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Heterogeneity of Myc expression in breast cancer exposes pharmacological vulnerabilities revealed through executable mechanistic modeling.

Kreuzaler P, Clarke MA, Brown EJ, Wilson CH, Kortlever RM, Piterman N, Littlewood T, Evan GI, Fisher J.

Proc Natl Acad Sci U S A. 2019 Oct 14. pii: 201903485. doi: 10.1073/pnas.1903485116. [Epub ahead of print]


Variability in body temperature in healthy adults and in patients receiving chemotherapy: prospective observational cohort study.

Frazer JS, Barnes GE, Woodcock V, Flanagan E, Littlewood T, Stevens RJ, Fleming S, Ashdown HF.

J Med Eng Technol. 2019 Jul;43(5):323-333. doi: 10.1080/03091902.2019.1667446. Epub 2019 Oct 3.


Management of anaemia and iron deficiency in patients with cancer: ESMO Clinical Practice Guidelines.

Aapro M, Beguin Y, Bokemeyer C, Dicato M, Gascón P, Glaspy J, Hofmann A, Link H, Littlewood T, Ludwig H, Österborg A, Pronzato P, Santini V, Schrijvers D, Stauder R, Jordan K, Herrstedt J; ESMO Guidelines Committee.

Ann Oncol. 2018 Oct 1;29(Suppl 4):iv271. doi: 10.1093/annonc/mdy323. No abstract available.


Tissue Inhibitor of Metalloproteinase-3 (TIMP-3) induces FAS dependent apoptosis in human vascular smooth muscle cells.

English WR, Ireland-Zecchini H, Baker AH, Littlewood TD, Bennett MR, Murphy G.

PLoS One. 2018 Apr 4;13(4):e0195116. doi: 10.1371/journal.pone.0195116. eCollection 2018.


Management of anaemia and iron deficiency in patients with cancer: ESMO Clinical Practice Guidelines.

Aapro M, Beguin Y, Bokemeyer C, Dicato M, Gascón P, Glaspy J, Hofmann A, Link H, Littlewood T, Ludwig H, Österborg A, Pronzato P, Santini V, Schrijvers D, Stauder R, Jordan K, Herrstedt J; ESMO Guidelines Committee.

Ann Oncol. 2018 Oct 1;29(Suppl 4):iv96-iv110. doi: 10.1093/annonc/mdx758. No abstract available. Erratum in: Ann Oncol. 2018 Oct 1;29(Suppl 4):iv271.


FOXO3a (Forkhead Transcription Factor O Subfamily Member 3a) Links Vascular Smooth Muscle Cell Apoptosis, Matrix Breakdown, Atherosclerosis, and Vascular Remodeling Through a Novel Pathway Involving MMP13 (Matrix Metalloproteinase 13).

Yu H, Fellows A, Foote K, Yang Z, Figg N, Littlewood T, Bennett M.

Arterioscler Thromb Vasc Biol. 2018 Mar;38(3):555-565. doi: 10.1161/ATVBAHA.117.310502. Epub 2018 Jan 11.


Myc Cooperates with Ras by Programming Inflammation and Immune Suppression.

Kortlever RM, Sodir NM, Wilson CH, Burkhart DL, Pellegrinet L, Brown Swigart L, Littlewood TD, Evan GI.

Cell. 2017 Nov 30;171(6):1301-1315.e14. doi: 10.1016/j.cell.2017.11.013.


Determination of the physiological and pathological roles of E2F3 in adult tissues.

Gamper I, Burkhart DL, Bywater MJ, Garcia D, Wilson CH, Kreuzaler PA, Arends MJ, Zheng YW, Perfetto A, Littlewood TD, Evan GI.

Sci Rep. 2017 Aug 30;7(1):9932. doi: 10.1038/s41598-017-09494-6.


Re-engineering the Pancreas Tumor Microenvironment: A "Regenerative Program" Hacked.

Evan GI, Hah N, Littlewood TD, Sodir NM, Campos T, Downes M, Evans RM.

Clin Cancer Res. 2017 Apr 1;23(7):1647-1655. doi: 10.1158/1078-0432.CCR-16-3275. Review.


SOX2 Drives Bronchial Dysplasia in a Novel Organotypic Model of Early Human Squamous Lung Cancer.

Correia LL, Johnson JA, McErlean P, Bauer J, Farah H, Rassl DM, Rintoul RC, Sethi T, Lavender P, Rawlins EL, Littlewood TD, Evan GI, McCaughan FM.

Am J Respir Crit Care Med. 2017 Jun 1;195(11):1494-1508. doi: 10.1164/rccm.201510-2084OC.


Developing a dedicated dermatology service for allogeneic bone marrow transplant recipients.

