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Non-steroidal anti-inflammatory drugs and covid-19.

Little P.

BMJ. 2020 Mar 27;368:m1185. doi: 10.1136/bmj.m1185. No abstract available.


Clinical scores in primary care.

Dambha-Miller H, Everitt H, Little P.

Br J Gen Pract. 2020 Mar 26;70(693):163. doi: 10.3399/bjgp20X708941. Print 2020 Apr. No abstract available.


Patients' views about screening for atrial fibrillation (AF): a qualitative study in primary care.

Lown M, Wilcox CR, Hughes S, Santer M, Lewith G, Moore M, Little P.

BMJ Open. 2020 Mar 18;10(3):e033061. doi: 10.1136/bmjopen-2019-033061.


Serious bacterial infections and antibiotic prescribing in primary care: cohort study using electronic health records in the UK.

Gulliford MC, Sun X, Charlton J, Winter JR, Bunce C, Boiko O, Fox R, Little P, Moore M, Hay AD, Ashworth M; And SafeAB Research Group.

BMJ Open. 2020 Feb 28;10(2):e036975. doi: 10.1136/bmjopen-2020-036975.


Economic evaluation of the OSAC randomised controlled trial: oral corticosteroids for non-asthmatic adults with acute lower respiratory tract infection in primary care.

Moure-Fernandez A, Hollinghurst S, Carroll FE, Downing H, Young G, Brookes S, May M, El-Gohary M, Harnden A, Kendrick D, Lafond N, Little P, Moore M, Orton E, Thompson M, Timmins D, Wang K, Hay AD.

BMJ Open. 2020 Feb 18;10(2):e033567. doi: 10.1136/bmjopen-2019-033567.


Placebos in primary care? a nominal group study explicating UK GP and patient views of six theoretically plausible models of placebo practice.

Ratnapalan M, Coghlan B, Tan M, Everitt H, Geraghty AWA, Little P, Lewith G, Bishop FL.

BMJ Open. 2020 Feb 18;10(2):e032524. doi: 10.1136/bmjopen-2019-032524.


Protocol for the feasibility and acceptability of a brief routine weight management intervention for postnatal women embedded within the national child immunisation programme: randomised controlled cluster feasibility trial with nested qualitative study (PIMMS-WL).

Parretti HM, Ives NJ, Tearne S, Vince A, Greenfield SM, Jolly K, Jebb SA, Frew E, Yardley L, Little P, Pritchett RV, Daley A.

BMJ Open. 2020 Feb 16;10(2):e033027. doi: 10.1136/bmjopen-2019-033027.


Digital interventions for parents of acutely ill children and their treatment-seeking behaviour: a systematic review.

Donovan E, Wilcox CR, Patel S, Hay AD, Little P, Willcox ML.

Br J Gen Pract. 2020 Feb 27;70(692):e172-e178. doi: 10.3399/bjgp20X708209. Print 2020 Mar.



Wilcox CR, Little P, Jones CE.

Br J Gen Pract. 2020 Jan 30;70(691):e179-e185. doi: 10.3399/bjgp20X708113. Print 2020 Feb. No abstract available.


Smad2 linker region phosphorylation is an autonomous cell signalling pathway: Implications for multiple disease pathologies.

Kamato D, Little PJ.

Biomed Pharmacother. 2020 Apr;124:109854. doi: 10.1016/j.biopha.2020.109854. Epub 2020 Jan 22. Review.


Machine learning detection of Atrial Fibrillation using wearable technology.

Lown M, Brown M, Brown C, Yue AM, Shah BN, Corbett SJ, Lewith G, Stuart B, Moore M, Little P.

PLoS One. 2020 Jan 24;15(1):e0227401. doi: 10.1371/journal.pone.0227401. eCollection 2020.


Relationship between microbiology of throat swab and clinical course among primary care patients with acute cough: a prospective cohort study.

Ordóñez-Mena JM, Fanshawe TR, Butler CC, Mant D, Longhurst D, Muir P, Vipond B, Little P, Moore M, Stuart B, Hay AD, Thornton HV, Thompson MJ, Smith S, Van den Bruel A, Hardy V, Cheah L, Crook D, Knox K.

Fam Pract. 2019 Dec 17. pii: cmz093. doi: 10.1093/fampra/cmz093. [Epub ahead of print]


'I mean what is depression?' A qualitative exploration of UK general practitioners' perceptions of distinctions between emotional distress and depressive disorder.

