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Items: 22

1.

The transcription factor STAT5 catalyzes Mannich ligation reactions yielding inhibitors of leukemic cell proliferation.

Wong EL, Nawrotzky E, Arkona C, Kim BG, Beligny S, Wang X, Wagner S, Lisurek M, Carstanjen D, Rademann J.

Nat Commun. 2019 Jan 8;10(1):66. doi: 10.1038/s41467-018-07923-2.

2.

Small Molecules Targeting Human N-Acetylmannosamine Kinase.

Hinderlich S, Neuenschwander M, Wratil PR, Oder A, Lisurek M, Nguyen LD, von Kries JP, Hackenberger CPR.

Chembiochem. 2017 Jul 4;18(13):1279-1285. doi: 10.1002/cbic.201700066. Epub 2017 Apr 27.

PMID:
28346741
3.

11th German Conference on Chemoinformatics (GCC 2015) : Fulda, Germany. 8-10 November 2015.

Fechner U, de Graaf C, Torda AE, Güssregen S, Evers A, Matter H, Hessler G, Richmond NJ, Schmidtke P, Segler MHS, Waller MP, Pleik S, Shea JE, Levine Z, Mullen R, van den Broek K, Epple M, Kuhn H, Truszkowski A, Zielesny A, Fraaije JH, Gracia RS, Kast SM, Bulusu KC, Bender A, Yosipof A, Nahum O, Senderowitz H, Krotzky T, Schulz R, Wolber G, Bietz S, Rarey M, Zimmermann MO, Lange A, Ruff M, Heidrich J, Onlia I, Exner TE, Boeckler FM, Bermudez M, Firaha DS, Hollóczki O, Kirchner B, Tautermann CS, Volkamer A, Eid S, Turk S, Rippmann F, Fulle S, Saleh N, Saladino G, Gervasio FL, Haensele E, Banting L, Whitley DC, Oliveira Santos JS, Bureau R, Clark T, Sandmann A, Lanig H, Kibies P, Heil J, Hoffgaard F, Frach R, Engel J, Smith S, Basu D, Rauh D, Kohlbacher O, Boeckler FM, Essex JW, Bodnarchuk MS, Ross GA, Finkelmann AR, Göller AH, Schneider G, Husch T, Schütter C, Balducci A, Korth M, Ntie-Kang F, Günther S, Sippl W, Mbaze LM, Ntie-Kang F, Simoben CV, Lifongo LL, Ntie-Kang F, Judson P, Barilla J, Lokajíček MV, Pisaková H, Simr P, Kireeva N, Petrov A, Ostroumov D, Solovev VP, Pervov VS, Friedrich NO, Sommer K, Rarey M, Kirchmair J, Proschak E, Weber J, Moser D, Kalinowski L, Achenbach J, Mackey M, Cheeseright T, Renner G, Renner G, Schmidt TC, Schram J, Egelkraut-Holtus M, van Oeyen A, Kalliokoski T, Fourches D, Ibezim A, Mbah CJ, Adikwu UM, Nwodo NJ, Steudle A, Masek BB, Nagy S, Baker D, Soltanshahi F, Dorfman R, Dubrucq K, Patel H, Koch O, Mrugalla F, Kast SM, Ain QU, Fuchs JE, Owen RM, Omoto K, Torella R, Pryde DC, Glen R, Bender A, Hošek P, Spiwok V, Mervin LH, Barrett I, Firth M, Murray DC, McWilliams L, Cao Q, Engkvist O, Warszycki D, Śmieja M, Bojarski AJ, Aniceto N, Freitas A, Ghafourian T, Herrmann G, Eigner-Pitto V, Naß A, Kurczab R, Bojarski AJ, Lange A, Günther MB, Hennig S, Büttner FM, Schall C, Sievers-Engler A, Ansideri F, Koch P, Stehle T, Laufer S, Böckler FM, Zdrazil B, Montanari F, Ecker GF, Grebner C, Hogner A, Ulander J, Edman K, Guallar V, Tyrchan C, Ulander J, Tyrchan C, Klute W, Bergström F, Kramer C, Nguyen QD, Frach R, Kibies P, Strohfeldt S, Böttcher S, Pongratz T, Horinek D, Kast SM, Rupp B, Al-Yamori R, Lisurek M, Kühne R, Furtado F, van den Broek K, Wessjohann L, Mathea M, Baumann K, Mohamad-Zobir SZ, Fu X, Fan TP, Bender A, Kuhn MA, Sotriffer CA, Zoufir A, Li X, Mervin L, Berg E, Polokoff M, Ihlenfeldt WD, Ihlenfeldt WD, Pretzel J, Alhalabi Z, Fraczkiewicz R, Waldman M, Clark RD, Shaikh N, Garg P, Kos A, Himmler HJ, Sandmann A, Jardin C, Sticht H, Steinbrecher TB, Dahlgren M, Cappel D, Lin T, Wang L, Krilov G, Abel R, Friesner R, Sherman W, Pöhner IA, Panecka J, Wade RC, Bietz S, Schomburg KT, Hilbig M, Rarey M, Jäger C, Wieczorek V, Westerhoff LM, Borbulevych OY, Demuth HU, Buchholz M, Schmidt D, Rickmeyer T, Krotzky T, Kolb P, Mittal S, Sánchez-García E, Nogueira MS, Oliveira TB, da Costa FB, Schmidt TJ.

J Cheminform. 2016 Apr 26;8(Suppl 1):18. doi: 10.1186/s13321-016-0119-5. No abstract available.

4.

Substrate Hunting for the Myxobacterial CYP260A1 Revealed New 1α-Hydroxylated Products from C-19 Steroids.

Khatri Y, Ringle M, Lisurek M, von Kries JP, Zapp J, Bernhardt R.

