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Items: 1 to 50 of 68

1.

Comparison of adalimumab serum drug levels when delivered by pen versus syringe in patients with inflammatory bowel disease. An international, multicentre cohort analysis.

Little RD, Chu IE, van der Zanden EP, Flanagan E, Bell SJ, Gibson PR, Sparrow MP, Shelton E, Connor SJ, Roblin X, Ward MG.

J Crohns Colitis. 2019 May 15. pii: jjz103. doi: 10.1093/ecco-jcc/jjz103. [Epub ahead of print]

PMID:
31094417
2.

Clinically, what ought we to believe?

Little JD, Davison L, Little RD.

Australas Psychiatry. 2019 Feb;27(1):72-74. doi: 10.1177/1039856218810160. Epub 2018 Oct 31.

PMID:
30379087
3.

Introduction: Electrochemistry: Technology, Synthesis, Energy, and Materials.

Little RD, Moeller KD.

Chem Rev. 2018 May 9;118(9):4483-4484. doi: 10.1021/acs.chemrev.8b00197. No abstract available.

PMID:
29739195
4.

High turnover in electro-oxidation of alcohols and ethers with a glassy carbon-supported phenanthroimidazole mediator.

Johnson BM, Francke R, Little RD, Berben LA.

Chem Sci. 2017 Sep 1;8(9):6493-6498. doi: 10.1039/c7sc02482g. Epub 2017 Jul 17.

5.

Compensatory anabolic signaling in the sarcopenia of experimental chronic arthritis.

Little RD, Prieto-Potin I, Pérez-Baos S, Villalvilla A, Gratal P, Cicuttini F, Largo R, Herrero-Beaumont G.

Sci Rep. 2017 Jul 24;7(1):6311. doi: 10.1038/s41598-017-06581-6.

6.

Electrochemical Oxidative Amination of Sodium Sulfinates: Synthesis of Sulfonamides Mediated by NH4I as a Redox Catalyst.

Jiang YY, Wang QQ, Liang S, Hu LM, Little RD, Zeng CC.

J Org Chem. 2016 Jun 3;81(11):4713-9. doi: 10.1021/acs.joc.6b00615. Epub 2016 May 18.

PMID:
27137813
7.

Aromatic C-H Bond Functionalization Induced by Electrochemically in Situ Generated Tris(p-bromophenyl)aminium Radical Cation: Cationic Chain Reactions of Electron-Rich Aromatics with Enamides.

Li LJ, Jiang YY, Lam CM, Zeng CC, Hu LM, Little RD.

J Org Chem. 2015 Nov 6;80(21):11021-30. doi: 10.1021/acs.joc.5b02222. Epub 2015 Oct 20.

PMID:
26444498
8.

DXA in the assessment of subchondral bone mineral density in knee osteoarthritis--A semi-standardized protocol after systematic review.

Sepriano A, Roman-Blas JA, Little RD, Pimentel-Santos F, Arribas JM, Largo R, Branco JC, Herrero-Beaumont G.

Semin Arthritis Rheum. 2015 Dec;45(3):275-83. doi: 10.1016/j.semarthrit.2015.06.012. Epub 2015 Jun 19.

PMID:
26188773
9.

Electrocatalytic aziridination of alkenes mediated by n-Bu4NI: a radical pathway.

Chen J, Yan WQ, Lam CM, Zeng CC, Hu LM, Little RD.

Org Lett. 2015 Feb 20;17(4):986-9. doi: 10.1021/acs.orglett.5b00083. Epub 2015 Feb 5.

PMID:
25654310
10.

Polymeric ionic liquid and carbon black composite as a reusable supporting electrolyte: modification of the electrode surface.

Yoo SJ, Li LJ, Zeng CC, Little RD.

Angew Chem Int Ed Engl. 2015 Mar 16;54(12):3744-7. doi: 10.1002/anie.201410207. Epub 2015 Jan 23.

PMID:
25619992
11.

Electrochemically induced ring-opening/Friedel–Crafts arylation of chalcone epoxides catalyzed by a triarylimidazole redox mediator.

