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Items: 1 to 50 of 262

1.

Continuous evolution of SpCas9 variants compatible with non-G PAMs.

Miller SM, Wang T, Randolph PB, Arbab M, Shen MW, Huang TP, Matuszek Z, Newby GA, Rees HA, Liu DR.

Nat Biotechnol. 2020 Feb 10. doi: 10.1038/s41587-020-0412-8. [Epub ahead of print]

PMID:
32042170
2.

Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors.

Doman JL, Raguram A, Newby GA, Liu DR.

Nat Biotechnol. 2020 Feb 10. doi: 10.1038/s41587-020-0414-6. [Epub ahead of print]

PMID:
32042165
3.

Defining "Swarming" as a New Model to Optimize Efficiency and Education in an Academic Emergency Department.

Perniciaro JL, Schmidt AR, Pham PK, Liu DR.

AEM Educ Train. 2019 Sep 12;4(1):43-53. doi: 10.1002/aet2.10388. eCollection 2020 Jan.

PMID:
31989070
4.

Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses.

Levy JM, Yeh WH, Pendse N, Davis JR, Hennessey E, Butcher R, Koblan LW, Comander J, Liu Q, Liu DR.

Nat Biomed Eng. 2020 Jan;4(1):97-110. doi: 10.1038/s41551-019-0501-5. Epub 2020 Jan 14.

PMID:
31937940
5.

High-throughput analysis of the activities of xCas9, SpCas9-NG and SpCas9 at matched and mismatched target sequences in human cells.

Kim HK, Lee S, Kim Y, Park J, Min S, Choi JW, Huang TP, Yoon S, Liu DR, Kim HH.

Nat Biomed Eng. 2020 Jan;4(1):111-124. doi: 10.1038/s41551-019-0505-1. Epub 2020 Jan 14.

PMID:
31937939
6.

MiR-378a-5p inhibits angiogenesis of oral squamous cell carcinoma by targeting KLK4.

Cui Z, Liu QL, Sun SQ, Jiao K, Liu DR, Zhou XC, Huang L.

Neoplasma. 2020 Jan;67(1):85-92. doi: 10.4149/neo_2019_190306N191. Epub 2019 Dec 9.

PMID:
31829025
7.

Assessing the Utility of Urine Testing in Febrile Infants 2 to 12 Months of Age With Bronchiolitis.

Elkhunovich MA, Wang VJ, Pham P, Arpilleda JC, Clingenpeel JM, Mansour K, Riech T, Yen K, Liu DR.

Pediatr Emerg Care. 2019 Dec 3. doi: 10.1097/PEC.0000000000001912. [Epub ahead of print]

PMID:
31804430
8.

Adenine base editing in an adult mouse model of tyrosinaemia.

Song CQ, Jiang T, Richter M, Rhym LH, Koblan LW, Zafra MP, Schatoff EM, Doman JL, Cao Y, Dow LE, Zhu LJ, Anderson DG, Liu DR, Yin H, Xue W.

Nat Biomed Eng. 2020 Jan;4(1):125-130. doi: 10.1038/s41551-019-0357-8. Epub 2019 Feb 25.

9.

Search-and-replace genome editing without double-strand breaks or donor DNA.

Anzalone AV, Randolph PB, Davis JR, Sousa AA, Koblan LW, Levy JM, Chen PJ, Wilson C, Newby GA, Raguram A, Liu DR.

Nature. 2019 Dec;576(7785):149-157. doi: 10.1038/s41586-019-1711-4. Epub 2019 Oct 21.

PMID:
31634902
10.

Author Correction: Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules.

Usanov DL, Chan AI, Maianti JP, Liu DR.

Nat Chem. 2019 Nov;11(11):1067. doi: 10.1038/s41557-019-0360-4.

PMID:
31576016
11.

Base Editor Correction of COL7A1 in Recessive Dystrophic Epidermolysis Bullosa Patient-Derived Fibroblasts and iPSCs.

Osborn MJ, Newby GA, McElroy AN, Knipping F, Nielsen SC, Riddle MJ, Xia L, Chen W, Eide CR, Webber BR, Wandall HH, Dabelsteen S, Blazar BR, Liu DR, Tolar J.

J Invest Dermatol. 2020 Feb;140(2):338-347.e5. doi: 10.1016/j.jid.2019.07.701. Epub 2019 Aug 19.

PMID:
31437443
12.

Publisher Correction: Continuous evolution of base editors with expanded target compatibility and improved activity.

Thuronyi BW, Koblan LW, Levy JM, Yeh WH, Zheng C, Newby GA, Wilson C, Bhaumik M, Shubina-Oleinik O, Holt JR, Liu DR.

