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Items: 1 to 50 of 996

1.

Barriers and facilitators to screening and treating malnutrition in older adults living in the community: a mixed-methods synthesis.

Harris PS, Payne L, Morrison L, Green SM, Ghio D, Hallett C, Parsons EL, Aveyard P, Roberts HC, Sutcliffe M, Robinson S, Slodkowska-Barabasz J, Little PS, Stroud MA, Yardley L.

BMC Fam Pract. 2019 Jul 15;20(1):100. doi: 10.1186/s12875-019-0983-y.

PMID:
31307402
Free Article
2.

Anaesthetic-analgesic ear drops to reduce antibiotic consumption in children with acute otitis media: the CEDAR RCT.

Hay AD, Downing H, Francis NA, Young GJ, Clement C, Harris SD, Ahern A, Schofield B, Thomas TE, Horwood J, Blair PS, Hollingworth W, Wilson V, Metcalfe C, Stoddart P, Nunez D, Lyttle MD, Little P, Moore MV.

Health Technol Assess. 2019 Jul;23(34):1-48. doi: 10.3310/hta23340.

PMID:
31304912
Free Article
3.

Mechanisms of PAR-1 mediated kinase receptor transactivation: Smad linker region phosphorylation.

Kamato D, Ta H, Afroz R, Xu S, Osman N, Little PJ.

J Cell Commun Signal. 2019 Jul 9. doi: 10.1007/s12079-019-00527-5. [Epub ahead of print]

PMID:
31290007
4.

Primer-free FISH probes from metagenomics/metatranscriptomics data permit the study of uncharacterised taxa in complex microbial communities.

Tan SM, Yung PYM, Hutchinson PE, Xie C, Teo GH, Ismail MH, Drautz-Moses DI, Little PFR, Williams RBH, Cohen Y.

NPJ Biofilms Microbiomes. 2019 Jun 25;5:17. doi: 10.1038/s41522-019-0090-9. eCollection 2019.

5.

Protocol for a double-blind placebo-controlled trial to evaluate the efficacy of probiotics in reducing antibiotics for infection in care home residents: the Probiotics to Reduce Infections iN CarE home reSidentS (PRINCESS) trial.

Owen-Jones E, Lowe R, Lown M, Gillespie D, Addison K, Bayer T, Calder PC, Davies J, Davoudianfar M, Downs J, Edwards A, Francis NA, Fuller R, Hobbs R, Hood K, Lau M, Little P, Moore M, Shepherd V, Stanton H, Toghill A, Wootton M, Butler CC.

BMJ Open. 2019 Jun 20;9(6):e027513. doi: 10.1136/bmjopen-2018-027513.

6.

Probiotics for preventing acute otitis media in children.

Scott AM, Clark J, Julien B, Islam F, Roos K, Grimwood K, Little P, Del Mar CB.

Cochrane Database Syst Rev. 2019 Jun 18;6:CD012941. doi: 10.1002/14651858.CD012941.pub2. Review.

PMID:
31210358
7.

Associating somatic mutations to clinical outcomes: a pan-cancer study of survival time.

Little P, Lin DY, Sun W.

Genome Med. 2019 May 28;11(1):37. doi: 10.1186/s13073-019-0643-9.

8.

Specialist call handlers' perspectives on providing help on a cancer helpline: A qualitative interview study.

Leydon GM, Halls A, Ekberg K, Latter S, Stuart B, Moynihan C, Salmon P, Danquah L, Brindle L, Howe S, Woods CJ, Little P.

Eur J Cancer Care (Engl). 2019 May 23:e13081. doi: 10.1111/ecc.13081. [Epub ahead of print]

PMID:
31124213
9.

Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia: a protocol for a randomIsed controlled Trial (CAP-IT).

