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N6-Furfuryladenine is protective in Huntington's disease models by signaling huntingtin phosphorylation.

Bowie LE, Maiuri T, Alpaugh M, Gabriel M, Arbez N, Galleguillos D, Hung CLK, Patel S, Xia J, Hertz NT, Ross CA, Litchfield DW, Sipione S, Truant R.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7081-E7090. doi: 10.1073/pnas.1801772115. Epub 2018 Jul 9.


CK2β regulates thrombopoiesis and Ca2+-triggered platelet activation in arterial thrombosis.

Münzer P, Walker-Allgaier B, Geue S, Langhauser F, Geuss E, Stegner D, Aurbach K, Semeniak D, Chatterjee M, Gonzalez Menendez I, Märklin M, Quintanilla-Martinez L, Salih HR, Litchfield DW, Buchou T, Kleinschnitz C, Lang F, Nieswandt B, Pleines I, Schulze H, Gawaz M, Borst O.

Blood. 2017 Dec 21;130(25):2774-2785. doi: 10.1182/blood-2017-05-784413. Epub 2017 Sep 19.


BIRC6 mediates imatinib resistance independently of Mcl-1.

Okumu DO, East MP, Levine M, Herring LE, Zhang R, Gilbert TSK, Litchfield DW, Zhang Y, Graves LM.

PLoS One. 2017 May 16;12(5):e0177871. doi: 10.1371/journal.pone.0177871. eCollection 2017.


Protein Kinase CK2: Intricate Relationships within Regulatory Cellular Networks.

Nuñez de Villavicencio-Diaz T, Rabalski AJ, Litchfield DW.

Pharmaceuticals (Basel). 2017 Mar 5;10(1). pii: E27. doi: 10.3390/ph10010027. Review.


Cellular interaction influenced by surface modification strategies of gelatin-based nanoparticles.

Tse WH, Gyenis L, Litchfield DW, Zhang J.

J Biomater Appl. 2017 Feb;31(7):1087-1096. doi: 10.1177/0885328216684651. Epub 2016 Dec 15.


Molecular Pathways: Emergence of Protein Kinase CK2 (CSNK2) as a Potential Target to Inhibit Survival and DNA Damage Response and Repair Pathways in Cancer Cells.

Rabalski AJ, Gyenis L, Litchfield DW.

Clin Cancer Res. 2016 Jun 15;22(12):2840-7. doi: 10.1158/1078-0432.CCR-15-1314.


GAR22β regulates cell migration, sperm motility, and axoneme structure.

Gamper I, Fleck D, Barlin M, Spehr M, El Sayad S, Kleine H, Maxeiner S, Schalla C, Aydin G, Hoss M, Litchfield DW, Lüscher B, Zenke M, Sechi A.

Mol Biol Cell. 2016 Jan 15;27(2):277-94. doi: 10.1091/mbc.E15-06-0426. Epub 2015 Nov 12.


Caspase 3 cleavage of Pax7 inhibits self-renewal of satellite cells.

Dick SA, Chang NC, Dumont NA, Bell RA, Putinski C, Kawabe Y, Litchfield DW, Rudnicki MA, Megeney LA.

Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):E5246-52. doi: 10.1073/pnas.1512869112. Epub 2015 Sep 8.


Pin1: Intimate involvement with the regulatory protein kinase networks in the global phosphorylation landscape.

Litchfield DW, Shilton BH, Brandl CJ, Gyenis L.

Biochim Biophys Acta. 2015 Oct;1850(10):2077-86. doi: 10.1016/j.bbagen.2015.02.018. Epub 2015 Mar 10. Review.


Peroxide-mediated oxidation and inhibition of the peptidyl-prolyl isomerase Pin1.

Innes BT, Sowole MA, Gyenis L, Dubinsky M, Konermann L, Litchfield DW, Brandl CJ, Shilton BH.

Biochim Biophys Acta. 2015 May;1852(5):905-12. doi: 10.1016/j.bbadis.2014.12.025. Epub 2015 Jan 13.


Systematic investigation of hierarchical phosphorylation by protein kinase CK2.

St-Denis N, Gabriel M, Turowec JP, Gloor GB, Li SS, Gingras AC, Litchfield DW.

J Proteomics. 2015 Apr 6;118:49-62. doi: 10.1016/j.jprot.2014.10.020. Epub 2014 Nov 5.


Regulation of DNA methylation patterns by CK2-mediated phosphorylation of Dnmt3a.

