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Items: 1 to 50 of 958

1.

Targeting epigenetics and non-coding RNAs in atherosclerosis: From mechanisms to therapeutics.

Xu S, Kamato D, Little PJ, Nakagawa S, Pelisek J, Jin ZG.

Pharmacol Ther. 2018 Nov 12. pii: S0163-7258(18)30200-6. doi: 10.1016/j.pharmthera.2018.11.003. [Epub ahead of print] Review.

PMID:
30439455
2.

Individual Smad2 linker region phosphorylation sites determine the expression of proteoglycan and glycosaminoglycan synthesizing genes.

Kamato D, Burch M, Yang Z, Mohamed R, Stow JL, Osman N, Little PJ.

Cell Signal. 2018 Nov 10. pii: S0898-6568(18)30275-4. doi: 10.1016/j.cellsig.2018.11.005. [Epub ahead of print]

PMID:
30423352
3.

Transforming growth factor-β1 mediated CHST11 and CHSY1 mRNA expression is ROS dependent in vascular smooth muscle cells.

Mohamed R, Dayati P, Mehr RN, Kamato D, Seif F, Babaahmadi-Rezaei H, Little PJ.

J Cell Commun Signal. 2018 Nov 11. doi: 10.1007/s12079-018-0495-x. [Epub ahead of print]

PMID:
30417274
4.

Danhong Injection in cardiovascular and cerebrovascular diseases: cardiovascular actions, molecular mechanisms, and therapeutic potential.

Feng X, Li Y, Wang Y, Li L, Little PJ, Xu SW, Liu S.

Pharmacol Res. 2018 Nov 5. pii: S1043-6618(18)30856-9. doi: 10.1016/j.phrs.2018.11.006. [Epub ahead of print] Review.

PMID:
30408571
5.

Targeting LOX-1 in atherosclerosis and vasculopathy: current knowledge and future perspectives.

Tian K, Ogura S, Little PJ, Xu SW, Sawamura T.

Ann N Y Acad Sci. 2018 Nov 1. doi: 10.1111/nyas.13984. [Epub ahead of print] Review.

PMID:
30381837
6.

'Trying to put a square peg into a round hole': a qualitative study of healthcare professionals' views of integrating complementary medicine into primary care for musculoskeletal and mental health comorbidity.

Sharp D, Lorenc A, Feder G, Little P, Hollinghurst S, Mercer S, MacPherson H.

BMC Complement Altern Med. 2018 Oct 29;18(1):290. doi: 10.1186/s12906-018-2349-8.

7.

Adding emollient bath additives to standard eczema management for children with eczema: the BATHE RCT.

Santer M, Rumsby K, Ridd MJ, Francis NA, Stuart B, Chorozoglou M, Roberts A, Liddiard L, Nollett C, Hooper J, Prude M, Wood W, Thomas-Jones E, Becque T, Thomas KS, Williams HC, Little P.

Health Technol Assess. 2018 Oct;22(57):1-116. doi: 10.3310/hta22570.

8.

Feasibility of weekly participant-reported data collection in a pragmatic randomised controlled trial in primary care: experiences from the BATHE trial (Bath Additives for the Treatment of cHildhood Eczema).

Stuart B, Rumsby K, Santer M, Ridd MJ, Francis NA, Chorozoglou M, Spreadbury C, Steele M, Nollett C, Liddiard L, Prude M, Hooper J, Thomas-Jones E, Roberts A, Thomas KS, Williams HC, Little P.

Trials. 2018 Oct 24;19(1):582. doi: 10.1186/s13063-018-2962-3.

9.

Scoping review of systematic reviews of complementary medicine for musculoskeletal and mental health conditions.

Lorenc A, Feder G, MacPherson H, Little P, Mercer SW, Sharp D.

BMJ Open. 2018 Oct 15;8(10):e020222. doi: 10.1136/bmjopen-2017-020222.

10.

Superselective endovascular tissue access using trans-vessel wall technique: feasibility study for treatment applications in heart, pancreas and kidney in swine.

Grankvist R, Jensen-Urstad M, Clarke J, Lehtinen M, Little P, Lundberg J, Arnberg F, Jonsson S, Chien KR, Holmin S.

J Intern Med. 2018 Oct 5. doi: 10.1111/joim.12841. [Epub ahead of print]

PMID:
30289186
11.

OPtimising Treatment for MIld Systolic hypertension in the Elderly (OPTiMISE): protocol for a randomised controlled non-inferiority trial.

