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Items: 1 to 50 of 1010

1.

Hydrogels Based on Poly(aspartic acid): Synthesis and Applications.

Adelnia H, Blakey I, Little PJ, Ta HT.

Front Chem. 2019 Nov 12;7:755. doi: 10.3389/fchem.2019.00755. eCollection 2019. Review.

2.

Young people's perceptions of acne and acne treatments: secondary analysis of qualitative interview data.

Ip A, Muller I, Geraghty AWA, McNiven A, Little P, Santer M.

Br J Dermatol. 2019 Nov 7. doi: 10.1111/bjd.18684. [Epub ahead of print]

PMID:
31701523
3.

ROS directly activates transforming growth factor β type 1 receptor signalling in human vascular smooth muscle cells.

Mohamed R, Cao Y, Afroz R, Xu S, Ta HT, Barras M, Zheng W, Little PJ, Kamato D.

Biochim Biophys Acta Gen Subj. 2020 Jan;1864(1):129463. doi: 10.1016/j.bbagen.2019.129463. Epub 2019 Oct 30.

PMID:
31676288
4.

Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care.

Roddy E, Clarkson K, Blagojevic-Bucknall M, Mehta R, Oppong R, Avery A, Hay EM, Heneghan C, Hartshorne L, Hooper J, Hughes G, Jowett S, Lewis M, Little P, McCartney K, Mahtani KR, Nunan D, Santer M, Williams S, Mallen CD.

Ann Rheum Dis. 2019 Oct 30. pii: annrheumdis-2019-216154. doi: 10.1136/annrheumdis-2019-216154. [Epub ahead of print]

5.

Exploring the appropriateness of antibiotic prescribing for common respiratory tract infections in UK primary care.

Stuart B, Brotherwood H, Van't Hoff C, Brown A, van den Bruel A, Hay AD, Moore M, Little P.

J Antimicrob Chemother. 2019 Oct 21. pii: dkz410. doi: 10.1093/jac/dkz410. [Epub ahead of print]

PMID:
31637421
6.

Developing a digital intervention for cancer survivors: an evidence-, theory- and person-based approach.

Bradbury K, Steele M, Corbett T, Geraghty AWA, Krusche A, Heber E, Easton S, Cheetham-Blake T, Slodkowska-Barabasz J, Müller AM, Smith K, Wilde LJ, Payne L, Singh K, Bacon R, Burford T, Summers K, Turner L, Richardson A, Watson E, Foster C, Little P, Yardley L.

NPJ Digit Med. 2019 Sep 2;2:85. doi: 10.1038/s41746-019-0163-4. eCollection 2019.

7.

Optimizing design of research to evaluate antibiotic stewardship interventions: consensus recommendations of a multinational working group.

Schweitzer VA, van Werkhoven CH, Rodríguez Baño J, Bielicki J, Harbarth S, Hulscher M, Huttner B, Islam J, Little P, Pulcini C, Savoldi A, Tacconelli E, Timsit JF, van Smeden M, Wolkewitz M, Bonten MJM, Walker AS, Llewelyn MJ; Joint Programming Initiative on Antimicrobial Resistance (JPIAMR) Working Group on Design of Antimicrobial Stewardship Evaluations.

Clin Microbiol Infect. 2019 Sep 4. pii: S1198-743X(19)30477-X. doi: 10.1016/j.cmi.2019.08.017. [Epub ahead of print]

8.

Cognitive behavioural therapy for irritable bowel syndrome: 24-month follow-up of participants in the ACTIB randomised trial.

Everitt HA, Landau S, O'Reilly G, Sibelli A, Hughes S, Windgassen S, Holland R, Little P, McCrone P, Bishop FL, Goldsmith K, Coleman N, Logan R, Chalder T, Moss-Morris R.

Lancet Gastroenterol Hepatol. 2019 Nov;4(11):863-872. doi: 10.1016/S2468-1253(19)30243-2. Epub 2019 Sep 3.

