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Retraction for Plotnikov et al., "Nuclear Extracellular Signal-Regulated Kinase 1 and 2 Translocation Is Mediated by Casein Kinase 2 and Accelerated by Autophosphorylation".

Plotnikov A, Chuderland D, Karamansha Y, Livnah O, Seger R.

Mol Cell Biol. 2018 May 15;38(11). pii: e00106-18. doi: 10.1128/MCB.00106-18. Print 2018 Jun 1. No abstract available.


Coupling Multi Angle Light Scattering to Ion Exchange chromatography (IEX-MALS) for protein characterization.

Amartely H, Avraham O, Friedler A, Livnah O, Lebendiker M.

Sci Rep. 2018 May 2;8(1):6907. doi: 10.1038/s41598-018-25246-6.


Tighter αC-helix-αL16-helix interactions seem to make p38α less prone to activation by autophosphorylation than Hog1.

Tesker M, Selamat SE, Beenstock J, Hayouka R, Livnah O, Engelberg D.

Biosci Rep. 2016 Apr 27;36(2). pii: e00324. doi: 10.1042/BSR20160020. Print 2016.


Intrinsically active variants of Erk oncogenically transform cells and disclose unexpected autophosphorylation capability that is independent of TEY phosphorylation.

Smorodinsky-Atias K, Goshen-Lago T, Goldberg-Carp A, Melamed D, Shir A, Mooshayef N, Beenstock J, Karamansha Y, Darlyuk-Saadon I, Livnah O, Ahn NG, Admon A, Engelberg D.

Mol Biol Cell. 2016 Mar 15;27(6):1026-39. doi: 10.1091/mbc.E15-07-0521. Epub 2015 Dec 10.


Hoefavidin: A dimeric bacterial avidin with a C-terminal binding tail.

Avraham O, Meir A, Fish A, Bayer EA, Livnah O.

J Struct Biol. 2015 Aug;191(2):139-48. doi: 10.1016/j.jsb.2015.06.020. Epub 2015 Jun 27.


Felix Frolow (1947-2014).

Livnah O, Shimon L.

Acta Crystallogr F Struct Biol Commun. 2014 Oct;70(Pt 10):1443-4. doi: 10.1107/S2053230X14020949. Epub 2014 Sep 30. No abstract available.


The p38β mitogen-activated protein kinase possesses an intrinsic autophosphorylation activity, generated by a short region composed of the α-G helix and MAPK insert.

Beenstock J, Ben-Yehuda S, Melamed D, Admon A, Livnah O, Ahn NG, Engelberg D.

J Biol Chem. 2014 Aug 22;289(34):23546-56. doi: 10.1074/jbc.M114.578237. Epub 2014 Jul 8.


A point mutation in the [2Fe-2S] cluster binding region of the NAF-1 protein (H114C) dramatically hinders the cluster donor properties.

Tamir S, Eisenberg-Domovich Y, Conlan AR, Stofleth JT, Lipper CH, Paddock ML, Mittler R, Jennings PA, Livnah O, Nechushtai R.

Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1572-8. doi: 10.1107/S1399004714005458. Epub 2014 May 23.


AChE and RACK1 promote the anti-inflammatory properties of fluoxetine.

Waiskopf N, Ofek K, Gilboa-Geffen A, Bekenstein U, Bahat A, Bennett ER, Podoly E, Livnah O, Hartmann G, Soreq H.

J Mol Neurosci. 2014 Jul;53(3):306-15. doi: 10.1007/s12031-013-0174-6. Epub 2013 Nov 21.


DEF pocket in p38α facilitates substrate selectivity and mediates autophosphorylation.

Tzarum N, Komornik N, Ben Chetrit D, Engelberg D, Livnah O.

J Biol Chem. 2013 Jul 5;288(27):19537-47. doi: 10.1074/jbc.M113.464511. Epub 2013 May 13.


The highly dynamic oligomeric structure of bradavidin II is unique among avidin proteins.

Leppiniemi J, Meir A, Kähkönen N, Kukkurainen S, Määttä JA, Ojanen M, Jänis J, Kulomaa MS, Livnah O, Hytönen VP.

Protein Sci. 2013 Jul;22(7):980-94. doi: 10.1002/pro.2281. Epub 2013 Jun 6.


Lipid molecules induce p38α activation via a novel molecular switch.

