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Items: 1 to 50 of 93


Single cell lineage tracing reveals a role for TgfβR2 in intestinal stem cell dynamics and differentiation.

Fischer JM, Calabrese PP, Miller AJ, Muñoz NM, Grady WM, Shibata D, Liskay RM.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12192-12197. Epub 2016 Oct 10.


An intact Pms2 ATPase domain is not essential for male fertility.

Fischer JM, Dudley S, Miller AJ, Liskay RM.

DNA Repair (Amst). 2016 Mar;39:46-51. doi: 10.1016/j.dnarep.2015.12.011. Epub 2015 Dec 29.


Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention.

Fischer JM, Schepers AG, Clevers H, Shibata D, Liskay RM.

Carcinogenesis. 2014 Jan;35(1):237-46. doi: 10.1093/carcin/bgt296. Epub 2013 Aug 29.


Different phenotypic consequences of simultaneous versus stepwise Apc loss.

Fischer JM, Miller AJ, Shibata D, Liskay RM.

Oncogene. 2012 Apr 19;31(16):2028-38. doi: 10.1038/onc.2011.385. Epub 2011 Sep 5.


Conservation of functional asymmetry in the mammalian MutLα ATPase.

Johnson JR, Erdeniz N, Nguyen M, Dudley S, Liskay RM.

DNA Repair (Amst). 2010 Nov 10;9(11):1209-13. doi: 10.1016/j.dnarep.2010.08.006.


Embryonic lethality after combined inactivation of Fancd2 and Mlh1 in mice.

van de Vrugt HJ, Eaton L, Hanlon Newell A, Al-Dhalimy M, Liskay RM, Olson SB, Grompe M.

Cancer Res. 2009 Dec 15;69(24):9431-8. doi: 10.1158/0008-5472.CAN-09-2452.


Tractable Cre-lox system for stochastic alteration of genes in mice.

Miller AJ, Dudley SD, Tsao JL, Shibata D, Liskay RM.

Nat Methods. 2008 Mar;5(3):227-9. doi: 10.1038/nmeth.1183. Epub 2008 Feb 10.


Involvement of deoxycytidylate deaminase in the response to S(n)1-type methylation DNA damage in budding yeast.

Liskay RM, Wheeler LJ, Mathews CK, Erdeniz N.

Curr Biol. 2007 Sep 4;17(17):R755-7. No abstract available.


A mutation in EXO1 defines separable roles in DNA mismatch repair and post-replication repair.

Tran PT, Fey JP, Erdeniz N, Gellon L, Boiteux S, Liskay RM.

DNA Repair (Amst). 2007 Nov;6(11):1572-83. Epub 2007 Jun 29.


Mutations affecting a putative MutLalpha endonuclease motif impact multiple mismatch repair functions.

Erdeniz N, Nguyen M, Deschênes SM, Liskay RM.

DNA Repair (Amst). 2007 Oct 1;6(10):1463-70. Epub 2007 Jun 12.


The E705K mutation in hPMS2 exerts recessive, not dominant, effects on mismatch repair.

Deschênes SM, Tomer G, Nguyen M, Erdeniz N, Juba NC, Sepúlveda N, Pisani JE, Liskay RM.

Cancer Lett. 2007 May 8;249(2):148-56. Epub 2006 Oct 9.


Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6.

Hegan DC, Narayanan L, Jirik FR, Edelmann W, Liskay RM, Glazer PM.

Carcinogenesis. 2006 Dec;27(12):2402-8. Epub 2006 May 25.


Overexpression of the DNA mismatch repair factor, PMS2, confers hypermutability and DNA damage tolerance.

Gibson SL, Narayanan L, Hegan DC, Buermeyer AB, Liskay RM, Glazer PM.

Cancer Lett. 2006 Dec 8;244(2):195-202. Epub 2006 Jan 19.


Crossover and noncrossover pathways in mouse meiosis.

Guillon H, Baudat F, Grey C, Liskay RM, de Massy B.

Mol Cell. 2005 Nov 23;20(4):563-73.


Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I.

Kolas NK, Svetlanov A, Lenzi ML, Macaluso FP, Lipkin SM, Liskay RM, Greally J, Edelmann W, Cohen PE.

