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The relationship between synovial inflammation, structural pathology, and pain in post-traumatic osteoarthritis: differential effect of stem cell and hyaluronan treatment.

Shu CC, Zaki S, Ravi V, Schiavinato A, Smith MM, Little CB.

Arthritis Res Ther. 2020 Feb 14;22(1):29. doi: 10.1186/s13075-020-2117-2.


Stem cell directed therapies for osteoarthritis: The promise and the practice: Concise review.

Ng J, Little CB, Woods S, Whittle S, Lee FY, Gronthos S, Mukherjee S, Hunter DJ, Worthley DL.

Stem Cells. 2019 Dec 14. doi: 10.1002/stem.3139. [Epub ahead of print]


Assessment for varicella zoster virus in patients newly suspected of having giant cell arteritis.

Sammel AM, Smith S, Nguyen K, Laurent R, Brewer J, Hall N, Little CB.

Rheumatology (Oxford). 2019 Nov 27. pii: kez556. doi: 10.1093/rheumatology/kez556. [Epub ahead of print]


Functionally distinct tendons have different biomechanical, biochemical and histological responses to in vitro unloading.

Choi RK, Smith MM, Smith S, Little CB, Clarke EC.

J Biomech. 2019 Oct 11;95:109321. doi: 10.1016/j.jbiomech.2019.109321. Epub 2019 Aug 19.


Efficacy of administered mesenchymal stem cells in the initiation and co-ordination of repair processes by resident disc cells in an ovine (Ovis aries) large destabilizing lesion model of experimental disc degeneration.

Shu CC, Dart A, Bell R, Dart C, Clarke E, Smith MM, Little CB, Melrose J.

JOR Spine. 2018 Oct 10;1(4):e1037. doi: 10.1002/jsp2.1037. eCollection 2018 Dec.


Disrupted type II collagenolysis impairs angiogenesis, delays endochondral ossification and initiates aberrant ossification in mouse limbs.

Gauci SJ, Golub SB, Tatarczuch L, Lee E, Chan D, Walsh NC, Little CB, Stanton H, Lokmic Z, Sims NA, Mackie EJ, Fosang AJ.

Matrix Biol. 2019 Oct;83:77-96. doi: 10.1016/j.matbio.2019.08.001. Epub 2019 Aug 2.


Adding insult to injury: synergistic effect of combining risk-factors in models of post-traumatic osteoarthritis.

Blaker CL, Clarke EC, Little CB.

Osteoarthritis Cartilage. 2019 Dec;27(12):1731-1734. doi: 10.1016/j.joca.2019.06.010. Epub 2019 Jul 2. No abstract available.


Disruption of glucocorticoid signalling in osteoblasts attenuates age-related surgically induced osteoarthritis.

Tu J, Zhang P, Ji Z, Henneicke H, Li J, Kim S, Swarbrick MM, Wu Y, Little CB, Seibel MJ, Zhou H.

Osteoarthritis Cartilage. 2019 Oct;27(10):1518-1525. doi: 10.1016/j.joca.2019.04.019. Epub 2019 Jun 5.


Effects of tendon injury on uninjured regional tendons in the distal limb: An in-vivo study using an ovine tendinopathy model.

Tsang AS, Dart AJ, Biasutti SA, Jeffcott LB, Smith MM, Little CB.

PLoS One. 2019 Apr 23;14(4):e0215830. doi: 10.1371/journal.pone.0215830. eCollection 2019.


Stem Cell-Derived Extracellular Vesicles for Treating Joint Injury and Osteoarthritis.

Li JJ, Hosseini-Beheshti E, Grau GE, Zreiqat H, Little CB.

Nanomaterials (Basel). 2019 Feb 14;9(2). pii: E261. doi: 10.3390/nano9020261. Review.


Developing strategic priorities in osteoarthritis research: Proceedings and recommendations arising from the 2017 Australian Osteoarthritis Summit.

Hunter DJ, Nicolson PJA, Little CB, Robbins SR, Wang X, Bennell KL.

BMC Musculoskelet Disord. 2019 Feb 13;20(1):74. doi: 10.1186/s12891-019-2455-x.


Activated protein C targets immune cells and rheumatoid synovial fibroblasts to prevent inflammatory arthritis in mice.

Xue M, Dervish S, McKelvey KJ, March L, Wang F, Little CB, Jackson CJ.

Rheumatology (Oxford). 2019 Oct 1;58(10):1850-1860. doi: 10.1093/rheumatology/key429.