9.

Antibiotic usage in chronic rhinosinusitis: analysis of national primary care electronic health records.

Hopkins C, Williamson E, Morris S, Clarke CS, Thomas M, Evans H, Little P, Lund VJ, Blackshaw H, Schilder A, Philpott C, Carpenter J, Denaxas S; MACRO programme team.

Rhinology. 2019 Sep 6. doi: 10.4193/Rhin19.136. [Epub ahead of print]

PMID:
31490466
10.

Lysophosphatidic acid and its receptors: pharmacology and therapeutic potential in atherosclerosis and vascular disease.

Zhou Y, Little PJ, Ta HT, Xu S, Kamato D.

Pharmacol Ther. 2019 Dec;204:107404. doi: 10.1016/j.pharmthera.2019.107404. Epub 2019 Aug 28. Review.

PMID:
31472182
11.

Smad linker region phosphorylation is a signalling pathway in its own right and not only a modulator of canonical TGF-β signalling.

Kamato D, Do BH, Osman N, Ross BP, Mohamed R, Xu S, Little PJ.

Cell Mol Life Sci. 2019 Aug 12. doi: 10.1007/s00018-019-03266-3. [Epub ahead of print] Review.

PMID:
31407020
12.

HATRIC: a study of Pelargonium sidoides root extract EPs®7630 (Kaloba®) for the treatment of acute cough due to lower respiratory tract infection in adults-study protocol for a double blind, placebo-controlled randomised feasibility trial.

Whitehead A, Simpson C, Willcox M, Webley F, Hay AD, Butler C, Yao L, Wrixon E, Bell M, Bostock J, Little P, Griffiths G, Moore M.

Pilot Feasibility Stud. 2019 Jul 31;5:98. doi: 10.1186/s40814-019-0478-6. eCollection 2019.

13.

Challenges in managing urinary tract infection and the potential of a point-of-care test guided care in primary care: an international qualitative study.

Brookes-Howell L, Thomas-Jones E, Bates J, Bekkers MJ, Brugman C, Coulman E, Francis N, Hashmi K, Hood K, Kirby N, Llor C, Little P, Moore M, Moragas A, Rumsby K, Verheij T, Butler C.

BJGP Open. 2019 Jul 23;3(2). pii: bjgpopen18X101630. doi: 10.3399/bjgpopen18X101630. Print 2019 Jul.

14.

Role of Corticotropin Releasing Factor in the Neuroimmune Mechanisms of Depression: Examination of Current Pharmaceutical and Herbal Therapies.

Jiang Y, Peng T, Gaur U, Silva M, Little P, Chen Z, Qiu W, Zhang Y, Zheng W.

Front Cell Neurosci. 2019 Jul 2;13:290. doi: 10.3389/fncel.2019.00290. eCollection 2019.

15.

Barriers and facilitators to screening and treating malnutrition in older adults living in the community: a mixed-methods synthesis.

Harris PS, Payne L, Morrison L, Green SM, Ghio D, Hallett C, Parsons EL, Aveyard P, Roberts HC, Sutcliffe M, Robinson S, Slodkowska-Barabasz J, Little PS, Stroud MA, Yardley L.

BMC Fam Pract. 2019 Jul 15;20(1):100. doi: 10.1186/s12875-019-0983-y.

16.

Anaesthetic-analgesic ear drops to reduce antibiotic consumption in children with acute otitis media: the CEDAR RCT.

Hay AD, Downing H, Francis NA, Young GJ, Clement C, Harris SD, Ahern A, Schofield B, Thomas TE, Horwood J, Blair PS, Hollingworth W, Wilson V, Metcalfe C, Stoddart P, Nunez D, Lyttle MD, Little P, Moore MV.

Health Technol Assess. 2019 Jul;23(34):1-48. doi: 10.3310/hta23340.

17.

Mechanisms of PAR-1 mediated kinase receptor transactivation: Smad linker region phosphorylation.