Deplus R, Blanchon L, Rajavelu A, Boukaba A, Defrance M, Luciani J, Rothé F, Dedeurwaerder S, Denis H, Brinkman AB, Simmer F, Müller F, Bertin B, Berdasco M, Putmans P, Calonne E, Litchfield DW, de Launoit Y, Jurkowski TP, Stunnenberg HG, Bock C, Sotiriou C, Fraga MF, Esteller M, Jeltsch A, Fuks F.

Cell Rep. 2014 Aug 7;8(3):743-53. doi: 10.1016/j.celrep.2014.06.048. Epub 2014 Jul 24.


An unbiased proteomic screen reveals caspase cleavage is positively and negatively regulated by substrate phosphorylation.

Turowec JP, Zukowski SA, Knight JD, Smalley DM, Graves LM, Johnson GL, Li SS, Lajoie GA, Litchfield DW.

Mol Cell Proteomics. 2014 May;13(5):1184-97. doi: 10.1074/mcp.M113.037374. Epub 2014 Feb 20.


Diverse post-translational modifications of the pannexin family of channel-forming proteins.

Penuela S, Lohman AW, Lai W, Gyenis L, Litchfield DW, Isakson BE, Laird DW.

Channels (Austin). 2014;8(2):124-30. doi: 10.4161/chan.27422. Epub 2014 Jan 13.


Mitotic regulation of SEPT9 protein by cyclin-dependent kinase 1 (Cdk1) and Pin1 protein is important for the completion of cytokinesis.

Estey MP, Di Ciano-Oliveira C, Froese CD, Fung KY, Steels JD, Litchfield DW, Trimble WS.

J Biol Chem. 2013 Oct 18;288(42):30075-86. doi: 10.1074/jbc.M113.474932. Epub 2013 Aug 29.


Chemical proteomics and functional proteomics strategies for protein kinase inhibitor validation and protein kinase substrate identification: applications to protein kinase CK2.

Gyenis L, Turowec JP, Bretner M, Litchfield DW.

Biochim Biophys Acta. 2013 Jul;1834(7):1352-8. doi: 10.1016/j.bbapap.2013.02.006. Epub 2013 Feb 14. Review.


Non-catalytic participation of the Pin1 peptidyl-prolyl isomerase domain in target binding.

Innes BT, Bailey ML, Brandl CJ, Shilton BH, Litchfield DW.

Front Physiol. 2013 Feb 13;4:18. doi: 10.3389/fphys.2013.00018. eCollection 2013.


Functional proteomics strategy for validation of protein kinase inhibitors reveals new targets for a TBB-derived inhibitor of protein kinase CK2.

Gyenis L, Kuś A, Bretner M, Litchfield DW.

J Proteomics. 2013 Apr 9;81:70-9. doi: 10.1016/j.jprot.2012.09.017. Epub 2012 Sep 25.


Electrochemical investigations of Tau protein phosphorylations and interactions with Pin1.

Martić S, Beheshti S, Kraatz HB, Litchfield DW.

Chem Biodivers. 2012 Sep;9(9):1693-702. doi: 10.1002/cbdv.201100418.


Versatile strategy for biochemical, electrochemical and immunoarray detection of protein phosphorylations.

Martić S, Gabriel M, Turowec JP, Litchfield DW, Kraatz HB.

J Am Chem Soc. 2012 Oct 17;134(41):17036-45. doi: 10.1021/ja302586q. Epub 2012 Jul 19.


Loss of pannexin 1 attenuates melanoma progression by reversion to a melanocytic phenotype.

Penuela S, Gyenis L, Ablack A, Churko JM, Berger AC, Litchfield DW, Lewis JD, Laird DW.

J Biol Chem. 2012 Aug 17;287(34):29184-93. doi: 10.1074/jbc.M112.377176. Epub 2012 Jun 29.


2-Triazenoazaindoles: α novel class of triazenes inducing transcriptional down-regulation of EGFR and HER-2 in human pancreatic cancer cells.

Kreutzer JN, Salvador A, Diana P, Cirrincione G, Vedaldi D, Litchfield DW, Issinger OG, Guerra B.

Int J Oncol. 2012 Apr;40(4):914-22. doi: 10.3892/ijo.2011.1272. Epub 2011 Nov 29.


Flavin adenine dinucleotide content of quinone reductase 2: analysis and optimization for structure-function studies.

Leung KK, Litchfield DW, Shilton BH.

Anal Biochem. 2012 Jan 1;420(1):84-9. doi: 10.1016/j.ab.2011.09.011. Epub 2011 Sep 16.


Chemoproteomic characterization of protein kinase inhibitors using immobilized ATP.

Duncan JS, Haystead TA, Litchfield DW.

Methods Mol Biol. 2012;795:119-34. doi: 10.1007/978-1-61779-337-0_8.