Sheppard JP, Burt J, Lown M, Temple E, Benson J, Ford GA, Heneghan C, Hobbs FDR, Jowett S, Little P, Mant J, Mollison J, Nickless A, Ogburn E, Payne R, Williams M, Yu LM, McManus RJ.

BMJ Open. 2018 Oct 4;8(9):e022930. doi: 10.1136/bmjopen-2018-022930.

12.

Multicentred randomised controlled trial of an augmented exercise referral scheme using web-based behavioural support in individuals with metabolic, musculoskeletal and mental health conditions: protocol for the e-coachER trial.

Ingram W, Webb D, Taylor RS, Anokye N, Yardley L, Jolly K, Mutrie N, Campbell JL, Dean SG, Greaves C, Steele M, Lambert JD, McAdam C, Jane B, King J, Jones RB, Little P, Woolf A, Erwin J, Charles N, Terry RH, Taylor AH; Trial Steering Committee.

BMJ Open. 2018 Sep 21;8(9):e022382. doi: 10.1136/bmjopen-2018-022382.

13.

Tanshinone IIA Attenuates Insulin Like Growth Factor 1 -Induced Cell Proliferation in PC12 Cells through the PI3K/Akt and MEK/ERK Pathways.

Wang H, Su X, Fang J, Xin X, Zhao X, Gaur U, Wen Q, Xu J, Little PJ, Zheng W.

Int J Mol Sci. 2018 Sep 12;19(9). pii: E2719. doi: 10.3390/ijms19092719.

14.

Impact of antibiotics for children presenting to general practice with cough on adverse outcomes: secondary analysis from a multicentre prospective cohort study.

Redmond NM, Turnbull S, Stuart B, Thornton HV, Christensen H, Blair PS, Delaney BC, Thompson M, Peters TJ, Hay AD, Little P.

Br J Gen Pract. 2018 Oct;68(675):e682-e693. doi: 10.3399/bjgp18X698873. Epub 2018 Sep 10.

15.

Cost-effectiveness of internet-based training for primary care clinicians on antibiotic prescribing for acute respiratory tract infections in Europe.

Oppong R, Smith RD, Little P, Verheij T, Butler CC, Goossens H, Coenen S, Jowett S, Roberts TE, Achana F, Stuart B, Coast J.

J Antimicrob Chemother. 2018 Nov 1;73(11):3189-3198. doi: 10.1093/jac/dky309.

PMID:
30165522
16.

Screening for Atrial Fibrillation Using Economical and Accurate Technology (From the SAFETY Study).

Lown M, Yue AM, Shah BN, Corbett SJ, Lewith G, Stuart B, Garrard J, Brown M, Little P, Moore M.

Am J Cardiol. 2018 Oct 15;122(8):1339-1344. doi: 10.1016/j.amjcard.2018.07.003. Epub 2018 Jul 19.

PMID:
30131106
17.

Clinical relevance of bacterial resistance in lower respiratory tract infection in primary care: secondary analysis of a multicentre European trial.

Teepe J, Broekhuizen BD, Goossens H, Hordijk PM, Loens K, Lammens C, Ieven M, Little P, Butler CC, Coenen S, Godycki-Cwirko M, Henriques-Normark B, Verheij TJ; GRACE consortium.

Br J Gen Pract. 2018 Sep;68(674):e627-e632. doi: 10.3399/bjgp18X698333. Epub 2018 Jul 30.

PMID:
30061194
18.

Activatable magnetic resonance nanosensor as a potential imaging agent for detecting and discriminating thrombosis.

Ta HT, Arndt N, Wu Y, Lim HJ, Landeen S, Zhang R, Kamato D, Little PJ, Whittaker AK, Xu ZP.

Nanoscale. 2018 Aug 9;10(31):15103-15115. doi: 10.1039/c8nr05095c.

PMID:
30059122
19.

Endothelial function and dysfunction: Impact of metformin.

Nafisa A, Gray SG, Cao Y, Wang T, Xu S, Wattoo FH, Barras M, Cohen N, Kamato D, Little PJ.

Pharmacol Ther. 2018 Jul 27. pii: S0163-7258(18)30132-3. doi: 10.1016/j.pharmthera.2018.07.007. [Epub ahead of print] Review.

PMID:
30056057
20.

Continuous low-dose antibiotic prophylaxis for adults with repeated urinary tract infections (AnTIC): a randomised, open-label trial.

Fisher H, Oluboyede Y, Chadwick T, Abdel-Fattah M, Brennand C, Fader M, Harrison S, Hilton P, Larcombe J, Little P, McClurg D, McColl E, N'Dow J, Ternent L, Thiruchelvam N, Timoney A, Vale L, Walton K, von Wilamowitz-Moellendorff A, Wilkinson J, Wood R, Pickard R.