Geraghty AWA, Santer M, Beavis C, Williams SJ, Kendrick T, Terluin B, Little P, Moore M.

BMJ Open. 2019 Dec 15;9(12):e032644. doi: 10.1136/bmjopen-2019-032644.


Oxygen metabolism MRI - A comparison with perfusion imaging in a rat model of MCA branch occlusion and reperfusion.

Little PV, Kraft SE, Chireh A, Damberg P, Holmin S.

J Cereb Blood Flow Metab. 2019 Dec 16:271678X19892271. doi: 10.1177/0271678X19892271. [Epub ahead of print] No abstract available.


Exploring Patients' Experiences of Internet-Based Self-Management Support for Low Back Pain in Primary Care.

Geraghty AWA, Roberts LC, Stanford R, Hill JC, Yoganantham D, Little P, Foster NE, Hay EM, Yardley L.

Pain Med. 2019 Dec 16. pii: pnz312. doi: 10.1093/pm/pnz312. [Epub ahead of print]


Oseltamivir plus usual care versus usual care for influenza-like illness in primary care: an open-label, pragmatic, randomised controlled trial.

Butler CC, van der Velden AW, Bongard E, Saville BR, Holmes J, Coenen S, Cook J, Francis NA, Lewis RJ, Godycki-Cwirko M, Llor C, Chlabicz S, Lionis C, Seifert B, Sundvall PD, Colliers A, Aabenhus R, Bjerrum L, Jonassen Harbin N, Lindbæk M, Glinz D, Bucher HC, Kovács B, Radzeviciene Jurgute R, Touboul Lundgren P, Little P, Murphy AW, De Sutter A, Openshaw P, de Jong MD, Connor JT, Matheeussen V, Ieven M, Goossens H, Verheij TJ.

Lancet. 2020 Jan 4;395(10217):42-52. doi: 10.1016/S0140-6736(19)32982-4. Epub 2019 Dec 12.


Hydrogels Based on Poly(aspartic acid): Synthesis and Applications.

Adelnia H, Blakey I, Little PJ, Ta HT.

Front Chem. 2019 Nov 12;7:755. doi: 10.3389/fchem.2019.00755. eCollection 2019. Review.


Young people's perceptions of acne and acne treatments: secondary analysis of qualitative interview data.

Ip A, Muller I, Geraghty AWA, McNiven A, Little P, Santer M.

Br J Dermatol. 2019 Nov 7. doi: 10.1111/bjd.18684. [Epub ahead of print]


ROS directly activates transforming growth factor β type 1 receptor signalling in human vascular smooth muscle cells.

Mohamed R, Cao Y, Afroz R, Xu S, Ta HT, Barras M, Zheng W, Little PJ, Kamato D.

Biochim Biophys Acta Gen Subj. 2020 Jan;1864(1):129463. doi: 10.1016/j.bbagen.2019.129463. Epub 2019 Oct 30.


Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care.

Roddy E, Clarkson K, Blagojevic-Bucknall M, Mehta R, Oppong R, Avery A, Hay EM, Heneghan C, Hartshorne L, Hooper J, Hughes G, Jowett S, Lewis M, Little P, McCartney K, Mahtani KR, Nunan D, Santer M, Williams S, Mallen CD.

Ann Rheum Dis. 2020 Feb;79(2):276-284. doi: 10.1136/annrheumdis-2019-216154. Epub 2019 Oct 30.


Exploring the appropriateness of antibiotic prescribing for common respiratory tract infections in UK primary care.

Stuart B, Brotherwood H, Van't Hoff C, Brown A, van den Bruel A, Hay AD, Moore M, Little P.

J Antimicrob Chemother. 2020 Jan 1;75(1):236-242. doi: 10.1093/jac/dkz410.


Developing a digital intervention for cancer survivors: an evidence-, theory- and person-based approach.

Bradbury K, Steele M, Corbett T, Geraghty AWA, Krusche A, Heber E, Easton S, Cheetham-Blake T, Slodkowska-Barabasz J, Müller AM, Smith K, Wilde LJ, Payne L, Singh K, Bacon R, Burford T, Summers K, Turner L, Richardson A, Watson E, Foster C, Little P, Yardley L.

