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Items: 1 to 50 of 312

1.

Critical Role for the Microbiota in CX3CR1+ Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell Responses.

Kim M, Galan C, Hill AA, Wu WJ, Fehlner-Peach H, Song HW, Schady D, Bettini ML, Simpson KW, Longman RS, Littman DR, Diehl GE.

Immunity. 2018 Jun 21. pii: S1074-7613(18)30245-0. doi: 10.1016/j.immuni.2018.05.009. [Epub ahead of print]

PMID:
29980437
2.

Retraction Note: DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions.

Huang W, Thomas B, Flynn RA, Gavzy SJ, Wu L, Kim SV, Hall JA, Miraldi ER, Ng CP, Rigo F, Meadows S, Montoya NR, Herrera NG, Domingos AI, Rastinejad F, Myers RM, Fuller-Pace FV, Bonneau R, Chang HY, Acuto O, Littman DR.

Nature. 2018 Jul 4. doi: 10.1038/s41586-018-0311-z. [Epub ahead of print]

PMID:
29973715
3.

Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection.

Johnson JS, Lucas SY, Amon LM, Skelton S, Nazitto R, Carbonetti S, Sather DN, Littman DR, Aderem A.

Cell Host Microbe. 2018 Mar 14;23(3):366-381.e9. doi: 10.1016/j.chom.2018.01.012.

PMID:
29544097
4.

c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont.

Xu M, Pokrovskii M, Ding Y, Yi R, Au C, Harrison OJ, Galan C, Belkaid Y, Bonneau R, Littman DR.

Nature. 2018 Feb 15;554(7692):373-377. doi: 10.1038/nature25500. Epub 2018 Feb 7.

PMID:
29414937
5.

New traffic light on Th17 Avenue.

Xu H, Littman DR.

Cell Res. 2018 Feb;28(2):139-140. doi: 10.1038/cr.2017.156. Epub 2017 Dec 8.

PMID:
29219146
6.

Segmented Filamentous Bacteria Provoke Lung Autoimmunity by Inducing Gut-Lung Axis Th17 Cells Expressing Dual TCRs.

Bradley CP, Teng F, Felix KM, Sano T, Naskar D, Block KE, Huang H, Knox KS, Littman DR, Wu HJ.

Cell Host Microbe. 2017 Nov 8;22(5):697-704.e4. doi: 10.1016/j.chom.2017.10.007.

PMID:
29120746
7.

From the Thymus to the Mucosa: A Three-Decade Journey.

Littman DR.

J Immunol. 2017 Oct 1;199(7):2183-2187. doi: 10.4049/jimmunol.1790016. No abstract available.

PMID:
28923979
8.

Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring.

Kim S, Kim H, Yim YS, Ha S, Atarashi K, Tan TG, Longman RS, Honda K, Littman DR, Choi GB, Huh JR.

Nature. 2017 Sep 28;549(7673):528-532. doi: 10.1038/nature23910. Epub 2017 Sep 13.

9.

Reversing behavioural abnormalities in mice exposed to maternal inflammation.

Shin Yim Y, Park A, Berrios J, Lafourcade M, Pascual LM, Soares N, Yeon Kim J, Kim S, Kim H, Waisman A, Littman DR, Wickersham IR, Harnett MT, Huh JR, Choi GB.

Nature. 2017 Sep 28;549(7673):482-487. doi: 10.1038/nature23909. Epub 2017 Sep 13.

10.

Quantitative Measurements of HIV-1 and Dextran Capture by Human Monocyte-derived Dendritic Cells (MDDCs).

Ménager MM, Littman DR.

Bio Protoc. 2016 Nov 20;6(22). pii: e2004. doi: 10.21769/BioProtoc.2004.

11.

Do the Microbiota Influence Vaccines and Protective Immunity to Pathogens? If So, Is There Potential for Efficacious Microbiota-Based Vaccines?

Littman DR.

Cold Spring Harb Perspect Biol. 2018 Feb 1;10(2). pii: a029355. doi: 10.1101/cshperspect.a029355. Review.

PMID:
28432131
12.

Heritable Gene Regulation in the CD4:CD8 T Cell Lineage Choice.

Issuree PD, Ng CP, Littman DR.

Front Immunol. 2017 Mar 22;8:291. doi: 10.3389/fimmu.2017.00291. eCollection 2017. Review.

13.

Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation.

Cheung KL, Zhang F, Jaganathan A, Sharma R, Zhang Q, Konuma T, Shen T, Lee JY, Ren C, Chen CH, Lu G, Olson MR, Zhang W, Kaplan MH, Littman DR, Walsh MJ, Xiong H, Zeng L, Zhou MM.

