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Items: 1 to 50 of 165

1.

DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation.

Wanner N, Vornweg J, Combes A, Wilson S, Plappert J, Rafflenbeul G, Puelles VG, Rahman RU, Liwinski T, Lindner S, Grahammer F, Kretz O, Wlodek ME, Romano T, Moritz KM, Boerries M, Busch H, Bonn S, Little MH, Bechtel-Walz W, Huber TB.

J Am Soc Nephrol. 2018 Dec 5. pii: ASN.2018070736. doi: 10.1681/ASN.2018070736. [Epub ahead of print]

PMID:
30518531
2.

Vascular bioengineering of scaffolds derived from human discarded transplant kidneys using human pluripotent stem cell-derived endothelium.

Leuning DG, Witjas FMR, Maanaoui M, de Graaf AMA, Lievers E, Geuens T, Avramut MC, Wiersma LE, van den Berg CW, Sol WMPJ, de Boer H, Wang G, la Pointe V, van der Vlag J, van Kooten C, van den Berg BM, Little MH, Engelse MA, Rabelink TJ.

Am J Transplant. 2018 Dec 1. doi: 10.1111/ajt.15200. [Epub ahead of print]

PMID:
30506641
3.

Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment.

O'Brien LL, Combes AN, Short KM, Lindström NO, Whitney PH, Cullen-McEwen LA, Ju A, Abdelhalim A, Michos O, Bertram JF, Smyth IM, Little MH, McMahon AP.

Elife. 2018 Dec 5;7. pii: e40392. doi: 10.7554/eLife.40392.

4.

3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening.

Hale LJ, Howden SE, Phipson B, Lonsdale A, Er PX, Ghobrial I, Hosawi S, Wilson S, Lawlor KT, Khan S, Oshlack A, Quinlan C, Lennon R, Little MH.

Nat Commun. 2018 Dec 4;9(1):5167. doi: 10.1038/s41467-018-07594-z.

5.

Recapitulating kidney development: Progress and challenges.

Little MH, Kumar SV, Forbes T.

Semin Cell Dev Biol. 2018 Sep 20. pii: S1084-9521(17)30426-3. doi: 10.1016/j.semcdb.2018.08.015. [Epub ahead of print] Review.

PMID:
30184476
6.

Branching morphogenesis in the developing kidney is not impacted by nephron formation or integration.

Short KM, Combes AN, Lisnyak V, Lefevre JG, Jones LK, Little MH, Hamilton NA, Smyth IM.

Elife. 2018 Jul 31;7. pii: e38992. doi: 10.7554/eLife.38992.

7.

Hamartin regulates cessation of mouse nephrogenesis independently of Mtor.

Volovelsky O, Nguyen T, Jarmas AE, Combes AN, Wilson SB, Little MH, Witte DP, Brunskill EW, Kopan R.

Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):5998-6003. doi: 10.1073/pnas.1712955115. Epub 2018 May 21.

8.

Shining a Light on Alport Syndrome.

Hale LJ, Little MH.

Cell Chem Biol. 2018 May 17;25(5):497-498. doi: 10.1016/j.chembiol.2018.05.001.

PMID:
29775602
9.

Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms.

Forbes TA, Howden SE, Lawlor K, Phipson B, Maksimovic J, Hale L, Wilson S, Quinlan C, Ho G, Holman K, Bennetts B, Crawford J, Trnka P, Oshlack A, Patel C, Mallett A, Simons C, Little MH.

Am J Hum Genet. 2018 May 3;102(5):816-831. doi: 10.1016/j.ajhg.2018.03.014. Epub 2018 Apr 26.

10.

Prolonged prenatal hypoxia selectively disrupts collecting duct patterning and postnatal function in male mouse offspring.

Walton SL, Singh RR, Little MH, Bowles J, Li J, Moritz KM.

J Physiol. 2018 Dec;596(23):5873-5889. doi: 10.1113/JP275918. Epub 2018 Jul 5.

PMID:
29676801
11.

Advances in predictive in vitro models of drug-induced nephrotoxicity.

Soo JY, Jansen J, Masereeuw R, Little MH.

Nat Rev Nephrol. 2018 Jun;14(6):378-393. doi: 10.1038/s41581-018-0003-9. Review.

12.

Simultaneous reprogramming and gene editing of human fibroblasts.

Howden SE, Thomson JA, Little MH.

Nat Protoc. 2018 May;13(5):875-898. doi: 10.1038/nprot.2018.007. Epub 2018 Apr 5.

