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BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation.

Li AG, Murphy EC, Culhane AC, Powell E, Wang H, Bronson RT, Von T, Giobbie-Hurder A, Gelman RS, Briggs KJ, Piwnica-Worms H, Zhao JJ, Kung AL, Kaelin WG Jr, Livingston DM.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9600-E9609. doi: 10.1073/pnas.1807112115. Epub 2018 Sep 25.


Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage.

Hill SJ, Mordes DA, Cameron LA, Neuberg DS, Landini S, Eggan K, Livingston DM.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7701-E7709. Epub 2016 Nov 14.


Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics.

Liu JF, Palakurthi S, Zeng Q, Zhou S, Ivanova E, Huang W, Zervantonakis IK, Selfors LM, Shen Y, Pritchard CC, Zheng M, Adleff V, Papp E, Piao H, Novak M, Fotheringham S, Wulf GM, English J, Kirschmeier PT, Velculescu VE, Paweletz C, Mills GB, Livingston DM, Brugge JS, Matulonis UA, Drapkin R.

Clin Cancer Res. 2017 Mar 1;23(5):1263-1273. doi: 10.1158/1078-0432.CCR-16-1237. Epub 2016 Aug 29.


BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells.

Wang H, Bierie B, Li AG, Pathania S, Toomire K, Dimitrov SD, Liu B, Gelman R, Giobbie-Hurder A, Feunteun J, Polyak K, Livingston DM.

Mol Cell. 2016 Jul 21;63(2):277-292. doi: 10.1016/j.molcel.2016.05.038. Epub 2016 Jun 30.


26th Pezcoller symposium: cancers driven by hormones.

Brown M, Chinnaiyan A, Farsetti A, Livingston DM, Loda M, Schuele R, Mihich E.

Cancer Res. 2015 Apr 1;75(7):1177-80. doi: 10.1158/0008-5472.CAN-14-2902. Epub 2015 Mar 18.


BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair.

Hatchi E, Skourti-Stathaki K, Ventz S, Pinello L, Yen A, Kamieniarz-Gdula K, Dimitrov S, Pathania S, McKinney KM, Eaton ML, Kellis M, Hill SJ, Parmigiani G, Proudfoot NJ, Livingston DM.

Mol Cell. 2015 Feb 19;57(4):636-647. doi: 10.1016/j.molcel.2015.01.011.


Papillomavirus E7 oncoproteins share functions with polyomavirus small T antigens.

White EA, Kramer RE, Hwang JH, Pores Fernando AT, Naetar N, Hahn WC, Roberts TM, Schaffhausen BS, Livingston DM, Howley PM.

J Virol. 2015 Mar;89(5):2857-65. doi: 10.1128/JVI.03282-14. Epub 2014 Dec 24.


An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma.

Baratta MG, Schinzel AC, Zwang Y, Bandopadhayay P, Bowman-Colin C, Kutt J, Curtis J, Piao H, Wong LC, Kung AL, Beroukhim R, Bradner JE, Drapkin R, Hahn WC, Liu JF, Livingston DM.

Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):232-7. doi: 10.1073/pnas.1422165112. Epub 2014 Dec 22.


BRCA1 haploinsufficiency for replication stress suppression in primary cells.

Pathania S, Bade S, Le Guillou M, Burke K, Reed R, Bowman-Colin C, Su Y, Ting DT, Polyak K, Richardson AL, Feunteun J, Garber JE, Livingston DM.

Nat Commun. 2014 Nov 17;5:5496. doi: 10.1038/ncomms6496.


PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair.

Hu Y, Petit SA, Ficarro SB, Toomire KJ, Xie A, Lim E, Cao SA, Park E, Eck MJ, Scully R, Brown M, Marto JA, Livingston DM.

Cancer Discov. 2014 Dec;4(12):1430-47. doi: 10.1158/2159-8290.CD-13-0891. Epub 2014 Sep 24.


SMCX and components of the TIP60 complex contribute to E2 regulation of the HPV E6/E7 promoter.

Smith JA, Haberstroh FS, White EA, Livingston DM, DeCaprio JA, Howley PM.

Virology. 2014 Nov;468-470:311-321. doi: 10.1016/j.virol.2014.08.022. Epub 2014 Sep 16.


Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.

