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Discovery of a Potent GLUT Inhibitor from a Library of Rapafucins by Using 3D Microarrays.

Guo Z, Cheng Z, Wang J, Liu W, Peng H, Wang Y, Rao AVS, Li RJ, Ying X, Korangath P, Liberti MV, Li Y, Xie Y, Hong SY, Schiene-Fischer C, Fischer G, Locasale JW, Sukumar S, Zhu H, Liu JO.

Angew Chem Int Ed Engl. 2019 Oct 7. doi: 10.1002/anie.201905578. [Epub ahead of print]


One-step Heck Reaction Generates Nonimmunosuppressive FK506 Analogs for Pharmacological BMP Activation.

Wang Y, Peiffer BJ, Su Q, Liu JO.

ACS Med Chem Lett. 2019 Aug 19;10(9):1279-1283. doi: 10.1021/acsmedchemlett.9b00144. eCollection 2019 Sep 12.


Pharmacophore-Directed Retrosynthesis Applied to Rameswaralide: Synthesis and Bioactivity of Sinularia Natural Product Tricyclic Cores.

Truax NJ, Ayinde S, Van K, Liu JO, Romo D.

Org Lett. 2019 Sep 20;21(18):7394-7399. doi: 10.1021/acs.orglett.9b02713. Epub 2019 Sep 9.


Pharmacologic Activation of Lytic Epstein-Barr Virus Gene Expression without Virion Production.

Lee J, Kosowicz JG, Hayward SD, Desai P, Stone J, Lee JM, Liu JO, Ambinder RF.

J Virol. 2019 Sep 30;93(20). pii: e00998-19. doi: 10.1128/JVI.00998-19. Print 2019 Oct 15.


Activation of BMP Signaling by FKBP12 Ligands Synergizes with Inhibition of CXCR4 to Accelerate Wound Healing.

Peiffer BJ, Qi L, Ahmadi AR, Wang Y, Guo Z, Peng H, Sun Z, Liu JO.

Cell Chem Biol. 2019 May 16;26(5):652-661.e4. doi: 10.1016/j.chembiol.2019.01.011. Epub 2019 Feb 28.


Rapamycin-inspired macrocycles with new target specificity.

Guo Z, Hong SY, Wang J, Rehan S, Liu W, Peng H, Das M, Li W, Bhat S, Peiffer B, Ullman BR, Tse CM, Tarmakova Z, Schiene-Fischer C, Fischer G, Coe I, Paavilainen VO, Sun Z, Liu JO.

Nat Chem. 2019 Mar;11(3):254-263. doi: 10.1038/s41557-018-0187-4. Epub 2018 Dec 10.


Novel Tetrazole-Containing Analogues of Itraconazole as Potent Antiangiogenic Agents with Reduced Cytochrome P450 3A4 Inhibition.

Li Y, Pasunooti KK, Li RJ, Liu W, Head SA, Shi WQ, Liu JO.

J Med Chem. 2018 Dec 27;61(24):11158-11168. doi: 10.1021/acs.jmedchem.8b01252. Epub 2018 Dec 10.


Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking.

Lyu J, Yang EJ, Head SA, Ai N, Zhang B, Wu C, Li RJ, Liu Y, Chakravarty H, Zhang S, Tam KY, Dang Y, Kwon HJ, Ge W, Liu JO, Shim JS.

Int J Biol Sci. 2018 Jun 23;14(10):1175-1185. doi: 10.7150/ijbs.26011. eCollection 2018.


Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP).

Bauer L, Ferla S, Head SA, Bhat S, Pasunooti KK, Shi WQ, Albulescu L, Liu JO, Brancale A, van Kuppeveld FJM, Strating JRPM.

Antiviral Res. 2018 Aug;156:55-63. doi: 10.1016/j.antiviral.2018.05.010. Epub 2018 May 26.


Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment.

Lam C, Ferguson ID, Mariano MC, Lin YT, Murnane M, Liu H, Smith GA, Wong SW, Taunton J, Liu JO, Mitsiades CS, Hann BC, Aftab BT, Wiita AP.

Haematologica. 2018 Jul;103(7):1218-1228. doi: 10.3324/haematol.2017.174482. Epub 2018 Apr 5.


Prolyl 4-hydroxylase 2 promotes B-cell lymphoma progression via hydroxylation of Carabin.

Jiang W, Zhou X, Li Z, Liu K, Wang W, Tan R, Cong X, Shan J, Zhan Y, Cui Z, Jiang L, Li Q, Shen S, Bai M, Cheng Y, Li B, Tan M, Ma DK, Liu JO, Dang Y.

Blood. 2018 Mar 22;131(12):1325-1336. doi: 10.1182/blood-2017-07-794875. Epub 2018 Feb 1.


USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1.