Lyttle MD, Bielicki JA, Barratt S, Dunn D, Finn A, Harper L, Jackson P, Powell CVE, Roland D, Stohr W, Sturgeon K, Wan M, Little P, Faust SN, Robotham J, Hay AD, Gibb DM, Sharland M; PERUKI, GAPRUKI and the CAP-IT trial team.

BMJ Open. 2019 May 22;9(5):e029875. doi: 10.1136/bmjopen-2019-029875.

10.

Predictors of Adverse Outcomes in Uncomplicated Lower Respiratory Tract Infections.

Moore M, Stuart B, Lown M, Van den Bruel A, Smith S, Knox K, Thompson MJ, Little P.

Ann Fam Med. 2019 May;17(3):231-238. doi: 10.1370/afm.2386.

11.

Therapist telephone-delivered CBT and web-based CBT compared with treatment as usual in refractory irritable bowel syndrome: the ACTIB three-arm RCT.

Everitt H, Landau S, Little P, Bishop FL, O'Reilly G, Sibelli A, Holland R, Hughes S, Windgassen S, McCrone P, Goldsmith K, Coleman N, Logan R, Chalder T, Moss-Morris R.

Health Technol Assess. 2019 Apr;23(17):1-154. doi: 10.3310/hta23170.

12.

Clarithromycin and endoscopic sinus surgery for adults with chronic rhinosinusitis with and without nasal polyps: study protocol for the MACRO randomised controlled trial.

Philpott C, le Conte S, Beard D, Cook J, Sones W, Morris S, Clarke CS, Thomas M, Little P, Vennik J, Lund V, Blackshaw H, Schilder A, Durham S, Denaxas S, Carpenter J, Boardman J, Hopkins C; MACRO programme team.

Trials. 2019 Apr 29;20(1):246. doi: 10.1186/s13063-019-3314-7.

13.

Treatment of atherosclerotic plaque: perspectives on theranostics.

Zhang Y, Koradia A, Kamato D, Popat A, Little PJ, Ta HT.

J Pharm Pharmacol. 2019 Jul;71(7):1029-1043. doi: 10.1111/jphp.13092. Epub 2019 Apr 25. Review.

PMID:
31025381
14.

Chronic rhinosinusitis: a qualitative study of patient views and experiences of current management in primary and secondary care.

Vennik J, Eyles C, Thomas M, Hopkins C, Little P, Blackshaw H, Schilder A, Savage I, Philpott CM.

BMJ Open. 2019 Apr 23;9(4):e022644. doi: 10.1136/bmjopen-2018-022644.

15.

Expert panel process to optimise the design of a randomised controlled trial in chronic rhinosinusitis (the MACRO programme).

Blackshaw H, Vennik J, Philpott C, Thomas M, Eyles C, Carpenter J, Clarke CS, Morris S, Schilder A, Lund V, Little P, Durham S, Denaxas S, Williamson E, Beard D, Cook J, Le Conte S, Airey K, Boardman J, Hopkins C.

Trials. 2019 Apr 23;20(1):230. doi: 10.1186/s13063-019-3318-3.

16.

Assessing telephone-delivered cognitive-behavioural therapy (CBT) and web-delivered CBT versus treatment as usual in irritable bowel syndrome (ACTIB): a multicentre randomised trial.

Everitt HA, Landau S, O'Reilly G, Sibelli A, Hughes S, Windgassen S, Holland R, Little P, McCrone P, Bishop F, Goldsmith K, Coleman N, Logan R, Chalder T, Moss-Morris R; ACTIB trial group.

Gut. 2019 Apr 10. pii: gutjnl-2018-317805. doi: 10.1136/gutjnl-2018-317805. [Epub ahead of print]

17.

Risk of mortality and cardiovascular events following macrolide prescription in chronic rhinosinusitis patients: a cohort study using linked primary care electronic health records.

Williamson E, Denaxas S, Morris S, Clarke CS, Thomas M, Evans H, Direk K, Gonzalez-Izquierdo A, Little P, Lund V, Blackshaw H, Schilder A, Philpott C, Hopkins C, Carpenter J; MACRO programme team.