Lu NN, Zhang NT, Zeng CC, Hu LM, Yoo SJ, Little RD.

J Org Chem. 2015 Jan 16;80(2):781-9.

PMID:
25458758
12.

Electrochemically initiated oxidative amination of benzoxazoles using tetraalkylammonium halides as redox catalysts.

Gao WJ, Li WC, Zeng CC, Tian HY, Hu LM, Little RD.

J Org Chem. 2014 Oct 17;79(20):9613-8. doi: 10.1021/jo501736w. Epub 2014 Oct 6.

PMID:
25255384
13.

Redox catalysis in organic electrosynthesis: basic principles and recent developments.

Francke R, Little RD.

Chem Soc Rev. 2014 Apr 21;43(8):2492-521. doi: 10.1039/c3cs60464k. Epub 2014 Feb 5. Erratum in: Chem Soc Rev. 2014 Sep 7;43(17):6471.

PMID:
24500279
14.
15.
16.

Triarylimidazole redox catalysts: electrochemical analysis and empirical correlations.

Zhang NT, Zeng CC, Lam CM, Gbur RK, Little RD.

J Org Chem. 2013 Mar 1;78(5):2104-10. doi: 10.1021/jo302309m. Epub 2012 Dec 11.

PMID:
23186059
17.

Unveiling the role of molecule-assisted homolysis: a mechanistic probe into the chemistry of a bicyclic peroxide.

Gbur RK, Little RD.

J Org Chem. 2012 Mar 2;77(5):2134-41. doi: 10.1021/jo300297u. Epub 2012 Feb 22.

PMID:
22356266
18.

Novel triarylimidazole redox catalysts: synthesis, electrochemical properties, and applicability to electrooxidative C-H activation.

Zeng CC, Zhang NT, Lam CM, Little RD.

Org Lett. 2012 Mar 2;14(5):1314-7. doi: 10.1021/ol300195c. Epub 2012 Feb 16.

PMID:
22339088
19.

Functional studies on the IBD susceptibility gene IL23R implicate reduced receptor function in the protective genetic variant R381Q.

Pidasheva S, Trifari S, Phillips A, Hackney JA, Ma Y, Smith A, Sohn SJ, Spits H, Little RD, Behrens TW, Honigberg L, Ghilardi N, Clark HF.

PLoS One. 2011;6(10):e25038. doi: 10.1371/journal.pone.0025038. Epub 2011 Oct 12.

20.

The odyssey of marine pharmaceuticals: a current pipeline perspective.

Mayer AM, Glaser KB, Cuevas C, Jacobs RS, Kem W, Little RD, McIntosh JM, Newman DJ, Potts BC, Shuster DE.

Trends Pharmacol Sci. 2010 Jun;31(6):255-65. doi: 10.1016/j.tips.2010.02.005. Epub 2010 Apr 2. Review.

PMID:
20363514
21.

Synthesis and an evaluation of the bioactivity of the C-glycoside of pseudopterosin A methyl ether.

Zhong W, Moya C, Jacobs RS, Little RD.

J Org Chem. 2008 Sep 19;73(18):7011-6. doi: 10.1021/jo801432t. Epub 2008 Aug 19.

PMID:
18710290
22.

Redox electron-transfer reactions: electrochemically mediated rearrangement, mechanism, and a total synthesis of daucene.

Park YS, Little RD.

J Org Chem. 2008 Sep 5;73(17):6807-15. doi: 10.1021/jo801199s. Epub 2008 Jul 30.

PMID:
18665647
23.

Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.

Raelson JV, Little RD, Ruether A, Fournier H, Paquin B, Van Eerdewegh P, Bradley WE, Croteau P, Nguyen-Huu Q, Segal J, Debrus S, Allard R, Rosenstiel P, Franke A, Jacobs G, Nikolaus S, Vidal JM, Szego P, Laplante N, Clark HF, Paulussen RJ, Hooper JW, Keith TP, Belouchi A, Schreiber S.

Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14747-52. Epub 2007 Sep 5.

24.

