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Items: 1 to 50 of 938

1.

Antivirals for influenza-Like Illness? A randomised Controlled trial of Clinical and Cost effectiveness in primary CarE (ALIC4 E): the ALIC4 E protocol.

Bongard E, van der Velden AW, Cook J, Saville B, Beutels P, Munck Aabenhus R, Brugman C, Chlabicz S, Coenen S, Colliers A, Davies M, De Paor M, De Sutter A, Francis NA, Glinz D, Godycki-Ćwirko M, Goossens H, Holmes J, Ieven M, de Jong M, Lindbaek M, Little P, Martinón-Torres F, Moragas A, Pauer J, Pfeiferová M, Radzeviciene-Jurgute R, Sundvall PD, Torres A, Touboul P, Varthalis D, Verheij T, Butler CC.

BMJ Open. 2018 Jul 12;8(7):e021032. doi: 10.1136/bmjopen-2017-021032.

PMID:
30002007
2.

LCCC 1025: a phase II study of everolimus, trastuzumab, and vinorelbine to treat progressive HER2-positive breast cancer brain metastases.

Van Swearingen AED, Siegel MB, Deal AM, Sambade MJ, Hoyle A, Hayes DN, Jo H, Little P, Dees EC, Muss H, Jolly T, Zagar TM, Patel N, Miller CR, Parker JS, Smith JK, Fisher J, Shah N, Nabell L, Nanda R, Dillon P, Abramson V, Carey LA, Anders CK.

Breast Cancer Res Treat. 2018 Jun 25. doi: 10.1007/s10549-018-4852-5. [Epub ahead of print]

PMID:
29938395
3.

Flow-dependent epigenetic regulation of IGFBP5 expression by H3K27me3 contributes to endothelial anti-inflammatory effects.

Xu S, Xu Y, Yin M, Zhang S, Liu P, Koroleva M, Si S, Little PJ, Pelisek J, Jin ZG.

Theranostics. 2018 Apr 30;8(11):3007-3021. doi: 10.7150/thno.21966. eCollection 2018.

4.

Do patients actually do what we ask: patient fidelity and persistence to the Targets and Self-Management for the Control of Blood Pressure in Stroke and at Risk Groups blood pressure self-management intervention.

Schwartz CL, Seyed-Safi A, Haque S, Bray EP, Greenfield S, Hobbs FDR, Little P, Mant J, Williams B, Mcmanus RJ.

J Hypertens. 2018 Aug;36(8):1753-1761. doi: 10.1097/HJH.0000000000001738.

PMID:
29889157
5.

Knowledge, Attitude, and Practice with Respect to Antibiotic Use among Chinese Medical Students: A Multicentre Cross-Sectional Study.

Hu Y, Wang X, Tucker JD, Little P, Moore M, Fukuda K, Zhou X.

Int J Environ Res Public Health. 2018 Jun 4;15(6). pii: E1165. doi: 10.3390/ijerph15061165.

6.

The clinical utility of the IRAC component of the Framework for Routine Outcome Measurement in Liaison Psychiatry (FROM-LP).

Guest C, Crockett S, Little P, Patel A.

BJPsych Bull. 2018 Jun 1:1-5. doi: 10.1192/bjb.2018.29. [Epub ahead of print]

7.

Early use of Antibiotics for at Risk CHildren with InfluEnza (ARCHIE): protocol for a double-blind, randomised, placebo-controlled trial.

Wang K, Carver T, Tonner S, Semple MG, Hay AD, Moore M, Little P, Butler C, Farmer A, Perera R, Yu LM, Mallett S, Wolstenholme J, Harnden A.

BMJ Open. 2018 May 16;8(5):e021144. doi: 10.1136/bmjopen-2017-021144.

8.

Continuous low-dose antibiotic prophylaxis to prevent urinary tract infection in adults who perform clean intermittent self-catheterisation: the AnTIC RCT.

Pickard R, Chadwick T, Oluboyede Y, Brennand C, von Wilamowitz-Moellendorff A, McClurg D, Wilkinson J, Ternent L, Fisher H, Walton K, McColl E, Vale L, Wood R, Abdel-Fattah M, Hilton P, Fader M, Harrison S, Larcombe J, Little P, Timoney A, N'Dow J, Armstrong H, Morris N, Walker K, Thiruchelvam N.

Health Technol Assess. 2018 May;22(24):1-102. doi: 10.3310/hta22240.

9.

