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Automated lifespan determination across Caenorhabditis strains and species reveals assay-specific effects of chemical interventions.

Banse SA, Lucanic M, Sedore CA, Coleman-Hulbert AL, Plummer WT, Chen E, Kish JL, Hall D, Onken B, Presley MP, Jones EG, Blue BW, Garrett T, Abbott M, Xue J, Guo S, Johnson E, Foulger AC, Chamoli M, Falkowski R, Melentijevic I, Harinath G, Huynh P, Patel S, Edgar D, Jarrett CM, Guo M, Kapahi P, Lithgow GJ, Driscoll M, Phillips PC.

Geroscience. 2019 Dec;41(6):945-960. doi: 10.1007/s11357-019-00108-9. Epub 2019 Dec 10.


From discoveries in ageing research to therapeutics for healthy ageing.

Campisi J, Kapahi P, Lithgow GJ, Melov S, Newman JC, Verdin E.

Nature. 2019 Jul;571(7764):183-192. doi: 10.1038/s41586-019-1365-2. Epub 2019 Jul 10. Review.


Drugs that target aging: how do we discover them?

Myers A, Lithgow GJ.

Expert Opin Drug Discov. 2019 Jun;14(6):541-548. doi: 10.1080/17460441.2019.1597049. Epub 2019 Apr 11.


Acarbose improves health and lifespan in aging HET3 mice.

Harrison DE, Strong R, Alavez S, Astle CM, DiGiovanni J, Fernandez E, Flurkey K, Garratt M, Gelfond JAL, Javors MA, Levi M, Lithgow GJ, Macchiarini F, Nelson JF, Sukoff Rizzo SJ, Slaga TJ, Stearns T, Wilkinson JE, Miller RA.

Aging Cell. 2019 Apr;18(2):e12898. doi: 10.1111/acel.12898. Epub 2019 Jan 27.


Natural Genetic Variation in Yeast Reveals That NEDD4 Is a Conserved Modifier of Mutant Polyglutamine Aggregation.

Peters TW, Nelson CS, Gerencser AA, Dumas KJ, Tavshanjian B, Chang KC, Lithgow GJ, Hughes RE.

G3 (Bethesda). 2018 Nov 6;8(11):3421-3431. doi: 10.1534/g3.118.200289.


A Simple Method for High Throughput Chemical Screening in Caenorhabditis Elegans.

Lucanic M, Garrett T, Gill MS, Lithgow GJ.

J Vis Exp. 2018 Mar 20;(133). doi: 10.3791/56892.


A long journey to reproducible results.

Lithgow GJ, Driscoll M, Phillips P.

Nature. 2017 Aug 22;548(7668):387-388. doi: 10.1038/548387a. No abstract available.


Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson's Disease.

Leonoudakis D, Rane A, Angeli S, Lithgow GJ, Andersen JK, Chinta SJ.

Mediators Inflamm. 2017;2017:8302636. doi: 10.1155/2017/8302636. Epub 2017 Apr 4.


Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects.

Lucanic M, Plummer WT, Chen E, Harke J, Foulger AC, Onken B, Coleman-Hulbert AL, Dumas KJ, Guo S, Johnson E, Bhaumik D, Xue J, Crist AB, Presley MP, Harinath G, Sedore CA, Chamoli M, Kamat S, Chen MK, Angeli S, Chang C, Willis JH, Edgar D, Royal MA, Chao EA, Patel S, Garrett T, Ibanez-Ventoso C, Hope J, Kish JL, Guo M, Lithgow GJ, Driscoll M, Phillips PC.

Nat Commun. 2017 Feb 21;8:14256. doi: 10.1038/ncomms14256.


Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1.

Mark KA, Dumas KJ, Bhaumik D, Schilling B, Davis S, Oron TR, Sorensen DJ, Lucanic M, Brem RB, Melov S, Ramanathan A, Gibson BW, Lithgow GJ.