Nat Biotechnol. 2019 Sep;37(9):1091. doi: 10.1038/s41587-019-0253-5.

PMID:
31406330
13.

Continuous evolution of base editors with expanded target compatibility and improved activity.

Thuronyi BW, Koblan LW, Levy JM, Yeh WH, Zheng C, Newby GA, Wilson C, Bhaumik M, Shubina-Oleinik O, Holt JR, Liu DR.

Nat Biotechnol. 2019 Sep;37(9):1070-1079. doi: 10.1038/s41587-019-0193-0. Epub 2019 Jul 22. Erratum in: Nat Biotechnol. 2019 Aug 12;:.

14.

An anionic human protein mediates cationic liposome delivery of genome editing proteins into mammalian cells.

Kim YB, Zhao KT, Thompson DB, Liu DR.

Nat Commun. 2019 Jul 2;10(1):2905. doi: 10.1038/s41467-019-10828-3.

15.

Addendum: High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases.

Bessen JL, Afeyan LK, Dančík V, Koblan LW, Thompson DB, Leichner C, Clemons PA, Liu DR.

Nat Commun. 2019 Jul 2;10(1):3003. doi: 10.1038/s41467-019-10892-9. No abstract available.

16.

Author Correction: Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors.

Huang TP, Zhao KT, Miller SM, Gaudelli NM, Oakes BL, Fellmann C, Savage DF, Liu DR.

Nat Biotechnol. 2019 Jul;37(7):820. doi: 10.1038/s41587-019-0168-1.

PMID:
31182863
17.

Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors.

Huang TP, Zhao KT, Miller SM, Gaudelli NM, Oakes BL, Fellmann C, Savage DF, Liu DR.

Nat Biotechnol. 2019 Jun;37(6):626-631. doi: 10.1038/s41587-019-0134-y. Epub 2019 May 20. Erratum in: Nat Biotechnol. 2019 Jun 10;:.

18.

Development of hRad51-Cas9 nickase fusions that mediate HDR without double-stranded breaks.

Rees HA, Yeh WH, Liu DR.

Nat Commun. 2019 May 17;10(1):2212. doi: 10.1038/s41467-019-09983-4.

19.

Analysis and minimization of cellular RNA editing by DNA adenine base editors.

Rees HA, Wilson C, Doman JL, Liu DR.

Sci Adv. 2019 May 8;5(5):eaax5717. doi: 10.1126/sciadv.aax5717. eCollection 2019 May.

20.

Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme.

Maianti JP, Tan GA, Vetere A, Welsh AJ, Wagner BK, Seeliger MA, Liu DR.

Nat Chem Biol. 2019 Jun;15(6):565-574. doi: 10.1038/s41589-019-0271-0. Epub 2019 May 13.

21.

A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9.

Maji B, Gangopadhyay SA, Lee M, Shi M, Wu P, Heler R, Mok B, Lim D, Siriwardena SU, Paul B, Dančík V, Vetere A, Mesleh MF, Marraffini LA, Liu DR, Clemons PA, Wagner BK, Choudhary A.

Cell. 2019 May 2;177(4):1067-1079.e19. doi: 10.1016/j.cell.2019.04.009.

PMID:
31051099
22.

High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases.

Bessen JL, Afeyan LK, Dančík V, Koblan LW, Thompson DB, Leichner C, Clemons PA, Liu DR.

Nat Commun. 2019 Apr 26;10(1):1937. doi: 10.1038/s41467-019-09987-0. Erratum in: Nat Commun. 2019 Jul 2;10(1):3003.

23.

Publisher Correction: Side chain determinants of biopolymer function during selection and replication.

Lichtor PA, Chen Z, Elowe NH, Chen JC, Liu DR.

Nat Chem Biol. 2019 May;15(5):550. doi: 10.1038/s41589-019-0254-1.

PMID:
30858597
24.

Phage-Assisted Evolution of Bacillus methanolicus Methanol Dehydrogenase 2.

Roth TB, Woolston BM, Stephanopoulos G, Liu DR.

ACS Synth Biol. 2019 Apr 19;8(4):796-806. doi: 10.1021/acssynbio.8b00481. Epub 2019 Mar 20.

25.

Genetic dissection of flowering time in Brassica rapa responses to temperature and photoperiod.

Xiao D, Shen HR, Zhao JJ, Wei YP, Liu DR, Hou XL, Bonnema G.

Plant Sci. 2019 Mar;280:110-119. doi: 10.1016/j.plantsci.2018.10.027. Epub 2018 Nov 3.