Hill SJ, Rolland T, Adelmant G, Xia X, Owen MS, Dricot A, Zack TI, Sahni N, Jacob Y, Hao T, McKinney KM, Clark AP, Reyon D, Tsai SQ, Joung JK, Beroukhim R, Marto JA, Vidal M, Gaudet S, Hill DE, Livingston DM.

Genes Dev. 2014 Sep 1;28(17):1957-75. doi: 10.1101/gad.241620.114.


BRCA1 pathway function in basal-like breast cancer cells.

Hill SJ, Clark AP, Silver DP, Livingston DM.

Mol Cell Biol. 2014 Oct;34(20):3828-42. doi: 10.1128/MCB.01646-13. Epub 2014 Aug 4.


Polyoma small T antigen triggers cell death via mitotic catastrophe.

Pores Fernando AT, Andrabi S, Cizmecioglu O, Zhu C, Livingston DM, Higgins JM, Schaffhausen BS, Roberts TM.

Oncogene. 2015 May 7;34(19):2483-92. doi: 10.1038/onc.2014.192. Epub 2014 Jul 7.


PP2A-mediated regulation of Ras signaling in G2 is essential for stable quiescence and normal G1 length.

Naetar N, Soundarapandian V, Litovchick L, Goguen KL, Sablina AA, Bowman-Colin C, Sicinski P, Hahn WC, DeCaprio JA, Livingston DM.

Mol Cell. 2014 Jun 19;54(6):932-45. doi: 10.1016/j.molcel.2014.04.023. Epub 2014 May 22.


Physiological modulation of endogenous BRCA1 p220 abundance suppresses DNA damage during the cell cycle.

Dimitrov SD, Lu D, Naetar N, Hu Y, Pathania S, Kanellopoulou C, Livingston DM.

Genes Dev. 2013 Oct 15;27(20):2274-91. doi: 10.1101/gad.225045.113.


Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer.

Bowman-Colin C, Xia B, Bunting S, Klijn C, Drost R, Bouwman P, Fineman L, Chen X, Culhane AC, Cai H, Rodig SJ, Bronson RT, Jonkers J, Nussenzweig A, Kanellopoulou C, Livingston DM.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8632-7. doi: 10.1073/pnas.1305362110. Epub 2013 May 8.


Proteomic identification of a direct role for cyclin d1 in DNA damage repair.

Jirawatnotai S, Hu Y, Livingston DM, Sicinski P.

Cancer Res. 2012 Sep 1;72(17):4289-93. doi: 10.1158/0008-5472.CAN-11-3549. Epub 2012 Aug 22. Review.


Mechanisms of BRCA1 tumor suppression.

Silver DP, Livingston DM.

Cancer Discov. 2012 Aug;2(8):679-84. doi: 10.1158/2159-8290.CD-12-0221. Epub 2012 Jul 27. Review.


Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.

Ciccia A, Nimonkar AV, Hu Y, Hajdu I, Achar YJ, Izhar L, Petit SA, Adamson B, Yoon JC, Kowalczykowski SC, Livingston DM, Haracska L, Elledge SJ.

Mol Cell. 2012 Aug 10;47(3):396-409. doi: 10.1016/j.molcel.2012.05.024. Epub 2012 Jun 14.


BRCA1 is required for postreplication repair after UV-induced DNA damage.

Pathania S, Nguyen J, Hill SJ, Scully R, Adelmant GO, Marto JA, Feunteun J, Livingston DM.

Mol Cell. 2011 Oct 21;44(2):235-51. doi: 10.1016/j.molcel.2011.09.002. Epub 2011 Sep 29.


A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers.

Jirawatnotai S, Hu Y, Michowski W, Elias JE, Becks L, Bienvenu F, Zagozdzon A, Goswami T, Wang YE, Clark AB, Kunkel TA, van Harn T, Xia B, Correll M, Quackenbush J, Livingston DM, Gygi SP, Sicinski P.

Nature. 2011 Jun 8;474(7350):230-4. doi: 10.1038/nature10155.


Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis.

Zimmer SN, Zhou Q, Zhou T, Cheng Z, Abboud-Werner SL, Horn D, Lecocke M, White R, Krivtsov AV, Armstrong SA, Kung AL, Livingston DM, Rebel VI.

Blood. 2011 Jul 7;118(1):69-79. doi: 10.1182/blood-2010-09-307942. Epub 2011 May 9.


RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci.

Hu Y, Scully R, Sobhian B, Xie A, Shestakova E, Livingston DM.