13.

Renal Subcapsular Transplantation of PSC-Derived Kidney Organoids Induces Neo-vasculogenesis and Significant Glomerular and Tubular Maturation In Vivo.

van den Berg CW, Ritsma L, Avramut MC, Wiersma LE, van den Berg BM, Leuning DG, Lievers E, Koning M, Vanslambrouck JM, Koster AJ, Howden SE, Takasato M, Little MH, Rabelink TJ.

Stem Cell Reports. 2018 Mar 13;10(3):751-765. doi: 10.1016/j.stemcr.2018.01.041. Epub 2018 Mar 1.

14.

Crim1 is required for maintenance of the ocular lens epithelium.

Tam OH, Pennisi D, Wilkinson L, Little MH, Wazin F, Wan VL, Lovicu FJ.

Exp Eye Res. 2018 May;170:58-66. doi: 10.1016/j.exer.2018.02.012. Epub 2018 Feb 16.

PMID:
29458060
15.

Bayesian inference of agent-based models: a tool for studying kidney branching morphogenesis.

Lambert B, MacLean AL, Fletcher AG, Combes AN, Little MH, Byrne HM.

J Math Biol. 2018 Jun;76(7):1673-1697. doi: 10.1007/s00285-018-1208-z. Epub 2018 Feb 1.

16.

Development of the Human Fetal Kidney from Mid to Late Gestation in Male and Female Infants.

Ryan D, Sutherland MR, Flores TJ, Kent AL, Dahlstrom JE, Puelles VG, Bertram JF, McMahon AP, Little MH, Moore L, Black MJ.

EBioMedicine. 2018 Jan;27:275-283. doi: 10.1016/j.ebiom.2017.12.016. Epub 2017 Dec 20.

17.

Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number.

Combes AN, Wilson S, Phipson B, Binnie BB, Ju A, Lawlor KT, Cebrian C, Walton SL, Smyth IM, Moritz KM, Kopan R, Oshlack A, Little MH.

Kidney Int. 2018 Mar;93(3):589-598. doi: 10.1016/j.kint.2017.09.015. Epub 2017 Dec 6.

PMID:
29217079
18.

The kids are OK: it is discrimination not same-sex parents that harms children.

Knight KW, Stephenson SE, West S, Delatycki MB, Jones CA, Little MH, Patton GC, Sawyer SM, Skinner SR, Telfer MM, Wake M, North KN, Oberklaid F.

Med J Aust. 2017 Nov 6;207(9):374-375. No abstract available.

PMID:
29092695
19.

Prenatal hypoxia leads to hypertension, renal renin-angiotensin system activation and exacerbates salt-induced pathology in a sex-specific manner.

Walton SL, Bielefeldt-Ohmann H, Singh RR, Li J, Paravicini TM, Little MH, Moritz KM.

Sci Rep. 2017 Aug 15;7(1):8241. doi: 10.1038/s41598-017-08365-4.

20.

Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease.

Lu H, Galeano MCR, Ott E, Kaeslin G, Kausalya PJ, Kramer C, Ortiz-Brüchle N, Hilger N, Metzis V, Hiersche M, Tay SY, Tunningley R, Vij S, Courtney AD, Whittle B, Wühl E, Vester U, Hartleben B, Neuber S, Frank V, Little MH, Epting D, Papathanasiou P, Perkins AC, Wright GD, Hunziker W, Gee HY, Otto EA, Zerres K, Hildebrandt F, Roy S, Wicking C, Bergmann C.

Nat Genet. 2017 Jul;49(7):1025-1034. doi: 10.1038/ng.3871. Epub 2017 May 22.

21.

Making a Kidney Organoid Using the Directed Differentiation of Human Pluripotent Stem Cells.

Takasato M, Little MH.

Methods Mol Biol. 2017;1597:195-206. doi: 10.1007/978-1-4939-6949-4_14.

PMID:
28361319
22.

Organoids: a Special Issue.

Little MH.

Development. 2017 Mar 15;144(6):935-937. doi: 10.1242/dev.150292. No abstract available.

23.

Clinical-Grade Isolated Human Kidney Perivascular Stromal Cells as an Organotypic Cell Source for Kidney Regenerative Medicine.

Leuning DG, Reinders ME, Li J, Peired AJ, Lievers E, de Boer HC, Fibbe WE, Romagnani P, van Kooten C, Little MH, Engelse MA, Rabelink TJ.