Cell Rep. 2016 Oct 25;17(5):1227-1237. doi: 10.1016/j.celrep.2016.09.086.


A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification.

Chaudhuri J, Bose N, Gong J, Hall D, Rifkind A, Bhaumik D, Peiris TH, Chamoli M, Le CH, Liu J, Lithgow GJ, Ramanathan A, Xu XZS, Kapahi P.

Curr Biol. 2016 Nov 21;26(22):3014-3025. doi: 10.1016/j.cub.2016.09.024. Epub 2016 Oct 20.


Chemical activation of a food deprivation signal extends lifespan.

Lucanic M, Garrett T, Yu I, Calahorro F, Asadi Shahmirzadi A, Miller A, Gill MS, Hughes RE, Holden-Dye L, Lithgow GJ.

Aging Cell. 2016 Oct;15(5):832-41. doi: 10.1111/acel.12492. Epub 2016 May 24.


Zinc Levels Modulate Lifespan through Multiple Longevity Pathways in Caenorhabditis elegans.

Kumar J, Barhydt T, Awasthi A, Lithgow GJ, Killilea DW, Kapahi P.

PLoS One. 2016 Apr 14;11(4):e0153513. doi: 10.1371/journal.pone.0153513. eCollection 2016.


Long live FOXO: unraveling the role of FOXO proteins in aging and longevity.

Martins R, Lithgow GJ, Link W.

Aging Cell. 2016 Apr;15(2):196-207. doi: 10.1111/acel.12427. Epub 2015 Dec 8. Review.


Mitochondrial Quality Control via the PGC1α-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin.

Siddiqui A, Bhaumik D, Chinta SJ, Rane A, Rajagopalan S, Lieu CA, Lithgow GJ, Andersen JK.

J Neurosci. 2015 Sep 16;35(37):12833-44. doi: 10.1523/JNEUROSCI.0109-15.2015.


Iron promotes protein insolubility and aging in C. elegans.

Klang IM, Schilling B, Sorensen DJ, Sahu AK, Kapahi P, Andersen JK, Swoboda P, Killilea DW, Gibson BW, Lithgow GJ.

Aging (Albany NY). 2014 Nov;6(11):975-91.


Geroscience: linking aging to chronic disease.

Kennedy BK, Berger SL, Brunet A, Campisi J, Cuervo AM, Epel ES, Franceschi C, Lithgow GJ, Morimoto RI, Pessin JE, Rando TA, Richardson A, Schadt EE, Wyss-Coray T, Sierra F.

Cell. 2014 Nov 6;159(4):709-13. doi: 10.1016/j.cell.2014.10.039.


Manganese disturbs metal and protein homeostasis in Caenorhabditis elegans.

Angeli S, Barhydt T, Jacobs R, Killilea DW, Lithgow GJ, Andersen JK.

Metallomics. 2014 Oct;6(10):1816-23. doi: 10.1039/c4mt00168k. Epub 2014 Jul 24.


Stress biology and aging mechanisms: toward understanding the deep connection between adaptation to stress and longevity.

Epel ES, Lithgow GJ.

J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S10-6. doi: 10.1093/gerona/glu055. Review.


Loss of NDG-4 extends lifespan and stress resistance in Caenorhabditis elegans.

Brejning J, Nørgaard S, Schøler L, Morthorst TH, Jakobsen H, Lithgow GJ, Jensen LT, Olsen A.

Aging Cell. 2014 Feb;13(1):156-64. doi: 10.1111/acel.12165. Epub 2013 Nov 28.


A DNA synthesis inhibitor is protective against proteotoxic stressors via modulation of fertility pathways in Caenorhabditis elegans.

Angeli S, Klang I, Sivapatham R, Mark K, Zucker D, Bhaumik D, Lithgow GJ, Andersen JK.

Aging (Albany NY). 2013 Oct;5(10):759-69.


Age-related micro-RNA abundance in individual C. elegans.

Lucanic M, Graham J, Scott G, Bhaumik D, Benz CC, Hubbard A, Lithgow GJ, Melov S.