Kamato D, Ta H, Afroz R, Xu S, Osman N, Little PJ.

J Cell Commun Signal. 2019 Jul 9. doi: 10.1007/s12079-019-00527-5. [Epub ahead of print]

PMID:
31290007
18.

Primer-free FISH probes from metagenomics/metatranscriptomics data permit the study of uncharacterised taxa in complex microbial communities.

Tan SM, Yung PYM, Hutchinson PE, Xie C, Teo GH, Ismail MH, Drautz-Moses DI, Little PFR, Williams RBH, Cohen Y.

NPJ Biofilms Microbiomes. 2019 Jun 25;5:17. doi: 10.1038/s41522-019-0090-9. eCollection 2019.

19.

Protocol for a double-blind placebo-controlled trial to evaluate the efficacy of probiotics in reducing antibiotics for infection in care home residents: the Probiotics to Reduce Infections iN CarE home reSidentS (PRINCESS) trial.

Owen-Jones E, Lowe R, Lown M, Gillespie D, Addison K, Bayer T, Calder PC, Davies J, Davoudianfar M, Downs J, Edwards A, Francis NA, Fuller R, Hobbs R, Hood K, Lau M, Little P, Moore M, Shepherd V, Stanton H, Toghill A, Wootton M, Butler CC.

BMJ Open. 2019 Jun 20;9(6):e027513. doi: 10.1136/bmjopen-2018-027513.

20.

Probiotics for preventing acute otitis media in children.

Scott AM, Clark J, Julien B, Islam F, Roos K, Grimwood K, Little P, Del Mar CB.

Cochrane Database Syst Rev. 2019 Jun 18;6:CD012941. doi: 10.1002/14651858.CD012941.pub2. Review.

PMID:
31210358
21.

Associating somatic mutations to clinical outcomes: a pan-cancer study of survival time.

Little P, Lin DY, Sun W.

Genome Med. 2019 May 28;11(1):37. doi: 10.1186/s13073-019-0643-9.

22.

Specialist call handlers' perspectives on providing help on a cancer helpline: A qualitative interview study.

Leydon GM, Halls A, Ekberg K, Latter S, Stuart B, Moynihan C, Salmon P, Danquah L, Brindle L, Howe S, Woods CJ, Little P.

Eur J Cancer Care (Engl). 2019 Sep;28(5):e13081. doi: 10.1111/ecc.13081. Epub 2019 May 23.

PMID:
31124213
23.

Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia: a protocol for a randomIsed controlled Trial (CAP-IT).

Lyttle MD, Bielicki JA, Barratt S, Dunn D, Finn A, Harper L, Jackson P, Powell CVE, Roland D, Stohr W, Sturgeon K, Wan M, Little P, Faust SN, Robotham J, Hay AD, Gibb DM, Sharland M; PERUKI, GAPRUKI and the CAP-IT trial team.

BMJ Open. 2019 May 22;9(5):e029875. doi: 10.1136/bmjopen-2019-029875.

24.

Predictors of Adverse Outcomes in Uncomplicated Lower Respiratory Tract Infections.

Moore M, Stuart B, Lown M, Van den Bruel A, Smith S, Knox K, Thompson MJ, Little P.

Ann Fam Med. 2019 May;17(3):231-238. doi: 10.1370/afm.2386.

25.

Therapist telephone-delivered CBT and web-based CBT compared with treatment as usual in refractory irritable bowel syndrome: the ACTIB three-arm RCT.

Everitt H, Landau S, Little P, Bishop FL, O'Reilly G, Sibelli A, Holland R, Hughes S, Windgassen S, McCrone P, Goldsmith K, Coleman N, Logan R, Chalder T, Moss-Morris R.

Health Technol Assess. 2019 Apr;23(17):1-154. doi: 10.3310/hta23170.

26.

Clarithromycin and endoscopic sinus surgery for adults with chronic rhinosinusitis with and without nasal polyps: study protocol for the MACRO randomised controlled trial.