Elevated hypertrophy, growth plate maturation, glycosaminoglycan deposition, and exostosis formation in the Hspg2 exon 3 null mouse intervertebral disc.

Shu CC, Smith SM, Little CB, Melrose J.

Biochem J. 2019 Jan 18;476(2):225-243. doi: 10.1042/BCJ20180695.


Identification of TGFβ-related genes regulated in murine osteoarthritis and chondrocyte hypertrophy by comparison of multiple microarray datasets.

de Kroon LMG, van den Akker GGH, Brachvogel B, Narcisi R, Belluoccio D, Jenner F, Bateman JF, Little CB, Brama PAJ, Blaney Davidson EN, van der Kraan PM, van Osch GJVM.

Bone. 2018 Nov;116:67-77. doi: 10.1016/j.bone.2018.07.008. Epub 2018 Jul 21.


Macrophage polarization contributes to local inflammation and structural change in the multifidus muscle after intervertebral disc injury.

James G, Sluka KA, Blomster L, Hall L, Schmid AB, Shu CC, Little CB, Melrose J, Hodges PW.

Eur Spine J. 2018 Aug;27(8):1744-1756. doi: 10.1007/s00586-018-5652-7. Epub 2018 Jun 12.


The role of fat and inflammation in the pathogenesis and management of osteoarthritis.

Urban H, Little CB.

Rheumatology (Oxford). 2018 May 1;57(suppl_4):iv10-iv21. doi: 10.1093/rheumatology/kex399. Review.


Comprehensive Expression Analysis of microRNAs and mRNAs in Synovial Tissue from a Mouse Model of Early Post-Traumatic Osteoarthritis.

Kung LHW, Ravi V, Rowley L, Bell KM, Little CB, Bateman JF.

Sci Rep. 2017 Dec 18;7(1):17701. doi: 10.1038/s41598-017-17545-1.


Cell Clusters Are Indicative of Stem Cell Activity in the Degenerate Intervertebral Disc: Can Their Properties Be Manipulated to Improve Intrinsic Repair of the Disc?

Brown S, Matta A, Erwin M, Roberts S, Gruber HE, Hanley EN Jr, Little CB, Melrose J.

Stem Cells Dev. 2018 Feb 1;27(3):147-165. doi: 10.1089/scd.2017.0213. Epub 2018 Jan 16. Review.


Cartilage MicroRNA Dysregulation During the Onset and Progression of Mouse Osteoarthritis Is Independent of Aggrecanolysis and Overlaps With Candidates From End-Stage Human Disease.

Kung LHW, Ravi V, Rowley L, Angelucci C, Fosang AJ, Bell KM, Little CB, Bateman JF.

Arthritis Rheumatol. 2018 Mar;70(3):383-395. doi: 10.1002/art.40378. Epub 2018 Feb 6.


Biomarkers for equine joint injury and osteoarthritis.

McIlwraith CW, Kawcak CE, Frisbie DD, Little CB, Clegg PD, Peffers MJ, Karsdal MA, Ekman S, Laverty S, Slayden RA, Sandell LJ, Lohmander LS, Kraus VB.

J Orthop Res. 2018 Mar;36(3):823-831. doi: 10.1002/jor.23738. Epub 2018 Jan 24.


Bioengineered Temporomandibular Joint Disk Implants: Study Protocol for a Two-Phase Exploratory Randomized Preclinical Pilot Trial in 18 Black Merino Sheep (TEMPOJIMS).

Ângelo DF, Monje FG, González-García R, Little CB, Mónico L, Pinho M, Santos FA, Carrapiço B, Gonçalves SC, Morouço P, Alves N, Moura C, Wang Y, Jeffries E, Gao J, Sousa R, Neto LL, Caldeira D, Salvado F.

JMIR Res Protoc. 2017 Mar 2;6(3):e37. doi: 10.2196/resprot.6779.


The biology of meniscal pathology in osteoarthritis and its contribution to joint disease: beyond simple mechanics.

Melrose J, Fuller ES, Little CB.

Connect Tissue Res. 2017 May - Jul;58(3-4):282-294. doi: 10.1080/03008207.2017.1284824. Epub 2017 Jan 25. Review.


Use of FGF-2 and FGF-18 to direct bone marrow stromal stem cells to chondrogenic and osteogenic lineages.

Shu C, Smith SM, Little CB, Melrose J.

