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Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia.

Paonessa F, Evans LD, Solanki R, Larrieu D, Wray S, Hardy J, Jackson SP, Livesey FJ.

Cell Rep. 2019 Jan 15;26(3):582-593.e5. doi: 10.1016/j.celrep.2018.12.085.


Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer's Disease.

Hung COY, Livesey FJ.

Cell Rep. 2018 Dec 26;25(13):3647-3660.e2. doi: 10.1016/j.celrep.2018.11.095.


In vivo modeling of human neuron dynamics and Down syndrome.

Real R, Peter M, Trabalza A, Khan S, Smith MA, Dopp J, Barnes SJ, Momoh A, Strano A, Volpi E, Knott G, Livesey FJ, De Paola V.

Science. 2018 Nov 16;362(6416). pii: eaau1810. doi: 10.1126/science.aau1810. Epub 2018 Oct 11.


Publisher Correction: Guided self-organization and cortical plate formation in human brain organoids.

Lancaster MA, Corsini NS, Wolfinger S, Gustafson EH, Phillips AW, Burkard TR, Otani T, Livesey FJ, Knoblich JA.

Nat Biotechnol. 2018 Oct 11;36(10):1016. doi: 10.1038/nbt1018-1016a.


Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics Study.

Volpato V, Smith J, Sandor C, Ried JS, Baud A, Handel A, Newey SE, Wessely F, Attar M, Whiteley E, Chintawar S, Verheyen A, Barta T, Lako M, Armstrong L, Muschet C, Artati A, Cusulin C, Christensen K, Patsch C, Sharma E, Nicod J, Brownjohn P, Stubbs V, Heywood WE, Gissen P, De Filippis R, Janssen K, Reinhardt P, Adamski J, Royaux I, Peeters PJ, Terstappen GC, Graf M, Livesey FJ, Akerman CJ, Mills K, Bowden R, Nicholson G, Webber C, Cader MZ, Lakics V.

Stem Cell Reports. 2018 Oct 9;11(4):897-911. doi: 10.1016/j.stemcr.2018.08.013. Epub 2018 Sep 20.


Chromatin Accessibility Impacts Transcriptional Reprogramming in Oocytes.

Miyamoto K, Nguyen KT, Allen GE, Jullien J, Kumar D, Otani T, Bradshaw CR, Livesey FJ, Kellis M, Gurdon JB.

Cell Rep. 2018 Jul 10;24(2):304-311. doi: 10.1016/j.celrep.2018.06.030.


Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer's Disease Disrupt Synaptic Plasticity.

Hu NW, Corbett GT, Moore S, Klyubin I, O'Malley TT, Walsh DM, Livesey FJ, Rowan MJ.

Cell Rep. 2018 May 15;23(7):1932-1938. doi: 10.1016/j.celrep.2018.04.040.


Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia.

Brownjohn PW, Smith J, Solanki R, Lohmann E, Houlden H, Hardy J, Dietmann S, Livesey FJ.

Stem Cell Reports. 2018 Apr 10;10(4):1294-1307. doi: 10.1016/j.stemcr.2018.03.003. Epub 2018 Mar 29.


Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways.

Evans LD, Wassmer T, Fraser G, Smith J, Perkinton M, Billinton A, Livesey FJ.

Cell Rep. 2018 Mar 27;22(13):3612-3624. doi: 10.1016/j.celrep.2018.03.021.


Filopodyan: An open-source pipeline for the analysis of filopodia.

Urbančič V, Butler R, Richier B, Peter M, Mason J, Livesey FJ, Holt CE, Gallop JL.

J Cell Biol. 2017 Oct 2;216(10):3405-3422. doi: 10.1083/jcb.201705113. Epub 2017 Jul 31.


Guided self-organization and cortical plate formation in human brain organoids.

Lancaster MA, Corsini NS, Wolfinger S, Gustafson EH, Phillips AW, Burkard TR, Otani T, Livesey FJ, Knoblich JA.