J Cell Biol. 2005 Nov 7;171(3):447-58. Epub 2005 Oct 31.


Novel PMS1 alleles preferentially affect the repair of primer strand loops during DNA replication.

Erdeniz N, Dudley S, Gealy R, Jinks-Robertson S, Liskay RM.

Mol Cell Biol. 2005 Nov;25(21):9221-31.


Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse.

Chen PC, Dudley S, Hagen W, Dizon D, Paxton L, Reichow D, Yoon SR, Yang K, Arnheim N, Liskay RM, Lipkin SM.

Cancer Res. 2005 Oct 1;65(19):8662-70.


EXO1-A multi-tasking eukaryotic nuclease.

Tran PT, Erdeniz N, Symington LS, Liskay RM.

DNA Repair (Amst). 2004 Dec 2;3(12):1549-59. Review.


Apoptosis and mutation in the murine small intestine: loss of Mlh1- and Pms2-dependent apoptosis leads to increased mutation in vivo.

Sansom OJ, Bishop SM, Court H, Dudley S, Liskay RM, Clarke AR.

DNA Repair (Amst). 2003 Sep 18;2(9):1029-39.


Mlh1 deficiency accelerates myeloid leukemogenesis in neurofibromatosis 1 (Nf1) heterozygous mice.

Gutmann DH, Winkeler E, Kabbarah O, Hedrick N, Dudley S, Goodfellow PJ, Liskay RM.

Oncogene. 2003 Jul 17;22(29):4581-5.


Characterization of nuclease-dependent functions of Exo1p in Saccharomyces cerevisiae.

Tran PT, Erdeniz N, Dudley S, Liskay RM.

DNA Repair (Amst). 2002 Nov 3;1(11):895-912.


Neurofibromatosis type 1 gene as a mutational target in a mismatch repair-deficient cell type.

Wang Q, Montmain G, Ruano E, Upadhyaya M, Dudley S, Liskay RM, Thibodeau SN, Puisieux A.

Hum Genet. 2003 Feb;112(2):117-23. Epub 2002 Nov 21.


Alleles of the yeast Pms1 mismatch-repair gene that differentially affect recombination- and replication-related processes.

Welz-Voegele C, Stone JE, Tran PT, Kearney HM, Liskay RM, Petes TD, Jinks-Robertson S.

Genetics. 2002 Nov;162(3):1131-45.


Diet, cancer and aging in DNA mismatch repair deficient mice.

Tsao JL, Dudley S, Kwok B, Nickel AE, Laird PW, Siegmund KD, Liskay RM, Shibata D.

Carcinogenesis. 2002 Nov;23(11):1807-10.


Evidence for the lack of mismatch-repair directed antirecombination during mouse meiosis.

Qin J, Baker S, Te Riele H, Liskay RM, Arnheim N.

J Hered. 2002 May-Jun;93(3):201-5.


Contribution of human mlh1 and pms2 ATPase activities to DNA mismatch repair.

Tomer G, Buermeyer AB, Nguyen MM, Liskay RM.

J Biol Chem. 2002 Jun 14;277(24):21801-9. Epub 2002 Mar 15.


Maternal effect for DNA mismatch repair in the mouse.

Gurtu VE, Verma S, Grossmann AH, Liskay RM, Skarnes WC, Baker SM.

Genetics. 2002 Jan;160(1):271-7.


Interactions of Exo1p with components of MutLalpha in Saccharomyces cerevisiae.

Tran PT, Simon JA, Liskay RM.

Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9760-5. Epub 2001 Jul 31.


Hypermutability to ionizing radiation in mismatch repair-deficient, Pms2 knockout mice.

Xu XS, Narayanan L, Dunklee B, Liskay RM, Glazer PM.

Cancer Res. 2001 May 1;61(9):3775-80.


MSH-MLH complexes formed at a DNA mismatch are disrupted by the PCNA sliding clamp.

Bowers J, Tran PT, Joshi A, Liskay RM, Alani E.

J Mol Biol. 2001 Mar 9;306(5):957-68.