Mol Cell. 2017 Mar 16;65(6):1068-1080.e5. doi: 10.1016/j.molcel.2016.12.022. Epub 2017 Mar 3.

14.

Disrupting Hepatocyte Cyp51 from Cholesterol Synthesis Leads to Progressive Liver Injury in the Developing Mouse and Decreases RORC Signalling.

Urlep Ž, Lorbek G, Perše M, Jeruc J, Juvan P, Matz-Soja M, Gebhardt R, Björkhem I, Hall JA, Bonneau R, Littman DR, Rozman D.

Sci Rep. 2017 Jan 18;7:40775. doi: 10.1038/srep40775.

15.

miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation.

Coffre M, Benhamou D, Rieß D, Blumenberg L, Snetkova V, Hines MJ, Chakraborty T, Bajwa S, Jensen K, Chong MMW, Getu L, Silverman GJ, Blelloch R, Littman DR, Calado D, Melamed D, Skok JA, Rajewsky K, Koralov SB.

Cell Rep. 2016 Nov 22;17(9):2271-2285. doi: 10.1016/j.celrep.2016.11.006.

16.

Short- and long-term effects of oral vancomycin on the human intestinal microbiota.

Isaac S, Scher JU, Djukovic A, Jiménez N, Littman DR, Abramson SB, Pamer EG, Ubeda C.

J Antimicrob Chemother. 2017 Jan;72(1):128-136. Epub 2016 Oct 5.

17.

The microbiota in adaptive immune homeostasis and disease.

Honda K, Littman DR.

Nature. 2016 Jul 7;535(7610):75-84. doi: 10.1038/nature18848. Review.

PMID:
27383982
18.

Tcf1 and Lef1 pack their own HDAC.

Ng CP, Littman DR.

Nat Immunol. 2016 May 19;17(6):615-6. doi: 10.1038/ni.3469. No abstract available.

19.

Regulation of RORγt in Inflammatory Lymphoid Cell Differentiation.

Huang W, Littman DR.

Cold Spring Harb Symp Quant Biol. 2015;80:257-63. doi: 10.1101/sqb.2015.80.027615. Epub 2016 Mar 11. Review.

PMID:
26968628
20.

How Thymocytes Achieve Their Fate.

Littman DR.

J Immunol. 2016 Mar 1;196(5):1983-4. doi: 10.4049/jimmunol.1600032. No abstract available.

21.

Actin Dynamics Regulates Dendritic Cell-Mediated Transfer of HIV-1 to T Cells.

Ménager MM, Littman DR.

Cell. 2016 Feb 11;164(4):695-709. doi: 10.1016/j.cell.2015.12.036. Epub 2016 Jan 28.

22.

The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring.

Choi GB, Yim YS, Wong H, Kim S, Kim H, Kim SV, Hoeffer CA, Littman DR, Huh JR.

Science. 2016 Feb 26;351(6276):933-9. doi: 10.1126/science.aad0314. Epub 2016 Jan 28.

23.

Corrigendum: DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions.

Huang W, Thomas B, Flynn RA, Gavzy SJ, Wu L, Kim SV, Hall JA, Miraldi ER, Ng CP, Rigo F, Meadows S, Montoya NR, Herrera NG, Domingos AI, Rastinejad F, Myers RM, Fuller-Pace FV, Bonneau R, Chang HY, Acuto O, Littman DR.

Nature. 2016 May 5;533(7601):130. doi: 10.1038/nature16968. Epub 2016 Jan 20. No abstract available.

PMID:
26789242
24.

An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses.

Sano T, Huang W, Hall JA, Yang Y, Chen A, Gavzy SJ, Lee JY, Ziel JW, Miraldi ER, Domingos AI, Bonneau R, Littman DR.

Cell. 2016 Jan 14;164(1-2):324. doi: 10.1016/j.cell.2015.12.047. Epub 2016 Jan 14. No abstract available.

25.

DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions.

Huang W, Thomas B, Flynn RA, Gavzy SJ, Wu L, Kim SV, Hall JA, Miraldi ER, Ng CP, Rigo F, Meadows S, Montoya NR, Herrera NG, Domingos AI, Rastinejad F, Myers RM, Fuller-Pace FV, Bonneau R, Chang HY, Acuto O, Littman DR.