Nat Biotechnol. 2017 Jul;35(7):659-666. doi: 10.1038/nbt.3906. Epub 2017 May 31. Erratum in: Nat Biotechnol. 2018 Oct 11;36(10):1016.


Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer's Disease.

Brownjohn PW, Smith J, Portelius E, Serneels L, Kvartsberg H, De Strooper B, Blennow K, Zetterberg H, Livesey FJ.

Stem Cell Reports. 2017 Apr 11;8(4):870-882. doi: 10.1016/j.stemcr.2017.02.006. Epub 2017 Mar 9.


Automated Synthesis and Analysis of Switching Gene Regulatory Networks.

Shavit Y, Yordanov B, Dunn SJ, Wintersteiger CM, Otani T, Hamadi Y, Livesey FJ, Kugler H.

Biosystems. 2016 Aug;146:26-34. doi: 10.1016/j.biosystems.2016.03.012. Epub 2016 May 10.


2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size.

Otani T, Marchetto MC, Gage FH, Simons BD, Livesey FJ.

Cell Stem Cell. 2016 Apr 7;18(4):467-80. doi: 10.1016/j.stem.2016.03.003. Epub 2016 Mar 31.


Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders.

Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R.

Stem Cell Reports. 2015 Dec 8;5(6):933-945. doi: 10.1016/j.stemcr.2015.10.011. Epub 2015 Nov 21.


Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro.

Kirwan P, Turner-Bridger B, Peter M, Momoh A, Arambepola D, Robinson HP, Livesey FJ.

Development. 2015 Sep 15;142(18):3178-87. doi: 10.1242/dev.123851.


η-Secretase processing of APP inhibits neuronal activity in the hippocampus.

Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, Müller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, Müller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H, Haass C.

Nature. 2015 Oct 15;526(7573):443-7. doi: 10.1038/nature14864. Epub 2015 Aug 31.


Cortical Differentiation of Human Pluripotent Cells for In Vitro Modeling of Alzheimer's Disease.

Saurat NG, Livesey FJ, Moore S.

Methods Mol Biol. 2016;1303:267-78. doi: 10.1007/978-1-4939-2627-5_16.


Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT.

Sposito T, Preza E, Mahoney CJ, Setó-Salvia N, Ryan NS, Morris HR, Arber C, Devine MJ, Houlden H, Warner TT, Bushell TJ, Zagnoni M, Kunath T, Livesey FJ, Fox NC, Rossor MN, Hardy J, Wray S.

Hum Mol Genet. 2015 Sep 15;24(18):5260-9. doi: 10.1093/hmg/ddv246. Epub 2015 Jul 1.


Reconstructing the neuronal milieu intérieur.

Livesey FJ.

Proc Natl Acad Sci U S A. 2015 May 19;112(20):6250-1. doi: 10.1073/pnas.1506303112. Epub 2015 May 11. No abstract available.


The methyl binding domain 3/nucleosome remodelling and deacetylase complex regulates neural cell fate determination and terminal differentiation in the cerebral cortex.

Knock E, Pereira J, Lombard PD, Dimond A, Leaford D, Livesey FJ, Hendrich B.

Neural Dev. 2015 May 2;10:13. doi: 10.1186/s13064-015-0040-z.


APP metabolism regulates tau proteostasis in human cerebral cortex neurons.

Moore S, Evans LD, Andersson T, Portelius E, Smith J, Dias TB, Saurat N, McGlade A, Kirwan P, Blennow K, Hardy J, Zetterberg H, Livesey FJ.

Cell Rep. 2015 May 5;11(5):689-96. doi: 10.1016/j.celrep.2015.03.068. Epub 2015 Apr 23.


G&T-seq: parallel sequencing of single-cell genomes and transcriptomes.

Macaulay IC, Haerty W, Kumar P, Li YI, Hu TX, Teng MJ, Goolam M, Saurat N, Coupland P, Shirley LM, Smith M, Van der Aa N, Banerjee R, Ellis PD, Quail MA, Swerdlow HP, Zernicka-Goetz M, Livesey FJ, Ponting CP, Voet T.

