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Items: 1 to 50 of 978

1.

Electronically delivered interventions to reduce antibiotic prescribing for respiratory infections in primary care: cluster RCT using electronic health records and cohort study.

Gulliford MC, Juszczyk D, Prevost AT, Soames J, McDermott L, Sultana K, Wright M, Fox R, Hay AD, Little P, Moore M, Yardley L, Ashworth M, Charlton J.

Health Technol Assess. 2019 Mar;23(11):1-70. doi: 10.3310/hta23110.

PMID:
30900550
2.

Parental and clinician agreement of illness severity in children with RTIs: secondary analysis of data from a prospective cohort study.

van der Werf ET, Redmond NM, Turnbull S, Thornton H, Thompson M, Little P, Peters TJ, Blair PS, Hay AD.

Br J Gen Pract. 2019 Mar 11. pii: bjgp19X701837. doi: 10.3399/bjgp19X701837. [Epub ahead of print]

PMID:
30858333
3.

Antibiotic Prescribing for Acute Respiratory Tract Infections 12 Months After Communication and CRP Training: A Randomized Trial.

Little P, Stuart B, Francis N, Douglas E, Tonkin-Crine S, Anthierens S, Cals JWL, Melbye H, Santer M, Moore M, Coenen S, Butler CC, Hood K, Kelson M, Godycki-Cwirko M, Mierzecki A, Torres A, Llor C, Davies M, Mullee M, O'Reilly G, van der Velden A, Geraghty AWA, Goossens H, Verheij T, Yardley L; GRACE consortium.

Ann Fam Med. 2019 Mar;17(2):125-132. doi: 10.1370/afm.2356.

4.

Subacute fatigue in primary care - two sides of the story.

Hulme K, Little P, Burrows A, Julia A, Moss-Morris R.

Br J Health Psychol. 2019 Mar 8. doi: 10.1111/bjhp.12361. [Epub ahead of print]

PMID:
30848557
5.

Renewed: Protocol for a randomised controlled trial of a digital intervention to support quality of life in cancer survivors.

Krusche A, Bradbury K, Corbett T, Barnett J, Stuart B, Yao GL, Bacon R, Böhning D, Cheetham-Blake T, Eccles D, Foster C, Geraghty AWA, Leydon G, Müller A, Neal RD, Osborne R, Rathod S, Richardson A, Sharman G, Summers K, Watson E, Wilde L, Wilkinson C, Yardley L, Little P.

BMJ Open. 2019 Mar 1;9(3):e024862. doi: 10.1136/bmjopen-2018-024862.

6.

Targeting Mechanosensitive Transcription Factors in Atherosclerosis.

Niu N, Xu S, Xu Y, Little PJ, Jin ZG.

Trends Pharmacol Sci. 2019 Feb 27. pii: S0165-6147(19)30035-5. doi: 10.1016/j.tips.2019.02.004. [Epub ahead of print] Review.

PMID:
30826122
7.

Endothelin-1 increases CHSY-1 expression in aortic endothelial cells via transactivation of transforming growth factor β type I receptor induced by type B receptor endothelin-1.

Seif F, Little PJ, Niayesh-Mehr R, Zamanpour M, Babaahmadi-Rezaei H.

J Pharm Pharmacol. 2019 Feb 27. doi: 10.1111/jphp.13081. [Epub ahead of print]

PMID:
30809816
8.

Effectiveness and safety of electronically delivered prescribing feedback and decision support on antibiotic use for respiratory illness in primary care: REDUCE cluster randomised trial.

Gulliford MC, Prevost AT, Charlton J, Juszczyk D, Soames J, McDermott L, Sultana K, Wright M, Fox R, Hay AD, Little P, Moore MV, Yardley L, Ashworth M.

BMJ. 2019 Feb 12;364:l236. doi: 10.1136/bmj.l236.

9.

COSUTI: a protocol for the development of a core outcome set (COS) for interventions for the treatment of uncomplicated urinary tract infection (UTI) in adults.

Duane S, Vellinga A, Murphy AW, Cormican M, Smyth A, Healy P, Moore M, Little P, Devane D.