Li Z, Cheng Z, Raghothama C, Cui Z, Liu K, Li X, Jiang C, Jiang W, Tan M, Ni X, Pandey A, Liu JO, Dang Y.

Nucleic Acids Res. 2018 Jan 25;46(2):823-839. doi: 10.1093/nar/gkx1226.


Inhibition of the SOCS1-JAK2-STAT3 Signaling Pathway Confers Neuroprotection in Rats with Ischemic Stroke.

Wang XL, Qiao CM, Liu JO, Li CY.

Cell Physiol Biochem. 2017;44(1):85-98. doi: 10.1159/000484585. Epub 2017 Nov 6.


Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth.

Lyu J, Yang EJ, Head SA, Ai N, Zhang B, Wu C, Li RJ, Liu Y, Yang C, Dang Y, Kwon HJ, Ge W, Liu JO, Shim JS.

Cancer Lett. 2017 Nov 28;409:91-103. doi: 10.1016/j.canlet.2017.09.009. Epub 2017 Sep 18.


Drug Modulators of B Cell Signaling Pathways and Epstein-Barr Virus Lytic Activation.

Kosowicz JG, Lee J, Peiffer B, Guo Z, Chen J, Liao G, Hayward SD, Liu JO, Ambinder RF.

J Virol. 2017 Jul 27;91(16). pii: e00747-17. doi: 10.1128/JVI.00747-17. Print 2017 Aug 15.


Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A.

McClary B, Zinshteyn B, Meyer M, Jouanneau M, Pellegrino S, Yusupova G, Schuller A, Reyes JCP, Lu J, Guo Z, Ayinde S, Luo C, Dang Y, Romo D, Yusupov M, Green R, Liu JO.

Cell Chem Biol. 2017 May 18;24(5):605-613.e5. doi: 10.1016/j.chembiol.2017.04.006. Epub 2017 Apr 27.


Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis.

Head SA, Shi WQ, Yang EJ, Nacev BA, Hong SY, Pasunooti KK, Li RJ, Shim JS, Liu JO.

ACS Chem Biol. 2017 Jan 20;12(1):174-182. doi: 10.1021/acschembio.6b00849. Epub 2016 Dec 2.


Characterization of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone as a novel inhibitor of methionine aminopeptidases from Mycobacterium tuberculosis.

John SF, Aniemeke E, Ha NP, Chong CR, Gu P, Zhou J, Zhang Y, Graviss EA, Liu JO, Olaleye OA.

Tuberculosis (Edinb). 2016 Dec;101S:S73-S77. doi: 10.1016/ Epub 2016 Sep 28.


Regulation of mTORC1 by lysosomal calcium and calmodulin.

Li RJ, Xu J, Fu C, Zhang J, Zheng YG, Jia H, Liu JO.

Elife. 2016 Oct 27;5. pii: e19360. doi: 10.7554/eLife.19360.


Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier.

Wang X, Maruvada R, Morris AJ, Liu JO, Wolfgang MJ, Baek DJ, Bittman R, Kim KS.

PLoS Pathog. 2016 Oct 6;12(10):e1005926. doi: 10.1371/journal.ppat.1005926. eCollection 2016 Oct.


Antidepressant indatraline induces autophagy and inhibits restenosis via suppression of mTOR/S6 kinase signaling pathway.

Cho YS, Yen CN, Shim JS, Kang DH, Kang SW, Liu JO, Kwon HJ.

Sci Rep. 2016 Oct 3;6:34655. doi: 10.1038/srep34655.


Insights into the structure-activity relationship of the anticancer compound ZJ-101, a derivative of marine natural product superstolide A: A role played by the lactone moiety.

Qiu H, Qian S, Head SA, Liu JO, Jin Z.

Bioorg Med Chem Lett. 2016 Oct 1;26(19):4702-4704. doi: 10.1016/j.bmcl.2016.08.046. Epub 2016 Aug 20.


Targeted Delivery and Sustained Antitumor Activity of Triptolide through Glucose Conjugation.

He QL, Minn I, Wang Q, Xu P, Head SA, Datan E, Yu B, Pomper MG, Liu JO.

Angew Chem Int Ed Engl. 2016 Sep 19;55(39):12035-9. doi: 10.1002/anie.201606121. Epub 2016 Aug 30.


Insights into the structure-activity relationship of the anticancer compound ZJ-101: A critical role played by the cyclohexene ring.

Shah AK, Qian S, Zhang D, Head SA, Liu JO, Jin Z.

Bioorg Med Chem Lett. 2016 Jun 15;26(12):2890-2892. doi: 10.1016/j.bmcl.2016.04.044. Epub 2016 Apr 19.


Editorial: Strategies for cellular target identification of natural products.

Romo D, Liu JO.

Nat Prod Rep. 2016 May 4;33(5):592-4. doi: 10.1039/c6np90016j. No abstract available.


