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Correction: Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk (doi:10.1242/dev.178673).

Combes AN, Phipson B, Lawlor KT, Dorison A, Patrick R, Zappia L, Harvey RP, Oshlack A, Little MH.

Development. 2019 Jul 11;146(13). pii: dev182162. doi: 10.1242/dev.182162. No abstract available.


Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk.

Combes AN, Phipson B, Lawlor KT, Dorison A, Patrick R, Zappia L, Harvey RP, Oshlack A, Little MH.

Development. 2019 Jun 12;146(12). pii: dev178673. doi: 10.1242/dev.178673. Erratum in: Development. 2019 Jul 11;146(13):.


Advances in our understanding of genetic kidney disease using kidney organoids.

Little MH, Quinlan C.

Pediatr Nephrol. 2019 May 7. doi: 10.1007/s00467-019-04259-x. [Epub ahead of print] Review.


Reporter-based fate mapping in human kidney organoids confirms nephron lineage relationships and reveals synchronous nephron formation.

Howden SE, Vanslambrouck JM, Wilson SB, Tan KS, Little MH.

EMBO Rep. 2019 Apr;20(4). pii: e47483. doi: 10.15252/embr.201847483. Epub 2019 Mar 11.


Kidney micro-organoids in suspension culture as a scalable source of human pluripotent stem cell-derived kidney cells.

Kumar SV, Er PX, Lawlor KT, Motazedian A, Scurr M, Ghobrial I, Combes AN, Zappia L, Oshlack A, Stanley EG, Little MH.

Development. 2019 Mar 7;146(5). pii: dev172361. doi: 10.1242/dev.172361.


Direct reprogramming to human nephron progenitor-like cells using inducible piggyBac transposon expression of SNAI2-EYA1-SIX1.

Vanslambrouck JM, Woodard LE, Suhaimi N, Williams FM, Howden SE, Wilson SB, Lonsdale A, Er PX, Li J, Maksimovic J, Oshlack A, Wilson MH, Little MH.

Kidney Int. 2019 May;95(5):1153-1166. doi: 10.1016/j.kint.2018.11.041. Epub 2019 Feb 28.


Generating Kidney from Stem Cells.

Little MH, Hale LJ, Howden SE, Kumar SV.

Annu Rev Physiol. 2019 Feb 10;81:335-357. doi: 10.1146/annurev-physiol-020518-114331.


Nephron progenitor commitment is a stochastic process influenced by cell migration.

Lawlor KT, Zappia L, Lefevre J, Park JS, Hamilton NA, Oshlack A, Little MH, Combes AN.

Elife. 2019 Jan 24;8. pii: e41156. doi: 10.7554/eLife.41156.


Single-cell analysis reveals congruence between kidney organoids and human fetal kidney.

Combes AN, Zappia L, Er PX, Oshlack A, Little MH.

Genome Med. 2019 Jan 23;11(1):3. doi: 10.1186/s13073-019-0615-0.


Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis.

Yermalovich AV, Osborne JK, Sousa P, Han A, Kinney MA, Chen MJ, Robinton DA, Montie H, Pearson DS, Wilson SB, Combes AN, Little MH, Daley GQ.

Nat Commun. 2019 Jan 11;10(1):168. doi: 10.1038/s41467-018-08127-4.


Testing longitudinal associations between executive function and academic achievement.

Willoughby MT, Wylie AC, Little MH.

Dev Psychol. 2019 Apr;55(4):767-779. doi: 10.1037/dev0000664. Epub 2018 Dec 27.


Evaluation of variability in human kidney organoids.

Phipson B, Er PX, Combes AN, Forbes TA, Howden SE, Zappia L, Yen HJ, Lawlor KT, Hale LJ, Sun J, Wolvetang E, Takasato M, Oshlack A, Little MH.

Nat Methods. 2019 Jan;16(1):79-87. doi: 10.1038/s41592-018-0253-2. Epub 2018 Dec 20.


DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation.

Wanner N, Vornweg J, Combes A, Wilson S, Plappert J, Rafflenbeul G, Puelles VG, Rahman RU, Liwinski T, Lindner S, Grahammer F, Kretz O, Wlodek ME, Romano T, Moritz KM, Boerries M, Busch H, Bonn S, Little MH, Bechtel-Walz W, Huber TB.