Trials. 2019 Feb 7;20(1):106. doi: 10.1186/s13063-019-3194-x.

10.

The impact of the national action plan on the epidemiology of antibiotic resistance among 352,238 isolates in a teaching hospital in China from 2015 to 2018.

Wang S, Hu YJ, Little P, Wang Y, Chang Q, Zhou X, Moore M, Harwell JI.

Antimicrob Resist Infect Control. 2019 Jan 29;8:22. doi: 10.1186/s13756-019-0473-y. eCollection 2019.

11.

Complementary medicine use, views, and experiences: a national survey in England.

Sharp D, Lorenc A, Morris R, Feder G, Little P, Hollinghurst S, Mercer SW, MacPherson H.

BJGP Open. 2018 Nov 14;2(4):bjgpopen18X101614. doi: 10.3399/bjgpopen18X101614. eCollection 2018 Dec.

12.

Uva-ursi extract and ibuprofen as alternative treatments for uncomplicated urinary tract infection in women (ATAFUTI): a factorial randomized trial.

Moore M, Trill J, Simpson C, Webley F, Radford M, Stanton L, Maishman T, Galanopoulou A, Flower A, Eyles C, Willcox M, Hay AD, van der Werf E, Gibbons S, Lewith G, Little P, Griffiths G.

Clin Microbiol Infect. 2019 Jan 25. pii: S1198-743X(19)30031-X. doi: 10.1016/j.cmi.2019.01.011. [Epub ahead of print]

13.

Delayed antibiotic prescribing for respiratory tract infections: protocol of an individual patient data meta-analysis.

Stuart B, Hounkpatin H, Becque T, Yao G, Zhu S, Alonso-Coello P, Altiner A, Arroll B, Böhning D, Bostock J, Bucher HCC, de la Poza M, Francis NA, Gillespie D, Hay AD, Kenealy T, Löffler C, Mas-Dalmau G, Muñoz L, Samuel K, Moore M, Little P.

BMJ Open. 2019 Jan 21;9(1):e026925. doi: 10.1136/bmjopen-2018-026925.

14.

The International Collaborative on Fatigue Following Infection (COFFI).

Katz BZ, Collin SM, Murphy G, Moss-Morris R, Wyller VB, Wensaas KA, Hautvast JLA, Bleeker-Rovers CP, Vollmer-Conna U, Buchwald D, Taylor R, Little P, Crawley E, White PD, Lloyd A.

Fatigue. 2018;6(2):106-121. doi: 10.1080/21641846.2018.1426086. Epub 2018 Jan 19.

15.

The Prognostic Significance of Low-Frequency Somatic Mutations in Metastatic Cutaneous Melanoma.

Zhao X, Little P, Hoyle AP, Pegna GJ, Hayward MC, Ivanova A, Parker JS, Marron DL, Soloway MG, Jo H, Salazar AH, Papakonstantinou MP, Bouchard DM, Jefferys SR, Hoadley KA, Ollila DW, Frank JS, Thomas NE, Googe PB, Ezzell AJ, Collichio FA, Lee CB, Earp HS, Sharpless NE, Hugo W, Wilmott JS, Quek C, Waddell N, Johansson PA, Thompson JF, Hayward NK, Mann GJ, Lo RS, Johnson DB, Scolyer RA, Hayes DN, Moschos SJ.

Front Oncol. 2019 Jan 4;8:584. doi: 10.3389/fonc.2018.00584. eCollection 2018.

16.

Effectiveness of the probiotic Streptococcus salivarius K12 for the treatment and/or prevention of sore throat: a systematic review.

Wilcox CR, Stuart B, Leaver H, Lown M, Willcox M, Moore M, Little P.

Clin Microbiol Infect. 2019 Jan 4. pii: S1198-743X(18)30843-7. doi: 10.1016/j.cmi.2018.12.031. [Epub ahead of print] Review.

PMID:
30616011
17.

Management strategies for chronic rhinosinusitis: a qualitative study of GP and ENT specialist views of current practice in the UK.