Matin RN, Danby R, Gibbons E, Venning V, Rowley L, Barton D, Pawson R, Littlewood T, Reed JR, Peniket A.

Br J Dermatol. 2017 Dec;177(6):1758-1759. doi: 10.1111/bjd.15343. Epub 2017 Sep 19. No abstract available.


Sustaining Progress towards NTD Elimination: An Opportunity to Leverage Lymphatic Filariasis Elimination Programs to Interrupt Transmission of Soil-Transmitted Helminths.

Means AR, Ásbjörnsdóttir K, Mwandawiro C, Rollinson D, Jacobson J, Littlewood T, Walson JL.

PLoS Negl Trop Dis. 2016 Jul 14;10(7):e0004737. doi: 10.1371/journal.pntd.0004737. eCollection 2016 Jul. No abstract available.


NCRI phase II study of CHOP in combination with ofatumumab in induction and maintenance in newly diagnosed Richter syndrome.

Eyre TA, Clifford R, Bloor A, Boyle L, Roberts C, Cabes M, Collins GP, Devereux S, Follows G, Fox CP, Gribben J, Hillmen P, Hatton CS, Littlewood TJ, McCarthy H, Murray J, Pettitt AR, Soilleux E, Stamatopoulos B, Love SB, Wotherspoon A, Schuh A.

Br J Haematol. 2016 Oct;175(1):43-54. doi: 10.1111/bjh.14177. Epub 2016 Jul 5.


Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer.

Hall Z, Ament Z, Wilson CH, Burkhart DL, Ashmore T, Koulman A, Littlewood T, Evan GI, Griffin JL.

Cancer Res. 2016 Aug 15;76(16):4608-18. doi: 10.1158/0008-5472.CAN-15-3403. Epub 2016 Jun 22.


Identification of MYC-Dependent Transcriptional Programs in Oncogene-Addicted Liver Tumors.

Kress TR, Pellanda P, Pellegrinet L, Bianchi V, Nicoli P, Doni M, Recordati C, Bianchi S, Rotta L, Capra T, Ravà M, Verrecchia A, Radaelli E, Littlewood TD, Evan GI, Amati B.

Cancer Res. 2016 Jun 15;76(12):3463-72. doi: 10.1158/0008-5472.CAN-16-0316. Epub 2016 Apr 13.


Time to standardize haematology terminology - response to Juneja and Wong.

Bain BJ, Littlewood TJ.

Br J Haematol. 2017 Jul;178(1):159-161. doi: 10.1111/bjh.14120. Epub 2016 May 12. No abstract available.


The finer points of writing and refereeing scientific articles.

Bain BJ, Littlewood TJ, Szydlo RM.

Br J Haematol. 2016 Feb;172(3):350-9. doi: 10.1111/bjh.13888. Epub 2016 Jan 11. Review.


Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease: A Randomized Clinical Trial.

Hawkey CJ, Allez M, Clark MM, Labopin M, Lindsay JO, Ricart E, Rogler G, Rovira M, Satsangi J, Danese S, Russell N, Gribben J, Johnson P, Larghero J, Thieblemont C, Ardizzone S, Dierickx D, Ibatici A, Littlewood T, Onida F, Schanz U, Vermeire S, Colombel JF, Jouet JP, Clark E, Saccardi R, Tyndall A, Travis S, Farge D.

JAMA. 2015 Dec 15;314(23):2524-34. doi: 10.1001/jama.2015.16700.


High proportions of regulatory T cells in PBSC grafts predict improved survival after allogeneic haematopoietic SCT.

Danby RD, Zhang W, Medd P, Littlewood TJ, Peniket A, Rocha V, Roberts DJ.

Bone Marrow Transplant. 2016 Jan;51(1):110-8. doi: 10.1038/bmt.2015.215. Epub 2015 Sep 21.


Cultivating candour about our mistakes.

Hibbs SP, Clarke RT, Littlewood TJ.

BMJ. 2015 Aug 5;351:h4121. doi: 10.1136/bmj.h4121. No abstract available.


Akt isoforms in vascular disease.

Yu H, Littlewood T, Bennett M.

Vascul Pharmacol. 2015 Aug;71:57-64. doi: 10.1016/j.vph.2015.03.003. Epub 2015 Apr 28. Review.


Impact of ABO blood group mismatch in alemtuzumab-based reduced-intensity conditioned haematopoietic SCT.

Brierley CK, Littlewood TJ, Peniket AJ, Gregg R, Ward J, Clark A, Parker A, Malladi R, Medd P.

Bone Marrow Transplant. 2015 Jul;50(7):931-8. doi: 10.1038/bmt.2015.51. Epub 2015 Apr 13.


The estrogen receptor fusion system in mouse models: a reversible switch.

Whitfield J, Littlewood T, Evan GI, Soucek L.