A trial like ALIC4E: why design a platform, response-adaptive, open, randomised controlled trial of antivirals for influenza-like illness?

Butler CC, Coenen S, Saville BR, Cook J, van der Velden A, Homes J, de Jong M, Little P, Goossens H, Beutels P, Ieven M, Francis N, Moons P, Bongard E, Verheij T.

ERJ Open Res. 2018 May 8;4(2). pii: 00046-2018. doi: 10.1183/23120541.00046-2018. eCollection 2018 Apr.

10.

Analytical performance of a platform for point-of-care CRP testing in adults consulting for lower respiratory tract infection in primary care.

Matheeussen V, Van Hoof V, Loens K, Lammens C, Vanderstraeten A, Coenen S, Butler CC, Little P, Verheij TJM, Goossens H, Ieven M; GRACE consortium.

Eur J Clin Microbiol Infect Dis. 2018 May 10. doi: 10.1007/s10096-018-3253-3. [Epub ahead of print]

PMID:
29744764
11.

Qualitative process study to explore the perceived burdens and benefits of a digital intervention for self-managing high blood pressure in Primary Care in the UK.

Morton K, Dennison L, Bradbury K, Band RJ, May C, Raftery J, Little P, McManus RJ, Yardley L.

BMJ Open. 2018 May 8;8(5):e020843. doi: 10.1136/bmjopen-2017-020843.

12.

Emollient bath additives for the treatment of childhood eczema (BATHE): multicentre pragmatic parallel group randomised controlled trial of clinical and cost effectiveness.

Santer M, Ridd MJ, Francis NA, Stuart B, Rumsby K, Chorozoglou M, Becque T, Roberts A, Liddiard L, Nollett C, Hooper J, Prude M, Wood W, Thomas KS, Thomas-Jones E, Williams HC, Little P.

BMJ. 2018 May 3;361:k1332. doi: 10.1136/bmj.k1332.

13.

Using the Person-Based Approach to optimise a digital intervention for the management of hypertension.

Bradbury K, Morton K, Band R, van Woezik A, Grist R, McManus RJ, Little P, Yardley L.

PLoS One. 2018 May 3;13(5):e0196868. doi: 10.1371/journal.pone.0196868. eCollection 2018.

14.

Economic analysis of oral dexamethasone for symptom relief of sore throat: the UK TOAST study.

Burns RM, Wolstenholme J, Jawad S, Williams N, Thompson M, Perera R, Hay AD, Heneghan C, Little P, Moore M, Hayward G; TOAST Trial Investigators.

BMJ Open. 2018 Apr 28;8(4):e019184. doi: 10.1136/bmjopen-2017-019184.

15.

Exploring cancer survivors' views of health behaviour change: "Where do you start, where do you stop with everything?"

Corbett T, Cheetham T, Müller AM, Slodkowska-Barabasz J, Wilde L, Krusche A, Richardson A, Foster C, Watson E, Little P, Yardley L, Bradbury K.

Psychooncology. 2018 Jul;27(7):1816-1824. doi: 10.1002/pon.4732. Epub 2018 May 1.

PMID:
29645327
17.

Development of a prediction tool for patients presenting with acute cough in primary care: a prognostic study spanning six European countries.

Bruyndonckx R, Hens N, Verheij TJ, Aerts M, Ieven M, Butler CC, Little P, Goossens H, Coenen S; GRACE project group.

Br J Gen Pract. 2018 May;68(670):e342-e350. doi: 10.3399/bjgp18X695789. Epub 2018 Apr 9.

PMID:
29632005
18.

Findings from a feasibility study to improve GP elicitation of patient concerns in UK general practice consultations.

Leydon GM, Stuart B, Summers RH, Little P, Ekberg S, Stevenson F, Chew-Graham CA, Brindle L, Heritage J, Drew P, Moore MV.

Patient Educ Couns. 2018 Aug;101(8):1394-1402. doi: 10.1016/j.pec.2018.03.009. Epub 2018 Mar 23.

PMID:
29627268
19.

Thrombin promotes PAI-1 expression and migration in keratinocytes via ERK dependent Smad linker region phosphorylation.

Talati N, Kamato D, Piva TJ, Little PJ, Osman N.

Cell Signal. 2018 Jul;47:37-43. doi: 10.1016/j.cellsig.2018.03.009. Epub 2018 Mar 22.

PMID:
29577978
20.

Changing environment of hyperglycemia in pregnancy: Gestational diabetes and diabetes mellitus in pregnancy.