Vennik J, Eyles C, Thomas M, Hopkins C, Little P, Blackshaw H, Schilder A, Boardman J, Philpott CM.

BMJ Open. 2018 Dec 19;8(12):e022643. doi: 10.1136/bmjopen-2018-022643.

18.

Practice variation in the use of tests in UK primary care: a retrospective analysis of 16 million tests performed over 3.3 million patient years in 2015/16.

O'Sullivan JW, Stevens S, Oke J, Hobbs FDR, Salisbury C, Little P, Goldacre B, Bankhead C, Aronson JK, Heneghan C, Perera R.

BMC Med. 2018 Dec 20;16(1):229. doi: 10.1186/s12916-018-1217-1.

19.

Temporal trends in use of tests in UK primary care, 2000-15: retrospective analysis of 250 million tests.

O'Sullivan JW, Stevens S, Hobbs FDR, Salisbury C, Little P, Goldacre B, Bankhead C, Aronson JK, Perera R, Heneghan C.

BMJ. 2018 Nov 28;363:k4666. doi: 10.1136/bmj.k4666. Erratum in: BMJ. 2019 Jan 29;364:l444.

20.

The elicitation and management of multiple health concerns in GP consultations.

Stuart B, Leydon G, Woods C, Gennery E, Elsey C, Summers R, Stevenson F, Chew-Graham C, Barnes R, Drew P, Moore M, Little P.

Patient Educ Couns. 2018 Nov 14. pii: S0738-3991(18)30372-0. doi: 10.1016/j.pec.2018.11.009. [Epub ahead of print]

21.

Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics.

Xu S, Kamato D, Little PJ, Nakagawa S, Pelisek J, Jin ZG.

Pharmacol Ther. 2018 Nov 13. pii: S0163-7258(18)30200-6. doi: 10.1016/j.pharmthera.2018.11.003. [Epub ahead of print] Review.

PMID:
30439455
22.

Individual Smad2 linker region phosphorylation sites determine the expression of proteoglycan and glycosaminoglycan synthesizing genes.

Kamato D, Burch M, Zhou Y, Mohamed R, Stow JL, Osman N, Zheng W, Little PJ.

Cell Signal. 2019 Jan;53:365-373. doi: 10.1016/j.cellsig.2018.11.005. Epub 2018 Nov 10.

PMID:
30423352
23.

Transforming growth factor-β1 mediated CHST11 and CHSY1 mRNA expression is ROS dependent in vascular smooth muscle cells.

Mohamed R, Dayati P, Mehr RN, Kamato D, Seif F, Babaahmadi-Rezaei H, Little PJ.

J Cell Commun Signal. 2018 Nov 11. doi: 10.1007/s12079-018-0495-x. [Epub ahead of print]

PMID:
30417274
24.

Danhong injection in cardiovascular and cerebrovascular diseases: Pharmacological actions, molecular mechanisms, and therapeutic potential.

Feng X, Li Y, Wang Y, Li L, Little PJ, Xu SW, Liu S.

Pharmacol Res. 2019 Jan;139:62-75. doi: 10.1016/j.phrs.2018.11.006. Epub 2018 Nov 5. Review.

PMID:
30408571
25.

Targeting LOX-1 in atherosclerosis and vasculopathy: current knowledge and future perspectives.

Tian K, Ogura S, Little PJ, Xu SW, Sawamura T.

Ann N Y Acad Sci. 2018 Nov 1. doi: 10.1111/nyas.13984. [Epub ahead of print] Review.

PMID:
30381837
26.

'Trying to put a square peg into a round hole': a qualitative study of healthcare professionals' views of integrating complementary medicine into primary care for musculoskeletal and mental health comorbidity.

Sharp D, Lorenc A, Feder G, Little P, Hollinghurst S, Mercer S, MacPherson H.

BMC Complement Altern Med. 2018 Oct 29;18(1):290. doi: 10.1186/s12906-018-2349-8.

27.

Adding emollient bath additives to standard eczema management for children with eczema: the BATHE RCT.

