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Items: 1 to 50 of 139


Synaptic Plasticity: Close Encounters of the Tonic and Phasic Kind.

Cunningham KL, Littleton JT.

Curr Biol. 2019 Nov 18;29(22):R1196-R1198. doi: 10.1016/j.cub.2019.09.033.


Glial Ca2+signaling links endocytosis to K+ buffering around neuronal somas to regulate excitability.

Weiss S, Melom JE, Ormerod KG, Zhang YV, Littleton JT.

Elife. 2019 Apr 26;8. pii: e44186. doi: 10.7554/eLife.44186.


Neurons regulate synaptic strength through homeostatic scaling of active zones.

Cunningham KL, Littleton JT.

J Cell Biol. 2019 May 6;218(5):1434-1435. doi: 10.1083/jcb.201903065. Epub 2019 Apr 12.


Identification of a new SYT2 variant validates an unusual distal motor neuropathy phenotype.

Montes-Chinea NI, Guan Z, Coutts M, Vidal C, Courel S, Rebelo AP, Abreu L, Zuchner S, Littleton JT, Saporta MA.

Neurol Genet. 2018 Oct 22;4(6):e282. doi: 10.1212/NXG.0000000000000282. eCollection 2018 Dec.


Postsynaptic Syntaxin 4 negatively regulates the efficiency of neurotransmitter release.

Harris KP, Littleton JT, Stewart BA.

J Neurogenet. 2018 Sep;32(3):221-229. doi: 10.1080/01677063.2018.1501372. Epub 2018 Sep 3.


Characterization of developmental and molecular factors underlying release heterogeneity at Drosophila synapses.

Akbergenova Y, Cunningham KL, Zhang YV, Weiss S, Littleton JT.

Elife. 2018 Jul 10;7. pii: e38268. doi: 10.7554/eLife.38268.


A synaptotagmin suppressor screen indicates SNARE binding controls the timing and Ca2+ cooperativity of vesicle fusion.

Guan Z, Bykhovskaia M, Jorquera RA, Sutton RB, Akbergenova Y, Littleton JT.

Elife. 2017 Sep 12;6. pii: e28409. doi: 10.7554/eLife.28409.


Astrocyte Ca2+ Influx Negatively Regulates Neuronal Activity.

Zhang YV, Ormerod KG, Littleton JT.

eNeuro. 2017 Mar 10;4(2). pii: ENEURO.0340-16.2017. doi: 10.1523/ENEURO.0340-16.2017. eCollection 2017 Mar-Apr.


Pathogenic Huntington Alters BMP Signaling and Synaptic Growth through Local Disruptions of Endosomal Compartments.

Akbergenova Y, Littleton JT.

J Neurosci. 2017 Mar 22;37(12):3425-3439. doi: 10.1523/JNEUROSCI.2752-16.2017. Epub 2017 Feb 24.


Complexin Mutants Reveal Partial Segregation between Recycling Pathways That Drive Evoked and Spontaneous Neurotransmission.

Sabeva N, Cho RW, Vasin A, Gonzalez A, Littleton JT, Bykhovskaia M.

J Neurosci. 2017 Jan 11;37(2):383-396. doi: 10.1523/JNEUROSCI.1854-16.2016.


Neurotoxicity Pathways in Drosophila Models of the Polyglutamine Disorders.

Krench M, Littleton JT.

Curr Top Dev Biol. 2017;121:201-223. doi: 10.1016/bs.ctdb.2016.07.006. Epub 2016 Aug 4. Review.


Interaction of the Complexin Accessory Helix with Synaptobrevin Regulates Spontaneous Fusion.

Vasin A, Volfson D, Littleton JT, Bykhovskaia M.

Biophys J. 2016 Nov 1;111(9):1954-1964. doi: 10.1016/j.bpj.2016.09.017.


Characterization of axonal transport defects in Drosophila Huntingtin mutants.

Weiss KR, Littleton JT.

J Neurogenet. 2016 Sep - Dec;30(3-4):212-221. Epub 2016 Jul 22.


A Drosophila model of Huntington disease-like 2 exhibits nuclear toxicity and distinct pathogenic mechanisms from Huntington disease.

Krench M, Cho RW, Littleton JT.

Hum Mol Genet. 2016 Aug 1;25(15):3164-3177. doi: 10.1093/hmg/ddw166. Epub 2016 Jun 10.


Shank Modulates Postsynaptic Wnt Signaling to Regulate Synaptic Development.

Harris KP, Akbergenova Y, Cho RW, Baas-Thomas MS, Littleton JT.

J Neurosci. 2016 May 25;36(21):5820-32. doi: 10.1523/JNEUROSCI.4279-15.2016.


The postsynaptic t-SNARE Syntaxin 4 controls traffic of Neuroligin 1 and Synaptotagmin 4 to regulate retrograde signaling.

Harris KP, Zhang YV, Piccioli ZD, Perrimon N, Littleton JT.

Elife. 2016 May 25;5. pii: e13881. doi: 10.7554/eLife.13881.


Drosophila Homolog of Human KIF22 at the Autism-Linked 16p11.2 Loci Influences Synaptic Connectivity at Larval Neuromuscular Junctions.