Philpott C, le Conte S, Beard D, Cook J, Sones W, Morris S, Clarke CS, Thomas M, Little P, Vennik J, Lund V, Blackshaw H, Schilder A, Durham S, Denaxas S, Carpenter J, Boardman J, Hopkins C; MACRO programme team.

Trials. 2019 Apr 29;20(1):246. doi: 10.1186/s13063-019-3314-7.

27.

Treatment of atherosclerotic plaque: perspectives on theranostics.

Zhang Y, Koradia A, Kamato D, Popat A, Little PJ, Ta HT.

J Pharm Pharmacol. 2019 Jul;71(7):1029-1043. doi: 10.1111/jphp.13092. Epub 2019 Apr 25. Review.

PMID:
31025381
28.

Chronic rhinosinusitis: a qualitative study of patient views and experiences of current management in primary and secondary care.

Vennik J, Eyles C, Thomas M, Hopkins C, Little P, Blackshaw H, Schilder A, Savage I, Philpott CM.

BMJ Open. 2019 Apr 23;9(4):e022644. doi: 10.1136/bmjopen-2018-022644.

29.

Expert panel process to optimise the design of a randomised controlled trial in chronic rhinosinusitis (the MACRO programme).

Blackshaw H, Vennik J, Philpott C, Thomas M, Eyles C, Carpenter J, Clarke CS, Morris S, Schilder A, Lund V, Little P, Durham S, Denaxas S, Williamson E, Beard D, Cook J, Le Conte S, Airey K, Boardman J, Hopkins C.

Trials. 2019 Apr 23;20(1):230. doi: 10.1186/s13063-019-3318-3.

30.

Assessing telephone-delivered cognitive-behavioural therapy (CBT) and web-delivered CBT versus treatment as usual in irritable bowel syndrome (ACTIB): a multicentre randomised trial.

Everitt HA, Landau S, O'Reilly G, Sibelli A, Hughes S, Windgassen S, Holland R, Little P, McCrone P, Bishop F, Goldsmith K, Coleman N, Logan R, Chalder T, Moss-Morris R; ACTIB trial group.

Gut. 2019 Sep;68(9):1613-1623. doi: 10.1136/gutjnl-2018-317805. Epub 2019 Apr 10.

31.

Risk of mortality and cardiovascular events following macrolide prescription in chronic rhinosinusitis patients: a cohort study using linked primary care electronic health records.

Williamson E, Denaxas S, Morris S, Clarke CS, Thomas M, Evans H, Direk K, Gonzalez-Izquierdo A, Little P, Lund V, Blackshaw H, Schilder A, Philpott C, Hopkins C, Carpenter J, Programme Team OBOTM.

Rhinology. 2019 Aug 1;57(4):252-260. doi: 10.4193/Rhin18.237.

PMID:
30928998
32.

Non-invasive imaging techniques for the differentiation of acute and chronic thrombosis.

Yusof NNM, McCann A, Little PJ, Ta HT.

Thromb Res. 2019 May;177:161-171. doi: 10.1016/j.thromres.2019.03.009. Epub 2019 Mar 14. Review.

PMID:
30921535
33.

Electronically delivered interventions to reduce antibiotic prescribing for respiratory infections in primary care: cluster RCT using electronic health records and cohort study.

Gulliford MC, Juszczyk D, Prevost AT, Soames J, McDermott L, Sultana K, Wright M, Fox R, Hay AD, Little P, Moore M, Yardley L, Ashworth M, Charlton J.

Health Technol Assess. 2019 Mar;23(11):1-70. doi: 10.3310/hta23110.

34.

Parental and clinician agreement of illness severity in children with RTIs: secondary analysis of data from a prospective cohort study.

van der Werf ET, Redmond NM, Turnbull S, Thornton H, Thompson M, Little P, Peters TJ, Blair PS, Hay AD.

Br J Gen Pract. 2019 Apr;69(681):e236-e245. doi: 10.3399/bjgp19X701837. Epub 2019 Mar 11.