Gray SG, Sweeting AN, Mcguire TM, Cohen N, Ross GP, Little PJ.

J Diabetes. 2018 Mar 23. doi: 10.1111/1753-0407.12660. [Epub ahead of print] Review.

PMID:
29573162
21.

Response to: 'Screening for atrial fibrillation in hospitalised geriatric patients' by Tavernier et al.

Lown M, Shah BN, Corbett SJ, Yue A, Little P, Moore M.

Heart. 2018 Apr;104(7):624. doi: 10.1136/heartjnl-2017-312672. No abstract available.

PMID:
29535216
22.

Multimorbidity and Socioeconomic Deprivation in Primary Care Consultations.

Mercer SW, Zhou Y, Humphris GM, McConnachie A, Bakhshi A, Bikker A, Higgins M, Little P, Fitzpatrick B, Watt GCM.

Ann Fam Med. 2018 Mar;16(2):127-131. doi: 10.1370/afm.2202.

23.

The association between copy number aberration, DNA methylation and gene expression in tumor samples.

Sun W, Bunn P, Jin C, Little P, Zhabotynsky V, Perou CM, Hayes DN, Chen M, Lin DY.

Nucleic Acids Res. 2018 Apr 6;46(6):3009-3018. doi: 10.1093/nar/gky131.

24.

Using an internet intervention to support self-management of low back pain in primary care: findings from a randomised controlled feasibility trial (SupportBack).

Geraghty AWA, Stanford R, Stuart B, Little P, Roberts LC, Foster NE, Hill JC, Hay EM, Turner D, Malakan W, Leigh L, Yardley L.

BMJ Open. 2018 Mar 9;8(3):e016768. doi: 10.1136/bmjopen-2017-016768.

25.

G protein coupled receptors can transduce signals through carboxy terminal and linker region phosphorylation of Smad transcription factors.

Dayati P, Rezaei HB, Sharifat N, Kamato D, Little PJ.

Life Sci. 2018 Apr 15;199:10-15. doi: 10.1016/j.lfs.2018.03.004. Epub 2018 Mar 3. Review.

PMID:
29510197
26.

Point-of-care urine culture for managing urinary tract infection in primary care: a randomised controlled trial of clinical and cost-effectiveness.

Butler CC, Francis NA, Thomas-Jones E, Longo M, Wootton M, Llor C, Little P, Moore M, Bates J, Pickles T, Kirby N, Gillespie D, Rumsby K, Brugman C, Gal M, Hood K, Verheij T.

Br J Gen Pract. 2018 Apr;68(669):e268-e278. doi: 10.3399/bjgp18X695285. Epub 2018 Feb 26.

PMID:
29483078
27.

Protection of sheep by vaccination against experimental challenge with Leptospira borgpetersenii serovar Hardjo and L. interrogans serovar Pomona.

Clough WJ, Little PR, Hodge A, Chapman VC, Holz DK.

N Z Vet J. 2018 May;66(3):138-143. doi: 10.1080/00480169.2018.1441078. Epub 2018 Mar 8.

PMID:
29457991
28.

Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: Implications for lipoprotein binding and atherosclerosis.

Afroz R, Cao Y, Rostam MA, Ta H, Xu S, Zheng W, Osman N, Kamato D, Little PJ.

Pharmacol Ther. 2018 Jul;187:88-97. doi: 10.1016/j.pharmthera.2018.02.005. Epub 2018 Feb 15. Review.

PMID:
29454855
29.

Aetiology of lower respiratory tract infection in adults in primary care: a prospective study in 11 European countries.

Ieven M, Coenen S, Loens K, Lammens C, Coenjaerts F, Vanderstraeten A, Henriques-Normark B, Crook D, Huygen K, Butler CC, Verheij TJM, Little P, Zlateva K, van Loon A, Claas ECJ, Goossens H; GRACE consortium.

Clin Microbiol Infect. 2018 Feb 12. pii: S1198-743X(18)30152-6. doi: 10.1016/j.cmi.2018.02.004. [Epub ahead of print]

PMID:
29447989
30.

Flavopiridol Inhibits TGF-β-Stimulated Biglycan Synthesis by Blocking Linker Region Phosphorylation and Nuclear Translocation of Smad2.

Rostam MA, Shajimoon A, Kamato D, Mitra P, Piva TJ, Getachew R, Cao Y, Zheng W, Osman N, Little PJ.