Unbiased functional proteomics strategy for protein kinase inhibitor validation and identification of bona fide protein kinase substrates: application to identification of EEF1D as a substrate for CK2.

Gyenis L, Duncan JS, Turowec JP, Bretner M, Litchfield DW.

J Proteome Res. 2011 Nov 4;10(11):4887-901. doi: 10.1021/pr2008994. Epub 2011 Oct 13.


Regulation of caspase pathways by protein kinase CK2: identification of proteins with overlapping CK2 and caspase consensus motifs.

Turowec JP, Duncan JS, Gloor GB, Litchfield DW.

Mol Cell Biochem. 2011 Oct;356(1-2):159-67. doi: 10.1007/s11010-011-0972-5. Epub 2011 Jul 13.


"Going KiNativ": probing the Native Kinome.

Graves LM, Litchfield DW.

Chem Biol. 2011 Jun 24;18(6):683-4. doi: 10.1016/j.chembiol.2011.06.001.


Localization of phosphorylated CK2alpha to the mitotic spindle requires the peptidyl-prolyl isomerase Pin1.

St-Denis NA, Bailey ML, Parker EL, Vilk G, Litchfield DW.

J Cell Sci. 2011 Jul 15;124(Pt 14):2341-8. doi: 10.1242/jcs.077446. Epub 2011 Jun 21.


A peptide-based target screen implicates the protein kinase CK2 in the global regulation of caspase signaling.

Duncan JS, Turowec JP, Duncan KE, Vilk G, Wu C, Lüscher B, Li SS, Gloor GB, Litchfield DW.

Sci Signal. 2011 May 10;4(172):ra30. doi: 10.1126/scisignal.2001682.


Discovery and characterization of a nonphosphorylated cyclic peptide inhibitor of the peptidylprolyl isomerase, Pin1.

Duncan KE, Dempsey BR, Killip LE, Adams J, Bailey ML, Lajoie GA, Litchfield DW, Brandl CJ, Shaw GS, Shilton BH.

J Med Chem. 2011 Jun 9;54(11):3854-65. doi: 10.1021/jm200156c. Epub 2011 May 5.


A CK2-dependent mechanism for activation of the JAK-STAT signaling pathway.

Zheng Y, Qin H, Frank SJ, Deng L, Litchfield DW, Tefferi A, Pardanani A, Lin FT, Li J, Sha B, Benveniste EN.

Blood. 2011 Jul 7;118(1):156-66. doi: 10.1182/blood-2010-01-266320. Epub 2011 Apr 28.


CK2 phosphorylation of an acidic Ser/Thr di-isoleucine motif in the Na+/H+ exchanger NHE5 isoform promotes association with beta-arrestin2 and endocytosis.

Lukashova V, Szabó EZ, Jinadasa T, Mokhov A, Litchfield DW, Orlowski J.

J Biol Chem. 2011 Apr 1;286(13):11456-68. doi: 10.1074/jbc.M110.182881. Epub 2011 Feb 4.


Interaction between CK2α and CK2β, the subunits of protein kinase CK2: thermodynamic contributions of key residues on the CK2α surface.

Raaf J, Bischoff N, Klopffleisch K, Brunstein E, Olsen BB, Vilk G, Litchfield DW, Issinger OG, Niefind K.

Biochemistry. 2011 Feb 1;50(4):512-22. doi: 10.1021/bi1013563. Epub 2010 Dec 31.


Protein kinase CK2 is a constitutively active enzyme that promotes cell survival: strategies to identify CK2 substrates and manipulate its activity in mammalian cells.

Turowec JP, Duncan JS, French AC, Gyenis L, St Denis NA, Vilk G, Litchfield DW.

Methods Enzymol. 2010;484:471-93. doi: 10.1016/B978-0-12-381298-8.00023-X.


Dual modes of interaction between XRCC4 and polynucleotide kinase/phosphatase: implications for nonhomologous end joining.

Mani RS, Yu Y, Fang S, Lu M, Fanta M, Zolner AE, Tahbaz N, Ramsden DA, Litchfield DW, Lees-Miller SP, Weinfeld M.

J Biol Chem. 2010 Nov 26;285(48):37619-29. doi: 10.1074/jbc.M109.058719. Epub 2010 Sep 17.


SH3TC2, a protein mutant in Charcot-Marie-Tooth neuropathy, links peripheral nerve myelination to endosomal recycling.

Stendel C, Roos A, Kleine H, Arnaud E, Ozçelik M, Sidiropoulos PN, Zenker J, Schüpfer F, Lehmann U, Sobota RM, Litchfield DW, Lüscher B, Chrast R, Suter U, Senderek J.