Future Sci OA. 2016 Sep 22;2(4):FSO142. doi: 10.4155/fsoa-2016-0034. eCollection 2016 Dec.


Considerations for the design and execution of protocols for animal research and treatment to improve reproducibility and standardization: "DEPART well-prepared and ARRIVE safely".

Smith MM, Clarke EC, Little CB.

Osteoarthritis Cartilage. 2017 Mar;25(3):354-363. doi: 10.1016/j.joca.2016.10.016. Epub 2016 Nov 2. Review.


Hyaluronan oligosaccharides stimulate matrix metalloproteinase and anabolic gene expression in vitro by intervertebral disc cells and annular repair in vivo.

Fuller ES, Shu C, Smith MM, Little CB, Melrose J.

J Tissue Eng Regen Med. 2018 Jan;12(1):e216-e226. doi: 10.1002/term.2319. Epub 2017 Mar 22.


Utility of circulating serum miRNAs as biomarkers of early cartilage degeneration in animal models of post-traumatic osteoarthritis and inflammatory arthritis.

Kung LH, Zaki S, Ravi V, Rowley L, Smith MM, Bell KM, Bateman JF, Little CB.

Osteoarthritis Cartilage. 2017 Mar;25(3):426-434. doi: 10.1016/j.joca.2016.09.002. Epub 2016 Sep 9.


Interleukin-1α induces focal degradation of biglycan and tissue degeneration in an in-vitro ovine meniscal model.

Fuller E, Little CB, Melrose J.

Exp Mol Pathol. 2016 Oct;101(2):214-220. doi: 10.1016/j.yexmp.2016.09.001. Epub 2016 Sep 9.


Joint loads resulting in ACL rupture: Effects of age, sex, and body mass on injury load and mode of failure in a mouse model.

Blaker CL, Little CB, Clarke EC.

J Orthop Res. 2017 Aug;35(8):1754-1763. doi: 10.1002/jor.23418. Epub 2016 Sep 19.


Pericellular colocalisation and interactive properties of type VI collagen and perlecan in the intervertebral disc.

Hayes AJ, Shu CC, Lord MS, Little CB, Whitelock JM, Melrose J.

Eur Cell Mater. 2016 Jul 5;32:40-57.


Reoxygenation enhances tumour necrosis factor alpha-induced degradation of the extracellular matrix produced by chondrogenic cells.

Markway BD, Cho H, Anderson DE, Holden P, Ravi V, Little CB, Johnstone B.

Eur Cell Mater. 2016 Jun 24;31:425-39.


Chondroitin sulphate glycosaminoglycans contribute to widespread inferior biomechanics in tendon after focal injury.

Choi RK, Smith MM, Martin JH, Clarke JL, Dart AJ, Little CB, Clarke EC.

J Biomech. 2016 Sep 6;49(13):2694-2701. doi: 10.1016/j.jbiomech.2016.06.006. Epub 2016 Jun 6.


Using mouse models to investigate the pathophysiology, treatment, and prevention of post-traumatic osteoarthritis.

Blaker CL, Clarke EC, Little CB.

J Orthop Res. 2017 Mar;35(3):424-439. doi: 10.1002/jor.23343. Epub 2016 Jun 28. Review.


Mesenchymal Stem Cell Treatment of Intervertebral Disc Lesion Prevents Fatty Infiltration and Fibrosis of the Multifidus Muscle, but not Cytokine and Muscle Fiber Changes.

James G, Blomster L, Hall L, Schmid AB, Shu CC, Little CB, Melrose J, Hodges PW.

Spine (Phila Pa 1976). 2016 Aug 1;41(15):1208-17. doi: 10.1097/BRS.0000000000001669.


The CS Sulfation Motifs 4C3, 7D4, 3B3[-]; and Perlecan Identify Stem Cell Populations and Their Niches, Activated Progenitor Cells and Transitional Areas of Tissue Development in the Fetal Human Elbow.

Hayes AJ, Hughes CE, Smith SM, Caterson B, Little CB, Melrose J.

Stem Cells Dev. 2016 Jun 1;25(11):836-47. doi: 10.1089/scd.2016.0054. Epub 2016 May 5.


Correction: Focal Experimental Injury Leads to Widespread Gene Expression and Histologic Changes in Equine Flexor Tendons.

Jacobson E, Dart AJ, Mondori T, Horadogoda N, Jeffcott LB, Little CB, Smith MM.