PMID:
30823988
26.

CRISPResso2 provides accurate and rapid genome editing sequence analysis.

Clement K, Rees H, Canver MC, Gehrke JM, Farouni R, Hsu JY, Cole MA, Liu DR, Joung JK, Bauer DE, Pinello L.

Nat Biotechnol. 2019 Mar;37(3):224-226. doi: 10.1038/s41587-019-0032-3. No abstract available.

27.

Author Correction: Predictable and precise template-free CRISPR editing of pathogenic variants.

Shen MW, Arbab M, Hsu JY, Worstell D, Culbertson SJ, Krabbe O, Cassa CA, Liu DR, Gifford DK, Sherwood RI.

Nature. 2019 Mar;567(7746):E1-E2. doi: 10.1038/s41586-019-0938-4.

PMID:
30765887
28.

Side chain determinants of biopolymer function during selection and replication.

Lichtor PA, Chen Z, Elowe NH, Chen JC, Liu DR.

Nat Chem Biol. 2019 Apr;15(4):419-426. doi: 10.1038/s41589-019-0229-2. Epub 2019 Feb 11. Erratum in: Nat Chem Biol. 2019 Mar 11;:.

29.

Simultaneous targeting of linked loci in mouse embryos using base editing.

Lee HK, Willi M, Smith HE, Miller SM, Liu DR, Liu C, Hennighausen L.

Sci Rep. 2019 Feb 7;9(1):1662. doi: 10.1038/s41598-018-33533-5.

30.

Increased expression of brain-derived neurotrophic factor is correlated with visceral hypersensitivity in patients with diarrhea-predominant irritable bowel syndrome.

Zhang Y, Qin G, Liu DR, Wang Y, Yao SK.

World J Gastroenterol. 2019 Jan 14;25(2):269-281. doi: 10.3748/wjg.v25.i2.269.

31.

Lymph node metastasis in Chinese patients with clinical T1 non-small cell lung cancer: A multicenter real-world observational study.

Chen B, Wang X, Yu X, Xia WJ, Zhao H, Li XF, Liu LX, Liu Y, Hu J, Fu XN, Li Y, Xu YJ, Liu DR, Yang HY, Xu L, Jiang F.

Thorac Cancer. 2019 Mar;10(3):533-542. doi: 10.1111/1759-7714.12970. Epub 2019 Jan 21. Erratum in: Thorac Cancer. 2019 Sep;10(9):1852.

32.

Applying comprehensive histologic assessment and genetic testing to synchronous multifocal lung adenocarcinomas and further survival analysis.

Xiao F, Zhang ZR, Wang XW, Liu DR, Guo YQ, Shi B, Song ZY, Liang CY.

Chin Med J (Engl). 2019 Jan 20;132(2):227-231. doi: 10.1097/CM9.0000000000000055. No abstract available.

33.

Targeting fidelity of adenine and cytosine base editors in mouse embryos.

Lee HK, Willi M, Miller SM, Kim S, Liu C, Liu DR, Hennighausen L.

Nat Commun. 2018 Nov 15;9(1):4804. doi: 10.1038/s41467-018-07322-7.

34.

Predictable and precise template-free CRISPR editing of pathogenic variants.

Shen MW, Arbab M, Hsu JY, Worstell D, Culbertson SJ, Krabbe O, Cassa CA, Liu DR, Gifford DK, Sherwood RI.

Nature. 2018 Nov;563(7733):646-651. doi: 10.1038/s41586-018-0686-x. Epub 2018 Nov 7. Erratum in: Nature. 2019 Mar;567(7746):E1-E2.

35.

Publisher Correction: Base editing: precision chemistry on the genome and transcriptome of living cells.

Rees HA, Liu DR.

Nat Rev Genet. 2018 Dec;19(12):801. doi: 10.1038/s41576-018-0068-0.

PMID:
30341440
36.

Base editing: precision chemistry on the genome and transcriptome of living cells.

Rees HA, Liu DR.

Nat Rev Genet. 2018 Dec;19(12):770-788. doi: 10.1038/s41576-018-0059-1. Review. Erratum in: Nat Rev Genet. 2018 Oct 19;:.

37.

One-Pot Dual Labeling of IgG 1 and Preparation of C-to-C Fusion Proteins Through a Combination of Sortase A and Butelase 1.

Harmand TJ, Bousbaine D, Chan A, Zhang X, Liu DR, Tam JP, Ploegh HL.

Bioconjug Chem. 2018 Oct 17;29(10):3245-3249. doi: 10.1021/acs.bioconjchem.8b00563. Epub 2018 Sep 21.