Santer M, Rumsby K, Ridd MJ, Francis NA, Stuart B, Chorozoglou M, Roberts A, Liddiard L, Nollett C, Hooper J, Prude M, Wood W, Thomas-Jones E, Becque T, Thomas KS, Williams HC, Little P.

Health Technol Assess. 2018 Oct;22(57):1-116. doi: 10.3310/hta22570.

28.

Feasibility of weekly participant-reported data collection in a pragmatic randomised controlled trial in primary care: experiences from the BATHE trial (Bath Additives for the Treatment of cHildhood Eczema).

Stuart B, Rumsby K, Santer M, Ridd MJ, Francis NA, Chorozoglou M, Spreadbury C, Steele M, Nollett C, Liddiard L, Prude M, Hooper J, Thomas-Jones E, Roberts A, Thomas KS, Williams HC, Little P.

Trials. 2018 Oct 24;19(1):582. doi: 10.1186/s13063-018-2962-3.

29.

Scoping review of systematic reviews of complementary medicine for musculoskeletal and mental health conditions.

Lorenc A, Feder G, MacPherson H, Little P, Mercer SW, Sharp D.

BMJ Open. 2018 Oct 15;8(10):e020222. doi: 10.1136/bmjopen-2017-020222.

30.

Superselective endovascular tissue access using trans-vessel wall technique: feasibility study for treatment applications in heart, pancreas and kidney in swine.

Grankvist R, Jensen-Urstad M, Clarke J, Lehtinen M, Little P, Lundberg J, Arnberg F, Jonsson S, Chien KR, Holmin S.

J Intern Med. 2019 Apr;285(4):398-406. doi: 10.1111/joim.12841. Epub 2018 Oct 28.

PMID:
30289186
31.

OPtimising Treatment for MIld Systolic hypertension in the Elderly (OPTiMISE): protocol for a randomised controlled non-inferiority trial.

Sheppard JP, Burt J, Lown M, Temple E, Benson J, Ford GA, Heneghan C, Hobbs FDR, Jowett S, Little P, Mant J, Mollison J, Nickless A, Ogburn E, Payne R, Williams M, Yu LM, McManus RJ.

BMJ Open. 2018 Oct 4;8(9):e022930. doi: 10.1136/bmjopen-2018-022930.

32.

Multicentred randomised controlled trial of an augmented exercise referral scheme using web-based behavioural support in individuals with metabolic, musculoskeletal and mental health conditions: protocol for the e-coachER trial.

Ingram W, Webb D, Taylor RS, Anokye N, Yardley L, Jolly K, Mutrie N, Campbell JL, Dean SG, Greaves C, Steele M, Lambert JD, McAdam C, Jane B, King J, Jones RB, Little P, Woolf A, Erwin J, Charles N, Terry RH, Taylor AH; Trial Steering Committee.

BMJ Open. 2018 Sep 21;8(9):e022382. doi: 10.1136/bmjopen-2018-022382.

33.

Tanshinone IIA Attenuates Insulin Like Growth Factor 1 -Induced Cell Proliferation in PC12 Cells through the PI3K/Akt and MEK/ERK Pathways.

Wang H, Su X, Fang J, Xin X, Zhao X, Gaur U, Wen Q, Xu J, Little PJ, Zheng W.

Int J Mol Sci. 2018 Sep 12;19(9). pii: E2719. doi: 10.3390/ijms19092719.

34.

Impact of antibiotics for children presenting to general practice with cough on adverse outcomes: secondary analysis from a multicentre prospective cohort study.

Redmond NM, Turnbull S, Stuart B, Thornton HV, Christensen H, Blair PS, Delaney BC, Thompson M, Peters TJ, Hay AD, Little P.

Br J Gen Pract. 2018 Oct;68(675):e682-e693. doi: 10.3399/bjgp18X698873. Epub 2018 Sep 10. Erratum in: Br J Gen Pract. 2019 Jan;69(678):14.

35.

Cost-effectiveness of internet-based training for primary care clinicians on antibiotic prescribing for acute respiratory tract infections in Europe.

Oppong R, Smith RD, Little P, Verheij T, Butler CC, Goossens H, Coenen S, Jowett S, Roberts TE, Achana F, Stuart B, Coast J.