PMID:
30858333
35.

Antibiotic Prescribing for Acute Respiratory Tract Infections 12 Months After Communication and CRP Training: A Randomized Trial.

Little P, Stuart B, Francis N, Douglas E, Tonkin-Crine S, Anthierens S, Cals JWL, Melbye H, Santer M, Moore M, Coenen S, Butler CC, Hood K, Kelson M, Godycki-Cwirko M, Mierzecki A, Torres A, Llor C, Davies M, Mullee M, O'Reilly G, van der Velden A, Geraghty AWA, Goossens H, Verheij T, Yardley L; GRACE consortium.

Ann Fam Med. 2019 Mar;17(2):125-132. doi: 10.1370/afm.2356.

36.

Subacute fatigue in primary care - two sides of the story.

Hulme K, Little P, Burrows A, Julia A, Moss-Morris R.

Br J Health Psychol. 2019 May;24(2):419-442. doi: 10.1111/bjhp.12361. Epub 2019 Mar 8.

37.

Renewed: Protocol for a randomised controlled trial of a digital intervention to support quality of life in cancer survivors.

Krusche A, Bradbury K, Corbett T, Barnett J, Stuart B, Yao GL, Bacon R, Böhning D, Cheetham-Blake T, Eccles D, Foster C, Geraghty AWA, Leydon G, Müller A, Neal RD, Osborne R, Rathod S, Richardson A, Sharman G, Summers K, Watson E, Wilde L, Wilkinson C, Yardley L, Little P.

BMJ Open. 2019 Mar 1;9(3):e024862. doi: 10.1136/bmjopen-2018-024862.

38.

Targeting Mechanosensitive Transcription Factors in Atherosclerosis.

Niu N, Xu S, Xu Y, Little PJ, Jin ZG.

Trends Pharmacol Sci. 2019 Apr;40(4):253-266. doi: 10.1016/j.tips.2019.02.004. Epub 2019 Feb 28. Review.

PMID:
30826122
39.

Endothelin-1 increases CHSY-1 expression in aortic endothelial cells via transactivation of transforming growth factor β type I receptor induced by type B receptor endothelin-1.

Seif F, Little PJ, Niayesh-Mehr R, Zamanpour M, Babaahmadi-Rezaei H.

J Pharm Pharmacol. 2019 Jun;71(6):988-995. doi: 10.1111/jphp.13081. Epub 2019 Feb 27.

PMID:
30809816
40.

Effectiveness and safety of electronically delivered prescribing feedback and decision support on antibiotic use for respiratory illness in primary care: REDUCE cluster randomised trial.

Gulliford MC, Prevost AT, Charlton J, Juszczyk D, Soames J, McDermott L, Sultana K, Wright M, Fox R, Hay AD, Little P, Moore MV, Yardley L, Ashworth M.

BMJ. 2019 Feb 12;364:l236. doi: 10.1136/bmj.l236.

41.

COSUTI: a protocol for the development of a core outcome set (COS) for interventions for the treatment of uncomplicated urinary tract infection (UTI) in adults.

Duane S, Vellinga A, Murphy AW, Cormican M, Smyth A, Healy P, Moore M, Little P, Devane D.

Trials. 2019 Feb 7;20(1):106. doi: 10.1186/s13063-019-3194-x.

42.

The impact of the national action plan on the epidemiology of antibiotic resistance among 352,238 isolates in a teaching hospital in China from 2015 to 2018.

Wang S, Hu YJ, Little P, Wang Y, Chang Q, Zhou X, Moore M, Harwell JI.

Antimicrob Resist Infect Control. 2019 Jan 29;8:22. doi: 10.1186/s13756-019-0473-y. eCollection 2019.

43.

Complementary medicine use, views, and experiences: a national survey in England.

Sharp D, Lorenc A, Morris R, Feder G, Little P, Hollinghurst S, Mercer SW, MacPherson H.