38.

Green fluorescent proteins engineered for cartilage-targeted drug delivery: Insights for transport into highly charged avascular tissues.

Krishnan Y, Rees HA, Rossitto CP, Kim SE, Hung HK, Frank EH, Olsen BD, Liu DR, Hammond PT, Grodzinsky AJ.

Biomaterials. 2018 Nov;183:218-233. doi: 10.1016/j.biomaterials.2018.08.050. Epub 2018 Aug 25.

39.

Continuous directed evolution of proteins with improved soluble expression.

Wang T, Badran AH, Huang TP, Liu DR.

Nat Chem Biol. 2018 Oct;14(10):972-980. doi: 10.1038/s41589-018-0121-5. Epub 2018 Aug 20.

40.

[Correlation between the new lung adenocarcinoma classification and epidermal growth factor receptor mutation].

Zhang XD, Liu DR.

Beijing Da Xue Xue Bao Yi Xue Ban. 2018 Aug 18;50(4):640-644. Chinese.

41.

Apelin-12 exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and P38MAPK signaling pathway in mouse.

Liu DR, Hu W, Chen GZ.

Eur Rev Med Pharmacol Sci. 2018 Jun;22(12):3888-3895. doi: 10.26355/eurrev_201806_15273.

42.

In vivo base editing of post-mitotic sensory cells.

Yeh WH, Chiang H, Rees HA, Edge ASB, Liu DR.

Nat Commun. 2018 Jun 5;9(1):2184. doi: 10.1038/s41467-018-04580-3.

43.

Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction.

Koblan LW, Doman JL, Wilson C, Levy JM, Tay T, Newby GA, Maianti JP, Raguram A, Liu DR.

Nat Biotechnol. 2018 Oct;36(9):843-846. doi: 10.1038/nbt.4172. Epub 2018 May 29.

44.

Publisher Correction: Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage.

Gaudelli NM, Komor AC, Rees HA, Packer MS, Badran AH, Bryson DI, Liu DR.

Nature. 2018 Jul;559(7714):E8. doi: 10.1038/s41586-018-0070-x.

PMID:
29720650
45.

[Antimicrobial susceptibility and drug-resistance genes of Yersinia spp. of retailed poultry in 4 provinces of China].

Peng ZX, Zou MY, Xu J, Guan WY, Li Y, Liu DR, Zhang SS, Hao Q, Yan SF, Wang W, Yu DM, Li FQ.

Zhonghua Yu Fang Yi Xue Za Zhi. 2018 Apr 6;52(4):358-363. doi: 10.3760/cma.j.issn.0253-9624.2018.04.006. Chinese.

PMID:
29614601
46.

Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules.

Usanov DL, Chan AI, Maianti JP, Liu DR.

Nat Chem. 2018 Jul;10(7):704-714. doi: 10.1038/s41557-018-0033-8. Epub 2018 Apr 2. Erratum in: Nat Chem. 2019 Nov;11(11):1067.

47.

Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.

Zhang Z, Liang WG, Bailey LJ, Tan YZ, Wei H, Wang A, Farcasanu M, Woods VA, McCord LA, Lee D, Shang W, Deprez-Poulain R, Deprez B, Liu DR, Koide A, Koide S, Kossiakoff AA, Li S, Carragher B, Potter CS, Tang WJ.

Elife. 2018 Mar 29;7. pii: e33572. doi: 10.7554/eLife.33572.

48.

[Clinical characteristics of human recombination activating gene 1 mutations in 8 immunodeficiency patients with diverse phenotypes].

Yu G, Wang WJ, Liu DR, Tao ZF, Hui XY, Hou J, Sun JQ, Wang XC.

Zhonghua Er Ke Za Zhi. 2018 Mar 2;56(3):186-191. doi: 10.3760/cma.j.issn.0578-1310.2018.03.007. Chinese.

PMID:
29518828
49.

Evolved Cas9 variants with broad PAM compatibility and high DNA specificity.

Hu JH, Miller SM, Geurts MH, Tang W, Chen L, Sun N, Zeina CM, Gao X, Rees HA, Lin Z, Liu DR.

Nature. 2018 Apr 5;556(7699):57-63. doi: 10.1038/nature26155. Epub 2018 Feb 28.

50.

Evolution of sequence-defined highly functionalized nucleic acid polymers.

Chen Z, Lichtor PA, Berliner AP, Chen JC, Liu DR.

Nat Chem. 2018 Apr;10(4):420-427. doi: 10.1038/s41557-018-0008-9. Epub 2018 Mar 5.

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