J Pharmacol Exp Ther. 2018 Apr;365(1):156-164. doi: 10.1124/jpet.117.244483. Epub 2018 Feb 9.

PMID:
29438988
31.

Effectiveness of general practitioner online training and an information booklet for parents on antibiotic prescribing for children with respiratory tract infection in primary care: a cluster randomized controlled trial.

Dekker ARJ, Verheij TJM, Broekhuizen BDL, Butler CC, Cals JWL, Francis NA, Little P, Sanders EAM, Yardley L, Zuithoff NPA, van der Velden AW.

J Antimicrob Chemother. 2018 May 1;73(5):1416-1422. doi: 10.1093/jac/dkx542.

PMID:
29438547
32.

What gives rise to clinician gut feeling, its influence on management decisions and its prognostic value for children with RTI in primary care: a prospective cohort study.

Turnbull S, Lucas PJ, Redmond NM, Christensen H, Thornton H, Cabral C, Blair PS, Delaney BC, Thompson M, Little P, Peters TJ, Hay AD.

BMC Fam Pract. 2018 Feb 5;19(1):25. doi: 10.1186/s12875-018-0716-7.

33.

Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl‑2‑like protein 11 and cyclin‑dependent kinase inhibitor 1B.

Yan F, Liao R, Lin S, Deng X, Little PJ, Zheng W.

Mol Med Rep. 2018 Feb;17(2):3109-3114. doi: 10.3892/mmr.2017.8215. Epub 2017 Dec 7.

PMID:
29257235
34.

Probiotic capsules and xylitol chewing gum to manage symptoms of pharyngitis: a randomized controlled factorial trial.

Little P, Stuart B, Wingrove Z, Mullee M, Thomas T, Johnson S, Leydon G, Richards-Hall S, Williamson I, Yao L, Zhu S, Moore M.

CMAJ. 2017 Dec 18;189(50):E1543-E1550. doi: 10.1503/cmaj.170599.

35.

Physiotherapy breathing retraining for asthma: a randomised controlled trial.

Bruton A, Lee A, Yardley L, Raftery J, Arden-Close E, Kirby S, Zhu S, Thiruvothiyur M, Webley F, Taylor L, Gibson D, Yao G, Stafford-Watson M, Versnel J, Moore M, George S, Little P, Djukanovic R, Price D, Pavord ID, Holgate ST, Thomas M.

Lancet Respir Med. 2018 Jan;6(1):19-28. doi: 10.1016/S2213-2600(17)30474-5. Epub 2017 Dec 14.

36.

Adverse Effects of Amoxicillin for Acute Lower Respiratory Tract Infection in Primary Care: Secondary and Subgroup Analysis of a Randomised Clinical Trial.

Tandan M, Vellinga A, Bruyndonckx R, Little P, Verheij T, Butler CC, Goossens H, Coenen S.

Antibiotics (Basel). 2017 Dec 13;6(4). pii: E36. doi: 10.3390/antibiotics6040036.

37.

General practitioner and nurse prescriber experiences of prescribing antibiotics for respiratory tract infections in UK primary care out-of-hours services (the UNITE study).

Williams SJ, Halls AV, Tonkin-Crine S, Moore MV, Latter SE, Little P, Eyles C, Postle K, Leydon GM.

J Antimicrob Chemother. 2017 Nov 27. doi: 10.1093/jac/dkx429. [Epub ahead of print]

38.

Qualitative interview study of antibiotics and self-management strategies for respiratory infections in primary care.

McDermott L, Leydon GM, Halls A, Kelly J, Nagle A, White J, Little P; PIPS investigators.

BMJ Open. 2017 Nov 26;7(11):e016903. doi: 10.1136/bmjopen-2017-016903.

39.

Predictors of pneumonia in lower respiratory tract infections: 3C prospective cough complication cohort study.

Moore M, Stuart B, Little P, Smith S, Thompson MJ, Knox K, van den Bruel A, Lown M, Mant D.

Eur Respir J. 2017 Nov 22;50(5). pii: 1700434. doi: 10.1183/13993003.00434-2017. Print 2017 Nov.

40.

Variations in presentation, management, and patient outcomes of urinary tract infection: a prospective four-country primary care observational cohort study.

Butler CC, Francis N, Thomas-Jones E, Llor C, Bongard E, Moore M, Little P, Bates J, Lau M, Pickles T, Gal M, Wootton M, Kirby N, Gillespie D, Rumbsy K, Brugman C, Hood K, Verheij T.