Lancet Infect Dis. 2018 Sep;18(9):957-968. doi: 10.1016/S1473-3099(18)30279-2. Epub 2018 Jun 28. Erratum in: Lancet Infect Dis. 2018 Sep;18(9):941.

21.

Antivirals for influenza-Like Illness? A randomised Controlled trial of Clinical and Cost effectiveness in primary CarE (ALIC4 E): the ALIC4 E protocol.

Bongard E, van der Velden AW, Cook J, Saville B, Beutels P, Munck Aabenhus R, Brugman C, Chlabicz S, Coenen S, Colliers A, Davies M, De Paor M, De Sutter A, Francis NA, Glinz D, Godycki-Ćwirko M, Goossens H, Holmes J, Ieven M, de Jong M, Lindbaek M, Little P, Martinón-Torres F, Moragas A, Pauer J, Pfeiferová M, Radzeviciene-Jurgute R, Sundvall PD, Torres A, Touboul P, Varthalis D, Verheij T, Butler CC.

BMJ Open. 2018 Jul 12;8(7):e021032. doi: 10.1136/bmjopen-2017-021032.

22.

LCCC 1025: a phase II study of everolimus, trastuzumab, and vinorelbine to treat progressive HER2-positive breast cancer brain metastases.

Van Swearingen AED, Siegel MB, Deal AM, Sambade MJ, Hoyle A, Hayes DN, Jo H, Little P, Dees EC, Muss H, Jolly T, Zagar TM, Patel N, Miller CR, Parker JS, Smith JK, Fisher J, Shah N, Nabell L, Nanda R, Dillon P, Abramson V, Carey LA, Anders CK.

Breast Cancer Res Treat. 2018 Jun 25. doi: 10.1007/s10549-018-4852-5. [Epub ahead of print]

PMID:
29938395
23.

Flow-dependent epigenetic regulation of IGFBP5 expression by H3K27me3 contributes to endothelial anti-inflammatory effects.

Xu S, Xu Y, Yin M, Zhang S, Liu P, Koroleva M, Si S, Little PJ, Pelisek J, Jin ZG.

Theranostics. 2018 Apr 30;8(11):3007-3021. doi: 10.7150/thno.21966. eCollection 2018.

24.

Do patients actually do what we ask: patient fidelity and persistence to the Targets and Self-Management for the Control of Blood Pressure in Stroke and at Risk Groups blood pressure self-management intervention.

Schwartz CL, Seyed-Safi A, Haque S, Bray EP, Greenfield S, Hobbs FDR, Little P, Mant J, Williams B, Mcmanus RJ.

J Hypertens. 2018 Aug;36(8):1753-1761. doi: 10.1097/HJH.0000000000001738.

PMID:
29889157
25.

Knowledge, Attitude, and Practice with Respect to Antibiotic Use among Chinese Medical Students: A Multicentre Cross-Sectional Study.

Hu Y, Wang X, Tucker JD, Little P, Moore M, Fukuda K, Zhou X.

Int J Environ Res Public Health. 2018 Jun 4;15(6). pii: E1165. doi: 10.3390/ijerph15061165.

26.

The clinical utility of the IRAC component of the Framework for Routine Outcome Measurement in Liaison Psychiatry (FROM-LP).

Guest C, Crockett S, Little P, Patel A.

BJPsych Bull. 2018 Aug;42(4):152-156. doi: 10.1192/bjb.2018.29. Epub 2018 Jun 1.

27.

Early use of Antibiotics for at Risk CHildren with InfluEnza (ARCHIE): protocol for a double-blind, randomised, placebo-controlled trial.

Wang K, Carver T, Tonner S, Semple MG, Hay AD, Moore M, Little P, Butler C, Farmer A, Perera R, Yu LM, Mallett S, Wolstenholme J, Harnden A.

BMJ Open. 2018 May 16;8(5):e021144. doi: 10.1136/bmjopen-2017-021144.

28.

Continuous low-dose antibiotic prophylaxis to prevent urinary tract infection in adults who perform clean intermittent self-catheterisation: the AnTIC RCT.

Pickard R, Chadwick T, Oluboyede Y, Brennand C, von Wilamowitz-Moellendorff A, McClurg D, Wilkinson J, Ternent L, Fisher H, Walton K, McColl E, Vale L, Wood R, Abdel-Fattah M, Hilton P, Fader M, Harrison S, Larcombe J, Little P, Timoney A, N'Dow J, Armstrong H, Morris N, Walker K, Thiruchelvam N.