Rhinology. 2019 Mar 30. doi: 10.4193/Rhin18.237. [Epub ahead of print]

PMID:
30928998
18.

Non-invasive imaging techniques for the differentiation of acute and chronic thrombosis.

Yusof NNM, McCann A, Little PJ, Ta HT.

Thromb Res. 2019 May;177:161-171. doi: 10.1016/j.thromres.2019.03.009. Epub 2019 Mar 14. Review.

PMID:
30921535
19.

Electronically delivered interventions to reduce antibiotic prescribing for respiratory infections in primary care: cluster RCT using electronic health records and cohort study.

Gulliford MC, Juszczyk D, Prevost AT, Soames J, McDermott L, Sultana K, Wright M, Fox R, Hay AD, Little P, Moore M, Yardley L, Ashworth M, Charlton J.

Health Technol Assess. 2019 Mar;23(11):1-70. doi: 10.3310/hta23110.

20.

Parental and clinician agreement of illness severity in children with RTIs: secondary analysis of data from a prospective cohort study.

van der Werf ET, Redmond NM, Turnbull S, Thornton H, Thompson M, Little P, Peters TJ, Blair PS, Hay AD.

Br J Gen Pract. 2019 Apr;69(681):e236-e245. doi: 10.3399/bjgp19X701837. Epub 2019 Mar 11.

PMID:
30858333
21.

Antibiotic Prescribing for Acute Respiratory Tract Infections 12 Months After Communication and CRP Training: A Randomized Trial.

Little P, Stuart B, Francis N, Douglas E, Tonkin-Crine S, Anthierens S, Cals JWL, Melbye H, Santer M, Moore M, Coenen S, Butler CC, Hood K, Kelson M, Godycki-Cwirko M, Mierzecki A, Torres A, Llor C, Davies M, Mullee M, O'Reilly G, van der Velden A, Geraghty AWA, Goossens H, Verheij T, Yardley L; GRACE consortium.

Ann Fam Med. 2019 Mar;17(2):125-132. doi: 10.1370/afm.2356.

22.

Subacute fatigue in primary care - two sides of the story.

Hulme K, Little P, Burrows A, Julia A, Moss-Morris R.

Br J Health Psychol. 2019 May;24(2):419-442. doi: 10.1111/bjhp.12361. Epub 2019 Mar 8.

23.

Renewed: Protocol for a randomised controlled trial of a digital intervention to support quality of life in cancer survivors.

Krusche A, Bradbury K, Corbett T, Barnett J, Stuart B, Yao GL, Bacon R, Böhning D, Cheetham-Blake T, Eccles D, Foster C, Geraghty AWA, Leydon G, Müller A, Neal RD, Osborne R, Rathod S, Richardson A, Sharman G, Summers K, Watson E, Wilde L, Wilkinson C, Yardley L, Little P.

BMJ Open. 2019 Mar 1;9(3):e024862. doi: 10.1136/bmjopen-2018-024862.

24.

Targeting Mechanosensitive Transcription Factors in Atherosclerosis.

Niu N, Xu S, Xu Y, Little PJ, Jin ZG.

Trends Pharmacol Sci. 2019 Apr;40(4):253-266. doi: 10.1016/j.tips.2019.02.004. Epub 2019 Feb 28. Review.

PMID:
30826122
25.

Endothelin-1 increases CHSY-1 expression in aortic endothelial cells via transactivation of transforming growth factor β type I receptor induced by type B receptor endothelin-1.

Seif F, Little PJ, Niayesh-Mehr R, Zamanpour M, Babaahmadi-Rezaei H.

J Pharm Pharmacol. 2019 Jun;71(6):988-995. doi: 10.1111/jphp.13081. Epub 2019 Feb 27.

PMID:
30809816
26.

