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Items: 1 to 50 of 213

1.

Design, Synthesis, and Evaluation of a Diazirine Photoaffinity Probe for Ligand-Based Receptor Capture Targeting G Protein-Coupled Receptors.

Müskens FM, Ward RJ, Herkt D, van de Langemheen H, Tobin AB, Liskamp RMJ, Milligan G.

Mol Pharmacol. 2019 Feb;95(2):196-209. doi: 10.1124/mol.118.114249. Epub 2018 Dec 4.

2.

Synthesis and cellular penetration properties of new phosphonium based cationic amphiphilic peptides.

Silva Nigenda E, Postma TM, Hezwani M, Pirvan A, Gannon S, Smith CA, Riehle M, Liskamp RMJ.

Medchemcomm. 2018 May 9;9(6):982-987. doi: 10.1039/c8md00113h. eCollection 2018 Jun 1.

PMID:
30108987
3.

Synthetic antibody protein mimics of infliximab by molecular scaffolding on novel CycloTriVeratrilene (CTV) derivatives.

Longin O, Hezwani M, van de Langemheen H, Liskamp RMJ.

Org Biomol Chem. 2018 Jul 25;16(29):5254-5274. doi: 10.1039/c8ob01104d.

PMID:
29892733
4.

Potent and Highly Selective Inhibitors of the Proteasome Trypsin-like Site by Incorporation of Basic Side Chain Containing Amino Acid Derived Sulfonyl Fluorides.

Artschwager R, Ward DJ, Gannon S, Brouwer AJ, van de Langemheen H, Kowalski H, Liskamp RMJ.

J Med Chem. 2018 Jun 28;61(12):5395-5411. doi: 10.1021/acs.jmedchem.8b00685. Epub 2018 Jun 13.

PMID:
29782167
5.

Targeted Covalent Inhibition of Prolyl Oligopeptidase (POP): Discovery of Sulfonylfluoride Peptidomimetics.

Guardiola S, Prades R, Mendieta L, Brouwer AJ, Streefkerk J, Nevola L, Tarragó T, Liskamp RMJ, Giralt E.

Cell Chem Biol. 2018 Aug 16;25(8):1031-1037.e4. doi: 10.1016/j.chembiol.2018.04.013. Epub 2018 May 17.

PMID:
29779956
6.

Tailoring Polyethers for Post-polymerization Functionalization by Cross Metathesis.

Morrison SD, Liskamp RMJ, Prunet J.

Org Lett. 2018 Apr 20;20(8):2253-2256. doi: 10.1021/acs.orglett.8b00595. Epub 2018 Mar 30.

PMID:
29600865
7.

Immobilization by Surface Conjugation of Cyclic Peptides for Effective Mimicry of the HCV-Envelope E2 Protein as a Strategy toward Synthetic Vaccines.

Meuleman TJ, Dunlop JI, Owsianka AM, van de Langemheen H, Patel AH, Liskamp RMJ.

Bioconjug Chem. 2018 Apr 18;29(4):1091-1101. doi: 10.1021/acs.bioconjchem.7b00755. Epub 2018 Feb 19.

8.

Potential peptidic proteasome inhibitors by incorporation of an electrophilic trap based on amino acid derived α-substituted sulfonyl fluorides.

Herrero Alvarez N, van de Langemheen H, Brouwer AJ, Liskamp RMJ.

Bioorg Med Chem. 2017 Oct 1;25(19):5055-5063. doi: 10.1016/j.bmc.2017.07.019. Epub 2017 Jul 12.

PMID:
28734665
9.

An orthogonally protected CycloTriVeratrylene (CTV) as a highly pre-organized molecular scaffold for subsequent ligation of different cyclic peptides towards protein mimics.

Longin O, van de Langemheen H, Liskamp RMJ.

Bioorg Med Chem. 2017 Sep 15;25(18):5008-5015. doi: 10.1016/j.bmc.2017.05.038. Epub 2017 May 18.

PMID:
28583807
10.

Polar Hinges as Functionalized Conformational Constraints in (Bi)cyclic Peptides.

van de Langemheen H, Korotkovs V, Bijl J, Wilson C, Kale SS, Heinis C, Liskamp RM.

