigenesis.

Wang L, Yang H, Abel EV, Ney GM, Palmbos PL, Bednar F, Zhang Y, Leflein J, Waghray M, Owens S, Wilkinson JE, Prasad J, Ljungman M, Rhim AD, Pasca di Magliano M, Simeone DM.

Genes Dev. 2015 Jan 15;29(2):171-83. doi: 10.1101/gad.253591.114.

48.

Benchmarking of gastric cancer sensitivity to anti-cancer drugs ex vivo as a basis for drug selection in systemic and intraperitoneal therapy.

Hultman B, Mahteme H, Sundbom M, Ljungman M, Larsson R, Nygren P.

J Exp Clin Cancer Res. 2014 Dec 21;33:110. doi: 10.1186/s13046-014-0110-9.

49.

The long non-coding RNA PCAT-1 promotes prostate cancer cell proliferation through cMyc.

Prensner JR, Chen W, Han S, Iyer MK, Cao Q, Kothari V, Evans JR, Knudsen KE, Paulsen MT, Ljungman M, Lawrence TS, Chinnaiyan AM, Feng FY.

Neoplasia. 2014 Nov 20;16(11):900-8. doi: 10.1016/j.neo.2014.09.001. eCollection 2014 Nov.

50.

Large transcription units unify copy number variants and common fragile sites arising under replication stress.

Wilson TE, Arlt MF, Park SH, Rajendran S, Paulsen M, Ljungman M, Glover TW.

Genome Res. 2015 Feb;25(2):189-200. doi: 10.1101/gr.177121.114. Epub 2014 Nov 4.

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