Genes Dev. 2011 Apr 1;25(7):685-700. doi: 10.1101/gad.2011011. Epub 2011 Mar 15.


DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors.

Rio Frio T, Bahubeshi A, Kanellopoulou C, Hamel N, Niedziela M, Sabbaghian N, Pouchet C, Gilbert L, O'Brien PK, Serfas K, Broderick P, Houlston RS, Lesueur F, Bonora E, Muljo S, Schimke RN, Bouron-Dal Soglio D, Arseneau J, Schultz KA, Priest JR, Nguyen VH, Harach HR, Livingston DM, Foulkes WD, Tischkowitz M.

JAMA. 2011 Jan 5;305(1):68-77. doi: 10.1001/jama.2010.1910.


Twenty-second annual Pezcoller Symposium: RNA biology and cancer.

Bernards R, Filipowicz W, Livingston DM, Mihich E.

Cancer Res. 2010 Dec 15;70(24):10034-7. doi: 10.1158/0008-5472.CAN-10-2978.


Centrosomal protein of 192 kDa (Cep192) promotes centrosome-driven spindle assembly by engaging in organelle-specific Aurora A activation.

Joukov V, De Nicolo A, Rodriguez A, Walter JC, Livingston DM.

Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21022-7. doi: 10.1073/pnas.1014664107. Epub 2010 Nov 19.


BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair.

O'Donovan PJ, Livingston DM.

Carcinogenesis. 2010 Jun;31(6):961-7. doi: 10.1093/carcin/bgq069. Epub 2010 Apr 16. Review.


An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells.

Sheng Q, Liu X, Fleming E, Yuan K, Piao H, Chen J, Moustafa Z, Thomas RK, Greulich H, Schinzel A, Zaghlul S, Batt D, Ettenberg S, Meyerson M, Schoeberl B, Kung AL, Hahn WC, Drapkin R, Livingston DM, Liu JF.

Cancer Cell. 2010 Mar 16;17(3):298-310. doi: 10.1016/j.ccr.2009.12.047. Erratum in: Cancer Cell. 2010 Apr 13;17(4):412.


Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1.

Barbie DA, Tamayo P, Boehm JS, Kim SY, Moody SE, Dunn IF, Schinzel AC, Sandy P, Meylan E, Scholl C, Fröhling S, Chan EM, Sos ML, Michel K, Mermel C, Silver SJ, Weir BA, Reiling JH, Sheng Q, Gupta PB, Wadlow RC, Le H, Hoersch S, Wittner BS, Ramaswamy S, Livingston DM, Sabatini DM, Meyerson M, Thomas RK, Lander ES, Mesirov JP, Root DE, Gilliland DG, Jacks T, Hahn WC.

Nature. 2009 Nov 5;462(7269):108-12. doi: 10.1038/nature08460. Epub 2009 Oct 21.


Cancer. Complicated supercomplexes.

Livingston DM.

Science. 2009 May 1;324(5927):602-3. doi: 10.1126/science.1174839. No abstract available.


Suppression of a DNA polymerase delta mutation by the absence of the high mobility group protein Hmo1 in Saccharomyces cerevisiae.

Kim H, Livingston DM.

Curr Genet. 2009 Apr;55(2):127-38. doi: 10.1007/s00294-009-0229-y. Epub 2009 Jan 31.


X chromosome inactivation in the absence of Dicer.

Kanellopoulou C, Muljo SA, Dimitrov SD, Chen X, Colin C, Plath K, Livingston DM.

Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1122-7. doi: 10.1073/pnas.0812210106. Epub 2009 Jan 21.


Small DNA tumor viruses: large contributors to biomedical sciences.

Howley PM, Livingston DM.

Virology. 2009 Feb 20;384(2):256-9. doi: 10.1016/j.virol.2008.12.006. Epub 2009 Jan 10. Review.


Penetrance analysis of the PALB2 c.1592delT founder mutation.

Erkko H, Dowty JG, Nikkilä J, Syrjäkoski K, Mannermaa A, Pylkäs K, Southey MC, Holli K, Kallioniemi A, Jukkola-Vuorinen A, Kataja V, Kosma VM, Xia B, Livingston DM, Winqvist R, Hopper JL.

Clin Cancer Res. 2008 Jul 15;14(14):4667-71. doi: 10.1158/1078-0432.CCR-08-0210.


Cancer: crossing over to drug resistance.

Livingston DM, Silver DP.