Nature. 2015 Dec 24;528(7583):517-22. doi: 10.1038/nature16193. Epub 2015 Dec 16. Erratum in: Nature. 2016 May 5;533(7601):130. Rigo, Frank W [Corrected to Rigo, Frank].. Retraction in: Nature. 2018 Jul 4;:.

26.

An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses.

Sano T, Huang W, Hall JA, Yang Y, Chen A, Gavzy SJ, Lee JY, Ziel JW, Miraldi ER, Domingos AI, Bonneau R, Littman DR.

Cell. 2015 Oct 8;163(2):381-93. doi: 10.1016/j.cell.2015.08.061. Epub 2015 Sep 24. Erratum in: Cell. 2016 Jan 14;164(1-2):324. Dosage error in article text.

27.

Releasing the Brakes on Cancer Immunotherapy.

Littman DR.

Cell. 2015 Sep 10;162(6):1186-90. doi: 10.1016/j.cell.2015.08.038.

28.

Microbiome in Inflammatory Arthritis and Human Rheumatic Diseases.

Scher JU, Littman DR, Abramson SB.

Arthritis Rheumatol. 2016 Jan;68(1):35-45. doi: 10.1002/art.39259. Review. No abstract available.

29.

CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance.

Pitt LA, Tikhonova AN, Hu H, Trimarchi T, King B, Gong Y, Sanchez-Martin M, Tsirigos A, Littman DR, Ferrando AA, Morrison SJ, Fooksman DR, Aifantis I, Schwab SR.

Cancer Cell. 2015 Jun 8;27(6):755-68. doi: 10.1016/j.ccell.2015.05.002.

30.

Regulation of DNA methylation dictates Cd4 expression during the development of helper and cytotoxic T cell lineages.

Sellars M, Huh JR, Day K, Issuree PD, Galan C, Gobeil S, Absher D, Green MR, Littman DR.

Nat Immunol. 2015 Jul;16(7):746-54. doi: 10.1038/ni.3198. Epub 2015 Jun 1.

31.

The functional impact of the intestinal microbiome on mucosal immunity and systemic autoimmunity.

Longman RS, Littman DR.

Curr Opin Rheumatol. 2015 Jul;27(4):381-7. doi: 10.1097/BOR.0000000000000190. Review.

32.

SIRT1 deacetylates RORγt and enhances Th17 cell generation.

Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E.

J Exp Med. 2015 Jun 1;212(6):973. doi: 10.1084/jem.2013237805062015c. Epub 2015 May 18. No abstract available.

33.

Sparse and compositionally robust inference of microbial ecological networks.

Kurtz ZD, Müller CL, Miraldi ER, Littman DR, Blaser MJ, Bonneau RA.

PLoS Comput Biol. 2015 May 7;11(5):e1004226. doi: 10.1371/journal.pcbi.1004226. eCollection 2015 May.

34.

SIRT1 deacetylates RORγt and enhances Th17 cell generation.

Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E.

J Exp Med. 2015 May 4;212(5):607-17. doi: 10.1084/jem.20132378. Epub 2015 Apr 27. Erratum in: J Exp Med. 2015 Jun 1;212(6):973.

35.

Identification of natural RORγ ligands that regulate the development of lymphoid cells.

Santori FR, Huang P, van de Pavert SA, Douglass EF Jr, Leaver DJ, Haubrich BA, Keber R, Lorbek G, Konijn T, Rosales BN, Rozman D, Horvat S, Rahier A, Mebius RE, Rastinejad F, Nes WD, Littman DR.

Cell Metab. 2015 Feb 3;21(2):286-298. doi: 10.1016/j.cmet.2015.01.004.

36.

Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease.

Scher JU, Ubeda C, Artacho A, Attur M, Isaac S, Reddy SM, Marmon S, Neimann A, Brusca S, Patel T, Manasson J, Pamer EG, Littman DR, Abramson SB.

Arthritis Rheumatol. 2015 Jan;67(1):128-39. doi: 10.1002/art.38892.

37.

CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22.

Longman RS, Diehl GE, Victorio DA, Huh JR, Galan C, Miraldi ER, Swaminath A, Bonneau R, Scherl EJ, Littman DR.

J Exp Med. 2014 Jul 28;211(8):1571-83. doi: 10.1084/jem.20140678. Epub 2014 Jul 14.

38.

Microbiota: host interactions in mucosal homeostasis and systemic autoimmunity.

Longman RS, Yang Y, Diehl GE, Kim SV, Littman DR.

Cold Spring Harb Symp Quant Biol. 2013;78:193-201. doi: 10.1101/sqb.2013.78.020081. Epub 2014 Jun 9. Review.

39.