Systematic association mapping identifies NELL1 as a novel IBD disease gene.

Franke A, Hampe J, Rosenstiel P, Becker C, Wagner F, Häsler R, Little RD, Huse K, Ruether A, Balschun T, Wittig M, Elsharawy A, Mayr G, Albrecht M, Prescott NJ, Onnie CM, Fournier H, Keith T, Radelof U, Platzer M, Mathew CG, Stoll M, Krawczak M, Nürnberg P, Schreiber S.

PLoS One. 2007 Aug 8;2(8):e691.

25.

Mechanistic role of a disease-associated genetic variant within the ADAM33 asthma susceptibility gene.

Del Mastro RG, Turenne L, Giese H, Keith TP, Van Eerdewegh P, May KJ, Little RD.

BMC Med Genet. 2007 Jul 17;8:46.

26.

A highly selective rearrangement of a housane-derived cation radical: an electrochemically mediated transformation.

Park YS, Wang SC, Tantillo DJ, Little RD.

J Org Chem. 2007 Jun 8;72(12):4351-7. Epub 2007 May 11.

PMID:
17497802
27.

Alexia without agraphia in a child with acute disseminated encephalomyelitis.

Little RD, Goldstein JL.

Neurology. 2006 Aug 22;67(4):725. No abstract available.

PMID:
16924040
28.

7,11-epi-thyrsiferol: completion of its synthesis, evaluation of its antimitotic properties, and the further development of an SAR model.

Nishiguchi GA, Graham J, Bouraoui A, Jacobs RS, Little RD.

J Org Chem. 2006 Aug 4;71(16):5936-41.

PMID:
16872175
29.

Indirect electroreductive cyclization and electrohydrocyclization using catalytic reduced nickel(II) salen.

Miranda JA, Wade CJ, Little RD.

J Org Chem. 2005 Sep 30;70(20):8017-26.

PMID:
16277323
30.
31.

Remote substituent effects upon the rearrangements of housane cation radicals.

Gerken JB, Wang SC, Preciado AB, Park YS, Nishiguchi G, Tantillo DJ, Little RD.

J Org Chem. 2005 Jun 10;70(12):4598-608.

PMID:
15932295
32.

From dimerization, to cycloaddition, to atom transfer cyclization: the further chemistry of TMM diradicals.

Maiti A, Gerken JB, Masjedizadeh MR, Mimieux YS, Little RD.

J Org Chem. 2004 Dec 10;69(25):8574-82.

PMID:
15575732
33.

Titanocene(III)-promoted Reformatsky additions.

Parrish JD, Shelton DR, Little RD.

Org Lett. 2003 Oct 2;5(20):3615-7.

PMID:
14507186
34.

Vanadium haloperoxidase-catalyzed bromination and cyclization of terpenes.

Carter-Franklin JN, Parrish JD, Tschirret-Guth RA, Little RD, Butler A.

J Am Chem Soc. 2003 Apr 2;125(13):3688-9.

PMID:
12656585
35.

High bone density due to a mutation in LDL-receptor-related protein 5.

Little RD, Recker RR, Johnson ML.

N Engl J Med. 2002 Sep 19;347(12):943-4; author reply 943-4. No abstract available.

PMID:
12239268
36.

Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness.

Van Eerdewegh P, Little RD, Dupuis J, Del Mastro RG, Falls K, Simon J, Torrey D, Pandit S, McKenny J, Braunschweiger K, Walsh A, Liu Z, Hayward B, Folz C, Manning SP, Bawa A, Saracino L, Thackston M, Benchekroun Y, Capparell N, Wang M, Adair R, Feng Y, Dubois J, FitzGerald MG, Huang H, Gibson R, Allen KM, Pedan A, Danzig MR, Umland SP, Egan RW, Cuss FM, Rorke S, Clough JB, Holloway JW, Holgate ST, Keith TP.

Nature. 2002 Jul 25;418(6896):426-30. Epub 2002 Jul 10.

PMID:
12110844
37.

Preparation of alpha-C-glycosides from glycals.

Parrish JD, Little RD.

