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Multiple QTL underlie milk phenotypes at the CSF2RB locus.

Lopdell TJ, Tiplady K, Couldrey C, Johnson TJJ, Keehan M, Davis SR, Harris BL, Spelman RJ, Snell RG, Littlejohn MD.

Genet Sel Evol. 2019 Jan 24;51(1):3. doi: 10.1186/s12711-019-0446-x.


Harnessing synergies at the interface of public health and the security sector.

Thomson N, Littlejohn M, Strathdee SA, Southby RF, Coghlan B, Rosenfeld JV, Galvani AP.

Lancet. 2019 Jan 19;393(10168):207-209. doi: 10.1016/S0140-6736(18)32999-4. No abstract available.


A Divergent Hepatitis D-Like Agent in Birds.

Wille M, Netter HJ, Littlejohn M, Yuen L, Shi M, Eden JS, Klaassen M, Holmes EC, Hurt AC.

Viruses. 2018 Dec 17;10(12). pii: E720. doi: 10.3390/v10120720.


Widespread cis-regulation of RNA editing in a large mammal.

Lopdell TJ, Hawkins V, Couldrey C, Tiplady K, Davis SR, Harris BL, Snell RG, Littlejohn MD.

RNA. 2019 Mar;25(3):319-335. doi: 10.1261/rna.066902.118. Epub 2018 Dec 10.


Insights From Deep Sequencing of the HBV Genome-Unique, Tiny, and Misunderstood.

McNaughton AL, D'Arienzo V, Ansari MA, Lumley SF, Littlejohn M, Revill P, McKeating JA, Matthews PC.

Gastroenterology. 2019 Jan;156(2):384-399. doi: 10.1053/j.gastro.2018.07.058. Epub 2018 Sep 27. Review.


Correction: Surveying the spatial distribution of feral sorghum (Sorghum bicolor L.) and its sympatry with johnsongrass (S. halepense) in South Texas.

Ohadi S, Littlejohn M, Mesgaran M, Rooney W, Bagavathiannan M.

PLoS One. 2018 Jul 16;13(7):e0200984. doi: 10.1371/journal.pone.0200984. eCollection 2018.


Molecular characterization of hepatitis B virus (HBV) in African children living in Australia identifies genotypes and variants associated with poor clinical outcome.

Bannister EG, Yuen L, Littlejohn M, Edwards R, Sozzi V, Colledge D, Li X, Locarnini S, Hardikar W, Revill PA.

J Gen Virol. 2018 Aug;99(8):1103-1114. doi: 10.1099/jgv.0.001086. Epub 2018 Jun 22.


Identification of an immune modulation locus utilising a bovine mammary gland infection challenge model.

Littlejohn MD, Turner SA, Walker CG, Berry SD, Tiplady K, Sherlock RG, Sutherland G, Swift S, Garrick D, Lacy-Hulbert SJ, McDougall S, Spelman RJ, Snell RG, Hillerton JE.

J Dairy Res. 2018 May;85(2):185-192. doi: 10.1017/S0022029918000158.


Epidemiology and phylogenetic analysis of hepatitis D virus infection in Australia.

Jackson K, MacLachlan J, Cowie B, Locarnini S, Bowden S, Higgins N, Karapanagiotidis T, Nicholson S, Littlejohn M.

Intern Med J. 2018 Nov;48(11):1308-1317. doi: 10.1111/imj.13967.


Sub-optimal protection against past hepatitis B virus infection where subtype mismatch exists between vaccine and circulating viral genotype in northern Australia.

Cheah BC, Davies J, Singh GR, Wood N, Jackson K, Littlejohn M, Davison B, McIntyre P, Locarnini S, Davis JS, Tong SYC.

Vaccine. 2018 Jun 7;36(24):3533-3540. doi: 10.1016/j.vaccine.2018.01.062. Epub 2018 May 4.


Surveying the spatial distribution of feral sorghum (Sorghum bicolor L.) and its sympatry with johnsongrass (S. halepense) in South Texas.

Ohadi S, Littlejohn M, Mesgaran M, Rooney W, Bagavathiannan M.