Tzarum N, Eisenberg-Domovich Y, Gills JJ, Dennis PA, Livnah O.

J Mol Biol. 2012 Dec 14;424(5):339-53. doi: 10.1016/j.jmb.2012.10.007. Epub 2012 Oct 16.


Osmostress induces autophosphorylation of Hog1 via a C-terminal regulatory region that is conserved in p38α.

Maayan I, Beenstock J, Marbach I, Tabachnick S, Livnah O, Engelberg D.

PLoS One. 2012;7(9):e44749. doi: 10.1371/journal.pone.0044749. Epub 2012 Sep 11.


Characterization of Arabidopsis NEET reveals an ancient role for NEET proteins in iron metabolism.

Nechushtai R, Conlan AR, Harir Y, Song L, Yogev O, Eisenberg-Domovich Y, Livnah O, Michaeli D, Rosen R, Ma V, Luo Y, Zuris JA, Paddock ML, Cabantchik ZI, Jennings PA, Mittler R.

Plant Cell. 2012 May;24(5):2139-54. doi: 10.1105/tpc.112.097634. Epub 2012 May 4.


Structural adaptation of a thermostable biotin-binding protein in a psychrophilic environment.

Meir A, Bayer EA, Livnah O.

J Biol Chem. 2012 May 25;287(22):17951-62. doi: 10.1074/jbc.M112.357186. Epub 2012 Apr 5.


Conformational bias imposed by source microseeds results in structural ambiguity.

Tzarum N, Engelberg D, Livnah O.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Aug 1;67(Pt 8):877-84. doi: 10.1107/S1744309111017970. Epub 2011 Jul 13.


Nuclear extracellular signal-regulated kinase 1 and 2 translocation is mediated by casein kinase 2 and accelerated by autophosphorylation.

Plotnikov A, Chuderland D, Karamansha Y, Livnah O, Seger R.

Mol Cell Biol. 2011 Sep;31(17):3515-30. doi: 10.1128/MCB.05424-11. Epub 2011 Jul 5. Retraction in: Mol Cell Biol. 2018 May 15;38(11):.


Allostery in the ferredoxin protein motif does not involve a conformational switch.

Nechushtai R, Lammert H, Michaeli D, Eisenberg-Domovich Y, Zuris JA, Luca MA, Capraro DT, Fish A, Shimshon O, Roy M, Schug A, Whitford PC, Livnah O, Onuchic JN, Jennings PA.

Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2240-5. doi: 10.1073/pnas.1019502108. Epub 2011 Jan 25.


Active mutants of the TCR-mediated p38α alternative activation site show changes in the phosphorylation lip and DEF site formation.

Tzarum N, Diskin R, Engelberg D, Livnah O.

J Mol Biol. 2011 Feb 4;405(5):1154-69. doi: 10.1016/j.jmb.2010.11.023. Epub 2010 Dec 10.


Chimeric avidin shows stability against harsh chemical conditions--biochemical analysis and 3D structure.

Määttä JA, Eisenberg-Domovich Y, Nordlund HR, Hayouka R, Kulomaa MS, Livnah O, Hytönen VP.

Biotechnol Bioeng. 2011 Mar;108(3):481-90. doi: 10.1002/bit.22962. Epub 2010 Nov 24.


A "molecular evolution" approach for isolation of intrinsically active (MEK-independent) MAP kinases.

Levin-Salomon V, Livnah O, Engelberg D.

Methods Mol Biol. 2010;661:257-72. doi: 10.1007/978-1-60761-795-2_15.


Challenging semi-bootstrapping molecular-replacement strategy reveals intriguing crystal packing of rhizavidin.

Meir A, Livnah O.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Apr 1;66(Pt 4):373-8. doi: 10.1107/S1744309110004112. Epub 2010 Mar 26.


The butyrylcholinesterase K variant confers structurally derived risks for Alzheimer pathology.

Podoly E, Shalev DE, Shenhar-Tsarfaty S, Bennett ER, Ben Assayag E, Wilgus H, Livnah O, Soreq H.

J Biol Chem. 2009 Jun 19;284(25):17170-9. doi: 10.1074/jbc.M109.004952. Epub 2009 Apr 21.


p38alpha is active in vitro and in vivo when monophosphorylated at threonine 180.