Nat Methods. 2015 Jun;12(6):519-22. doi: 10.1038/nmeth.3370. Epub 2015 Apr 27.


On human development: lessons from stem cell systems.

Medvinsky A, Livesey FJ.

Development. 2015 Jan 1;142(1):17-20. doi: 10.1242/dev.114868.


Human stem cell models of dementia.

Livesey FJ.

Hum Mol Genet. 2014 Sep 15;23(R1):R35-9. doi: 10.1093/hmg/ddu302. Epub 2014 Jun 16. Review.


The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro.

Ali FR, Cheng K, Kirwan P, Metcalfe S, Livesey FJ, Barker RA, Philpott A.

Development. 2014 Jun;141(11):2216-24. doi: 10.1242/dev.106377. Epub 2014 May 12.


Imatinib treatment and Aβ42 in humans.

Olsson B, Legros L, Guilhot F, Strömberg K, Smith J, Livesey FJ, Wilson DH, Zetterberg H, Blennow K.

Alzheimers Dement. 2014 Oct;10(5 Suppl):S374-80. doi: 10.1016/j.jalz.2013.08.283. Epub 2013 Dec 10.


Dicer is required for neural stem cell multipotency and lineage progression during cerebral cortex development.

Saurat N, Andersson T, Vasistha NA, Molnár Z, Livesey FJ.

Neural Dev. 2013 Jul 29;8:14. doi: 10.1186/1749-8104-8-14.


Chromatin regulation by BAF170 controls cerebral cortical size and thickness.

Tuoc TC, Boretius S, Sansom SN, Pitulescu ME, Frahm J, Livesey FJ, Stoykova A.

Dev Cell. 2013 May 13;25(3):256-69. doi: 10.1016/j.devcel.2013.04.005. Epub 2013 May 2.


Pax6 exerts regional control of cortical progenitor proliferation via direct repression of Cdk6 and hypophosphorylation of pRb.

Mi D, Carr CB, Georgala PA, Huang YT, Manuel MN, Jeanes E, Niisato E, Sansom SN, Livesey FJ, Theil T, Hasenpusch-Theil K, Simpson TI, Mason JO, Price DJ.

Neuron. 2013 Apr 24;78(2):269-84. doi: 10.1016/j.neuron.2013.02.012.


Ikaros promotes early-born neuronal fates in the cerebral cortex.

Alsiö JM, Tarchini B, Cayouette M, Livesey FJ.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E716-25. doi: 10.1073/pnas.1215707110. Epub 2013 Feb 4. Erratum in: Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):E3088.


Stem cell models of Alzheimer's disease and related neurological disorders.

Livesey FJ.

Alzheimers Res Ther. 2012 Nov 6;4(6):44. doi: 10.1186/alzrt147. eCollection 2012. Review.


A potential link between obesity and neural stem cell dysfunction.

Livesey FJ.

Nat Cell Biol. 2012 Oct;14(10):987-9. doi: 10.1038/ncb2599.


Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks.

Shi Y, Kirwan P, Livesey FJ.

Nat Protoc. 2012 Oct;7(10):1836-46. doi: 10.1038/nprot.2012.116. Epub 2012 Sep 13.


A human stem cell model of early Alzheimer's disease pathology in Down syndrome.

Shi Y, Kirwan P, Smith J, MacLean G, Orkin SH, Livesey FJ.

Sci Transl Med. 2012 Mar 7;4(124):124ra29. doi: 10.1126/scitranslmed.3003771. Epub 2012 Feb 15.


Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses.

Shi Y, Kirwan P, Smith J, Robinson HP, Livesey FJ.

Nat Neurosci. 2012 Feb 5;15(3):477-86, S1. doi: 10.1038/nn.3041.


Neural stem cell biology in vertebrates and invertebrates: more alike than different?

Brand AH, Livesey FJ.