Effectiveness and safety of electronically delivered prescribing feedback and decision support on antibiotic use for respiratory illness in primary care: REDUCE cluster randomised trial.

Gulliford MC, Prevost AT, Charlton J, Juszczyk D, Soames J, McDermott L, Sultana K, Wright M, Fox R, Hay AD, Little P, Moore MV, Yardley L, Ashworth M.

BMJ. 2019 Feb 12;364:l236. doi: 10.1136/bmj.l236.

27.

COSUTI: a protocol for the development of a core outcome set (COS) for interventions for the treatment of uncomplicated urinary tract infection (UTI) in adults.

Duane S, Vellinga A, Murphy AW, Cormican M, Smyth A, Healy P, Moore M, Little P, Devane D.

Trials. 2019 Feb 7;20(1):106. doi: 10.1186/s13063-019-3194-x.

28.

The impact of the national action plan on the epidemiology of antibiotic resistance among 352,238 isolates in a teaching hospital in China from 2015 to 2018.

Wang S, Hu YJ, Little P, Wang Y, Chang Q, Zhou X, Moore M, Harwell JI.

Antimicrob Resist Infect Control. 2019 Jan 29;8:22. doi: 10.1186/s13756-019-0473-y. eCollection 2019.

29.

Complementary medicine use, views, and experiences: a national survey in England.

Sharp D, Lorenc A, Morris R, Feder G, Little P, Hollinghurst S, Mercer SW, MacPherson H.

BJGP Open. 2018 Nov 14;2(4):bjgpopen18X101614. doi: 10.3399/bjgpopen18X101614. eCollection 2018 Dec.

30.

Uva-ursi extract and ibuprofen as alternative treatments for uncomplicated urinary tract infection in women (ATAFUTI): a factorial randomized trial.

Moore M, Trill J, Simpson C, Webley F, Radford M, Stanton L, Maishman T, Galanopoulou A, Flower A, Eyles C, Willcox M, Hay AD, van der Werf E, Gibbons S, Lewith G, Little P, Griffiths G.

Clin Microbiol Infect. 2019 Aug;25(8):973-980. doi: 10.1016/j.cmi.2019.01.011. Epub 2019 Jan 25.

31.

Delayed antibiotic prescribing for respiratory tract infections: protocol of an individual patient data meta-analysis.

Stuart B, Hounkpatin H, Becque T, Yao G, Zhu S, Alonso-Coello P, Altiner A, Arroll B, Böhning D, Bostock J, Bucher HCC, de la Poza M, Francis NA, Gillespie D, Hay AD, Kenealy T, Löffler C, Mas-Dalmau G, Muñoz L, Samuel K, Moore M, Little P.

BMJ Open. 2019 Jan 21;9(1):e026925. doi: 10.1136/bmjopen-2018-026925.

32.

The International Collaborative on Fatigue Following Infection (COFFI).

Katz BZ, Collin SM, Murphy G, Moss-Morris R, Wyller VB, Wensaas KA, Hautvast JLA, Bleeker-Rovers CP, Vollmer-Conna U, Buchwald D, Taylor R, Little P, Crawley E, White PD, Lloyd A.

Fatigue. 2018;6(2):106-121. doi: 10.1080/21641846.2018.1426086. Epub 2018 Jan 19.

33.

The Prognostic Significance of Low-Frequency Somatic Mutations in Metastatic Cutaneous Melanoma.

Zhao X, Little P, Hoyle AP, Pegna GJ, Hayward MC, Ivanova A, Parker JS, Marron DL, Soloway MG, Jo H, Salazar AH, Papakonstantinou MP, Bouchard DM, Jefferys SR, Hoadley KA, Ollila DW, Frank JS, Thomas NE, Googe PB, Ezzell AJ, Collichio FA, Lee CB, Earp HS, Sharpless NE, Hugo W, Wilmott JS, Quek C, Waddell N, Johansson PA, Thompson JF, Hayward NK, Mann GJ, Lo RS, Johnson DB, Scolyer RA, Hayes DN, Moschos SJ.