Health Technol Assess. 2018 May;22(24):1-102. doi: 10.3310/hta22240.

29.

A trial like ALIC4E: why design a platform, response-adaptive, open, randomised controlled trial of antivirals for influenza-like illness?

Butler CC, Coenen S, Saville BR, Cook J, van der Velden A, Homes J, de Jong M, Little P, Goossens H, Beutels P, Ieven M, Francis N, Moons P, Bongard E, Verheij T.

ERJ Open Res. 2018 May 8;4(2). pii: 00046-2018. doi: 10.1183/23120541.00046-2018. eCollection 2018 Apr.

30.

Analytical performance of a platform for point-of-care CRP testing in adults consulting for lower respiratory tract infection in primary care.

Matheeussen V, Van Hoof V, Loens K, Lammens C, Vanderstraeten A, Coenen S, Butler CC, Little P, Verheij TJM, Goossens H, Ieven M; GRACE consortium.

Eur J Clin Microbiol Infect Dis. 2018 May 10. doi: 10.1007/s10096-018-3253-3. [Epub ahead of print]

PMID:
29744764
31.

Qualitative process study to explore the perceived burdens and benefits of a digital intervention for self-managing high blood pressure in Primary Care in the UK.

Morton K, Dennison L, Bradbury K, Band RJ, May C, Raftery J, Little P, McManus RJ, Yardley L.

BMJ Open. 2018 May 8;8(5):e020843. doi: 10.1136/bmjopen-2017-020843.

32.

Emollient bath additives for the treatment of childhood eczema (BATHE): multicentre pragmatic parallel group randomised controlled trial of clinical and cost effectiveness.

Santer M, Ridd MJ, Francis NA, Stuart B, Rumsby K, Chorozoglou M, Becque T, Roberts A, Liddiard L, Nollett C, Hooper J, Prude M, Wood W, Thomas KS, Thomas-Jones E, Williams HC, Little P.

BMJ. 2018 May 3;361:k1332. doi: 10.1136/bmj.k1332.

33.

Using the Person-Based Approach to optimise a digital intervention for the management of hypertension.

Bradbury K, Morton K, Band R, van Woezik A, Grist R, McManus RJ, Little P, Yardley L.

PLoS One. 2018 May 3;13(5):e0196868. doi: 10.1371/journal.pone.0196868. eCollection 2018.

34.

Economic analysis of oral dexamethasone for symptom relief of sore throat: the UK TOAST study.

Burns RM, Wolstenholme J, Jawad S, Williams N, Thompson M, Perera R, Hay AD, Heneghan C, Little P, Moore M, Hayward G; TOAST Trial Investigators.

BMJ Open. 2018 Apr 28;8(4):e019184. doi: 10.1136/bmjopen-2017-019184.

35.

Exploring cancer survivors' views of health behaviour change: "Where do you start, where do you stop with everything?"

Corbett T, Cheetham T, Müller AM, Slodkowska-Barabasz J, Wilde L, Krusche A, Richardson A, Foster C, Watson E, Little P, Yardley L, Bradbury K.

Psychooncology. 2018 Jul;27(7):1816-1824. doi: 10.1002/pon.4732. Epub 2018 May 1.

PMID:
29645327
37.

Development of a prediction tool for patients presenting with acute cough in primary care: a prognostic study spanning six European countries.

Bruyndonckx R, Hens N, Verheij TJ, Aerts M, Ieven M, Butler CC, Little P, Goossens H, Coenen S; GRACE project group.

Br J Gen Pract. 2018 May;68(670):e342-e350. doi: 10.3399/bjgp18X695789. Epub 2018 Apr 9.

PMID:
29632005
38.

Findings from a feasibility study to improve GP elicitation of patient concerns in UK general practice consultations.

Leydon GM, Stuart B, Summers RH, Little P, Ekberg S, Stevenson F, Chew-Graham CA, Brindle L, Heritage J, Drew P, Moore MV.

Patient Educ Couns. 2018 Aug;101(8):1394-1402. doi: 10.1016/j.pec.2018.03.009. Epub 2018 Mar 23.

PMID:
29627268
39.

Thrombin promotes PAI-1 expression and migration in keratinocytes via ERK dependent Smad linker region phosphorylation.

Talati N, Kamato D, Piva TJ, Little PJ, Osman N.

Cell Signal. 2018 Jul;47:37-43. doi: 10.1016/j.cellsig.2018.03.009. Epub 2018 Mar 22.

PMID:
29577978
40.

Changing environment of hyperglycemia in pregnancy: Gestational diabetes and diabetes mellitus in pregnancy.