Nature. 2008 Feb 28;451(7182):1066-7. doi: 10.1038/4511066a. No abstract available.


Network modeling links breast cancer susceptibility and centrosome dysfunction.

Pujana MA, Han JD, Starita LM, Stevens KN, Tewari M, Ahn JS, Rennert G, Moreno V, Kirchhoff T, Gold B, Assmann V, Elshamy WM, Rual JF, Levine D, Rozek LS, Gelman RS, Gunsalus KC, Greenberg RA, Sobhian B, Bertin N, Venkatesan K, Ayivi-Guedehoussou N, Solé X, Hernández P, Lázaro C, Nathanson KL, Weber BL, Cusick ME, Hill DE, Offit K, Livingston DM, Gruber SB, Parvin JD, Vidal M.

Nat Genet. 2007 Nov;39(11):1338-49. Epub 2007 Oct 7.


p21 transcription is regulated by differential localization of histone H2A.Z.

Gévry N, Chan HM, Laflamme L, Livingston DM, Gaudreau L.

Genes Dev. 2007 Aug 1;21(15):1869-81.


The disappearing Barr body in breast and ovarian cancers.

Pageau GJ, Hall LL, Ganesan S, Livingston DM, Lawrence JB.

Nat Rev Cancer. 2007 Aug;7(8):628-33. Epub 2007 Jul 5. Review.


RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites.

Sobhian B, Shao G, Lilli DR, Culhane AC, Moreau LA, Xia B, Livingston DM, Greenberg RA.

Science. 2007 May 25;316(5828):1198-202.


Analysis of PALB2/FANCN-associated breast cancer families.

Tischkowitz M, Xia B, Sabbaghian N, Reis-Filho JS, Hamel N, Li G, van Beers EH, Li L, Khalil T, Quenneville LA, Omeroglu A, Poll A, Lepage P, Wong N, Nederlof PM, Ashworth A, Tonin PN, Narod SA, Livingston DM, Foulkes WD.

Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6788-93. Epub 2007 Apr 9.


Further evidence for BRCA1 communication with the inactive X chromosome.

Silver DP, Dimitrov SD, Feunteun J, Gelman R, Drapkin R, Lu SD, Shestakova E, Velmurugan S, Denunzio N, Dragomir S, Mar J, Liu X, Rottenberg S, Jonkers J, Ganesan S, Livingston DM.

Cell. 2007 Mar 9;128(5):991-1002.


A recurrent mutation in PALB2 in Finnish cancer families.

Erkko H, Xia B, Nikkilä J, Schleutker J, Syrjäkoski K, Mannermaa A, Kallioniemi A, Pylkäs K, Karppinen SM, Rapakko K, Miron A, Sheng Q, Li G, Mattila H, Bell DW, Haber DA, Grip M, Reiman M, Jukkola-Vuorinen A, Mustonen A, Kere J, Aaltonen LA, Kosma VM, Kataja V, Soini Y, Drapkin RI, Livingston DM, Winqvist R.

Nature. 2007 Mar 15;446(7133):316-9. Epub 2007 Feb 7.


Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.

Xia B, Dorsman JC, Ameziane N, de Vries Y, Rooimans MA, Sheng Q, Pals G, Errami A, Gluckman E, Llera J, Wang W, Livingston DM, Joenje H, de Winter JP.

Nat Genet. 2007 Feb;39(2):159-61. Epub 2006 Dec 31.


The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly.

Joukov V, Groen AC, Prokhorova T, Gerson R, White E, Rodriguez A, Walter JC, Livingston DM.

Cell. 2006 Nov 3;127(3):539-52.


Abnormalities of the inactive X chromosome are a common feature of BRCA1 mutant and sporadic basal-like breast cancer.

Ganesan S, Richardson AL, Wang ZC, Iglehart JD, Miron A, Feunteun J, Silver D, Livingston DM.

Cold Spring Harb Symp Quant Biol. 2005;70:93-7.


Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.

Xia B, Sheng Q, Nakanishi K, Ohashi A, Wu J, Christ N, Liu X, Jasin M, Couch FJ, Livingston DM.

Mol Cell. 2006 Jun 23;22(6):719-29.


X chromosomal abnormalities in basal-like human breast cancer.

Richardson AL, Wang ZC, De Nicolo A, Lu X, Brown M, Miron A, Liao X, Iglehart JD, Livingston DM, Ganesan S.

Cancer Cell. 2006 Feb;9(2):121-32.

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