J Antimicrob Chemother. 2018 Nov 1;73(11):3189-3198. doi: 10.1093/jac/dky309.

PMID:
30165522
36.

Screening for Atrial Fibrillation Using Economical and Accurate Technology (From the SAFETY Study).

Lown M, Yue AM, Shah BN, Corbett SJ, Lewith G, Stuart B, Garrard J, Brown M, Little P, Moore M.

Am J Cardiol. 2018 Oct 15;122(8):1339-1344. doi: 10.1016/j.amjcard.2018.07.003. Epub 2018 Jul 19.

PMID:
30131106
37.

Clinical relevance of bacterial resistance in lower respiratory tract infection in primary care: secondary analysis of a multicentre European trial.

Teepe J, Broekhuizen BD, Goossens H, Hordijk PM, Loens K, Lammens C, Ieven M, Little P, Butler CC, Coenen S, Godycki-Cwirko M, Henriques-Normark B, Verheij TJ; GRACE consortium.

Br J Gen Pract. 2018 Sep;68(674):e627-e632. doi: 10.3399/bjgp18X698333. Epub 2018 Jul 30.

PMID:
30061194
38.

Activatable magnetic resonance nanosensor as a potential imaging agent for detecting and discriminating thrombosis.

Ta HT, Arndt N, Wu Y, Lim HJ, Landeen S, Zhang R, Kamato D, Little PJ, Whittaker AK, Xu ZP.

Nanoscale. 2018 Aug 9;10(31):15103-15115. doi: 10.1039/c8nr05095c.

PMID:
30059122
39.

Endothelial function and dysfunction: Impact of metformin.

Nafisa A, Gray SG, Cao Y, Wang T, Xu S, Wattoo FH, Barras M, Cohen N, Kamato D, Little PJ.

Pharmacol Ther. 2018 Dec;192:150-162. doi: 10.1016/j.pharmthera.2018.07.007. Epub 2018 Jul 27. Review.

PMID:
30056057
40.

Continuous low-dose antibiotic prophylaxis for adults with repeated urinary tract infections (AnTIC): a randomised, open-label trial.

Fisher H, Oluboyede Y, Chadwick T, Abdel-Fattah M, Brennand C, Fader M, Harrison S, Hilton P, Larcombe J, Little P, McClurg D, McColl E, N'Dow J, Ternent L, Thiruchelvam N, Timoney A, Vale L, Walton K, von Wilamowitz-Moellendorff A, Wilkinson J, Wood R, Pickard R.

Lancet Infect Dis. 2018 Sep;18(9):957-968. doi: 10.1016/S1473-3099(18)30279-2. Epub 2018 Jun 28. Erratum in: Lancet Infect Dis. 2018 Sep;18(9):941.

41.

Antivirals for influenza-Like Illness? A randomised Controlled trial of Clinical and Cost effectiveness in primary CarE (ALIC4 E): the ALIC4 E protocol.

Bongard E, van der Velden AW, Cook J, Saville B, Beutels P, Munck Aabenhus R, Brugman C, Chlabicz S, Coenen S, Colliers A, Davies M, De Paor M, De Sutter A, Francis NA, Glinz D, Godycki-Ćwirko M, Goossens H, Holmes J, Ieven M, de Jong M, Lindbaek M, Little P, Martinón-Torres F, Moragas A, Pauer J, Pfeiferová M, Radzeviciene-Jurgute R, Sundvall PD, Torres A, Touboul P, Varthalis D, Verheij T, Butler CC.

BMJ Open. 2018 Jul 12;8(7):e021032. doi: 10.1136/bmjopen-2017-021032.

42.

LCCC 1025: a phase II study of everolimus, trastuzumab, and vinorelbine to treat progressive HER2-positive breast cancer brain metastases.

Van Swearingen AED, Siegel MB, Deal AM, Sambade MJ, Hoyle A, Hayes DN, Jo H, Little P, Dees EC, Muss H, Jolly T, Zagar TM, Patel N, Miller CR, Parker JS, Smith JK, Fisher J, Shah N, Nabell L, Nanda R, Dillon P, Abramson V, Carey LA, Anders CK.