Chembiochem. 2016 Jan 1;17(1):90-101. doi: 10.1002/cbic.201500420. Epub 2015 Nov 20.

PMID:
26478560
5.

Design of a general-purpose European compound screening library for EU-OPENSCREEN.

Horvath D, Lisurek M, Rupp B, Kühne R, Specker E, von Kries J, Rognan D, Andersson CD, Almqvist F, Elofsson M, Enqvist PA, Gustavsson AL, Remez N, Mestres J, Marcou G, Varnek A, Hibert M, Quintana J, Frank R.

ChemMedChem. 2014 Oct;9(10):2309-26. doi: 10.1002/cmdc.201402126. Epub 2014 Jul 15.

PMID:
25044981
6.

Fluorescent mimetics of CMP-Neu5Ac are highly potent, cell-permeable polarization probes of eukaryotic and bacterial sialyltransferases and inhibit cellular sialylation.

Preidl JJ, Gnanapragassam VS, Lisurek M, Saupe J, Horstkorte R, Rademann J.

Angew Chem Int Ed Engl. 2014 May 26;53(22):5700-5. doi: 10.1002/anie.201400394. Epub 2014 Apr 15. Erratum in: Angew Chem Int Ed Engl. 2014 Jul 28;53(31):7977.

PMID:
24737687
7.

Alzheimer's disease: identification and development of β-secretase (BACE-1) binding fragments and inhibitors by dynamic ligation screening (DLS).

Fernández-Bachiller MI, Horatscheck A, Lisurek M, Rademann J.

ChemMedChem. 2013 Jul;8(7):1041-56. doi: 10.1002/cmdc.201300078. Epub 2013 Jun 11.

PMID:
23757181
8.

Benzoylphosphonate-based photoactive phosphopeptide mimetics for modulation of protein tyrosine phosphatases and highly specific labeling of SH2 domains.

Horatscheck A, Wagner S, Ortwein J, Kim BG, Lisurek M, Beligny S, Schütz A, Rademann J.

Angew Chem Int Ed Engl. 2012 Sep 10;51(37):9441-7. doi: 10.1002/anie.201201475. Epub 2012 Aug 21. No abstract available.

PMID:
22907897
9.

Identification of CYP106A2 as a regioselective allylic bacterial diterpene hydroxylase.

Bleif S, Hannemann F, Lisurek M, von Kries JP, Zapp J, Dietzen M, Antes I, Bernhardt R.

Chembiochem. 2011 Mar 7;12(4):576-82. doi: 10.1002/cbic.201000404. Epub 2011 Jan 26.

PMID:
21271628
10.

Design of chemical libraries with potentially bioactive molecules applying a maximum common substructure concept.

Lisurek M, Rupp B, Wichard J, Neuenschwander M, von Kries JP, Frank R, Rademann J, Kühne R.

Mol Divers. 2010 May;14(2):401-8. doi: 10.1007/s11030-009-9187-z. Epub 2009 Aug 15.

PMID:
19685275
11.

Cyanobacterial electron carrier proteins as electron donors to CYP106A2 from Bacillus megaterium ATCC 13368.

Goñi G, Zöllner A, Lisurek M, Velázquez-Campoy A, Pinto S, Gómez-Moreno C, Hannemann F, Bernhardt R, Medina M.

Biochim Biophys Acta. 2009 Nov;1794(11):1635-42. doi: 10.1016/j.bbapap.2009.07.012. Epub 2009 Jul 25.

PMID:
19635596
12.

Theoretical and experimental evaluation of a CYP106A2 low homology model and production of mutants with changed activity and selectivity of hydroxylation.

Lisurek M, Simgen B, Antes I, Bernhardt R.

Chembiochem. 2008 Jun 16;9(9):1439-49. doi: 10.1002/cbic.200700670.

PMID:
18481342
13.

Sensitized detection of inhibitory fragments and iterative development of non-peptidic protease inhibitors by dynamic ligation screening.

Schmidt MF, Isidro-Llobet A, Lisurek M, El-Dahshan A, Tan J, Hilgenfeld R, Rademann J.

Angew Chem Int Ed Engl. 2008;47(17):3275-8. doi: 10.1002/anie.200704594. No abstract available.

PMID:
18348134
14.

Function and engineering of the 15beta-hydroxylase CYP106A2.

Virus C, Lisurek M, Simgen B, Hannemann F, Bernhardt R.

Biochem Soc Trans. 2006 Dec;34(Pt 6):1215-8.

PMID:
17073788
15.

The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation.

Mueller-Dieckmann C, Kernstock S, Lisurek M, von Kries JP, Haag F, Weiss MS, Koch-Nolte F.

Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15026-31. Epub 2006 Oct 2.

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Modulation of aldosterone and cortisol synthesis on the molecular level.

Lisurek M, Bernhardt R.

Mol Cell Endocrinol. 2004 Feb 27;215(1-2):149-59. Review.

PMID:
15026188
19.

The human steroid hydroxylases CYP1B1 and CYP11B2.

Bureik M, Lisurek M, Bernhardt R.

Biol Chem. 2002 Oct;383(10):1537-51. Review.

PMID:
12452430
21.

Unfolding and conformational studies on bovine adrenodoxin probed by engineered intrinsic tryptophan fluorescence.

Hannemann F, Bera AK, Fischer B, Lisurek M, Teuchner K, Bernhardt R.

Biochemistry. 2002 Sep 10;41(36):11008-16.

PMID:
12206673
22.

Modelling of three-dimensional structures of cytochromes P450 11B1 and 11B2.

Belkina NV, Lisurek M, Ivanov AS, Bernhardt R.

J Inorg Biochem. 2001 Dec 15;87(4):197-207.

PMID:
11744057

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