Cold Spring Harb Protoc. 2015 Mar 2;2015(3):227-34. doi: 10.1101/pdb.top069815.


Tamoxifen administration to mice.

Whitfield J, Littlewood T, Soucek L.

Cold Spring Harb Protoc. 2015 Mar 2;2015(3):269-71. doi: 10.1101/pdb.prot077966.


Key stages of bone marrow B-cell maturation are defective in patients with common variable immunodeficiency disorders.

Anzilotti C, Kienzler AK, Lopez-Granados E, Gooding S, Davies B, Pandit H, Lucas M, Price A, Littlewood T, van der Burg M, Patel SY, Chapel H.

J Allergy Clin Immunol. 2015 Aug;136(2):487-90.e2. doi: 10.1016/j.jaci.2014.12.1943. Epub 2015 Feb 26. No abstract available.


The signs, symptoms and help-seeking experiences of neutropenic sepsis patients before they reach hospital: a qualitative study.

Clarke RT, Bird S, Kakuchi I, Littlewood TJ, van Hamel Parsons V.

Support Care Cancer. 2015 Sep;23(9):2687-94. doi: 10.1007/s00520-015-2631-y. Epub 2015 Feb 10.


Effects of DNA damage in smooth muscle cells in atherosclerosis.

Gray K, Kumar S, Figg N, Harrison J, Baker L, Mercer J, Littlewood T, Bennett M.

Circ Res. 2015 Feb 27;116(5):816-26. doi: 10.1161/CIRCRESAHA.116.304921. Epub 2014 Dec 18.


Impact of pre-transplant co-morbidities on outcome after alemtuzumab-based reduced intensity conditioning allo-SCT in elderly patients: a British Society of Blood and Marrow Transplantation study.

Nikolousis E, Nagra S, Pearce R, Perry J, Kirkland K, Byrne J, Dignan F, Tholouli E, Gilleece M, Russell N, Littlewood T, Cook M, Peniket A, Shaw BE, Cook G, Craddock C.

Bone Marrow Transplant. 2015 Jan;50(1):82-6. doi: 10.1038/bmt.2014.215. Epub 2014 Oct 6.


Akt1 regulates vascular smooth muscle cell apoptosis through FoxO3a and Apaf1 and protects against arterial remodeling and atherosclerosis.

Tucka J, Yu H, Gray K, Figg N, Maguire J, Lam B, Bennett M, Littlewood T.

Arterioscler Thromb Vasc Biol. 2014 Nov;34(11):2421-8. doi: 10.1161/ATVBAHA.114.304284. Epub 2014 Sep 18.


Neutropenia in primary care.

Hay D, Hill M, Littlewood T.

BMJ. 2014 Sep 11;349:g5340. doi: 10.1136/bmj.g5340. No abstract available.


Dutcher bodies: cytoplasmic inclusions within the nucleus.

Eyre TA, Littlewood TJ, Bain BJ.

Br J Haematol. 2014 Sep;166(6):946-7. doi: 10.1111/bjh.12911. Epub 2014 Apr 18. No abstract available.


Lacunar infarction associated with anabolic steroids and polycythemia: a case report.

Harston GW, Batt F, Fan L, Okell TW, Sheerin F, Littlewood T, Kennedy J.

Case Rep Neurol. 2014 Feb 8;6(1):34-7. doi: 10.1159/000360076. eCollection 2014 Jan.


The kinetics of ER fusion protein activation in vivo.

Wilson CH, Gamper I, Perfetto A, Auw J, Littlewood TD, Evan GI.

Oncogene. 2014 Oct 2;33(40):4877-80. doi: 10.1038/onc.2014.78. Epub 2014 Mar 24.


A European patient record study on diagnosis and treatment of chemotherapy-induced anaemia.

Ludwig H, Aapro M, Bokemeyer C, Glaspy J, Hedenus M, Littlewood TJ, Österborg A, Rzychon B, Mitchell D, Beguin Y.

Support Care Cancer. 2014 Aug;22(8):2197-206.


Obstructive sleep apnoea does not lead to clinically significant erythrocytosis.

King AJ, Eyre T, Littlewood T.

BMJ. 2013 Dec 9;347:f7340. doi: 10.1136/bmj.f7340. No abstract available.


Methods for determining Myc-induced apoptosis.

Lu D, Littlewood TD.

Methods Mol Biol. 2013;1012:85-98. doi: 10.1007/978-1-62703-429-6_7.


Anaemia in congestive heart failure.

Eyre T, Littlewood TJ.

Br J Hosp Med (Lond). 2013 May;74(5):252-7. Review. No abstract available.


A no-prophylaxis platelet-transfusion strategy for hematologic cancers.