Chembiochem. 2017 Feb 16;18(4):387-395. doi: 10.1002/cbic.201600612. Epub 2017 Jan 16.

PMID:
27982494
11.

Proteasome inhibition by new dual warhead containing peptido vinyl sulfonyl fluorides.

Brouwer AJ, Herrero Álvarez N, Ciaffoni A, van de Langemheen H, Liskamp RM.

Bioorg Med Chem. 2016 Aug 15;24(16):3429-35. doi: 10.1016/j.bmc.2016.05.042. Epub 2016 May 24.

PMID:
27316540
12.

The presence of C/EBPα and its degradation are both required for TRIB2-mediated leukaemia.

O'Connor C, Lohan F, Campos J, Ohlsson E, Salomè M, Forde C, Artschwager R, Liskamp RM, Cahill MR, Kiely PA, Porse B, Keeshan K.

Oncogene. 2016 Oct 6;35(40):5272-5281. doi: 10.1038/onc.2016.66. Epub 2016 Mar 21.

PMID:
26996668
13.

Molecular construction of HIV-gp120 discontinuous epitope mimics by assembly of cyclic peptides on an orthogonal alkyne functionalized TAC-scaffold.

Werkhoven PR, Elwakiel M, Meuleman TJ, Quarles van Ufford HC, Kruijtzer JAW, Liskamp RMJ.

Org Biomol Chem. 2016 Jan 14;14(2):701-710. doi: 10.1039/c5ob02014j.

PMID:
26552661
14.

Synthesis of nisin AB dicarba analogs using ring-closing metathesis: influence of sp(3) versus sp(2) hybridization of the α-carbon atom of residues dehydrobutyrine-2 and dehydroalanine-5 on the lipid II binding affinity.

Slootweg JC, van Herwerden EF, van Doremalen MF, Breukink E, Liskamp RM, Rijkers DT.

Org Biomol Chem. 2015 Jun 7;13(21):5997-6009. doi: 10.1039/c5ob00336a.

PMID:
25940216
15.

Synthesis of pyrazole containing α-amino acids via a highly regioselective condensation/aza-Michael reaction of β-aryl α,β-unsaturated ketones.

Gilfillan L, Artschwager R, Harkiss AH, Liskamp RM, Sutherland A.

Org Biomol Chem. 2015 Apr 21;13(15):4514-23. doi: 10.1039/c5ob00364d.

PMID:
25774874
16.

Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site.

Dubiella C, Cui H, Gersch M, Brouwer AJ, Sieber SA, Krüger A, Liskamp RM, Groll M.

Angew Chem Int Ed Engl. 2014 Oct 27;53(44):11969-73. doi: 10.1002/anie.201406964. Epub 2014 Sep 22.

PMID:
25244435
17.

Peptides: Bicycling into cells.

Liskamp RM.

Nat Chem. 2014 Oct;6(10):855-7. doi: 10.1038/nchem.2073. No abstract available.

PMID:
25242478
18.

Semi-synthesis of biologically active nisin hybrids composed of the native lanthionine ABC-fragment and a cross-stapled synthetic DE-fragment.

Slootweg JC, Peters N, Quarles van Ufford HL, Breukink E, Liskamp RM, Rijkers DT.

Bioorg Med Chem. 2014 Oct 1;22(19):5345-53. doi: 10.1016/j.bmc.2014.07.046. Epub 2014 Aug 2.

PMID:
25199583
19.

A proteinaceous fraction of wheat bran may interfere in the attachment of enterotoxigenic E. coli K88 (F4+) to porcine epithelial cells.

González-Ortiz G, Bronsoms S, Quarles Van Ufford HC, Halkes SB, Virkola R, Liskamp RM, Beukelman CJ, Pieters RJ, Pérez JF, Martín-Orúe SM.

PLoS One. 2014 Aug 13;9(8):e104258. doi: 10.1371/journal.pone.0104258. eCollection 2014.

20.

Characterization and activity of an immobilized antimicrobial peptide containing bactericidal PEG-hydrogel.

Cleophas RT, Sjollema J, Busscher HJ, Kruijtzer JA, Liskamp RM.