Askari N, Beenstock J, Livnah O, Engelberg D.

Biochemistry. 2009 Mar 24;48(11):2497-504. doi: 10.1021/bi900024v.


Crystal structure of rhizavidin: insights into the enigmatic high-affinity interaction of an innate biotin-binding protein dimer.

Meir A, Helppolainen SH, Podoly E, Nordlund HR, Hytönen VP, Määttä JA, Wilchek M, Bayer EA, Kulomaa MS, Livnah O.

J Mol Biol. 2009 Feb 20;386(2):379-90. doi: 10.1016/j.jmb.2008.11.061. Epub 2008 Dec 24.


Isolation of intrinsically active (MEK-independent) variants of the ERK family of mitogen-activated protein (MAP) kinases.

Levin-Salomon V, Kogan K, Ahn NG, Livnah O, Engelberg D.

J Biol Chem. 2008 Dec 12;283(50):34500-10. doi: 10.1074/jbc.M806443200. Epub 2008 Oct 1.


When expressed in yeast, mammalian mitogen-activated protein kinases lose proper regulation and become spontaneously phosphorylated.

Levin-Salomon V, Maayan I, Avrahami-Moyal L, Marbach I, Livnah O, Engelberg D.

Biochem J. 2009 Jan 1;417(1):331-40. doi: 10.1042/BJ20081335.


Critical importance of loop conformation to avidin-enhanced hydrolysis of an active biotin ester.

Hayouka R, Eisenberg-Domovich Y, Hytönen VP, Määttä JA, Nordlund HR, Kulomaa MS, Wilchek M, Bayer EA, Livnah O.

Acta Crystallogr D Biol Crystallogr. 2008 Mar;64(Pt 3):302-8. doi: 10.1107/S0907444907067844. Epub 2008 Feb 20.


Human recombinant butyrylcholinesterase purified from the milk of transgenic goats interacts with beta-amyloid fibrils and suppresses their formation in vitro.

Podoly E, Bruck T, Diamant S, Melamed-Book N, Weiss A, Huang Y, Livnah O, Langermann S, Wilgus H, Soreq H.

Neurodegener Dis. 2008;5(3-4):232-6. doi: 10.1159/000113711. Epub 2008 Mar 6.


A novel lipid binding site formed by the MAP kinase insert in p38 alpha.

Diskin R, Engelberg D, Livnah O.

J Mol Biol. 2008 Jan 4;375(1):70-9. Epub 2007 Sep 8.


Peripheral site acetylcholinesterase blockade induces RACK1-associated neuronal remodeling.

Farchi N, Ofek K, Podoly E, Dong H, Xiang YY, Diamant S, Livnah O, Li J, Hochner B, Lu WY, Soreq H.

Neurodegener Dis. 2007;4(2-3):171-84.


A novel substrate mimetic inhibitor of PKB/Akt inhibits prostate cancer tumor growth in mice by blocking the PKB pathway.

Litman P, Ohne O, Ben-Yaakov S, Shemesh-Darvish L, Yechezkel T, Salitra Y, Rubnov S, Cohen I, Senderowitz H, Kidron D, Livnah O, Levitzki A, Livnah N.

Biochemistry. 2007 Apr 24;46(16):4716-24. Epub 2007 Mar 31.


High-resolution diffracting crystals of intrinsically active p38alpha MAP kinase: a case study for low-throughput approaches.

Diskin R, Engelberg D, Livnah O.

Acta Crystallogr D Biol Crystallogr. 2007 Feb;63(Pt 2):260-5. Epub 2007 Jan 16.


Intrinsically active variants of all human p38 isoforms.

Avitzour M, Diskin R, Raboy B, Askari N, Engelberg D, Livnah O.

FEBS J. 2007 Feb;274(4):963-75. Epub 2007 Jan 22.


Hyperactive variants of p38alpha induce, whereas hyperactive variants of p38gamma suppress, activating protein 1-mediated transcription.

Askari N, Diskin R, Avitzour M, Capone R, Livnah O, Engelberg D.

J Biol Chem. 2007 Jan 5;282(1):91-9. Epub 2006 Nov 6.


Structures of p38alpha active mutants reveal conformational changes in L16 loop that induce autophosphorylation and activation.

Diskin R, Lebendiker M, Engelberg D, Livnah O.