J Am Soc Nephrol. 2019 Jan;30(1):63-78. doi: 10.1681/ASN.2018070736. Epub 2018 Dec 5.


Vascular bioengineering of scaffolds derived from human discarded transplant kidneys using human pluripotent stem cell-derived endothelium.

Leuning DG, Witjas FMR, Maanaoui M, de Graaf AMA, Lievers E, Geuens T, Avramut CM, Wiersma LE, van den Berg CW, Sol WMPJ, de Boer H, Wang G, LaPointe VLS, van der Vlag J, van Kooten C, van den Berg BM, Little MH, Engelse MA, Rabelink TJ.

Am J Transplant. 2019 May;19(5):1328-1343. doi: 10.1111/ajt.15200. Epub 2019 Jan 10.


Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment.

O'Brien LL, Combes AN, Short KM, Lindström NO, Whitney PH, Cullen-McEwen LA, Ju A, Abdelhalim A, Michos O, Bertram JF, Smyth IM, Little MH, McMahon AP.

Elife. 2018 Dec 5;7. pii: e40392. doi: 10.7554/eLife.40392.


3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening.

Hale LJ, Howden SE, Phipson B, Lonsdale A, Er PX, Ghobrial I, Hosawi S, Wilson S, Lawlor KT, Khan S, Oshlack A, Quinlan C, Lennon R, Little MH.

Nat Commun. 2018 Dec 4;9(1):5167. doi: 10.1038/s41467-018-07594-z.


Recapitulating kidney development: Progress and challenges.

Little MH, Kumar SV, Forbes T.

Semin Cell Dev Biol. 2019 Jul;91:153-168. doi: 10.1016/j.semcdb.2018.08.015. Epub 2018 Sep 20. Review.


Branching morphogenesis in the developing kidney is not impacted by nephron formation or integration.

Short KM, Combes AN, Lisnyak V, Lefevre JG, Jones LK, Little MH, Hamilton NA, Smyth IM.

Elife. 2018 Jul 31;7. pii: e38992. doi: 10.7554/eLife.38992.


Hamartin regulates cessation of mouse nephrogenesis independently of Mtor.

Volovelsky O, Nguyen T, Jarmas AE, Combes AN, Wilson SB, Little MH, Witte DP, Brunskill EW, Kopan R.

Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):5998-6003. doi: 10.1073/pnas.1712955115. Epub 2018 May 21.


Shining a Light on Alport Syndrome.

Hale LJ, Little MH.

Cell Chem Biol. 2018 May 17;25(5):497-498. doi: 10.1016/j.chembiol.2018.05.001.


Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms.

Forbes TA, Howden SE, Lawlor K, Phipson B, Maksimovic J, Hale L, Wilson S, Quinlan C, Ho G, Holman K, Bennetts B, Crawford J, Trnka P, Oshlack A, Patel C, Mallett A, Simons C, Little MH.

Am J Hum Genet. 2018 May 3;102(5):816-831. doi: 10.1016/j.ajhg.2018.03.014. Epub 2018 Apr 26.


Prolonged prenatal hypoxia selectively disrupts collecting duct patterning and postnatal function in male mouse offspring.

Walton SL, Singh RR, Little MH, Bowles J, Li J, Moritz KM.

J Physiol. 2018 Dec;596(23):5873-5889. doi: 10.1113/JP275918. Epub 2018 Jul 5.


Advances in predictive in vitro models of drug-induced nephrotoxicity.

Soo JY, Jansen J, Masereeuw R, Little MH.

Nat Rev Nephrol. 2018 Jun;14(6):378-393. doi: 10.1038/s41581-018-0003-9. Review.


Simultaneous reprogramming and gene editing of human fibroblasts.

Howden SE, Thomson JA, Little MH.

Nat Protoc. 2018 May;13(5):875-898. doi: 10.1038/nprot.2018.007. Epub 2018 Apr 5.


Renal Subcapsular Transplantation of PSC-Derived Kidney Organoids Induces Neo-vasculogenesis and Significant Glomerular and Tubular Maturation In Vivo.

van den Berg CW, Ritsma L, Avramut MC, Wiersma LE, van den Berg BM, Leuning DG, Lievers E, Koning M, Vanslambrouck JM, Koster AJ, Howden SE, Takasato M, Little MH, Rabelink TJ.