Br J Gen Pract. 2017 Dec;67(665):e830-e841. doi: 10.3399/bjgp17X693641.

PMID:
29158245
41.

Antibiotics or NSAIDs for uncomplicated urinary tract infection?

Little P.

BMJ. 2017 Nov 8;359:j5037. doi: 10.1136/bmj.j5037. No abstract available.

PMID:
29117972
42.

Amoxicillin for acute lower respiratory tract infection in primary care: subgroup analysis by bacterial and viral aetiology.

Bruyndonckx R, Stuart B, Little P, Hens N, Ieven M, Butler CC, Verheij T, Goossens H, Coenen S; GRACE project group.

Clin Microbiol Infect. 2017 Nov 3. pii: S1198-743X(17)30626-2. doi: 10.1016/j.cmi.2017.10.032. [Epub ahead of print]

PMID:
29108950
43.

'Well, it literally stops me from having a life when it's really bad': a nested qualitative interview study of patient views on the use of self-management treatments for the management of recurrent sinusitis (SNIFS trial).

Leydon GM, McDermott L, Thomas T, Halls A, Holdstock-Brown B, Petley S, Wiseman C, Little P; SNIFS Investigators.

BMJ Open. 2017 Nov 3;7(11):e017130. doi: 10.1136/bmjopen-2017-017130.

44.

Understanding acceptability of and engagement with Web-based interventions aiming to improve quality of life in cancer survivors: A synthesis of current research.

Corbett T, Singh K, Payne L, Bradbury K, Foster C, Watson E, Richardson A, Little P, Yardley L.

Psychooncology. 2018 Jan;27(1):22-33. doi: 10.1002/pon.4566. Epub 2017 Nov 21. Review.

PMID:
29044832
45.

Reducing early career general practitioners' antibiotic prescribing for respiratory tract infections: a pragmatic prospective non-randomised controlled trial.

Magin P, Tapley A, Morgan S, Davis JS, McElduff P, Yardley L, Henderson K, Dallas A, McArthur L, Mulquiney K, Davey A, Little P, Spike N, van Driel ML.

Fam Pract. 2018 Jan 16;35(1):53-60. doi: 10.1093/fampra/cmx070.

PMID:
28985369
46.

Focus on early-career GPs: qualitative evaluation of a multi-faceted educational intervention to improve antibiotic prescribing.

Deckx L, Anthierens S, Magin PJ, Morgan S, McArthur L, Yardley L, Dallas A, Little P, van Driel ML.

Fam Pract. 2018 Jan 16;35(1):99-104. doi: 10.1093/fampra/cmx074.

PMID:
28985300
47.

Corporate Mortality Files and Late Industrial Necropolitics.

Little PC.

Med Anthropol Q. 2018 Jun;32(2):161-176. doi: 10.1111/maq.12417. Epub 2017 Dec 12.

PMID:
28980396
48.

A randomised controlled study of the effectiveness of breathing retraining exercises taught by a physiotherapist either by instructional DVD or in face-to-face sessions in the management of asthma in adults.

Thomas M, Bruton A, Little P, Holgate S, Lee A, Yardley L, George S, Raftery J, Versnel J, Price D, Pavord I, Djukanovic R, Moore M, Kirby S, Yao G, Zhu S, Arden-Close E, Thiruvothiyur M, Webley F, Stafford-Watson M, Dixon E, Taylor L.

Health Technol Assess. 2017 Sep;21(53):1-162. doi: 10.3310/hta21530.

49.

Establishing multiple omics baselines for three Southeast Asian populations in the Singapore Integrative Omics Study.

Saw WY, Tantoso E, Begum H, Zhou L, Zou R, He C, Chan SL, Tan LW, Wong LP, Xu W, Moong DKN, Lim Y, Li B, Pillai NE, Peterson TA, Bielawny T, Meikle PJ, Mundra PA, Lim WY, Luo M, Chia KS, Ong RT, Brunham LR, Khor CC, Too HP, Soong R, Wenk MR, Little P, Teo YY.

Nat Commun. 2017 Sep 21;8(1):653. doi: 10.1038/s41467-017-00413-x.

50.

Qualitative interview study of parents' perspectives, concerns and experiences of the management of lower respiratory tract infections in children in primary care.

Halls A, Van't Hoff C, Little P, Verheij T, Leydon GM.

BMJ Open. 2017 Sep 15;7(9):e015701. doi: 10.1136/bmjopen-2016-015701.

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