J Mol Biol. 2007 Jan 5;365(1):66-76. Epub 2006 Aug 22.


Isolation of intrinsically active mutants of MAP kinases via genetic screens in yeast.

Engelberg D, Livnah O.

Methods. 2006 Nov;40(3):255-61.


Butyrylcholinesterase attenuates amyloid fibril formation in vitro.

Diamant S, Podoly E, Friedler A, Ligumsky H, Livnah O, Soreq H.

Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8628-33. Epub 2006 May 26.


MAP-quest: could we produce constitutively active variants of MAP kinases?

Askari N, Diskin R, Avitzour M, Yaakov G, Livnah O, Engelberg D.

Mol Cell Endocrinol. 2006 Jun 27;252(1-2):231-40. Epub 2006 May 2. Review.


Factors dictating the pseudocatalytic efficiency of avidins.

Prizant M, Eisenberg-Domovich Y, Hytönen VP, Kulomaa MS, Wilchek M, Bayer EA, Livnah O.

J Mol Biol. 2006 May 5;358(3):754-63. Epub 2006 Mar 3.


Essentials of biorecognition: the (strept)avidin-biotin system as a model for protein-protein and protein-ligand interaction.

Wilchek M, Bayer EA, Livnah O.

Immunol Lett. 2006 Feb 28;103(1):27-32. Epub 2005 Nov 21. Review.


Structural basis for the thermostability of ferredoxin from the cyanobacterium Mastigocladus laminosus.

Fish A, Danieli T, Ohad I, Nechushtai R, Livnah O.

J Mol Biol. 2005 Jul 15;350(3):599-608.


High-resolution crystal structure of an avidin-related protein: insight into high-affinity biotin binding and protein stability.

Eisenberg-Domovich Y, Hytönen VP, Wilchek M, Bayer EA, Kulomaa MS, Livnah O.

Acta Crystallogr D Biol Crystallogr. 2005 May;61(Pt 5):528-38. Epub 2005 Apr 20.


Mapping leptin-interacting sites in recombinant leptin-binding domain (LBD) subcloned from chicken leptin receptor.

Niv-Spector L, Raver N, Friedman-Einat M, Grosclaude J, Gussakovsky EE, Livnah O, Gertler A.

Biochem J. 2005 Sep 1;390(Pt 2):475-84.


Inherited and acquired interactions between ACHE and PON1 polymorphisms modulate plasma acetylcholinesterase and paraoxonase activities.

Bryk B, BenMoyal-Segal L, Podoly E, Livnah O, Eisenkraft A, Luria S, Cohen A, Yehezkelli Y, Hourvitz A, Soreq H.

J Neurochem. 2005 Mar;92(5):1216-27.


Design and construction of highly stable, protease-resistant chimeric avidins.

Hytönen VP, Määttä JA, Nyholm TK, Livnah O, Eisenberg-Domovich Y, Hyre D, Nordlund HR, Hörhä J, Niskanen EA, Paldanius T, Kulomaa T, Porkka EJ, Stayton PS, Laitinen OH, Kulomaa MS.

J Biol Chem. 2005 Mar 18;280(11):10228-33. Epub 2005 Jan 13.


Active mutants of the human p38alpha mitogen-activated protein kinase.

Diskin R, Askari N, Capone R, Engelberg D, Livnah O.

J Biol Chem. 2004 Nov 5;279(45):47040-9. Epub 2004 Jul 28.


Structural elements responsible for conversion of streptavidin to a pseudoenzyme.

Eisenberg-Domovich Y, Pazy Y, Nir O, Raboy B, Bayer EA, Wilchek M, Livnah O.

Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5916-21. Epub 2004 Apr 12.


Dimer-tetramer transition between solution and crystalline states of streptavidin and avidin mutants.

Pazy Y, Eisenberg-Domovich Y, Laitinen OH, Kulomaa MS, Bayer EA, Wilchek M, Livnah O.

J Bacteriol. 2003 Jul;185(14):4050-6.


Purification, crystallization and preliminary X-ray analysis of ferredoxin isolated from thermophilic cyanobacterium Mastigocladus laminosus.

Fish A, Lebendiker M, Nechushtai R, Livnah O.

Acta Crystallogr D Biol Crystallogr. 2003 Apr;59(Pt 4):734-6. Epub 2003 Mar 25.


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