Biomacromolecules. 2014 Sep 8;15(9):3390-5. doi: 10.1021/bm500899r. Epub 2014 Aug 22.

PMID:
25109707
21.

pH-controlled aggregation polymorphism of amyloidogenic Aβ(16-22): insights for obtaining peptide tapes and peptide nanotubes, as function of the N-terminal capping moiety.

Elgersma RC, Kroon-Batenburg LM, Posthuma G, Meeldijk JD, Rijkers DT, Liskamp RM.

Eur J Med Chem. 2014 Dec 17;88:55-65. doi: 10.1016/j.ejmech.2014.07.089. Epub 2014 Jul 25.

PMID:
25087966
22.

Synthesis of the TACO scaffold as a new selectively deprotectable conformationally restricted triazacyclophane based scaffold.

Brouwer AJ, van de Langemheen H, Ciaffoni A, Schilder KE, Liskamp RM.

Org Lett. 2014 Jun 6;16(11):3106-9. doi: 10.1021/ol5012218. Epub 2014 May 23.

PMID:
24856258
23.

Scaffolded multiple cyclic peptide libraries for protein mimics by native chemical ligation.

van de Langemheen H, van Hoeke M, Quarles van Ufford HC, Kruijtzer JA, Liskamp RM.

Org Biomol Chem. 2014 Jul 7;12(25):4471-8. doi: 10.1039/c4ob00190g.

PMID:
24849139
24.

Efficient synthesis of protein mimics by sequential native chemical ligation.

van de Langemheen H, Quarles van Ufford HL, Kruijtzer JA, Liskamp RM.

Org Lett. 2014 Apr 18;16(8):2138-41. doi: 10.1021/ol500604h. Epub 2014 Apr 7.

PMID:
24708093
25.

Versatile convergent synthesis of a three peptide loop containing protein mimic of whooping cough pertactin by successive Cu(I)-catalyzed azide alkyne cycloaddition on an orthogonal alkyne functionalized TAC-scaffold.

Werkhoven PR, van de Langemheen H, van der Wal S, Kruijtzer JA, Liskamp RM.

J Pept Sci. 2014 Apr;20(4):235-9. doi: 10.1002/psc.2624. Epub 2014 Mar 6.

PMID:
24599619
26.

New properties of wheat bran: anti-biofilm activity and interference with bacteria quorum-sensing systems.

González-Ortiz G, Quarles Van Ufford HC, Halkes SB, Cerdà-Cuéllar M, Beukelman CJ, Pieters RJ, Liskamp RM, Pérez JF, Martín-Orue SM.

Environ Microbiol. 2014 May;16(5):1346-53. doi: 10.1111/1462-2920.12441. Epub 2014 Apr 4.

PMID:
24588934
27.

Azide-alkyne cycloaddition affording enzymatically tunable bisubstrate based inhibitors of histone acetyltransferase PCAF.

van Ameijde J, Zwiebel AP, Ruijtenbeek R, Liskamp RM.

Bioorg Med Chem Lett. 2014 Jan 1;24(1):113-6. doi: 10.1016/j.bmcl.2013.11.060. Epub 2013 Dec 4.

PMID:
24345448
28.

A versatile spectrophotometric protein tyrosine phosphatase assay based on 3-nitrophosphotyrosine containing substrates.

van Ameijde J, Overvoorde J, Knapp S, den Hertog J, Ruijtenbeek R, Liskamp RM.

Anal Biochem. 2014 Mar 1;448:9-13. doi: 10.1016/j.ab.2013.11.023. Epub 2013 Dec 3.

PMID:
24309020
29.

Synthesis, antimicrobial activity, and membrane permeabilizing properties of C-terminally modified nisin conjugates accessed by CuAAC.

Slootweg JC, van der Wal S, Quarles van Ufford HC, Breukink E, Liskamp RM, Rijkers DT.

Bioconjug Chem. 2013 Dec 18;24(12):2058-66. doi: 10.1021/bc400401k. Epub 2013 Dec 5.

PMID:
24266643
30.

Synthesis and structural characterization of the individual diastereoisomers of a cross-stapled alkene-bridged nisin DE-ring mimic.