Park SM, Littleton JT, Park HR, Lee JH.

Exp Neurobiol. 2016 Feb;25(1):33-9. doi: 10.5607/en.2016.25.1.33. Epub 2016 Feb 22.


Phosphorylation of Complexin by PKA Regulates Activity-Dependent Spontaneous Neurotransmitter Release and Structural Synaptic Plasticity.

Cho RW, Buhl LK, Volfson D, Tran A, Li F, Akbergenova Y, Littleton JT.

Neuron. 2015 Nov 18;88(4):749-61. doi: 10.1016/j.neuron.2015.10.011.


Electrophysiologic features of SYT2 mutations causing a treatable neuromuscular syndrome.

Whittaker RG, Herrmann DN, Bansagi B, Hasan BA, Lofra RM, Logigian EL, Sowden JE, Almodovar JL, Littleton JT, Zuchner S, Horvath R, Lochmüller H.

Neurology. 2015 Dec 1;85(22):1964-71. doi: 10.1212/WNL.0000000000002185. Epub 2015 Oct 30.


Transmission, Development, and Plasticity of Synapses.

Harris KP, Littleton JT.

Genetics. 2015 Oct;201(2):345-75. doi: 10.1534/genetics.115.176529. Review.


Transmembrane tethering of synaptotagmin to synaptic vesicles controls multiple modes of neurotransmitter release.

Lee J, Littleton JT.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3793-8. doi: 10.1073/pnas.1420312112. Epub 2015 Mar 9.


Synaptotagmin 2 mutations cause an autosomal-dominant form of lambert-eaton myasthenic syndrome and nonprogressive motor neuropathy.

Herrmann DN, Horvath R, Sowden JE, Gonzalez M, Sanchez-Mejias A, Guan Z, Whittaker RG, Almodovar JL, Lane M, Bansagi B, Pyle A, Boczonadi V, Lochmüller H, Griffin H, Chinnery PF, Lloyd TE, Littleton JT, Zuchner S.

Am J Hum Genet. 2014 Sep 4;95(3):332-9. doi: 10.1016/j.ajhg.2014.08.007. Erratum in: Am J Hum Genet. 2014 Oct 2;95(4):472. Gonzales, Michael [corrected to Gonzalez, Michael].


Synapsin regulates activity-dependent outgrowth of synaptic boutons at the Drosophila neuromuscular junction.

Vasin A, Zueva L, Torrez C, Volfson D, Littleton JT, Bykhovskaia M.

J Neurosci. 2014 Aug 6;34(32):10554-63. doi: 10.1523/JNEUROSCI.5074-13.2014.


Postsynaptic actin regulates active zone spacing and glutamate receptor apposition at the Drosophila neuromuscular junction.

Blunk AD, Akbergenova Y, Cho RW, Lee J, Walldorf U, Xu K, Zhong G, Zhuang X, Littleton JT.

Mol Cell Neurosci. 2014 Jul;61:241-54. doi: 10.1016/j.mcn.2014.07.005. Epub 2014 Jul 24.


Genetic analysis of the Complexin trans-clamping model for cross-linking SNARE complexes in vivo.

Cho RW, Kümmel D, Li F, Baguley SW, Coleman J, Rothman JE, Littleton JT.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10317-22. doi: 10.1073/pnas.1409311111. Epub 2014 Jun 30.


Retrograde BMP signaling modulates rapid activity-dependent synaptic growth via presynaptic LIM kinase regulation of cofilin.

Piccioli ZD, Littleton JT.

J Neurosci. 2014 Mar 19;34(12):4371-81. doi: 10.1523/JNEUROSCI.4943-13.2014.


Spontaneous and evoked release are independently regulated at individual active zones.

Melom JE, Akbergenova Y, Gavornik JP, Littleton JT.

J Neurosci. 2013 Oct 30;33(44):17253-63. doi: 10.1523/JNEUROSCI.3334-13.2013.


Modeling Huntington disease in Drosophila: Insights into axonal transport defects and modifiers of toxicity.

Krench M, Littleton JT.

Fly (Austin). 2013 Oct-Dec;7(4):229-36. doi: 10.4161/fly.26279. Epub 2013 Sep 10.


Interaction of the complexin accessory helix with the C-terminus of the SNARE complex: molecular-dynamics model of the fusion clamp.

Bykhovskaia M, Jagota A, Gonzalez A, Vasin A, Littleton JT.

Biophys J. 2013 Aug 6;105(3):679-90. doi: 10.1016/j.bpj.2013.06.018.


Mutation of a NCKX eliminates glial microdomain calcium oscillations and enhances seizure susceptibility.

Melom JE, Littleton JT.

J Neurosci. 2013 Jan 16;33(3):1169-78. doi: 10.1523/JNEUROSCI.3920-12.2013.


Genetic analysis of synaptotagmin C2 domain specificity in regulating spontaneous and evoked neurotransmitter release.

Lee J, Guan Z, Akbergenova Y, Littleton JT.

J Neurosci. 2013 Jan 2;33(1):187-200. doi: 10.1523/JNEUROSCI.3214-12.2013.


Complexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activity.

Jorquera RA, Huntwork-Rodriguez S, Akbergenova Y, Cho RW, Littleton JT.

J Neurosci. 2012 Dec 12;32(50):18234-45. doi: 10.1523/JNEUROSCI.3212-12.2012.


Abnormal synaptic vesicle biogenesis in Drosophila synaptogyrin mutants.

Stevens RJ, Akbergenova Y, Jorquera RA, Littleton JT.

J Neurosci. 2012 Dec 12;32(50):18054-67, 18067a. doi: 10.1523/JNEUROSCI.2668-12.2012.


Differential regulation of evoked and spontaneous neurotransmitter release by C-terminal modifications of complexin.

Buhl LK, Jorquera RA, Akbergenova Y, Huntwork-Rodriguez S, Volfson D, Littleton JT.

Mol Cell Neurosci. 2013 Jan;52:161-72. doi: 10.1016/j.mcn.2012.11.009. Epub 2012 Nov 16.


Huntingtin aggregation kinetics and their pathological role in a Drosophila Huntington's disease model.

Weiss KR, Kimura Y, Lee WC, Littleton JT.

Genetics. 2012 Feb;190(2):581-600. doi: 10.1534/genetics.111.133710. Epub 2011 Nov 17.


Vesicle trafficking: a Rab family profile.

Harris KP, Littleton JT.

Curr Biol. 2011 Oct 25;21(20):R841-3. doi: 10.1016/j.cub.2011.08.061.


High-content chemical and RNAi screens for suppressors of neurotoxicity in a Huntington's disease model.

Schulte J, Sepp KJ, Wu C, Hong P, Littleton JT.

PLoS One. 2011;6(8):e23841. doi: 10.1371/journal.pone.0023841. Epub 2011 Aug 31.


Synaptic growth: dancing with adducin.

Stevens RJ, Littleton JT.

Curr Biol. 2011 May 24;21(10):R402-5. doi: 10.1016/j.cub.2011.04.020.


A presynaptic endosomal trafficking pathway controls synaptic growth signaling.

Rodal AA, Blunk AD, Akbergenova Y, Jorquera RA, Buhl LK, Littleton JT.

J Cell Biol. 2011 Apr 4;193(1):201-17. doi: 10.1083/jcb.201009052.


Altered gene regulation and synaptic morphology in Drosophila learning and memory mutants.

Guan Z, Buhl LK, Quinn WG, Littleton JT.

Learn Mem. 2011 Mar 21;18(4):191-206. doi: 10.1101/lm.2027111. Print 2011.


Synapse development in health and disease.

Melom JE, Littleton JT.

Curr Opin Genet Dev. 2011 Jun;21(3):256-61. doi: 10.1016/j.gde.2011.01.002. Epub 2011 Jan 27. Review.


Differential regulation of synchronous versus asynchronous neurotransmitter release by the C2 domains of synaptotagmin 1.

Yoshihara M, Guan Z, Littleton JT.

Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14869-74. doi: 10.1073/pnas.1000606107. Epub 2010 Aug 2.


Comparative analysis of Drosophila and mammalian complexins as fusion clamps and facilitators of neurotransmitter release.

Cho RW, Song Y, Littleton JT.

Mol Cell Neurosci. 2010 Dec;45(4):389-97. doi: 10.1016/j.mcn.2010.07.012. Epub 2010 Jul 30.


Automatic robust neurite detection and morphological analysis of neuronal cell cultures in high-content screening.

Wu C, Schulte J, Sepp KJ, Littleton JT, Hong P.

Neuroinformatics. 2010 Jun;8(2):83-100. doi: 10.1007/s12021-010-9067-9.


DMob4/Phocein regulates synapse formation, axonal transport, and microtubule organization.

Schulte J, Sepp KJ, Jorquera RA, Wu C, Song Y, Hong P, Littleton JT.

J Neurosci. 2010 Apr 14;30(15):5189-203. doi: 10.1523/JNEUROSCI.5823-09.2010.


Postsynaptic regulation of synaptic plasticity by synaptotagmin 4 requires both C2 domains.

Barber CF, Jorquera RA, Melom JE, Littleton JT.

J Cell Biol. 2009 Oct 19;187(2):295-310. doi: 10.1083/jcb.200903098. Epub 2009 Oct 12.


Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model.

Zhang S, Feany MB, Saraswati S, Littleton JT, Perrimon N.

Dis Model Mech. 2009 May-Jun;2(5-6):247-66. doi: 10.1242/dmm.000653. Epub 2009 Apr 6.


Nervous wreck and Cdc42 cooperate to regulate endocytic actin assembly during synaptic growth.

Rodal AA, Motola-Barnes RN, Littleton JT.

J Neurosci. 2008 Aug 13;28(33):8316-25. doi: 10.1523/JNEUROSCI.2304-08.2008.


Synaptic endocytosis: illuminating the role of clathrin assembly.

Rodal AA, Littleton JT.

Curr Biol. 2008 Mar 25;18(6):R259-61. doi: 10.1016/j.cub.2008.02.014.

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