Breast Cancer Res Treat. 2018 Oct;171(3):637-648. doi: 10.1007/s10549-018-4852-5. Epub 2018 Jun 25.

PMID:
29938395
43.

Flow-dependent epigenetic regulation of IGFBP5 expression by H3K27me3 contributes to endothelial anti-inflammatory effects.

Xu S, Xu Y, Yin M, Zhang S, Liu P, Koroleva M, Si S, Little PJ, Pelisek J, Jin ZG.

Theranostics. 2018 Apr 30;8(11):3007-3021. doi: 10.7150/thno.21966. eCollection 2018.

44.

Do patients actually do what we ask: patient fidelity and persistence to the Targets and Self-Management for the Control of Blood Pressure in Stroke and at Risk Groups blood pressure self-management intervention.

Schwartz CL, Seyed-Safi A, Haque S, Bray EP, Greenfield S, Hobbs FDR, Little P, Mant J, Williams B, Mcmanus RJ.

J Hypertens. 2018 Aug;36(8):1753-1761. doi: 10.1097/HJH.0000000000001738.

PMID:
29889157
45.

Knowledge, Attitude, and Practice with Respect to Antibiotic Use among Chinese Medical Students: A Multicentre Cross-Sectional Study.

Hu Y, Wang X, Tucker JD, Little P, Moore M, Fukuda K, Zhou X.

Int J Environ Res Public Health. 2018 Jun 4;15(6). pii: E1165. doi: 10.3390/ijerph15061165.

46.

The clinical utility of the IRAC component of the Framework for Routine Outcome Measurement in Liaison Psychiatry (FROM-LP).

Guest C, Crockett S, Little P, Patel A.

BJPsych Bull. 2018 Aug;42(4):152-156. doi: 10.1192/bjb.2018.29. Epub 2018 Jun 1.

47.

Early use of Antibiotics for at Risk CHildren with InfluEnza (ARCHIE): protocol for a double-blind, randomised, placebo-controlled trial.

Wang K, Carver T, Tonner S, Semple MG, Hay AD, Moore M, Little P, Butler C, Farmer A, Perera R, Yu LM, Mallett S, Wolstenholme J, Harnden A.

BMJ Open. 2018 May 16;8(5):e021144. doi: 10.1136/bmjopen-2017-021144.

48.

Continuous low-dose antibiotic prophylaxis to prevent urinary tract infection in adults who perform clean intermittent self-catheterisation: the AnTIC RCT.

Pickard R, Chadwick T, Oluboyede Y, Brennand C, von Wilamowitz-Moellendorff A, McClurg D, Wilkinson J, Ternent L, Fisher H, Walton K, McColl E, Vale L, Wood R, Abdel-Fattah M, Hilton P, Fader M, Harrison S, Larcombe J, Little P, Timoney A, N'Dow J, Armstrong H, Morris N, Walker K, Thiruchelvam N.

Health Technol Assess. 2018 May;22(24):1-102. doi: 10.3310/hta22240.

49.

A trial like ALIC4E: why design a platform, response-adaptive, open, randomised controlled trial of antivirals for influenza-like illness?

Butler CC, Coenen S, Saville BR, Cook J, van der Velden A, Homes J, de Jong M, Little P, Goossens H, Beutels P, Ieven M, Francis N, Moons P, Bongard E, Verheij T.

ERJ Open Res. 2018 May 8;4(2). pii: 00046-2018. doi: 10.1183/23120541.00046-2018. eCollection 2018 Apr.

50.

Analytical performance of a platform for point-of-care CRP testing in adults consulting for lower respiratory tract infection in primary care.

Matheeussen V, Van Hoof V, Loens K, Lammens C, Vanderstraeten A, Coenen S, Butler CC, Little P, Verheij TJM, Goossens H, Ieven M; GRACE consortium.

Eur J Clin Microbiol Infect Dis. 2018 Jul;37(7):1319-1323. doi: 10.1007/s10096-018-3253-3. Epub 2018 May 10.

PMID:
29744764

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