Front Oncol. 2019 Jan 4;8:584. doi: 10.3389/fonc.2018.00584. eCollection 2018.

34.

Effectiveness of the probiotic Streptococcus salivarius K12 for the treatment and/or prevention of sore throat: a systematic review.

Wilcox CR, Stuart B, Leaver H, Lown M, Willcox M, Moore M, Little P.

Clin Microbiol Infect. 2019 Jun;25(6):673-680. doi: 10.1016/j.cmi.2018.12.031. Epub 2019 Jan 4. Review.

PMID:
30616011
35.

Management strategies for chronic rhinosinusitis: a qualitative study of GP and ENT specialist views of current practice in the UK.

Vennik J, Eyles C, Thomas M, Hopkins C, Little P, Blackshaw H, Schilder A, Boardman J, Philpott CM.

BMJ Open. 2018 Dec 19;8(12):e022643. doi: 10.1136/bmjopen-2018-022643.

36.

Practice variation in the use of tests in UK primary care: a retrospective analysis of 16 million tests performed over 3.3 million patient years in 2015/16.

O'Sullivan JW, Stevens S, Oke J, Hobbs FDR, Salisbury C, Little P, Goldacre B, Bankhead C, Aronson JK, Heneghan C, Perera R.

BMC Med. 2018 Dec 20;16(1):229. doi: 10.1186/s12916-018-1217-1.

37.

Temporal trends in use of tests in UK primary care, 2000-15: retrospective analysis of 250 million tests.

O'Sullivan JW, Stevens S, Hobbs FDR, Salisbury C, Little P, Goldacre B, Bankhead C, Aronson JK, Perera R, Heneghan C.

BMJ. 2018 Nov 28;363:k4666. doi: 10.1136/bmj.k4666. Erratum in: BMJ. 2019 Jan 29;364:l444.

38.

The elicitation and management of multiple health concerns in GP consultations.

Stuart B, Leydon G, Woods C, Gennery E, Elsey C, Summers R, Stevenson F, Chew-Graham C, Barnes R, Drew P, Moore M, Little P.

Patient Educ Couns. 2019 Apr;102(4):687-693. doi: 10.1016/j.pec.2018.11.009. Epub 2018 Nov 14.

39.

Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics.

Xu S, Kamato D, Little PJ, Nakagawa S, Pelisek J, Jin ZG.

Pharmacol Ther. 2019 Apr;196:15-43. doi: 10.1016/j.pharmthera.2018.11.003. Epub 2018 Nov 13. Review.

PMID:
30439455
40.

Individual Smad2 linker region phosphorylation sites determine the expression of proteoglycan and glycosaminoglycan synthesizing genes.

Kamato D, Burch M, Zhou Y, Mohamed R, Stow JL, Osman N, Zheng W, Little PJ.

Cell Signal. 2019 Jan;53:365-373. doi: 10.1016/j.cellsig.2018.11.005. Epub 2018 Nov 10.

PMID:
30423352
41.

Transforming growth factor-β1 mediated CHST11 and CHSY1 mRNA expression is ROS dependent in vascular smooth muscle cells.

Mohamed R, Dayati P, Mehr RN, Kamato D, Seif F, Babaahmadi-Rezaei H, Little PJ.

J Cell Commun Signal. 2019 Jun;13(2):225-233. doi: 10.1007/s12079-018-0495-x. Epub 2018 Nov 11.

42.

Danhong injection in cardiovascular and cerebrovascular diseases: Pharmacological actions, molecular mechanisms, and therapeutic potential.

Feng X, Li Y, Wang Y, Li L, Little PJ, Xu SW, Liu S.

Pharmacol Res. 2019 Jan;139:62-75. doi: 10.1016/j.phrs.2018.11.006. Epub 2018 Nov 5. Review.