Stem Cells Transl Med. 2017 Feb;6(2):405-418. doi: 10.5966/sctm.2016-0053. Epub 2016 Sep 20.

24.

Self-organisation after embryonic kidney dissociation is driven via selective adhesion of ureteric epithelial cells.

Lefevre JG, Chiu HS, Combes AN, Vanslambrouck JM, Ju A, Hamilton NA, Little MH.

Development. 2017 Mar 15;144(6):1087-1096. doi: 10.1242/dev.140228. Epub 2017 Feb 7.

25.

(Re)Building a Kidney.

Oxburgh L, Carroll TJ, Cleaver O, Gossett DR, Hoshizaki DK, Hubbell JA, Humphreys BD, Jain S, Jensen J, Kaplan DL, Kesselman C, Ketchum CJ, Little MH, McMahon AP, Shankland SJ, Spence JR, Valerius MT, Wertheim JA, Wessely O, Zheng Y, Drummond IA.

J Am Soc Nephrol. 2017 May;28(5):1370-1378. doi: 10.1681/ASN.2016101077. Epub 2017 Jan 17.

26.

Does Renal Repair Recapitulate Kidney Development?

Little MH, Kairath P.

J Am Soc Nephrol. 2017 Jan;28(1):34-46. doi: 10.1681/ASN.2016070748. Epub 2016 Oct 26. Review.

27.

Analysed cap mesenchyme track data from live imaging of mouse kidney development.

Lefevre JG, Combes AN, Little MH, Hamilton NA.

Data Brief. 2016 Sep 1;9:149-54. doi: 10.1016/j.dib.2016.08.053. eCollection 2016 Dec.

28.

Understanding kidney morphogenesis to guide renal tissue regeneration.

Little MH, Combes AN, Takasato M.

Nat Rev Nephrol. 2016 Oct;12(10):624-35. doi: 10.1038/nrneph.2016.126. Epub 2016 Aug 30. Review.

PMID:
27573726
29.

A strategy for generating kidney organoids: Recapitulating the development in human pluripotent stem cells.

Takasato M, Little MH.

Dev Biol. 2016 Dec 15;420(2):210-220. doi: 10.1016/j.ydbio.2016.08.024. Epub 2016 Aug 23. Review.

30.

Generation of kidney organoids from human pluripotent stem cells.

Takasato M, Er PX, Chiu HS, Little MH.

Nat Protoc. 2016 Sep;11(9):1681-92. doi: 10.1038/nprot.2016.098. Epub 2016 Aug 18.

31.

Generating kidney tissue from pluripotent stem cells.

Little MH.

Cell Death Discov. 2016 Jul 18;2:16053. doi: 10.1038/cddiscovery.2016.53. eCollection 2016. Review.

32.

A Cas9 Variant for Efficient Generation of Indel-Free Knockin or Gene-Corrected Human Pluripotent Stem Cells.

Howden SE, McColl B, Glaser A, Vadolas J, Petrou S, Little MH, Elefanty AG, Stanley EG.

Stem Cell Reports. 2016 Sep 13;7(3):508-517. doi: 10.1016/j.stemcr.2016.07.001. Epub 2016 Aug 4.

33.

Implicating municipalities in addressing household food insecurity in Canada: A pan-Canadian analysis of news print media coverage.

Collins PA, Gaucher M, Power EM, Little MH.

Can J Public Health. 2016 Jun 27;107(1):e68-74. doi: 10.17269/cjph.107.5231.

PMID:
27348113
34.

Cap mesenchyme cell swarming during kidney development is influenced by attraction, repulsion, and adhesion to the ureteric tip.

Combes AN, Lefevre JG, Wilson S, Hamilton NA, Little MH.

Dev Biol. 2016 Oct 15;418(2):297-306. doi: 10.1016/j.ydbio.2016.06.028. Epub 2016 Jun 23.

35.

Growing Kidney Tissue from Stem Cells: How Far from "Party Trick" to Medical Application?

Little MH.

Cell Stem Cell. 2016 Jun 2;18(6):695-8. doi: 10.1016/j.stem.2016.05.015.

36.

Regenerative medicine in kidney disease.

Little MH, Kairath P.

Kidney Int. 2016 Aug;90(2):289-299. doi: 10.1016/j.kint.2016.03.030. Epub 2016 May 24. Review.

PMID:
27234568
37.

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis.

Takasato M, Er PX, Chiu HS, Maier B, Baillie GJ, Ferguson C, Parton RG, Wolvetang EJ, Roost MS, Lopes SM, Little MH.