NPJ Digit Med. 2019 Sep 2;2:85. doi: 10.1038/s41746-019-0163-4. eCollection 2019.


Optimizing design of research to evaluate antibiotic stewardship interventions: consensus recommendations of a multinational working group.

Schweitzer VA, van Werkhoven CH, Rodríguez Baño J, Bielicki J, Harbarth S, Hulscher M, Huttner B, Islam J, Little P, Pulcini C, Savoldi A, Tacconelli E, Timsit JF, van Smeden M, Wolkewitz M, Bonten MJM, Walker AS, Llewelyn MJ; Joint Programming Initiative on Antimicrobial Resistance (JPIAMR) Working Group on Design of Antimicrobial Stewardship Evaluations.

Clin Microbiol Infect. 2020 Jan;26(1):41-50. doi: 10.1016/j.cmi.2019.08.017. Epub 2019 Sep 4.


Cognitive behavioural therapy for irritable bowel syndrome: 24-month follow-up of participants in the ACTIB randomised trial.

Everitt HA, Landau S, O'Reilly G, Sibelli A, Hughes S, Windgassen S, Holland R, Little P, McCrone P, Bishop FL, Goldsmith K, Coleman N, Logan R, Chalder T, Moss-Morris R.

Lancet Gastroenterol Hepatol. 2019 Nov;4(11):863-872. doi: 10.1016/S2468-1253(19)30243-2. Epub 2019 Sep 3.


Antibiotic usage in chronic rhinosinusitis: analysis of national primary care electronic health records.

Hopkins C, Williamson E, Morris S, Clarke CS, Thomas M, Evans H, Little P, Lund VJ, Blackshaw H, Schilder A, Philpott C, Carpenter J, Denaxas S; MACRO programme team.

Rhinology. 2019 Dec 1;57(6):420-429. doi: 10.4193/Rhin19.136.


Lysophosphatidic acid and its receptors: pharmacology and therapeutic potential in atherosclerosis and vascular disease.

Zhou Y, Little PJ, Ta HT, Xu S, Kamato D.

Pharmacol Ther. 2019 Dec;204:107404. doi: 10.1016/j.pharmthera.2019.107404. Epub 2019 Aug 28. Review.


Smad linker region phosphorylation is a signalling pathway in its own right and not only a modulator of canonical TGF-β signalling.

Kamato D, Do BH, Osman N, Ross BP, Mohamed R, Xu S, Little PJ.

Cell Mol Life Sci. 2020 Jan;77(2):243-251. doi: 10.1007/s00018-019-03266-3. Epub 2019 Aug 12. Review.


HATRIC: a study of Pelargonium sidoides root extract EPs®7630 (Kaloba®) for the treatment of acute cough due to lower respiratory tract infection in adults-study protocol for a double blind, placebo-controlled randomised feasibility trial.

Whitehead A, Simpson C, Willcox M, Webley F, Hay AD, Butler C, Yao L, Wrixon E, Bell M, Bostock J, Little P, Griffiths G, Moore M.

Pilot Feasibility Stud. 2019 Jul 31;5:98. doi: 10.1186/s40814-019-0478-6. eCollection 2019.


Challenges in managing urinary tract infection and the potential of a point-of-care test guided care in primary care: an international qualitative study.

Brookes-Howell L, Thomas-Jones E, Bates J, Bekkers MJ, Brugman C, Coulman E, Francis N, Hashmi K, Hood K, Kirby N, Llor C, Little P, Moore M, Moragas A, Rumsby K, Verheij T, Butler C.

BJGP Open. 2019 Jul 23;3(2). pii: bjgpopen18X101630. doi: 10.3399/bjgpopen18X101630. Print 2019 Jul.


Role of Corticotropin Releasing Factor in the Neuroimmune Mechanisms of Depression: Examination of Current Pharmaceutical and Herbal Therapies.

Jiang Y, Peng T, Gaur U, Silva M, Little P, Chen Z, Qiu W, Zhang Y, Zheng W.

Front Cell Neurosci. 2019 Jul 2;13:290. doi: 10.3389/fncel.2019.00290. eCollection 2019.


Barriers and facilitators to screening and treating malnutrition in older adults living in the community: a mixed-methods synthesis.