Derivatization of agelastatin A leading to bioactive analogs and a trifunctional probe.

Jouanneau M, McClary B, Reyes JC, Chen R, Chen Y, Plunkett W, Cheng X, Milinichik AZ, Albone EF, Liu JO, Romo D.

Bioorg Med Chem Lett. 2016 Apr 15;26(8):2092-7. doi: 10.1016/j.bmcl.2016.02.051. Epub 2016 Feb 23.


Divergence of Antiangiogenic Activity and Hepatotoxicity of Different Stereoisomers of Itraconazole.

Shim JS, Li RJ, Bumpus NN, Head SA, Kumar Pasunooti K, Yang EJ, Lv J, Shi W, Liu JO.

Clin Cancer Res. 2016 Jun 1;22(11):2709-20. doi: 10.1158/1078-0432.CCR-15-1888. Epub 2016 Jan 22.


Artemisinin-derived dimer ART-838 potently inhibited human acute leukemias, persisted in vivo, and synergized with antileukemic drugs.

Fox JM, Moynihan JR, Mott BT, Mazzone JR, Anders NM, Brown PA, Rudek MA, Liu JO, Arav-Boger R, Posner GH, Civin CI, Chen X.

Oncotarget. 2016 Feb 9;7(6):7268-79. doi: 10.18632/oncotarget.6896.


Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells.

Head SA, Shi W, Zhao L, Gorshkov K, Pasunooti K, Chen Y, Deng Z, Li RJ, Shim JS, Tan W, Hartung T, Zhang J, Zhao Y, Colombini M, Liu JO.

Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):E7276-85. doi: 10.1073/pnas.1512867112. Epub 2015 Dec 10.


A gating mechanism for Pi release governs the mRNA unwinding by eIF4AI during translation initiation.

Lu J, Jiang C, Li X, Jiang L, Li Z, Schneider-Poetsch T, Liu J, Yu K, Liu JO, Jiang H, Luo C, Dang Y.

Nucleic Acids Res. 2015 Dec 2;43(21):10157-67. doi: 10.1093/nar/gkv1033. Epub 2015 Oct 12.


Targeted therapy for Epstein-Barr virus-associated gastric carcinoma using low-dose gemcitabine-induced lytic activation.

Lee HG, Kim H, Kim EJ, Park PG, Dong SM, Choi TH, Kim H, Chong CR, Liu JO, Chen J, Ambinder RF, Hayward SD, Park JH, Lee JM.

Oncotarget. 2015 Oct 13;6(31):31018-29. doi: 10.18632/oncotarget.5041.


First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass.

Wang G, Rajpurohit SK, Delaspre F, Walker SL, White DT, Ceasrine A, Kuruvilla R, Li RJ, Shim JS, Liu JO, Parsons MJ, Mumm JS.

Elife. 2015 Jul 28;4. doi: 10.7554/eLife.08261.


Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors.

He R, Yu ZH, Zhang RY, Wu L, Gunawan AM, Lane BS, Shim JS, Zeng LF, He Y, Chen L, Wells CD, Liu JO, Zhang ZY.

ACS Med Chem Lett. 2015 Jun 8;6(7):782-6. doi: 10.1021/acsmedchemlett.5b00118. eCollection 2015 Jul 9.


Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B.

Jiang DK, Ma XP, Yu H, Cao G, Ding DL, Chen H, Huang HX, Gao YZ, Wu XP, Long XD, Zhang H, Zhang Y, Gao Y, Chen TY, Ren WH, Zhang P, Shi Z, Jiang W, Wan B, Saiyin H, Yin J, Zhou YF, Zhai Y, Lu PX, Zhang H, Gu X, Tan A, Wang JB, Zuo XB, Sun LD, Liu JO, Yi Q, Mo Z, Zhou G, Liu Y, Sun J, Shugart YY, Zheng SL, Zhang XJ, Xu J, Yu L.

Hepatology. 2015 Jul;62(1):118-28. doi: 10.1002/hep.27794. Epub 2015 Apr 28.


Inhibition of angiogenesis by selective estrogen receptor modulators through blockade of cholesterol trafficking rather than estrogen receptor antagonism.

Shim JS, Li RJ, Lv J, Head SA, Yang EJ, Liu JO.

Cancer Lett. 2015 Jun 28;362(1):106-15. doi: 10.1016/j.canlet.2015.03.022. Epub 2015 Mar 20.


Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein.

Strating JR, van der Linden L, Albulescu L, Bigay J, Arita M, Delang L, Leyssen P, van der Schaar HM, Lanke KH, Thibaut HJ, Ulferts R, Drin G, Schlinck N, Wubbolts RW, Sever N, Head SA, Liu JO, Beachy PA, De Matteis MA, Shair MD, Olkkonen VM, Neyts J, van Kuppeveld FJ.