PLoS One. 2018 Apr 26;13(4):e0195511. doi: 10.1371/journal.pone.0195511. eCollection 2018. Erratum in: PLoS One. 2018 Jul 16;13(7):e0200984.


ALT flares during nucleotide analogue therapy are associated with HBsAg loss in genotype A HBeAg-positive chronic hepatitis B.

Wong D, Littlejohn M, Edwards R, Jackson K, Revill P, Gaggar A, Kitrinos K, Subramanian M, Marcellin P, Buti-Ferret M, Janssen H, Gane E, Locarnini S, Thompson A.

Liver Int. 2018 Oct;38(10):1760-1769. doi: 10.1111/liv.13716. Epub 2018 Mar 6.


DNA and RNA-sequence based GWAS highlights membrane-transport genes as key modulators of milk lactose content.

Lopdell TJ, Tiplady K, Struchalin M, Johnson TJJ, Keehan M, Sherlock R, Couldrey C, Davis SR, Snell RG, Spelman RJ, Littlejohn MD.

BMC Genomics. 2017 Dec 15;18(1):968. doi: 10.1186/s12864-017-4320-3.


HBeAg levels at week 24 predict response to 8 years of tenofovir in HBeAg-positive chronic hepatitis B patients.

Wong D, Littlejohn M, Yuen L, Jackson K, Mason H, Bayliss J, Rosenberg G, Gaggar A, Kitrinos K, Subramanian M, Marcellin P, Buti M, Janssen HLA, Gane E, Locarnini S, Thompson A, Revill PA.

Aliment Pharmacol Ther. 2018 Jan;47(1):114-122. doi: 10.1111/apt.14362. Epub 2017 Oct 11.


Hepatitis B among immigrants from Myanmar: Genotypes and their clinical relevance.

Schulz TR, Edwards R, Thurnheer MC, Yuen L, Littlejohn M, Revill P, Chu M, Tanyeri F, Wade A, Biggs BA, Sasadeusz J.

J Med Virol. 2018 Feb;90(2):271-276. doi: 10.1002/jmv.24939. Epub 2017 Sep 26.


Antiviral drug resistance and hepatitis B: a continuing public health problem.

Littlejohn M.

Antivir Ther. 2017;22(8):643-644. doi: 10.3851/IMP3176.


Bovine mammary gland X chromosome inactivation.

Couldrey C, Johnson T, Lopdell T, Zhang IL, Littlejohn MD, Keehan M, Sherlock RG, Tiplady K, Scott A, Davis SR, Spelman RJ.

J Dairy Sci. 2017 Jul;100(7):5491-5500. doi: 10.3168/jds.2016-12490. Epub 2017 May 3.


BREEDING AND GENETICS SYMPOSIUM:Breeding heat tolerant dairy cattle: the case for introgression of the "slick" prolactin receptor variant into dairy breeds.

Davis SR, Spelman RJ, Littlejohn MD.

J Anim Sci. 2017 Apr;95(4):1788-1800. doi: 10.2527/jas.2016.0956.


Detection and assessment of copy number variation using PacBio long-read and Illumina sequencing in New Zealand dairy cattle.

Couldrey C, Keehan M, Johnson T, Tiplady K, Winkelman A, Littlejohn MD, Scott A, Kemper KE, Hayes B, Davis SR, Spelman RJ.

J Dairy Sci. 2017 Jul;100(7):5472-5478. doi: 10.3168/jds.2016-12199. Epub 2017 Apr 27.


Functional confirmation of PLAG1 as the candidate causative gene underlying major pleiotropic effects on body weight and milk characteristics.

Fink T, Tiplady K, Lopdell T, Johnson T, Snell RG, Spelman RJ, Davis SR, Littlejohn MD.

Sci Rep. 2017 Mar 21;7:44793. doi: 10.1038/srep44793.


Genotypic profiles of hepatitis B in African immigrants and their clinical relevance.

Thurnheer MC, Edwards R, Schulz TR, Yuen L, Littlejohn M, Revill P, Bannister E, Chu M, Tanyeri F, Wade A, Biggs BA, Sasadeusz J.