Brain. 2010 Aug;133(Pt 8):2462-74. doi: 10.1093/brain/awq168.


Casein kinase 2 beta-subunit is a regulator of bone morphogenetic protein 2 signaling.

Bragdon B, Thinakaran S, Moseychuk O, King D, Young K, Litchfield DW, Petersen NO, Nohe A.

Biophys J. 2010 Aug 4;99(3):897-904. doi: 10.1016/j.bpj.2010.04.070.


Enzymatic site-specific functionalization of protein methyltransferase substrates with alkynes for click labeling.

Peters W, Willnow S, Duisken M, Kleine H, Macherey T, Duncan KE, Litchfield DW, Lüscher B, Weinhold E.

Angew Chem Int Ed Engl. 2010 Jul 12;49(30):5170-3. doi: 10.1002/anie.201001240. No abstract available.


Activity of protein kinase CK2 uncouples Bid cleavage from caspase-8 activation.

Hellwig CT, Ludwig-Galezowska AH, Concannon CG, Litchfield DW, Prehn JH, Rehm M.

J Cell Sci. 2010 May 1;123(Pt 9):1401-6. doi: 10.1242/jcs.061143. Epub 2010 Mar 31.


Opposing regulatory roles of phosphorylation and acetylation in DNA mispair processing by thymine DNA glycosylase.

Mohan RD, Litchfield DW, Torchia J, Tini M.

Nucleic Acids Res. 2010 Mar;38(4):1135-48. doi: 10.1093/nar/gkp1097. Epub 2009 Dec 4.


EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin.

Ji H, Wang J, Nika H, Hawke D, Keezer S, Ge Q, Fang B, Fang X, Fang D, Litchfield DW, Aldape K, Lu Z.

Mol Cell. 2009 Nov 25;36(4):547-59. doi: 10.1016/j.molcel.2009.09.034.


Regulation of cell proliferation and survival: convergence of protein kinases and caspases.

Duncan JS, Turowec JP, Vilk G, Li SS, Gloor GB, Litchfield DW.

Biochim Biophys Acta. 2010 Mar;1804(3):505-10. doi: 10.1016/j.bbapap.2009.11.001. Epub 2009 Nov 10. Review.


Protein kinase CK2 in health and disease: From birth to death: the role of protein kinase CK2 in the regulation of cell proliferation and survival.

St-Denis NA, Litchfield DW.

Cell Mol Life Sci. 2009 Jun;66(11-12):1817-29. doi: 10.1007/s00018-009-9150-2. Review.


Evidence for regulation of mitotic progression through temporal phosphorylation and dephosphorylation of CK2alpha.

St-Denis NA, Derksen DR, Litchfield DW.

Mol Cell Biol. 2009 Apr;29(8):2068-81. doi: 10.1128/MCB.01563-08. Epub 2009 Feb 2.


A multiplex human syndrome implicates a key role for intestinal cell kinase in development of central nervous, skeletal, and endocrine systems.

Lahiry P, Wang J, Robinson JF, Turowec JP, Litchfield DW, Lanktree MB, Gloor GB, Puffenberger EG, Strauss KA, Martens MB, Ramsay DA, Rupar CA, Siu V, Hegele RA.

Am J Hum Genet. 2009 Feb;84(2):134-47. doi: 10.1016/j.ajhg.2008.12.017. Epub 2009 Jan 29. Erratum in: Am J Hum Genet. 2009 Jun;84(6):822.


Peptide biosensors for the electrochemical measurement of protein kinase activity.

Kerman K, Song H, Duncan JS, Litchfield DW, Kraatz HB.

Anal Chem. 2008 Dec 15;80(24):9395-401. doi: 10.1021/ac801208e.


Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation.

Kleine H, Poreba E, Lesniewicz K, Hassa PO, Hottiger MO, Litchfield DW, Shilton BH, Lüscher B.

Mol Cell. 2008 Oct 10;32(1):57-69. doi: 10.1016/j.molcel.2008.08.009.


The dual histidine motif in the active site of Pin1 has a structural rather than catalytic role.

Bailey ML, Shilton BH, Brandl CJ, Litchfield DW.

Biochemistry. 2008 Nov 4;47(44):11481-9. doi: 10.1021/bi800964q. Epub 2008 Oct 10.


Neurotransmitter modulation of small-conductance Ca2+-activated K+ channels by regulation of Ca2+ gating.

Maingret F, Coste B, Hao J, Giamarchi A, Allen D, Crest M, Litchfield DW, Adelman JP, Delmas P.

Neuron. 2008 Aug 14;59(3):439-49. doi: 10.1016/j.neuron.2008.05.026.

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