Slootweg JC, Kemmink J, Liskamp RM, Rijkers DT.

Org Biomol Chem. 2013 Nov 21;11(43):7486-96. doi: 10.1039/c3ob41359d.

PMID:
24081149
31.

Scalable purification of the lantibiotic nisin and isolation of chemical/enzymatic cleavage fragments suitable for semi-synthesis.

Slootweg JC, Liskamp RM, Rijkers DT.

J Pept Sci. 2013 Nov;19(11):692-9. doi: 10.1002/psc.2551. Epub 2013 Sep 11.

PMID:
24023046
32.

Improving the biological activity of the antimicrobial peptide anoplin by membrane anchoring through a lipophilic amino acid derivative.

Slootweg JC, van Schaik TB, Quarles van Ufford HL, Breukink E, Liskamp RM, Rijkers DT.

Bioorg Med Chem Lett. 2013 Jul 1;23(13):3749-52. doi: 10.1016/j.bmcl.2013.05.002. Epub 2013 May 9.

PMID:
23719232
33.

Broad-spectrum antimalarial activity of peptido sulfonyl fluorides, a new class of proteasome inhibitors.

Tschan S, Brouwer AJ, Werkhoven PR, Jonker AM, Wagner L, Knittel S, Aminake MN, Pradel G, Joanny F, Liskamp RM, Mordmüller B.

Antimicrob Agents Chemother. 2013 Aug;57(8):3576-84. doi: 10.1128/AAC.00742-12. Epub 2013 May 20.

34.

Cell-penetrating bisubstrate-based protein kinase C inhibitors.

van Wandelen LT, van Ameijde J, Ismail-Ali AF, van Ufford HC, Vijftigschild LA, Beekman JM, Martin NI, Ruijtenbeek R, Liskamp RM.

ACS Chem Biol. 2013 Jul 19;8(7):1479-87. doi: 10.1021/cb300709g. Epub 2013 May 8.

PMID:
23621550
35.

Synthesis of 1,5-triazole bridged vancomycin CDE-ring bicyclic mimics using RuAAC macrocyclization.

Zhang J, Kemmink J, Rijkers DT, Liskamp RM.

Chem Commun (Camb). 2013 May 18;49(40):4498-500. doi: 10.1039/c3cc40628h. Epub 2013 Apr 10.

PMID:
23571454
36.

Scaffold optimization in discontinuous epitope containing protein mimics of gp120 using smart libraries.

Mulder GE, Quarles van Ufford HL, van Ameijde J, Brouwer AJ, Kruijtzer JA, Liskamp RM.

Org Biomol Chem. 2013 Apr 28;11(16):2676-84. doi: 10.1039/c3ob27470e.

PMID:
23467699
37.

Activity-based probes for rhomboid proteases discovered in a mass spectrometry-based assay.

Vosyka O, Vinothkumar KR, Wolf EV, Brouwer AJ, Liskamp RM, Verhelst SH.

Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2472-7. doi: 10.1073/pnas.1215076110. Epub 2013 Jan 28.

38.

Peptido sulfonyl fluorides as new powerful proteasome inhibitors.

Brouwer AJ, Jonker A, Werkhoven P, Kuo E, Li N, Gallastegui N, Kemmink J, Florea BI, Groll M, Overkleeft HS, Liskamp RM.

J Med Chem. 2012 Dec 27;55(24):10995-1003. doi: 10.1021/jm301443r. Epub 2012 Dec 13.

PMID:
23170994
39.

Unusual binding of Grb2 protein to a bivalent polyproline-ligand immobilized on a SPR sensor: intermolecular bivalent binding.

de Mol NJ, Kruijtzer JA, Moret EE, Broutin I, Liskamp RM.

Biochim Biophys Acta. 2013 Feb;1834(2):524-35. doi: 10.1016/j.bbapap.2012.11.001. Epub 2012 Nov 15.

PMID:
23159538
40.

Directed modulation of protein kinase C isozyme selectivity with bisubstrate-based inhibitors.

van Wandelen LT, van Ameijde J, Mady AS, Wammes AE, Bode A, Poot AJ, Ruijtenbeek R, Liskamp RM.