Ionizing radiation-induced apoptosis via separate Pms2- and p53-dependent pathways.

Zeng M, Narayanan L, Xu XS, Prolla TA, Liskay RM, Glazer PM.

Cancer Res. 2000 Sep 1;60(17):4889-93.


Analysis of yeast MSH2-MSH6 suggests that the initiation of mismatch repair can be separated into discrete steps.

Bowers J, Tran PT, Liskay RM, Alani E.

J Mol Biol. 2000 Sep 15;302(2):327-38.


Mutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshifts.

Andrew SE, Xu XS, Baross-Francis A, Narayanan L, Milhausen K, Liskay RM, Jirik FR, Glazer PM.

Carcinogenesis. 2000 Jul;21(7):1291-5.


Mlh1 deficiency enhances several phenotypes of Apc(Min)/+ mice.

Shoemaker AR, Haigis KM, Baker SM, Dudley S, Liskay RM, Dove WF.

Oncogene. 2000 May 25;19(23):2774-9.


Mammalian DNA mismatch repair.

Buermeyer AB, Deschênes SM, Baker SM, Liskay RM.

Annu Rev Genet. 1999;33:533-64. Review.


Different mutator phenotypes in Mlh1- versus Pms2-deficient mice.

Yao X, Buermeyer AB, Narayanan L, Tran D, Baker SM, Prolla TA, Glazer PM, Liskay RM, Arnheim N.

Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6850-5.


The human MLH1 cDNA complements DNA mismatch repair defects in Mlh1-deficient mouse embryonic fibroblasts.

Buermeyer AB, Wilson-Van Patten C, Baker SM, Liskay RM.

Cancer Res. 1999 Feb 1;59(3):538-41.


A mutation of the yeast gene encoding PCNA destabilizes both microsatellite and minisatellite DNA sequences.

Kokoska RJ, Stefanovic L, Buermeyer AB, Liskay RM, Petes TD.

Genetics. 1999 Feb;151(2):511-9.


Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2.

Winter DB, Phung QH, Umar A, Baker SM, Tarone RE, Tanaka K, Liskay RM, Kunkel TA, Bohr VA, Gearhart PJ.

Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6953-8.


Enhanced intestinal adenomatous polyp formation in Pms2-/-;Min mice.

Baker SM, Harris AC, Tsao JL, Flath TJ, Bronner CE, Gordon M, Shibata D, Liskay RM.

Cancer Res. 1998 Mar 15;58(6):1087-9.


Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair.

Prolla TA, Baker SM, Harris AC, Tsao JL, Yao X, Bronner CE, Zheng B, Gordon M, Reneker J, Arnheim N, Shibata D, Bradley A, Liskay RM.

Nat Genet. 1998 Mar;18(3):276-9.


Role of DNA mismatch repair in the cytotoxicity of ionizing radiation.

Fritzell JA, Narayanan L, Baker SM, Bronner CE, Andrew SE, Prolla TA, Bradley A, Jirik FR, Liskay RM, Glazer PM.

Cancer Res. 1997 Nov 15;57(22):5143-7.


Intestinal stem cell division and genetic diversity. A computer and experimental analysis.

Tsao JL, Davis SD, Baker SM, Liskay RM, Shibata D.

Am J Pathol. 1997 Aug;151(2):573-9.


Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2.

Narayanan L, Fritzell JA, Baker SM, Liskay RM, Glazer PM.

Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3122-7.


Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes.

Thibodeau SN, French AJ, Roche PC, Cunningham JM, Tester DJ, Lindor NM, Moslein G, Baker SM, Liskay RM, Burgart LJ, Honchel R, Halling KC.

Cancer Res. 1996 Nov 1;56(21):4836-40.


Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis.

Umar A, Buermeyer AB, Simon JA, Thomas DC, Clark AB, Liskay RM, Kunkel TA.

Cell. 1996 Oct 4;87(1):65-73.


Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over.

Baker SM, Plug AW, Prolla TA, Bronner CE, Harris AC, Yao X, Christie DM, Monell C, Arnheim N, Bradley A, Ashley T, Liskay RM.

Nat Genet. 1996 Jul;13(3):336-42.


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