Stem Cell Reports. 2018 Mar 13;10(3):751-765. doi: 10.1016/j.stemcr.2018.01.041. Epub 2018 Mar 1.


Crim1 is required for maintenance of the ocular lens epithelium.

Tam OH, Pennisi D, Wilkinson L, Little MH, Wazin F, Wan VL, Lovicu FJ.

Exp Eye Res. 2018 May;170:58-66. doi: 10.1016/j.exer.2018.02.012. Epub 2018 Feb 16.


Bayesian inference of agent-based models: a tool for studying kidney branching morphogenesis.

Lambert B, MacLean AL, Fletcher AG, Combes AN, Little MH, Byrne HM.

J Math Biol. 2018 Jun;76(7):1673-1697. doi: 10.1007/s00285-018-1208-z. Epub 2018 Feb 1.


Development of the Human Fetal Kidney from Mid to Late Gestation in Male and Female Infants.

Ryan D, Sutherland MR, Flores TJ, Kent AL, Dahlstrom JE, Puelles VG, Bertram JF, McMahon AP, Little MH, Moore L, Black MJ.

EBioMedicine. 2018 Jan;27:275-283. doi: 10.1016/j.ebiom.2017.12.016. Epub 2017 Dec 20.


Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number.

Combes AN, Wilson S, Phipson B, Binnie BB, Ju A, Lawlor KT, Cebrian C, Walton SL, Smyth IM, Moritz KM, Kopan R, Oshlack A, Little MH.

Kidney Int. 2018 Mar;93(3):589-598. doi: 10.1016/j.kint.2017.09.015. Epub 2017 Dec 6.


The kids are OK: it is discrimination not same-sex parents that harms children.

Knight KW, Stephenson SE, West S, Delatycki MB, Jones CA, Little MH, Patton GC, Sawyer SM, Skinner SR, Telfer MM, Wake M, North KN, Oberklaid F.

Med J Aust. 2017 Nov 6;207(9):374-375. No abstract available.


Prenatal hypoxia leads to hypertension, renal renin-angiotensin system activation and exacerbates salt-induced pathology in a sex-specific manner.

Walton SL, Bielefeldt-Ohmann H, Singh RR, Li J, Paravicini TM, Little MH, Moritz KM.

Sci Rep. 2017 Aug 15;7(1):8241. doi: 10.1038/s41598-017-08365-4.


Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease.

Lu H, Galeano MCR, Ott E, Kaeslin G, Kausalya PJ, Kramer C, Ortiz-Brüchle N, Hilger N, Metzis V, Hiersche M, Tay SY, Tunningley R, Vij S, Courtney AD, Whittle B, Wühl E, Vester U, Hartleben B, Neuber S, Frank V, Little MH, Epting D, Papathanasiou P, Perkins AC, Wright GD, Hunziker W, Gee HY, Otto EA, Zerres K, Hildebrandt F, Roy S, Wicking C, Bergmann C.

Nat Genet. 2017 Jul;49(7):1025-1034. doi: 10.1038/ng.3871. Epub 2017 May 22.


Making a Kidney Organoid Using the Directed Differentiation of Human Pluripotent Stem Cells.

Takasato M, Little MH.

Methods Mol Biol. 2017;1597:195-206. doi: 10.1007/978-1-4939-6949-4_14.


Organoids: a Special Issue.

Little MH.

Development. 2017 Mar 15;144(6):935-937. doi: 10.1242/dev.150292. No abstract available.


Clinical-Grade Isolated Human Kidney Perivascular Stromal Cells as an Organotypic Cell Source for Kidney Regenerative Medicine.

Leuning DG, Reinders ME, Li J, Peired AJ, Lievers E, de Boer HC, Fibbe WE, Romagnani P, van Kooten C, Little MH, Engelse MA, Rabelink TJ.

Stem Cells Transl Med. 2017 Feb;6(2):405-418. doi: 10.5966/sctm.2016-0053. Epub 2016 Sep 20.


Self-organisation after embryonic kidney dissociation is driven via selective adhesion of ureteric epithelial cells.

Lefevre JG, Chiu HS, Combes AN, Vanslambrouck JM, Ju A, Hamilton NA, Little MH.