Org Lett. 2002 May 2;4(9):1439-42.

PMID:
11975598
38.

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait.

Little RD, Carulli JP, Del Mastro RG, Dupuis J, Osborne M, Folz C, Manning SP, Swain PM, Zhao SC, Eustace B, Lappe MM, Spitzer L, Zweier S, Braunschweiger K, Benchekroun Y, Hu X, Adair R, Chee L, FitzGerald MG, Tulig C, Caruso A, Tzellas N, Bawa A, Franklin B, McGuire S, Nogues X, Gong G, Allen KM, Anisowicz A, Morales AJ, Lomedico PT, Recker SM, Van Eerdewegh P, Recker RR, Johnson ML.

Am J Hum Genet. 2002 Jan;70(1):11-9. Epub 2001 Dec 3.

39.

On the regiospecificity of vanadium bromoperoxidase.

Martinez JS, Carroll GL, Tschirret-Guth RA, Altenhoff G, Little RD, Butler A.

J Am Chem Soc. 2001 Apr 11;123(14):3289-94.

PMID:
11457064
40.

A facile synthesis of 5-acyl-6-alkyl/aryl-2,2-dimethyl-1, 3-dioxin-4-ones

Little RD, Russu WA.

J Org Chem. 2000 Nov 17;65(23):8096-9. No abstract available.

PMID:
11073628
41.

Inter- and intramolecular reductive coupling reactions: an approach to the phorbol skeleton.

Carroll GL, Little RD.

Org Lett. 2000 Sep 7;2(18):2873-6.

PMID:
10964387
42.

Atom transfer reactions of TMM diyls directed toward the synthesis of rudmollin.

Carroll GL, Allan AK, Schwaebe MK, Little RD.

Org Lett. 2000 Aug 10;2(16):2531-4.

PMID:
10956539
43.

Evidence that a single replication fork proceeds from early to late replicating domains in the IgH locus in a non-B cell line.

Ermakova OV, Nguyen LH, Little RD, Chevillard C, Riblet R, Ashouian N, Birshtein BK, Schildkraut CL.

Mol Cell. 1999 Mar;3(3):321-30.

44.

Radiation down-regulates replication origin activity throughout the S phase in mammalian cells.

Larner JM, Lee H, Little RD, Dijkwel PA, Schildkraut CL, Hamlin JL.

Nucleic Acids Res. 1999 Feb 1;27(3):803-9.

45.

Dyad symmetry within the mouse 3' IgH regulatory region includes two virtually identical enhancers (C alpha3'E and hs3).

Saleque S, Singh M, Little RD, Giannini SL, Michaelson JS, Birshtein BK.

J Immunol. 1997 May 15;158(10):4780-7.

PMID:
9144492
46.

Murine and human 3'IgH regulatory sequences.

Birshtein BK, Chen C, Saleque S, Michaelson JS, Singh M, Little RD.

Curr Top Microbiol Immunol. 1997;224:73-80. Review. No abstract available.

PMID:
9308230
47.

Cycloaddition-Fragmentation as a Route to Bicyclic Ring Systems. Use of the Intermolecular Diyl Trapping Reaction.

Leonetti JA, Gross T, Little RD.

J Org Chem. 1996 Dec 13;61(25):9072. No abstract available.

PMID:
11667905
48.

Cycloaddition-Fragmentation as a Route to Bicyclic Ring Systems. Use of the Intermolecular Diyl Trapping Reaction.

Leonetti JA, Gross T, Little RD.

J Org Chem. 1996 Mar 8;61(5):1787-1793.

PMID:
11667050
49.

Diyl Trapping and Electroreductive Cyclization Reactions.

Little RD.

Chem Rev. 1996 Feb 1;96(1):93-114. No abstract available.

PMID:
11848745
50.

Yeast and mammalian replication intermediates migrate similarly in two-dimensional gels.

Brun C, Dijkwel PA, Little RD, Hamlin JL, Schildkraut CL, Huberman JA.

Chromosoma. 1995 Nov;104(2):92-102.

PMID:
8585995

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