Gray SG, Sweeting AN, Mcguire TM, Cohen N, Ross GP, Little PJ.

J Diabetes. 2018 Aug;10(8):633-640. doi: 10.1111/1753-0407.12660. Epub 2018 Apr 26. Review.

PMID:
29573162
41.

Response to: 'Screening for atrial fibrillation in hospitalised geriatric patients' by Tavernier et al.

Lown M, Shah BN, Corbett SJ, Yue A, Little P, Moore M.

Heart. 2018 Apr;104(7):624. doi: 10.1136/heartjnl-2017-312672. No abstract available.

PMID:
29535216
42.

Multimorbidity and Socioeconomic Deprivation in Primary Care Consultations.

Mercer SW, Zhou Y, Humphris GM, McConnachie A, Bakhshi A, Bikker A, Higgins M, Little P, Fitzpatrick B, Watt GCM.

Ann Fam Med. 2018 Mar;16(2):127-131. doi: 10.1370/afm.2202.

43.

The association between copy number aberration, DNA methylation and gene expression in tumor samples.

Sun W, Bunn P, Jin C, Little P, Zhabotynsky V, Perou CM, Hayes DN, Chen M, Lin DY.

Nucleic Acids Res. 2018 Apr 6;46(6):3009-3018. doi: 10.1093/nar/gky131.

44.

Using an internet intervention to support self-management of low back pain in primary care: findings from a randomised controlled feasibility trial (SupportBack).

Geraghty AWA, Stanford R, Stuart B, Little P, Roberts LC, Foster NE, Hill JC, Hay EM, Turner D, Malakan W, Leigh L, Yardley L.

BMJ Open. 2018 Mar 9;8(3):e016768. doi: 10.1136/bmjopen-2017-016768.

45.

G protein coupled receptors can transduce signals through carboxy terminal and linker region phosphorylation of Smad transcription factors.

Dayati P, Rezaei HB, Sharifat N, Kamato D, Little PJ.

Life Sci. 2018 Apr 15;199:10-15. doi: 10.1016/j.lfs.2018.03.004. Epub 2018 Mar 3. Review.

PMID:
29510197
46.

Point-of-care urine culture for managing urinary tract infection in primary care: a randomised controlled trial of clinical and cost-effectiveness.

Butler CC, Francis NA, Thomas-Jones E, Longo M, Wootton M, Llor C, Little P, Moore M, Bates J, Pickles T, Kirby N, Gillespie D, Rumsby K, Brugman C, Gal M, Hood K, Verheij T.

Br J Gen Pract. 2018 Apr;68(669):e268-e278. doi: 10.3399/bjgp18X695285. Epub 2018 Feb 26.

PMID:
29483078
47.

Protection of sheep by vaccination against experimental challenge with Leptospira borgpetersenii serovar Hardjo and L. interrogans serovar Pomona.

Clough WJ, Little PR, Hodge A, Chapman VC, Holz DK.

N Z Vet J. 2018 May;66(3):138-143. doi: 10.1080/00480169.2018.1441078. Epub 2018 Mar 8.

PMID:
29457991
48.

Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: Implications for lipoprotein binding and atherosclerosis.

Afroz R, Cao Y, Rostam MA, Ta H, Xu S, Zheng W, Osman N, Kamato D, Little PJ.

Pharmacol Ther. 2018 Jul;187:88-97. doi: 10.1016/j.pharmthera.2018.02.005. Epub 2018 Feb 15. Review.

PMID:
29454855
49.

Aetiology of lower respiratory tract infection in adults in primary care: a prospective study in 11 European countries.

Ieven M, Coenen S, Loens K, Lammens C, Coenjaerts F, Vanderstraeten A, Henriques-Normark B, Crook D, Huygen K, Butler CC, Verheij TJM, Little P, Zlateva K, van Loon A, Claas ECJ, Goossens H; GRACE consortium.

Clin Microbiol Infect. 2018 Nov;24(11):1158-1163. doi: 10.1016/j.cmi.2018.02.004. Epub 2018 Feb 12.

PMID:
29447989
50.

Flavopiridol Inhibits TGF-β-Stimulated Biglycan Synthesis by Blocking Linker Region Phosphorylation and Nuclear Translocation of Smad2.

Rostam MA, Shajimoon A, Kamato D, Mitra P, Piva TJ, Getachew R, Cao Y, Zheng W, Osman N, Little PJ.

J Pharmacol Exp Ther. 2018 Apr;365(1):156-164. doi: 10.1124/jpet.117.244483. Epub 2018 Feb 9.

PMID:
29438988

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