BJGP Open. 2018 Nov 14;2(4):bjgpopen18X101614. doi: 10.3399/bjgpopen18X101614. eCollection 2018 Dec.

44.

Uva-ursi extract and ibuprofen as alternative treatments for uncomplicated urinary tract infection in women (ATAFUTI): a factorial randomized trial.

Moore M, Trill J, Simpson C, Webley F, Radford M, Stanton L, Maishman T, Galanopoulou A, Flower A, Eyles C, Willcox M, Hay AD, van der Werf E, Gibbons S, Lewith G, Little P, Griffiths G.

Clin Microbiol Infect. 2019 Aug;25(8):973-980. doi: 10.1016/j.cmi.2019.01.011. Epub 2019 Jan 25.

45.

Delayed antibiotic prescribing for respiratory tract infections: protocol of an individual patient data meta-analysis.

Stuart B, Hounkpatin H, Becque T, Yao G, Zhu S, Alonso-Coello P, Altiner A, Arroll B, Böhning D, Bostock J, Bucher HCC, de la Poza M, Francis NA, Gillespie D, Hay AD, Kenealy T, Löffler C, Mas-Dalmau G, Muñoz L, Samuel K, Moore M, Little P.

BMJ Open. 2019 Jan 21;9(1):e026925. doi: 10.1136/bmjopen-2018-026925.

46.

The International Collaborative on Fatigue Following Infection (COFFI).

Katz BZ, Collin SM, Murphy G, Moss-Morris R, Wyller VB, Wensaas KA, Hautvast JLA, Bleeker-Rovers CP, Vollmer-Conna U, Buchwald D, Taylor R, Little P, Crawley E, White PD, Lloyd A.

Fatigue. 2018;6(2):106-121. doi: 10.1080/21641846.2018.1426086. Epub 2018 Jan 19.

47.

The Prognostic Significance of Low-Frequency Somatic Mutations in Metastatic Cutaneous Melanoma.

Zhao X, Little P, Hoyle AP, Pegna GJ, Hayward MC, Ivanova A, Parker JS, Marron DL, Soloway MG, Jo H, Salazar AH, Papakonstantinou MP, Bouchard DM, Jefferys SR, Hoadley KA, Ollila DW, Frank JS, Thomas NE, Googe PB, Ezzell AJ, Collichio FA, Lee CB, Earp HS, Sharpless NE, Hugo W, Wilmott JS, Quek C, Waddell N, Johansson PA, Thompson JF, Hayward NK, Mann GJ, Lo RS, Johnson DB, Scolyer RA, Hayes DN, Moschos SJ.

Front Oncol. 2019 Jan 4;8:584. doi: 10.3389/fonc.2018.00584. eCollection 2018.

48.

Effectiveness of the probiotic Streptococcus salivarius K12 for the treatment and/or prevention of sore throat: a systematic review.

Wilcox CR, Stuart B, Leaver H, Lown M, Willcox M, Moore M, Little P.

Clin Microbiol Infect. 2019 Jun;25(6):673-680. doi: 10.1016/j.cmi.2018.12.031. Epub 2019 Jan 4.

PMID:
30616011
49.

Management strategies for chronic rhinosinusitis: a qualitative study of GP and ENT specialist views of current practice in the UK.

Vennik J, Eyles C, Thomas M, Hopkins C, Little P, Blackshaw H, Schilder A, Boardman J, Philpott CM.

BMJ Open. 2018 Dec 19;8(12):e022643. doi: 10.1136/bmjopen-2018-022643.

50.

Practice variation in the use of tests in UK primary care: a retrospective analysis of 16 million tests performed over 3.3 million patient years in 2015/16.

O'Sullivan JW, Stevens S, Oke J, Hobbs FDR, Salisbury C, Little P, Goldacre B, Bankhead C, Aronson JK, Heneghan C, Perera R.

BMC Med. 2018 Dec 20;16(1):229. doi: 10.1186/s12916-018-1217-1.

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