Aging (Albany NY). 2013 Jun;5(6):394-411.


Dimethyl sulfoxide and dimethyl formamide increase lifespan of C. elegans in liquid.

Frankowski H, Alavez S, Spilman P, Mark KA, Nelson JD, Mollahan P, Rao RV, Chen SF, Lithgow GJ, Ellerby HM.

Mech Ageing Dev. 2013 Mar;134(3-4):69-78. doi: 10.1016/j.mad.2012.10.002. Epub 2013 Jan 11.


Curcumin and neurodegenerative diseases.

Monroy A, Lithgow GJ, Alavez S.

Biofactors. 2013 Jan-Feb;39(1):122-32. doi: 10.1002/biof.1063. Epub 2013 Jan 10. Review.


Tor1 regulates protein solubility in Saccharomyces cerevisiae.

Peters TW, Rardin MJ, Czerwieniec G, Evani US, Reis-Rodrigues P, Lithgow GJ, Mooney SD, Gibson BW, Hughes RE.

Mol Biol Cell. 2012 Dec;23(24):4679-88. doi: 10.1091/mbc.E12-08-0620. Epub 2012 Oct 24.


Pharmacological lifespan extension of invertebrates.

Lucanic M, Lithgow GJ, Alavez S.

Ageing Res Rev. 2013 Jan;12(1):445-58. doi: 10.1016/j.arr.2012.06.006. Epub 2012 Jul 6. Review.


Anti-inflammatory role of the isoflavone diadzein in lipopolysaccharide-stimulated microglia: implications for Parkinson's disease.

Chinta SJ, Ganesan A, Reis-Rodrigues P, Lithgow GJ, Andersen JK.

Neurotox Res. 2013 Feb;23(2):145-53. doi: 10.1007/s12640-012-9328-5. Epub 2012 May 10.


Aluminium exposure disrupts elemental homeostasis in Caenorhabditis elegans.

Page KE, White KN, McCrohan CR, Killilea DW, Lithgow GJ.

Metallomics. 2012 May;4(5):512-22. doi: 10.1039/c2mt00146b. Epub 2012 Apr 26.


Pharmacological maintenance of protein homeostasis could postpone age-related disease.

Alavez S, Lithgow GJ.

Aging Cell. 2012 Apr;11(2):187-91. doi: 10.1111/j.1474-9726.2012.00789.x. Epub 2012 Feb 1.


Translating longevity research into healthspan.

Lithgow GJ, Lord JM, Kirkland JL.

Longev Healthspan. 2012 Sep 3;1:1. doi: 10.1186/2046-2395-1-1. eCollection 2012. No abstract available.


Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan.

Reis-Rodrigues P, Czerwieniec G, Peters TW, Evani US, Alavez S, Gaman EA, Vantipalli M, Mooney SD, Gibson BW, Lithgow GJ, Hughes RE.

Aging Cell. 2012 Feb;11(1):120-7. doi: 10.1111/j.1474-9726.2011.00765.x. Epub 2011 Dec 11.


Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans.

Rogers AN, Chen D, McColl G, Czerwieniec G, Felkey K, Gibson BW, Hubbard A, Melov S, Lithgow GJ, Kapahi P.

Cell Metab. 2011 Jul 6;14(1):55-66. doi: 10.1016/j.cmet.2011.05.010.


N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans.

Lucanic M, Held JM, Vantipalli MC, Klang IM, Graham JB, Gibson BW, Lithgow GJ, Gill MS.

Nature. 2011 May 12;473(7346):226-9. doi: 10.1038/nature10007.


A new look at old compounds.

Alavez S, Lithgow GJ.

Aging (Albany NY). 2011 Apr;3(4):338-9. No abstract available.


Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan.

Alavez S, Vantipalli MC, Zucker DJ, Klang IM, Lithgow GJ.

Nature. 2011 Apr 14;472(7342):226-9. doi: 10.1038/nature09873. Epub 2011 Mar 30.


Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans.

McColl G, Rogers AN, Alavez S, Hubbard AE, Melov S, Link CD, Bush AI, Kapahi P, Lithgow GJ.

Cell Metab. 2010 Sep 8;12(3):260-72. doi: 10.1016/j.cmet.2010.08.004.


MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8.

Bhaumik D, Scott GK, Schokrpur S, Patil CK, Orjalo AV, Rodier F, Lithgow GJ, Campisi J.

Aging (Albany NY). 2009 Apr;1(4):402-11.


Compounds that confer thermal stress resistance and extended lifespan.

Benedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ.

Exp Gerontol. 2008 Oct;43(10):882-91. doi: 10.1016/j.exger.2008.08.049. Epub 2008 Sep 20.


The Caenorhabditis elegans K10C2.4 gene encodes a member of the fumarylacetoacetate hydrolase family: a Caenorhabditis elegans model of type I tyrosinemia.

Fisher AL, Page KE, Lithgow GJ, Nash L.

J Biol Chem. 2008 Apr 4;283(14):9127-35. doi: 10.1074/jbc.M708341200. Epub 2008 Jan 28.


Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans.

McColl G, Killilea DW, Hubbard AE, Vantipalli MC, Melov S, Lithgow GJ.

J Biol Chem. 2008 Jan 4;283(1):350-7. Epub 2007 Oct 24.


Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans.

Pan KZ, Palter JE, Rogers AN, Olsen A, Chen D, Lithgow GJ, Kapahi P.

Aging Cell. 2007 Feb;6(1):111-9.


Why aging isn't regulated: a lamentation on the use of language in aging literature.

Lithgow GJ.

Exp Gerontol. 2006 Oct;41(10):890-3. Epub 2006 Sep 7. Review.


DAF-12-dependent rescue of dauer formation in Caenorhabditis elegans by (25S)-cholestenoic acid.

Held JM, White MP, Fisher AL, Gibson BW, Lithgow GJ, Gill MS.

Aging Cell. 2006 Aug;5(4):283-91.


Lifespan extension of Caenorhabditis elegans following repeated mild hormetic heat treatments.

Olsen A, Vantipalli MC, Lithgow GJ.

Biogerontology. 2006 Aug;7(4):221-30. Epub 2006 Jul 7.


Using Caenorhabditis elegans as a model for aging and age-related diseases.

Olsen A, Vantipalli MC, Lithgow GJ.

Ann N Y Acad Sci. 2006 May;1067:120-8. Review.


Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans.

Olsen A, Vantipalli MC, Lithgow GJ.

Science. 2006 Jun 2;312(5778):1381-5.


Manganous ion supplementation accelerates wild type development, enhances stress resistance, and rescues the life span of a short-lived Caenorhabditis elegans mutant.

Lin YT, Hoang H, Hsieh SI, Rangel N, Foster AL, Sampayo JN, Lithgow GJ, Srinivasan C.

Free Radic Biol Med. 2006 Apr 1;40(7):1185-93. Epub 2005 Dec 12.


Science fact and the SENS agenda. What can we reasonably expect from ageing research?

Warner H, Anderson J, Austad S, Bergamini E, Bredesen D, Butler R, Carnes BA, Clark BF, Cristofalo V, Faulkner J, Guarente L, Harrison DE, Kirkwood T, Lithgow G, Martin G, Masoro E, Melov S, Miller RA, Olshansky SJ, Partridge L, Pereira-Smith O, Perls T, Richardson A, Smith J, von Zglinicki T, Wang E, Wei JY, Williams TF.

EMBO Rep. 2005 Nov;6(11):1006-8. No abstract available.


Pharmacological intervention in invertebrate aging.

Lithgow GJ, Gill MS, Olsen A, Sampayo JN.

Age (Dordr). 2005 Sep;27(3):213-23. doi: 10.1007/s11357-005-3625-3. Epub 2005 Dec 31. No abstract available.

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