Stanworth SJ, Estcourt LJ, Powter G, Kahan BC, Dyer C, Choo L, Bakrania L, Llewelyn C, Littlewood T, Soutar R, Norfolk D, Copplestone A, Smith N, Kerr P, Jones G, Raj K, Westerman DA, Szer J, Jackson N, Bardy PG, Plews D, Lyons S, Bielby L, Wood EM, Murphy MF; TOPPS Investigators.

N Engl J Med. 2013 May 9;368(19):1771-80. doi: 10.1056/NEJMoa1212772.


Guideline for the laboratory diagnosis of functional iron deficiency.

Thomas DW, Hinchliffe RF, Briggs C, Macdougall IC, Littlewood T, Cavill I; British Committee for Standards in Haematology.

Br J Haematol. 2013 Jun;161(5):639-48. doi: 10.1111/bjh.12311. Epub 2013 Apr 10. No abstract available.


Evidence for a GVL effect following reduced-intensity allo-SCT in ALL: a British Society of Blood and Marrow Transplantation study.

Medd PG, Peniket AJ, Littlewood TJ, Pearce R, Perry J, Kirkland KE, Shaw BE, Potter MN, Craddock CF, Milligan DW, Fielding AK, Marks DI, Cook G; British Society of Blood and Marrow Transplantation.

Bone Marrow Transplant. 2013 Jul;48(7):982-7. doi: 10.1038/bmt.2012.261. Epub 2013 Jan 14. Erratum in: Bone Marrow Transplant. 2013 Oct;48(10):1368.


Episomal amplification of NUP214-ABL1 fusion gene in B-cell acute lymphoblastic leukemia.

Eyre T, Schwab CJ, Kinstrie R, McGuire AK, Strefford J, Peniket A, Mead A, Littlewood T, Holyoake TL, Copland M, Moorman AV, Harrison CJ, Vyas P.

Blood. 2012 Nov 22;120(22):4441-3. doi: 10.1182/blood-2012-09-456517. No abstract available.


All things to all people.

Littlewood TD, Kreuzaler P, Evan GI.

Cell. 2012 Sep 28;151(1):11-3. doi: 10.1016/j.cell.2012.09.006.


Cell death and survival signalling in the cardiovascular system.

Tucka J, Bennett M, Littlewood T.

Front Biosci (Landmark Ed). 2012 Jan 1;17:248-61. Review.


Intravenous or oral iron?

Littlewood TJ.

Am J Hematol. 2012 Feb;87(2):134-5. doi: 10.1002/ajh.22249. Epub 2011 Dec 3. No abstract available.


The investigation and treatment of secondary anaemia.

Davis SL, Littlewood TJ.

Blood Rev. 2012 Mar;26(2):65-71. doi: 10.1016/j.blre.2011.10.003. Epub 2011 Dec 1. Review.


Methotrexate dose delivery is more important than ciclosporin level in graft-versus-host disease prophylaxis following T-replete reduced-intensity sibling allogeneic stem cell transplant.

Medd P, Monk I, Danby R, Malladi R, Clifford R, Ellis A, Roberts D, Hatton C, Vyas P, Littlewood T, Peniket A.

Int J Hematol. 2011 Sep;94(3):266-278. doi: 10.1007/s12185-011-0920-x. Epub 2011 Sep 7.


Smooth muscle cell apoptosis promotes vessel remodeling and repair via activation of cell migration, proliferation, and collagen synthesis.

Yu H, Clarke MC, Figg N, Littlewood TD, Bennett MR.

Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2402-9. doi: 10.1161/ATVBAHA.111.235622.


Cardiac iron overload in transfusion-dependent patients with myelodysplastic syndromes.

Roy NB, Myerson S, Schuh AH, Bignell P, Patel R, Wainscoat JS, McGowan S, Marchi E, Atoyebi W, Littlewood T, Chacko J, Vyas P, Killick SB.

Br J Haematol. 2011 Aug;154(4):521-4. doi: 10.1111/j.1365-2141.2011.08749.x. Epub 2011 Jun 21.


MicroRNA expression in multiple myeloma is associated with genetic subtype, isotype and survival.

Chi J, Ballabio E, Chen XH, Kušec R, Taylor S, Hay D, Tramonti D, Saunders NJ, Littlewood T, Pezzella F, Boultwood J, Wainscoat JS, Hatton CS, Lawrie CH.

Biol Direct. 2011 May 18;6:23. doi: 10.1186/1745-6150-6-23.


Improving the immediate management of neutropenic sepsis in the UK: lessons from a national audit.

Clarke RT, Warnick J, Stretton K, Littlewood TJ.

Br J Haematol. 2011 Jun;153(6):773-9. doi: 10.1111/j.1365-2141.2011.08693.x. Epub 2011 Apr 22. Review.


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