J Med Virol. 2017 Jun;89(6):1000-1007. doi: 10.1002/jmv.24732. Epub 2016 Dec 9.


Leveraging genetically simple traits to identify small-effect variants for complex phenotypes.

Kemper KE, Littlejohn MD, Lopdell T, Hayes BJ, Bennett LE, Williams RP, Xu XQ, Visscher PM, Carrick MJ, Goddard ME.

BMC Genomics. 2016 Nov 3;17(1):858.


In Vitro Studies Show that Sequence Variability Contributes to Marked Variation in Hepatitis B Virus Replication, Protein Expression, and Function Observed across Genotypes.

Sozzi V, Walsh R, Littlejohn M, Colledge D, Jackson K, Warner N, Yuen L, Locarnini SA, Revill PA.

J Virol. 2016 Oct 28;90(22):10054-10064. Print 2016 Nov 15.


NGS-based reverse genetic screen for common embryonic lethal mutations compromising fertility in livestock.

Charlier C, Li W, Harland C, Littlejohn M, Coppieters W, Creagh F, Davis S, Druet T, Faux P, Guillaume F, Karim L, Keehan M, Kadri NK, Tamma N, Spelman R, Georges M.

Genome Res. 2016 Oct;26(10):1333-1341. Epub 2016 Sep 19.


Deep sequencing shows that HBV basal core promoter and precore variants reduce the likelihood of HBsAg loss following tenofovir disoproxil fumarate therapy in HBeAg-positive chronic hepatitis B.

Bayliss J, Yuen L, Rosenberg G, Wong D, Littlejohn M, Jackson K, Gaggar A, Kitrinos KM, Subramanian GM, Marcellin P, Buti M, Janssen HLA, Gane E, Sozzi V, Colledge D, Hammond R, Edwards R, Locarnini S, Thompson A, Revill PA.

Gut. 2017 Nov;66(11):2013-2023. doi: 10.1136/gutjnl-2015-309300. Epub 2016 Aug 17.


Acoustic and tongue kinematic vowel space in speakers with and without dysarthria.

Lee J, Littlejohn MA, Simmons Z.

Int J Speech Lang Pathol. 2017 Apr;19(2):195-204. doi: 10.1080/17549507.2016.1193899. Epub 2016 Jun 23.


Single-Molecule Sequencing Reveals Complex Genome Variation of Hepatitis B Virus during 15 Years of Chronic Infection following Liver Transplantation.

Betz-Stablein BD, Töpfer A, Littlejohn M, Yuen L, Colledge D, Sozzi V, Angus P, Thompson A, Revill P, Beerenwinkel N, Warner N, Luciani F.

J Virol. 2016 Jul 27;90(16):7171-7183. doi: 10.1128/JVI.00243-16. Print 2016 Aug 15.


Sequence-based Association Analysis Reveals an MGST1 eQTL with Pleiotropic Effects on Bovine Milk Composition.

Littlejohn MD, Tiplady K, Fink TA, Lehnert K, Lopdell T, Johnson T, Couldrey C, Keehan M, Sherlock RG, Harland C, Scott A, Snell RG, Davis SR, Spelman RJ.

Sci Rep. 2016 May 5;6:25376. doi: 10.1038/srep25376.


Effects of long-term tenofovir-based combination antiretroviral therapy in HIV-hepatitis B virus coinfection on persistent hepatitis B virus viremia and the role of hepatitis B virus quasispecies diversity.

Audsley J, Bent SJ, Littlejohn M, Avihingsanon A, Matthews G, Bowden S, Bayliss J, Luciani F, Yuen L, Fairley CK, Locarnini S, Lewin SR, Sasadeusz J.

AIDS. 2016 Jun 19;30(10):1597-606. doi: 10.1097/QAD.0000000000001080.


A novel rodent model of severe renal ischemia reperfusion injury.

Whalen H, Shiels P, Littlejohn M, Clancy M.