Focused specificity of intestinal TH17 cells towards commensal bacterial antigens.

Yang Y, Torchinsky MB, Gobert M, Xiong H, Xu M, Linehan JL, Alonzo F, Ng C, Chen A, Lin X, Sczesnak A, Liao JJ, Torres VJ, Jenkins MK, Lafaille JJ, Littman DR.

Nature. 2014 Jun 5;510(7503):152-6. doi: 10.1038/nature13279. Epub 2014 Apr 13.

40.

Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity.

van de Pavert SA, Ferreira M, Domingues RG, Ribeiro H, Molenaar R, Moreira-Santos L, Almeida FF, Ibiza S, Barbosa I, Goverse G, Labão-Almeida C, Godinho-Silva C, Konijn T, Schooneman D, O'Toole T, Mizee MR, Habani Y, Haak E, Santori FR, Littman DR, Schulte-Merker S, Dzierzak E, Simas JP, Mebius RE, Veiga-Fernandes H.

Nature. 2014 Apr 3;508(7494):123-7. doi: 10.1038/nature13158. Epub 2014 Mar 19.

41.

Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.

Parkhurst CN, Yang G, Ninan I, Savas JN, Yates JR 3rd, Lafaille JJ, Hempstead BL, Littman DR, Gan WB.

Cell. 2013 Dec 19;155(7):1596-609. doi: 10.1016/j.cell.2013.11.030.

42.

Nonredundant function of soluble LTα3 produced by innate lymphoid cells in intestinal homeostasis.

Kruglov AA, Grivennikov SI, Kuprash DV, Winsauer C, Prepens S, Seleznik GM, Eberl G, Littman DR, Heikenwalder M, Tumanov AV, Nedospasov SA.

Science. 2013 Dec 6;342(6163):1243-6. doi: 10.1126/science.1243364.

43.

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis.

Scher JU, Sczesnak A, Longman RS, Segata N, Ubeda C, Bielski C, Rostron T, Cerundolo V, Pamer EG, Abramson SB, Huttenhower C, Littman DR.

Elife. 2013 Nov 5;2:e01202. doi: 10.7554/eLife.01202.

44.

Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors.

Huh JR, Englund EE, Wang H, Huang R, Huang P, Rastinejad F, Inglese J, Austin CP, Johnson RL, Huang W, Littman DR.

ACS Med Chem Lett. 2013 Jan 10;4(1):79-84.

45.

Mice transgenic for CD4-specific human CD4, CCR5 and cyclin T1 expression: a new model for investigating HIV-1 transmission and treatment efficacy.

Seay K, Qi X, Zheng JH, Zhang C, Chen K, Dutta M, Deneroff K, Ochsenbauer C, Kappes JC, Littman DR, Goldstein H.

PLoS One. 2013 May 15;8(5):e63537. doi: 10.1371/journal.pone.0063537. Print 2013.

46.

GPR15-mediated homing controls immune homeostasis in the large intestine mucosa.

Kim SV, Xiang WV, Kwak C, Yang Y, Lin XW, Ota M, Sarpel U, Rifkin DB, Xu R, Littman DR.

Science. 2013 Jun 21;340(6139):1456-9. doi: 10.1126/science.1237013. Epub 2013 May 9.

47.

Identification of Potent and Selective RORγ Antagonists.

Huang W, Wang H, Johnson RL, Huang R, Englund EE, Huh J, Littman DR.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2010 Dec 15 [updated 2013 Feb 25].

48.

Harnessing CD4⁺ T cell responses in HIV vaccine development.

Streeck H, D'Souza MP, Littman DR, Crotty S.

Nat Med. 2013 Feb;19(2):143-9. doi: 10.1038/nm.3054. Epub 2013 Feb 6. Review.

49.

Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells.

Diehl GE, Longman RS, Zhang JX, Breart B, Galan C, Cuesta A, Schwab SR, Littman DR.

Nature. 2013 Feb 7;494(7435):116-20. doi: 10.1038/nature11809. Epub 2013 Jan 13.

50.

A validated regulatory network for Th17 cell specification.

Ciofani M, Madar A, Galan C, Sellars M, Mace K, Pauli F, Agarwal A, Huang W, Parkhurst CN, Muratet M, Newberry KM, Meadows S, Greenfield A, Yang Y, Jain P, Kirigin FK, Birchmeier C, Wagner EF, Murphy KM, Myers RM, Bonneau R, Littman DR.

Cell. 2012 Oct 12;151(2):289-303. doi: 10.1016/j.cell.2012.09.016. Epub 2012 Sep 25.

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