Nature. 2016 Aug 11;536(7615):238. doi: 10.1038/nature17982. Epub 2016 Apr 27. No abstract available.

PMID:
27120161
38.

Closing the circle: from organoids back to development.

Little MH.

Development. 2016 Mar 15;143(6):905-6. doi: 10.1242/dev.136150. No abstract available.

39.

Crim1 has cell-autonomous and paracrine roles during embryonic heart development.

Iyer S, Chou FY, Wang R, Chiu HS, Raju VK, Little MH, Thomas WG, Piper M, Pennisi DJ.

Sci Rep. 2016 Jan 29;6:19832. doi: 10.1038/srep19832.

40.

Neonatal vascularization and oxygen tension regulate appropriate perinatal renal medulla/papilla maturation.

Phua YL, Gilbert T, Combes A, Wilkinson L, Little MH.

J Pathol. 2016 Apr;238(5):665-76. doi: 10.1002/path.4690.

PMID:
26800422
41.

The Life Cycle of the Nephron Progenitor.

Little MH.

Dev Cell. 2015 Oct 12;35(1):5-6. doi: 10.1016/j.devcel.2015.09.023.

42.

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis.

Takasato M, Er PX, Chiu HS, Maier B, Baillie GJ, Ferguson C, Parton RG, Wolvetang EJ, Roost MS, Chuva de Sousa Lopes SM, Little MH.

Nature. 2015 Oct 22;526(7574):564-8. doi: 10.1038/nature15695. Epub 2015 Oct 7. Erratum in: Nature. 2016 Aug 11;536(7615):238.

PMID:
26444236
43.

Direct transcriptional reprogramming to nephron progenitors.

Vanslambrouck JM, Little MH.

Curr Opin Genet Dev. 2015 Oct;34:10-6. doi: 10.1016/j.gde.2015.06.001. Epub 2015 Jul 12. Review.

PMID:
26177475
44.

Evaluation of biomarkers for in vitro prediction of drug-induced nephrotoxicity: comparison of HK-2, immortalized human proximal tubule epithelial, and primary cultures of human proximal tubular cells.

Huang JX, Kaeslin G, Ranall MV, Blaskovich MA, Becker B, Butler MS, Little MH, Lash LH, Cooper MA.

Pharmacol Res Perspect. 2015 Jun;3(3):e00148. doi: 10.1002/prp2.148. Epub 2015 May 15.

45.

ROBO2 restricts the nephrogenic field and regulates Wolffian duct-nephrogenic cord separation.

Wainwright EN, Wilhelm D, Combes AN, Little MH, Koopman P.

Dev Biol. 2015 Aug 15;404(2):88-102. doi: 10.1016/j.ydbio.2015.05.023. Epub 2015 Jun 23.

46.

The origin of the mammalian kidney: implications for recreating the kidney in vitro.

Takasato M, Little MH.

Development. 2015 Jun 1;142(11):1937-47. doi: 10.1242/dev.104802. Review.

47.

An illustrated anatomical ontology of the developing mouse lower urogenital tract.

Georgas KM, Armstrong J, Keast JR, Larkins CE, McHugh KM, Southard-Smith EM, Cohn MJ, Batourina E, Dan H, Schneider K, Buehler DP, Wiese CB, Brennan J, Davies JA, Harding SD, Baldock RA, Little MH, Vezina CM, Mendelsohn C.

Development. 2015 May 15;142(10):1893-908. doi: 10.1242/dev.117903. Epub 2015 May 12.

48.

A spatially-averaged mathematical model of kidney branching morphogenesis.

Zubkov VS, Combes AN, Short KM, Lefevre J, Hamilton NA, Smyth IM, Little MH, Byrne HM.

J Theor Biol. 2015 Aug 21;379:24-37. doi: 10.1016/j.jtbi.2015.04.015. Epub 2015 Apr 24.

PMID:
25913880
49.

Generating a self-organizing kidney from pluripotent cells.

Little MH, Takasato M.

Curr Opin Organ Transplant. 2015 Apr;20(2):178-86. doi: 10.1097/MOT.0000000000000174. Review.

PMID:
25856180
50.

Improving our resolution of kidney morphogenesis across time and space.

Little MH.

Curr Opin Genet Dev. 2015 Jun;32:135-43. doi: 10.1016/j.gde.2015.03.001. Epub 2015 Mar 26. Review.

PMID:
25819979

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