Development. 2017 Mar 15;144(6):1087-1096. doi: 10.1242/dev.140228. Epub 2017 Feb 7.


(Re)Building a Kidney.

Oxburgh L, Carroll TJ, Cleaver O, Gossett DR, Hoshizaki DK, Hubbell JA, Humphreys BD, Jain S, Jensen J, Kaplan DL, Kesselman C, Ketchum CJ, Little MH, McMahon AP, Shankland SJ, Spence JR, Valerius MT, Wertheim JA, Wessely O, Zheng Y, Drummond IA.

J Am Soc Nephrol. 2017 May;28(5):1370-1378. doi: 10.1681/ASN.2016101077. Epub 2017 Jan 17.


Does Renal Repair Recapitulate Kidney Development?

Little MH, Kairath P.

J Am Soc Nephrol. 2017 Jan;28(1):34-46. doi: 10.1681/ASN.2016070748. Epub 2016 Oct 26. Review.


Analysed cap mesenchyme track data from live imaging of mouse kidney development.

Lefevre JG, Combes AN, Little MH, Hamilton NA.

Data Brief. 2016 Sep 1;9:149-54. doi: 10.1016/j.dib.2016.08.053. eCollection 2016 Dec.


Understanding kidney morphogenesis to guide renal tissue regeneration.

Little MH, Combes AN, Takasato M.

Nat Rev Nephrol. 2016 Oct;12(10):624-35. doi: 10.1038/nrneph.2016.126. Epub 2016 Aug 30. Review.


A strategy for generating kidney organoids: Recapitulating the development in human pluripotent stem cells.

Takasato M, Little MH.

Dev Biol. 2016 Dec 15;420(2):210-220. doi: 10.1016/j.ydbio.2016.08.024. Epub 2016 Aug 23. Review.


Generation of kidney organoids from human pluripotent stem cells.

Takasato M, Er PX, Chiu HS, Little MH.

Nat Protoc. 2016 Sep;11(9):1681-92. doi: 10.1038/nprot.2016.098. Epub 2016 Aug 18.


Generating kidney tissue from pluripotent stem cells.

Little MH.

Cell Death Discov. 2016 Jul 18;2:16053. doi: 10.1038/cddiscovery.2016.53. eCollection 2016. Review.


A Cas9 Variant for Efficient Generation of Indel-Free Knockin or Gene-Corrected Human Pluripotent Stem Cells.

Howden SE, McColl B, Glaser A, Vadolas J, Petrou S, Little MH, Elefanty AG, Stanley EG.

Stem Cell Reports. 2016 Sep 13;7(3):508-517. doi: 10.1016/j.stemcr.2016.07.001. Epub 2016 Aug 4.


Implicating municipalities in addressing household food insecurity in Canada: A pan-Canadian analysis of news print media coverage.

Collins PA, Gaucher M, Power EM, Little MH.

Can J Public Health. 2016 Jun 27;107(1):e68-74. doi: 10.17269/cjph.107.5231.


Cap mesenchyme cell swarming during kidney development is influenced by attraction, repulsion, and adhesion to the ureteric tip.

Combes AN, Lefevre JG, Wilson S, Hamilton NA, Little MH.

Dev Biol. 2016 Oct 15;418(2):297-306. doi: 10.1016/j.ydbio.2016.06.028. Epub 2016 Jun 23.


Growing Kidney Tissue from Stem Cells: How Far from "Party Trick" to Medical Application?

Little MH.

Cell Stem Cell. 2016 Jun 2;18(6):695-8. doi: 10.1016/j.stem.2016.05.015.


Regenerative medicine in kidney disease.

Little MH, Kairath P.

Kidney Int. 2016 Aug;90(2):289-299. doi: 10.1016/j.kint.2016.03.030. Epub 2016 May 24. Review.


Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis.

Takasato M, Er PX, Chiu HS, Maier B, Baillie GJ, Ferguson C, Parton RG, Wolvetang EJ, Roost MS, Lopes SM, Little MH.

Nature. 2016 Aug 11;536(7615):238. doi: 10.1038/nature17982. Epub 2016 Apr 27. No abstract available.


Closing the circle: from organoids back to development.

Little MH.

Development. 2016 Mar 15;143(6):905-6. doi: 10.1242/dev.136150. No abstract available.

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