ChemMedChem. 2012 Dec;7(12):2113-21. doi: 10.1002/cmdc.201200349. Epub 2012 Nov 8.

PMID:
23139239
41.

Synthesis of cyclic peptides containing a thioester handle for native chemical ligation.

van de Langemheen H, Brouwer AJ, Kemmink J, Kruijtzer JA, Liskamp RM.

J Org Chem. 2012 Nov 16;77(22):10058-64. doi: 10.1021/jo3015566. Epub 2012 Nov 5.

PMID:
23078179
42.

A combinatorial approach toward smart libraries of discontinuous epitopes of HIV gp120 on a TAC synthetic scaffold.

Mulder GE, Kruijtzer JA, Liskamp RM.

Chem Commun (Camb). 2012 Oct 14;48(80):10007-9. doi: 10.1039/c2cc35310e.

PMID:
22935751
43.

Mutual influence of backbone proline substitution and lipophilic tail character on the biological activity of simplified analogues of caspofungin.

Mulder MP, Fodran P, Kemmink J, Breukink EJ, Kruijtzer JA, Minnaard AJ, Liskamp RM.

Org Biomol Chem. 2012 Oct 7;10(37):7491-502. doi: 10.1039/c2ob25951f.

PMID:
22878559
44.

Imprinted polymers displaying high affinity for sulfated protein fragments.

Shinde S, Bunschoten A, Kruijtzer JA, Liskamp RM, Sellergren B.

Angew Chem Int Ed Engl. 2012 Aug 13;51(33):8326-9. doi: 10.1002/anie.201201314. Epub 2012 Jul 5. No abstract available.

PMID:
22767441
45.

Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis.

Crielaard BJ, Rijcken CJ, Quan L, van der Wal S, Altintas I, van der Pot M, Kruijtzer JA, Liskamp RM, Schiffelers RM, van Nostrum CF, Hennink WE, Wang D, Lammers T, Storm G.

Angew Chem Int Ed Engl. 2012 Jul 16;51(29):7254-8. doi: 10.1002/anie.201202713. Epub 2012 Jun 12.

46.

Chemical-biological exploration of the limits of the Ras de- and repalmitoylating machinery.

Görmer K, Bürger M, Kruijtzer JA, Vetter I, Vartak N, Brunsveld L, Bastiaens PI, Liskamp RM, Triola G, Waldmann H.

Chembiochem. 2012 May 7;13(7):1017-23. doi: 10.1002/cbic.201200078. Epub 2012 Apr 5.

PMID:
22488913
47.

Trivalent ultrashort lipopeptides are potent pH dependent antifungal agents.

Arnusch CJ, Albada HB, van Vaardegem M, Liskamp RM, Sahl HG, Shadkchan Y, Osherov N, Shai Y.

J Med Chem. 2012 Feb 9;55(3):1296-302. doi: 10.1021/jm2014474. Epub 2012 Feb 1.

PMID:
22243686
48.

Triazacyclophane (TAC)-scaffolded histidine and aspartic acid residues as mimics of non-heme metalloenzyme active sites.

Albada HB, Soulimani F, Jacobs HJ, Versluis C, Weckhuysen BM, Liskamp RM.

Org Biomol Chem. 2012 Feb 7;10(5):1088-92. doi: 10.1039/c1ob06806g. Epub 2011 Dec 19.

PMID:
22179680
49.

Probing the lipid-protein interface using model transmembrane peptides with a covalently linked acyl chain.

Nyholm TK, van Duyl B, Rijkers DT, Liskamp RM, Killian JA.

Biophys J. 2011 Oct 19;101(8):1959-67. doi: 10.1016/j.bpj.2011.09.020.

50.

Synthesis and evaluation of novel macrocyclic antifungal peptides.

Mulder MP, Kruijtzer JA, Breukink EJ, Kemmink J, Pieters RJ, Liskamp RM.

Bioorg Med Chem. 2011 Nov 1;19(21):6505-17. doi: 10.1016/j.bmc.2011.08.034. Epub 2011 Aug 22.

PMID:
21940175

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