Cell Rep. 2015 Feb 3;10(4):600-15. doi: 10.1016/j.celrep.2014.12.054. Epub 2015 Jan 29.


Identification of novel vascular projections with cellular trafficking abilities on the microvasculature of pancreatic ductal adenocarcinoma.

Hexige S, Ardito-Abraham CM, Wu Y, Wei Y, Fang Y, Han X, Li J, Zhou P, Yi Q, Maitra A, Liu JO, Tuveson DA, Lou W, Yu L.

J Pathol. 2015 Jun;236(2):142-154. doi: 10.1002/path.4506. Epub 2015 Feb 17.


Covalent modification of a cysteine residue in the XPB subunit of the general transcription factor TFIIH through single epoxide cleavage of the transcription inhibitor triptolide.

He QL, Titov DV, Li J, Tan M, Ye Z, Zhao Y, Romo D, Liu JO.

Angew Chem Int Ed Engl. 2015 Feb 2;54(6):1859-63. doi: 10.1002/anie.201408817. Epub 2014 Dec 12.


Regulation of cell cycle of hepatocellular carcinoma by NF90 through modulation of cyclin E1 mRNA stability.

Jiang W, Huang H, Ding L, Zhu P, Saiyin H, Ji G, Zuo J, Han D, Pan Y, Ding D, Ma X, Zhang Y, Wu J, Yi Q, Liu JO, Huang H, Dang Y, Yu L.

Oncogene. 2015 Aug 20;34(34):4460-70. doi: 10.1038/onc.2014.373. Epub 2014 Nov 17.


Multifunctional atomic force microscope cantilevers with Lorentz force actuation and self-heating capability.

Somnath S, Liu JO, Bakir M, Prater CB, King WP.

Nanotechnology. 2014 Oct 3;25(39):395501. doi: 10.1088/0957-4484/25/39/395501. Epub 2014 Sep 5.


Recent advances in drug repositioning for the discovery of new anticancer drugs.

Shim JS, Liu JO.

Int J Biol Sci. 2014 Jun 10;10(7):654-63. doi: 10.7150/ijbs.9224. eCollection 2014. Review.


Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer.

Wang M, Shim JS, Li RJ, Dang Y, He Q, Das M, Liu JO.

Br J Pharmacol. 2014 Oct;171(19):4478-89. doi: 10.1111/bph.12800. Epub 2014 Sep 5.


Small-molecule screening of PC3 prostate cancer cells identifies tilorone dihydrochloride to selectively inhibit cell growth based on cyclin-dependent kinase 5 expression.

Wissing MD, Dadon T, Kim E, Piontek KB, Shim JS, Kaelber NS, Liu JO, Kachhap SK, Nelkin BD.

Oncol Rep. 2014 Jul;32(1):419-24. doi: 10.3892/or.2014.3174. Epub 2014 May 13.


Pharmacological mobilization of endogenous stem cells significantly promotes skin regeneration after full-thickness excision: the synergistic activity of AMD3100 and tacrolimus.

Lin Q, Wesson RN, Maeda H, Wang Y, Cui Z, Liu JO, Cameron AM, Gao B, Montgomery RA, Williams GM, Sun Z.

J Invest Dermatol. 2014 Sep;134(9):2458-2468. doi: 10.1038/jid.2014.162. Epub 2014 Mar 28.


Second-generation derivatives of the eukaryotic translation initiation inhibitor pateamine A targeting eIF4A as potential anticancer agents.

Low WK, Li J, Zhu M, Kommaraju SS, Shah-Mittal J, Hull K, Liu JO, Romo D.

Bioorg Med Chem. 2014 Jan 1;22(1):116-25. doi: 10.1016/j.bmc.2013.11.046. Epub 2013 Dec 4.


Identification, biochemical and structural evaluation of species-specific inhibitors against type I methionine aminopeptidases.

Kishor C, Arya T, Reddi R, Chen X, Saddanapu V, Marapaka AK, Gumpena R, Ma D, Liu JO, Addlagatta A.

J Med Chem. 2013 Jul 11;56(13):5295-305. doi: 10.1021/jm400395p. Epub 2013 Jun 27.


Arginine68 is an essential residue for the C-terminal cleavage of human Atg8 family proteins.

Liu C, Ma H, Wu J, Huang Q, Liu JO, Yu L.

BMC Cell Biol. 2013 May 30;14:27. doi: 10.1186/1471-2121-14-27.


p53 Represses transcription of RING finger LIM domain-binding protein RLIM through Sp1.

Kong X, Peng B, Yang Y, Zhang P, Qin B, Han D, Wang C, Dang Y, Liu JO, Yu L.

PLoS One. 2013 May 1;8(5):e62832. doi: 10.1371/journal.pone.0062832. Print 2013.

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