Harris PS, Payne L, Morrison L, Green SM, Ghio D, Hallett C, Parsons EL, Aveyard P, Roberts HC, Sutcliffe M, Robinson S, Slodkowska-Barabasz J, Little PS, Stroud MA, Yardley L.

BMC Fam Pract. 2019 Jul 15;20(1):100. doi: 10.1186/s12875-019-0983-y.


Anaesthetic-analgesic ear drops to reduce antibiotic consumption in children with acute otitis media: the CEDAR RCT.

Hay AD, Downing H, Francis NA, Young GJ, Clement C, Harris SD, Ahern A, Schofield B, Thomas TE, Horwood J, Blair PS, Hollingworth W, Wilson V, Metcalfe C, Stoddart P, Nunez D, Lyttle MD, Little P, Moore MV.

Health Technol Assess. 2019 Jul;23(34):1-48. doi: 10.3310/hta23340.


Mechanisms of PAR-1 mediated kinase receptor transactivation: Smad linker region phosphorylation.

Kamato D, Ta H, Afroz R, Xu S, Osman N, Little PJ.

J Cell Commun Signal. 2019 Dec;13(4):539-548. doi: 10.1007/s12079-019-00527-5. Epub 2019 Jul 9.


Primer-free FISH probes from metagenomics/metatranscriptomics data permit the study of uncharacterised taxa in complex microbial communities.

Tan SM, Yung PYM, Hutchinson PE, Xie C, Teo GH, Ismail MH, Drautz-Moses DI, Little PFR, Williams RBH, Cohen Y.

NPJ Biofilms Microbiomes. 2019 Jun 25;5:17. doi: 10.1038/s41522-019-0090-9. eCollection 2019.


Protocol for a double-blind placebo-controlled trial to evaluate the efficacy of probiotics in reducing antibiotics for infection in care home residents: the Probiotics to Reduce Infections iN CarE home reSidentS (PRINCESS) trial.

Owen-Jones E, Lowe R, Lown M, Gillespie D, Addison K, Bayer T, Calder PC, Davies J, Davoudianfar M, Downs J, Edwards A, Francis NA, Fuller R, Hobbs R, Hood K, Lau M, Little P, Moore M, Shepherd V, Stanton H, Toghill A, Wootton M, Butler CC.

BMJ Open. 2019 Jun 20;9(6):e027513. doi: 10.1136/bmjopen-2018-027513.


Probiotics for preventing acute otitis media in children.

Scott AM, Clark J, Julien B, Islam F, Roos K, Grimwood K, Little P, Del Mar CB.

Cochrane Database Syst Rev. 2019 Jun 18;6:CD012941. doi: 10.1002/14651858.CD012941.pub2.


Associating somatic mutations to clinical outcomes: a pan-cancer study of survival time.

Little P, Lin DY, Sun W.

Genome Med. 2019 May 28;11(1):37. doi: 10.1186/s13073-019-0643-9.


Specialist call handlers' perspectives on providing help on a cancer helpline: A qualitative interview study.

Leydon GM, Halls A, Ekberg K, Latter S, Stuart B, Moynihan C, Salmon P, Danquah L, Brindle L, Howe S, Woods CJ, Little P.

Eur J Cancer Care (Engl). 2019 Sep;28(5):e13081. doi: 10.1111/ecc.13081. Epub 2019 May 23.


Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia: a protocol for a randomIsed controlled Trial (CAP-IT).

Lyttle MD, Bielicki JA, Barratt S, Dunn D, Finn A, Harper L, Jackson P, Powell CVE, Roland D, Stohr W, Sturgeon K, Wan M, Little P, Faust SN, Robotham J, Hay AD, Gibb DM, Sharland M; PERUKI, GAPRUKI and the CAP-IT trial team.

BMJ Open. 2019 May 22;9(5):e029875. doi: 10.1136/bmjopen-2019-029875.


Predictors of Adverse Outcomes in Uncomplicated Lower Respiratory Tract Infections.

Moore M, Stuart B, Lown M, Van den Bruel A, Smith S, Knox K, Thompson MJ, Little P.

Ann Fam Med. 2019 May;17(3):231-238. doi: 10.1370/afm.2386.


Therapist telephone-delivered CBT and web-based CBT compared with treatment as usual in refractory irritable bowel syndrome: the ACTIB three-arm RCT.

