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Items: 10

1.

Rho-mediated signaling promotes BRAF inhibitor resistance in de-differentiated melanoma cells.

Misek SA, Appleton KM, Dexheimer TS, Lisabeth EM, Lo RS, Larsen SD, Gallo KA, Neubig RR.

Oncogene. 2019 Oct 28. doi: 10.1038/s41388-019-1074-1. [Epub ahead of print]

PMID:
31659259

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2.

The Rho/MRTF pathway inhibitor CCG-222740 reduces stellate cell activation and modulates immune cell populations in KrasG12D; Pdx1-Cre (KC) mice.

Leal AS, Misek SA, Lisabeth EM, Neubig RR, Liby KT.

Sci Rep. 2019 May 8;9(1):7072. doi: 10.1038/s41598-019-43430-0.

PMID:
31068602
Free PMC Article

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3.

5-Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Response Factor (SRF)-Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma.

Kahl DJ, Hutchings KM, Lisabeth EM, Haak AJ, Leipprandt JR, Dexheimer T, Khanna D, Tsou PS, Campbell PL, Fox DA, Wen B, Sun D, Bailie M, Neubig RR, Larsen SD.

J Med Chem. 2019 May 9;62(9):4350-4369. doi: 10.1021/acs.jmedchem.8b01772. Epub 2019 Apr 18.

PMID:
30951312
Free PMC Article

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4.

Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis.

Yu-Wai-Man C, Spencer-Dene B, Lee RMH, Hutchings K, Lisabeth EM, Treisman R, Bailly M, Larsen SD, Neubig RR, Khaw PT.

Sci Rep. 2017 Mar 31;7(1):518. doi: 10.1038/s41598-017-00212-w.

PMID:
28364121
Free PMC Article

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5.

Pharmacokinetic optimitzation of CCG-203971: Novel inhibitors of the Rho/MRTF/SRF transcriptional pathway as potential antifibrotic therapeutics for systemic scleroderma.

Hutchings KM, Lisabeth EM, Rajeswaran W, Wilson MW, Sorenson RJ, Campbell PL, Ruth JH, Amin A, Tsou PS, Leipprandt JR, Olson SR, Wen B, Zhao T, Sun D, Khanna D, Fox DA, Neubig RR, Larsen SD.

Bioorg Med Chem Lett. 2017 Apr 15;27(8):1744-1749. doi: 10.1016/j.bmcl.2017.02.070. Epub 2017 Mar 10.

PMID:
28285914
Free PMC Article

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6.

Pharmacological Inhibition of Myocardin-related Transcription Factor Pathway Blocks Lung Metastases of RhoC-Overexpressing Melanoma.

Haak AJ, Appleton KM, Lisabeth EM, Misek SA, Ji Y, Wade SM, Bell JL, Rockwell CE, Airik M, Krook MA, Larsen SD, Verhaegen M, Lawlor ER, Neubig RR.

Mol Cancer Ther. 2017 Jan;16(1):193-204. doi: 10.1158/1535-7163.MCT-16-0482. Epub 2016 Nov 11.

PMID:
27837031
Free PMC Article

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7.

Small-Molecule Inhibition of Rho/MKL/SRF Transcription in Prostate Cancer Cells: Modulation of Cell Cycle, ER Stress, and Metastasis Gene Networks.

Evelyn CR, Lisabeth EM, Wade SM, Haak AJ, Johnson CN, Lawlor ER, Neubig RR.

Microarrays (Basel). 2016 May 28;5(2). pii: E13. doi: 10.3390/microarrays5020013.

PMID:
27600078
Free PMC Article

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8.

Attenuation of eph receptor kinase activation in cancer cells by coexpressed ephrin ligands.

Falivelli G, Lisabeth EM, Rubio de la Torre E, Perez-Tenorio G, Tosato G, Salvucci O, Pasquale EB.

PLoS One. 2013 Nov 29;8(11):e81445. doi: 10.1371/journal.pone.0081445. eCollection 2013.

PMID:
24348920
Free PMC Article

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9.

Eph receptor signaling and ephrins.

Lisabeth EM, Falivelli G, Pasquale EB.

Cold Spring Harb Perspect Biol. 2013 Sep 1;5(9). pii: a009159. doi: 10.1101/cshperspect.a009159. Review.

PMID:
24003208
Free PMC Article

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10.

Cancer somatic mutations disrupt functions of the EphA3 receptor tyrosine kinase through multiple mechanisms.

Lisabeth EM, Fernandez C, Pasquale EB.

Biochemistry. 2012 Feb 21;51(7):1464-75. doi: 10.1021/bi2014079. Epub 2012 Feb 8.

PMID:
22242939
Free PMC Article

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