Ren Fail. 2016 Nov;38(10):1694-1701. doi: 10.3109/0886022X.2016.1144024. Epub 2016 Feb 18.


Origins and Evolution of Hepatitis B Virus and Hepatitis D Virus.

Littlejohn M, Locarnini S, Yuen L.

Cold Spring Harb Perspect Med. 2016 Jan 4;6(1):a021360. doi: 10.1101/cshperspect.a021360. Review.


Functionally reciprocal mutations of the prolactin signalling pathway define hairy and slick cattle.

Littlejohn MD, Henty KM, Tiplady K, Johnson T, Harland C, Lopdell T, Sherlock RG, Li W, Lukefahr SD, Shanks BC, Garrick DJ, Snell RG, Spelman RJ, Davis SR.

Nat Commun. 2014 Dec 18;5:5861. doi: 10.1038/ncomms6861.


A novel hepatitis B virus S gene insertion associated with reduced humoral immunity and diagnostic escape.

Flanagan E, Thompson AJ, Colledge D, Edwards R, Littlejohn M, Walsh R, Warner N, Bowden DS, Iser DM.

Intern Med J. 2014 Jul;44(7):709-10. doi: 10.1111/imj.12465. No abstract available.


Molecular epidemiology of hepatitis delta virus in the Western Pacific region.

Han M, Littlejohn M, Yuen L, Edwards R, Devi U, Bowden S, Ning Q, Locarnini S, Jackson K.

J Clin Virol. 2014 Sep;61(1):34-9. doi: 10.1016/j.jcv.2014.05.021. Epub 2014 Jun 5.


Gene expression in liver and adipose tissue is altered during and after temporary changes to postpartum milking frequency.

Grala TM, Phyn CV, Kay JK, Rius AG, Lucy MC, Littlejohn MD, Snell RG, Roche JR.

J Dairy Sci. 2014 May;97(5):2701-17. doi: 10.3168/jds.2013-7024. Epub 2014 Mar 5.


Molecular virology of hepatitis B virus, sub-genotype C4 in northern Australian Indigenous populations.

Littlejohn M, Davies J, Yuen L, Edwards R, Sozzi T, Jackson K, Cowie B, Tong S, Davis J, Locarnini S.

J Med Virol. 2014 Apr;86(4):695-706. doi: 10.1002/jmv.23888. Epub 2014 Jan 13.


Expression variants of the lipogenic AGPAT6 gene affect diverse milk composition phenotypes in Bos taurus.

Littlejohn MD, Tiplady K, Lopdell T, Law TA, Scott A, Harland C, Sherlock R, Henty K, Obolonkin V, Lehnert K, Macgibbon A, Spelman RJ, Davis SR, Snell RG.

PLoS One. 2014 Jan 21;9(1):e85757. doi: 10.1371/journal.pone.0085757. eCollection 2014.


Sit, breathe, smile: effects of single and weekly seated Qigong on blood pressure and quality of life in long-term care.

Freeman SR, Hanik SA, Littlejohn ML, Malandruccolo AA, Coughlin J, Warren B, McGowan CL.

Complement Ther Clin Pract. 2014 Feb;20(1):48-53. doi: 10.1016/j.ctcp.2013.10.004. Epub 2013 Oct 25.


The expression of genes involved in hepatic metabolism is altered by temporary changes to milking frequency.

Grala TM, Roche JR, Kay JK, Rius AG, White HM, Donkin SS, Littlejohn MD, Snell RG, Phyn CV.

J Dairy Sci. 2014 Feb;97(2):838-50. doi: 10.3168/jds.2013-7321. Epub 2013 Dec 15.


Possible origins and evolution of the hepatitis B virus (HBV).

Locarnini S, Littlejohn M, Aziz MN, Yuen L.

Semin Cancer Biol. 2013 Dec;23(6 Pt B):561-75. doi: 10.1016/j.semcancer.2013.08.006. Epub 2013 Sep 3. Review.


Quantitative HBsAg and HBeAg predict hepatitis B seroconversion after initiation of HAART in HIV-HBV coinfected individuals.