PMID:
30408571
43.

Targeting LOX-1 in atherosclerosis and vasculopathy: current knowledge and future perspectives.

Tian K, Ogura S, Little PJ, Xu SW, Sawamura T.

Ann N Y Acad Sci. 2019 May;1443(1):34-53. doi: 10.1111/nyas.13984. Epub 2018 Nov 1. Review.

PMID:
30381837
44.

'Trying to put a square peg into a round hole': a qualitative study of healthcare professionals' views of integrating complementary medicine into primary care for musculoskeletal and mental health comorbidity.

Sharp D, Lorenc A, Feder G, Little P, Hollinghurst S, Mercer S, MacPherson H.

BMC Complement Altern Med. 2018 Oct 29;18(1):290. doi: 10.1186/s12906-018-2349-8.

45.

Adding emollient bath additives to standard eczema management for children with eczema: the BATHE RCT.

Santer M, Rumsby K, Ridd MJ, Francis NA, Stuart B, Chorozoglou M, Roberts A, Liddiard L, Nollett C, Hooper J, Prude M, Wood W, Thomas-Jones E, Becque T, Thomas KS, Williams HC, Little P.

Health Technol Assess. 2018 Oct;22(57):1-116. doi: 10.3310/hta22570.

46.

Feasibility of weekly participant-reported data collection in a pragmatic randomised controlled trial in primary care: experiences from the BATHE trial (Bath Additives for the Treatment of cHildhood Eczema).

Stuart B, Rumsby K, Santer M, Ridd MJ, Francis NA, Chorozoglou M, Spreadbury C, Steele M, Nollett C, Liddiard L, Prude M, Hooper J, Thomas-Jones E, Roberts A, Thomas KS, Williams HC, Little P.

Trials. 2018 Oct 24;19(1):582. doi: 10.1186/s13063-018-2962-3.

47.

Scoping review of systematic reviews of complementary medicine for musculoskeletal and mental health conditions.

Lorenc A, Feder G, MacPherson H, Little P, Mercer SW, Sharp D.

BMJ Open. 2018 Oct 15;8(10):e020222. doi: 10.1136/bmjopen-2017-020222.

48.

Superselective endovascular tissue access using trans-vessel wall technique: feasibility study for treatment applications in heart, pancreas and kidney in swine.

Grankvist R, Jensen-Urstad M, Clarke J, Lehtinen M, Little P, Lundberg J, Arnberg F, Jonsson S, Chien KR, Holmin S.

J Intern Med. 2019 Apr;285(4):398-406. doi: 10.1111/joim.12841. Epub 2018 Oct 28.

PMID:
30289186
49.

OPtimising Treatment for MIld Systolic hypertension in the Elderly (OPTiMISE): protocol for a randomised controlled non-inferiority trial.

Sheppard JP, Burt J, Lown M, Temple E, Benson J, Ford GA, Heneghan C, Hobbs FDR, Jowett S, Little P, Mant J, Mollison J, Nickless A, Ogburn E, Payne R, Williams M, Yu LM, McManus RJ.

BMJ Open. 2018 Oct 4;8(9):e022930. doi: 10.1136/bmjopen-2018-022930.

50.

Multicentred randomised controlled trial of an augmented exercise referral scheme using web-based behavioural support in individuals with metabolic, musculoskeletal and mental health conditions: protocol for the e-coachER trial.

Ingram W, Webb D, Taylor RS, Anokye N, Yardley L, Jolly K, Mutrie N, Campbell JL, Dean SG, Greaves C, Steele M, Lambert JD, McAdam C, Jane B, King J, Jones RB, Little P, Woolf A, Erwin J, Charles N, Terry RH, Taylor AH; Trial Steering Committee.

BMJ Open. 2018 Sep 21;8(9):e022382. doi: 10.1136/bmjopen-2018-022382.

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