PLoS One. 2016 Mar 1;11(3):e0150823. doi: 10.1371/journal.pone.0150823. eCollection 2016. No abstract available.


Effect of Manuka honey gel on the transforming growth factor β1 and β3 concentrations, bacterial counts and histomorphology of contaminated full-thickness skin wounds in equine distal limbs.

Bischofberger AS, Dart CM, Horadagoda N, Perkins NR, Jeffcott LB, Little CB, Dart AJ.

Aust Vet J. 2016 Jan-Feb;94(1-2):27-34. doi: 10.1111/avj.12405.


The great debate: Should Osteoarthritis Research Focus on "Mice" or "Men"?

Hunter DJ, Little CB.

Osteoarthritis Cartilage. 2016 Jan;24(1):4-8. doi: 10.1016/j.joca.2015.07.029. No abstract available.


Ablation of Perlecan Domain 1 Heparan Sulfate Reduces Progressive Cartilage Degradation, Synovitis, and Osteophyte Size in a Preclinical Model of Posttraumatic Osteoarthritis.

Shu CC, Jackson MT, Smith MM, Smith SM, Penm S, Lord MS, Whitelock JM, Little CB, Melrose J.

Arthritis Rheumatol. 2016 Apr;68(4):868-79. doi: 10.1002/art.39529.


The role of proteoglycans in the nanoindentation creep behavior of human dentin.

Bertassoni LE, Kury M, Rathsam C, Little CB, Swain MV.

J Mech Behav Biomed Mater. 2015 Mar;55:264-270. doi: 10.1016/j.jmbbm.2015.10.018. Epub 2015 Nov 10.


Immunolocalization and distribution of proteoglycans in carious dentine.

Stankoska K, Sarram L, Smith S, Bedran-Russo AK, Little CB, Swain MV, Bertassoni LE.

Aust Dent J. 2016 Sep;61(3):288-97. doi: 10.1111/adj.12376.


On the predictive utility of animal models of osteoarthritis.

Malfait AM, Little CB.

Arthritis Res Ther. 2015 Sep 14;17:225. doi: 10.1186/s13075-015-0747-6. Review.


Focal experimental injury leads to widespread gene expression and histologic changes in equine flexor tendons.

Jacobson E, Dart AJ, Mondori T, Horadogoda N, Jeffcott LB, Little CB, Smith MM.

PLoS One. 2015 Apr 2;10(4):e0122220. doi: 10.1371/journal.pone.0122220. eCollection 2015. Erratum in: PLoS One. 2016;11(3):e0150823. Jacobsen, Else [corrected to Jacobson, Else].


Depletion of protease-activated receptor 2 but not protease-activated receptor 1 may confer protection against osteoarthritis in mice through extracartilaginous mechanisms.

Jackson MT, Moradi B, Zaki S, Smith MM, McCracken S, Smith SM, Jackson CJ, Little CB.

Arthritis Rheumatol. 2014 Dec;66(12):3337-48. doi: 10.1002/art.38876.


Treatment of experimentally induced osteoarthritis in horses using an intravenous combination of sodium pentosan polysulfate, N-acetyl glucosamine, and sodium hyaluronan.

Koenig TJ, Dart AJ, McIlwraith CW, Horadagoda N, Bell RJ, Perkins N, Dart C, Krockenberger M, Jeffcott LB, Little CB.

Vet Surg. 2014 Jul;43(5):612-22. doi: 10.1111/j.1532-950X.2014.12203.x. Epub 2014 May 13.


Activation of matrix metalloproteinases 2, 9, and 13 by activated protein C in human osteoarthritic cartilage chondrocytes.

Jackson MT, Moradi B, Smith MM, Jackson CJ, Little CB.

Arthritis Rheumatol. 2014 Jun;66(6):1525-36. doi: 10.1002/art.38401.


Endothelial protein C receptor-associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2.

Xue M, Shen K, McKelvey K, Li J, Chan YK, Hatzis V, March L, Little CB, Tonkin M, Jackson CJ.

Arthritis Res Ther. 2014 Feb 5;16(1):R44. doi: 10.1186/ar4473.


Modulation of endochondral ossification by MEK inhibitors PD0325901 and AZD6244 (Selumetinib).

El-Hoss J, Kolind M, Jackson MT, Deo N, Mikulec K, McDonald MM, Little CB, Little DG, Schindeler A.

Bone. 2014 Feb;59:151-61. doi: 10.1016/j.bone.2013.11.013. Epub 2013 Nov 20.


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