Matthews GV, Ali RJ, Avihingsanon A, Amin J, Hammond R, Bowden S, Lewin SR, Sasadeusz J, Littlejohn M, Locarnini SL, Ruxrungtham K, Dore GJ.

PLoS One. 2013 Apr 9;8(4):e61297. doi: 10.1371/journal.pone.0061297. Print 2013.


Molecular epidemiology of hepatitis B in the Indigenous people of northern Australia.

Davies J, Littlejohn M, Locarnini SA, Whiting S, Hajkowicz K, Cowie BC, Bowden DS, Tong SY, Davis JS.

J Gastroenterol Hepatol. 2013 Jul;28(7):1234-41. doi: 10.1111/jgh.12177.


DNA methylation is correlated with gene expression during early pregnancy in Bos taurus.

Walker CG, Littlejohn MD, Meier S, Roche JR, Mitchell MD.

Physiol Genomics. 2013 Apr 1;45(7):276-86. doi: 10.1152/physiolgenomics.00145.2012. Epub 2013 Feb 5.


Comprehensive mutation analysis for congenital muscular dystrophy: a clinical PCR-based enrichment and next-generation sequencing panel.

Valencia CA, Ankala A, Rhodenizer D, Bhide S, Littlejohn MR, Keong LM, Rutkowski A, Sparks S, Bonnemann C, Hegde M.

PLoS One. 2013;8(1):e53083. doi: 10.1371/journal.pone.0053083. Epub 2013 Jan 11.


Patterns and causes of suboptimal response to tenofovir-based therapy in individuals coinfected with HIV and hepatitis B virus.

Matthews GV, Seaberg EC, Avihingsanon A, Bowden S, Dore GJ, Lewin SR, Sasadeusz J, Revill PA, Littlejohn M, Hoy JF, Finlayson R, Ruxrungtham K, Saulynas M, Locarnini S, Thio CL.

Clin Infect Dis. 2013 May;56(9):e87-94. doi: 10.1093/cid/cit002. Epub 2013 Jan 11.


Understanding the resilience of mail-back survey methods: An analysis of 20years of change in response rates to national park surveys.

Rookey BD, Le L, Littlejohn M, Dillman DA.

Soc Sci Res. 2012 Nov;41(6):1404-14. doi: 10.1016/j.ssresearch.2012.06.004. Epub 2012 Jun 27.


In vitro replication phenotype of a novel (-1G) hepatitis B virus variant associated with HIV co-infection.

Cabuang LM, Shaw T, Littlejohn M, Colledge D, Sozzi V, Soppe S, Warner N, Thompson A, Preiss S, Lam N, Walsh R, Lewin SR, Thio CL, Matthews G, Locarnini SA, Revill PA.

J Med Virol. 2012 Aug;84(8):1166-76. doi: 10.1002/jmv.23328.


Genetic variation in PLAG1 associates with early life body weight and peripubertal weight and growth in Bos taurus.

Littlejohn M, Grala T, Sanders K, Walker C, Waghorn G, Macdonald K, Coppieters W, Georges M, Spelman R, Hillerton E, Davis S, Snell R.

Anim Genet. 2012 Oct;43(5):591-4. doi: 10.1111/j.1365-2052.2011.02293.x. Epub 2011 Dec 7.


Non-replication of genome-wide-based associations of efficient food conversion in dairy cows.

Littlejohn M, Grala T, Sanders K, Walker C, Waghorn G, Macdonald K, Spelman R, Davis S, Snell R.

Anim Genet. 2012 Dec;43(6):781-4. doi: 10.1111/j.1365-2052.2012.02327.x. Epub 2012 Feb 27.


Assessment of target enrichment platforms using massively parallel sequencing for the mutation detection for congenital muscular dystrophy.

Valencia CA, Rhodenizer D, Bhide S, Chin E, Littlejohn MR, Keong LM, Rutkowski A, Bonnemann C, Hegde M.

J Mol Diagn. 2012 May-Jun;14(3):233-46. doi: 10.1016/j.jmoldx.2012.01.009. Epub 2012 Mar 16.

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