Neuron. 2011 May 26;70(4):719-29. doi: 10.1016/j.neuron.2011.05.016. Review.


Reversible block of mouse neural stem cell differentiation in the absence of dicer and microRNAs.

Andersson T, Rahman S, Sansom SN, Alsiö JM, Kaneda M, Smith J, O'Carroll D, Tarakhovsky A, Livesey FJ.

PLoS One. 2010 Oct 18;5(10):e13453. doi: 10.1371/journal.pone.0013453.


Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex.

Pereira JD, Sansom SN, Smith J, Dobenecker MW, Tarakhovsky A, Livesey FJ.

Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15957-62. doi: 10.1073/pnas.1002530107. Epub 2010 Aug 23.


Grouping and classifying electrophysiologically-defined classes of neocortical neurons by single cell, whole-genome expression profiling.

Subkhankulova T, Yano K, Robinson HP, Livesey FJ.

Front Mol Neurosci. 2010 Apr 13;3:10. doi: 10.3389/fnmol.2010.00010. eCollection 2010.


Gradients in the brain: the control of the development of form and function in the cerebral cortex.

Sansom SN, Livesey FJ.

Cold Spring Harb Perspect Biol. 2009 Aug;1(2):a002519. doi: 10.1101/cshperspect.a002519. Review.


The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.

Sansom SN, Griffiths DS, Faedo A, Kleinjan DJ, Ruan Y, Smith J, van Heyningen V, Rubenstein JL, Livesey FJ.

PLoS Genet. 2009 Jun;5(6):e1000511. doi: 10.1371/journal.pgen.1000511. Epub 2009 Jun 12.


Prolonged illumination up-regulates arrestin and two guanylate cyclase activating proteins: a novel mechanism for light adaptation.

Codega P, Della Santina L, Gargini C, Bedolla DE, Subkhankulova T, Livesey FJ, Cervetto L, Torre V.

J Physiol. 2009 Jun 1;587(Pt 11):2457-72. doi: 10.1113/jphysiol.2009.168609. Epub 2009 Mar 30.


PMC42, a breast progenitor cancer cell line, has normal-like mRNA and microRNA transcriptomes.

Git A, Spiteri I, Blenkiron C, Dunning MJ, Pole JC, Chin SF, Wang Y, Smith J, Livesey FJ, Caldas C.

Breast Cancer Res. 2008;10(3):R54. doi: 10.1186/bcr2109. Epub 2008 Jun 27.


Modelling and measuring single cell RNA expression levels find considerable transcriptional differences among phenotypically identical cells.

Subkhankulova T, Gilchrist MJ, Livesey FJ.

BMC Genomics. 2008 Jun 3;9:268. doi: 10.1186/1471-2164-9-268.


Differential display of mRNA by PCR.

Livesey FJ, Hunt CP.

Curr Protoc Neurosci. 2001 May;Chapter 5:Unit 5.2. doi: 10.1002/0471142301.ns0502s00.


Differential display of mRNA by PCR.

Livesey FJ, Hunt SP.

Curr Protoc Hum Genet. 2001 May;Chapter 11:Unit 11.5. doi: 10.1002/0471142905.hg1105s10.


A role for the transcriptional repressor REST in maintaining the phenotype of neurosecretory-deficient PC12 cells.

Pance A, Livesey FJ, Jackson AP.

J Neurochem. 2006 Dec;99(5):1435-44. Epub 2006 Oct 25.


A role for Dicer in immune regulation.

Cobb BS, Hertweck A, Smith J, O'Connor E, Graf D, Cook T, Smale ST, Sakaguchi S, Livesey FJ, Fisher AG, Merkenschlager M.

J Exp Med. 2006 Oct 30;203(11):2519-27. Epub 2006 Oct 23.


Electrophysiological and gene expression profiling of neuronal cell types in mammalian neocortex.

Yano K, Subkhankulova T, Livesey FJ, Robinson HP.

J Physiol. 2006 Sep 1;575(Pt 2):361-5. Epub 2006 Jul 13. Review.

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