Everitt H, Landau S, Little P, Bishop FL, O'Reilly G, Sibelli A, Holland R, Hughes S, Windgassen S, McCrone P, Goldsmith K, Coleman N, Logan R, Chalder T, Moss-Morris R.

Health Technol Assess. 2019 Apr;23(17):1-154. doi: 10.3310/hta23170.


Clarithromycin and endoscopic sinus surgery for adults with chronic rhinosinusitis with and without nasal polyps: study protocol for the MACRO randomised controlled trial.

Philpott C, le Conte S, Beard D, Cook J, Sones W, Morris S, Clarke CS, Thomas M, Little P, Vennik J, Lund V, Blackshaw H, Schilder A, Durham S, Denaxas S, Carpenter J, Boardman J, Hopkins C; MACRO programme team.

Trials. 2019 Apr 29;20(1):246. doi: 10.1186/s13063-019-3314-7.


Treatment of atherosclerotic plaque: perspectives on theranostics.

Zhang Y, Koradia A, Kamato D, Popat A, Little PJ, Ta HT.

J Pharm Pharmacol. 2019 Jul;71(7):1029-1043. doi: 10.1111/jphp.13092. Epub 2019 Apr 25. Review.


Chronic rhinosinusitis: a qualitative study of patient views and experiences of current management in primary and secondary care.

Vennik J, Eyles C, Thomas M, Hopkins C, Little P, Blackshaw H, Schilder A, Savage I, Philpott CM.

BMJ Open. 2019 Apr 23;9(4):e022644. doi: 10.1136/bmjopen-2018-022644.


Expert panel process to optimise the design of a randomised controlled trial in chronic rhinosinusitis (the MACRO programme).

Blackshaw H, Vennik J, Philpott C, Thomas M, Eyles C, Carpenter J, Clarke CS, Morris S, Schilder A, Lund V, Little P, Durham S, Denaxas S, Williamson E, Beard D, Cook J, Le Conte S, Airey K, Boardman J, Hopkins C.

Trials. 2019 Apr 23;20(1):230. doi: 10.1186/s13063-019-3318-3. Review.


Assessing telephone-delivered cognitive-behavioural therapy (CBT) and web-delivered CBT versus treatment as usual in irritable bowel syndrome (ACTIB): a multicentre randomised trial.

Everitt HA, Landau S, O'Reilly G, Sibelli A, Hughes S, Windgassen S, Holland R, Little P, McCrone P, Bishop F, Goldsmith K, Coleman N, Logan R, Chalder T, Moss-Morris R; ACTIB trial group.

Gut. 2019 Sep;68(9):1613-1623. doi: 10.1136/gutjnl-2018-317805. Epub 2019 Apr 10.


Risk of mortality and cardiovascular events following macrolide prescription in chronic rhinosinusitis patients: a cohort study using linked primary care electronic health records.

Williamson E, Denaxas S, Morris S, Clarke CS, Thomas M, Evans H, Direk K, Gonzalez-Izquierdo A, Little P, Lund V, Blackshaw H, Schilder A, Philpott C, Hopkins C, Carpenter J, Programme Team OBOTM.

Rhinology. 2019 Aug 1;57(4):252-260. doi: 10.4193/Rhin18.237.


Non-invasive imaging techniques for the differentiation of acute and chronic thrombosis.

Yusof NNM, McCann A, Little PJ, Ta HT.

Thromb Res. 2019 May;177:161-171. doi: 10.1016/j.thromres.2019.03.009. Epub 2019 Mar 14. Review.


Electronically delivered interventions to reduce antibiotic prescribing for respiratory infections in primary care: cluster RCT using electronic health records and cohort study.

Gulliford MC, Juszczyk D, Prevost AT, Soames J, McDermott L, Sultana K, Wright M, Fox R, Hay AD, Little P, Moore M, Yardley L, Ashworth M, Charlton J.

Health Technol Assess. 2019 Mar;23(11):1-70. doi: 10.3310/hta23110.


Parental and clinician agreement of illness severity in children with RTIs: secondary analysis of data from a prospective cohort study.

van der Werf ET, Redmond NM, Turnbull S, Thornton H, Thompson M, Little P, Peters TJ, Blair PS, Hay AD.

Br J Gen Pract. 2019 Apr;69(681):e236-e245. doi: 10.3399/bjgp19X701837. Epub 2019 Mar 11.

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