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Items: 1 to 50 of 116

1.

Regulation of Geldanamycin Biosynthesis by Cluster-Situated Transcription Factors and the Master Regulator PhoP.

Martín JF, Ramos A, Liras P.

Antibiotics (Basel). 2019 Jun 30;8(3). pii: E87. doi: 10.3390/antibiotics8030087. Review.

2.

Sensing and transduction of nutritional and chemical signals in filamentous fungi: Impact on cell development and secondary metabolites biosynthesis.

Martín JF, van den Berg MA, Ver Loren van Themaat E, Liras P.

Biotechnol Adv. 2019 Nov 1;37(6):107392. doi: 10.1016/j.biotechadv.2019.04.014. Epub 2019 Apr 26. Review.

PMID:
31034961
3.

Activation of Secondary Metabolite Gene Clusters in Streptomyces clavuligerus by the PimM Regulator of Streptomyces natalensis.

Martínez-Burgo Y, Santos-Aberturas J, Rodríguez-García A, Barreales EG, Tormo JR, Truman AW, Reyes F, Aparicio JF, Liras P.

Front Microbiol. 2019 Mar 26;10:580. doi: 10.3389/fmicb.2019.00580. eCollection 2019.

4.

Harnessing microbiota interactions to produce bioactive metabolites: communication signals and receptor proteins.

Martín JF, Liras P.

Curr Opin Pharmacol. 2019 Oct;48:8-16. doi: 10.1016/j.coph.2019.02.014. Epub 2019 Mar 30. Review.

PMID:
30933876
5.

Transcriptional Studies on a Streptomyces clavuligerus oppA2 Deletion Mutant: N-Acetylglycyl-Clavaminic Acid Is an Intermediate of Clavulanic Acid Biosynthesis.

Álvarez-Álvarez R, Rodríguez-García A, Martínez-Burgo Y, Martín JF, Liras P.

Appl Environ Microbiol. 2018 Oct 30;84(22). pii: e01701-18. doi: 10.1128/AEM.01701-18. Print 2018 Nov 15.

6.

ArgR of Streptomyces coelicolor Is a Pleiotropic Transcriptional Regulator: Effect on the Transcriptome, Antibiotic Production, and Differentiation in Liquid Cultures.

Botas A, Pérez-Redondo R, Rodríguez-García A, Álvarez-Álvarez R, Yagüe P, Manteca A, Liras P.

Front Microbiol. 2018 Mar 1;9:361. doi: 10.3389/fmicb.2018.00361. eCollection 2018.

7.

Clavine Alkaloids Gene Clusters of Penicillium and Related Fungi: Evolutionary Combination of Prenyltransferases, Monooxygenases and Dioxygenases.

Martin JF, Álvarez-Álvarez R, Liras P.

Genes (Basel). 2017 Nov 24;8(12). pii: E342. doi: 10.3390/genes8120342. Review.

8.

Discovering the potential of S. clavuligerus for bioactive compound production: cross-talk between the chromosome and the pSCL4 megaplasmid.

Álvarez-Álvarez R, Martínez-Burgo Y, Rodríguez-García A, Liras P.

BMC Genomics. 2017 Nov 25;18(1):907. doi: 10.1186/s12864-017-4289-y. No abstract available.

9.

Streptomyces tsukubaensis as a new model for carbon repression: transcriptomic response to tacrolimus repressing carbon sources.

Ordóñez-Robles M, Santos-Beneit F, Albillos SM, Liras P, Martín JF, Rodríguez-García A.

Appl Microbiol Biotechnol. 2017 Nov;101(22):8181-8195. doi: 10.1007/s00253-017-8545-5. Epub 2017 Oct 5.

PMID:
28983826
10.

Erratum to: Silencing of a second dimethylallyltryptophan synthase of Penicillium roqueforti reveals a novel clavine alkaloid gene cluster.

Fernández-Bodega Á, Álvarez-Álvarez R, Liras P, Martín JF.

Appl Microbiol Biotechnol. 2017 Oct;101(20):7767-7768. doi: 10.1007/s00253-017-8478-z. No abstract available.

PMID:
28900651
11.

Silencing of a second dimethylallyltryptophan synthase of Penicillium roqueforti reveals a novel clavine alkaloid gene cluster.

Fernández-Bodega Á, Álvarez-Álvarez R, Liras P, Martín JF.

Appl Microbiol Biotechnol. 2017 Aug;101(15):6111-6121. doi: 10.1007/s00253-017-8366-6. Epub 2017 Jun 16. Erratum in: Appl Microbiol Biotechnol. 2017 Sep 12;:.

PMID:
28620689
12.

The master regulator PhoP coordinates phosphate and nitrogen metabolism, respiration, cell differentiation and antibiotic biosynthesis: comparison in Streptomyces coelicolor and Streptomyces avermitilis.

Martín JF, Rodríguez-García A, Liras P.

J Antibiot (Tokyo). 2017 May;70(5):534-541. doi: 10.1038/ja.2017.19. Epub 2017 Mar 15. Review.

PMID:
28293039
13.

Evolutionary formation of gene clusters by reorganization: the meleagrin/roquefortine paradigm in different fungi.

Martín JF, Liras P.

Appl Microbiol Biotechnol. 2016 Feb;100(4):1579-87. doi: 10.1007/s00253-015-7192-y. Epub 2015 Dec 15. Review.

PMID:
26668029
14.

Molecular genetics of naringenin biosynthesis, a typical plant secondary metabolite produced by Streptomyces clavuligerus.

Álvarez-Álvarez R, Botas A, Albillos SM, Rumbero A, Martín JF, Liras P.

Microb Cell Fact. 2015 Nov 9;14:178. doi: 10.1186/s12934-015-0373-7.

15.

The Pathway-Specific Regulator ClaR of Streptomyces clavuligerus Has a Global Effect on the Expression of Genes for Secondary Metabolism and Differentiation.

Martínez-Burgo Y, Álvarez-Álvarez R, Rodríguez-García A, Liras P.

Appl Environ Microbiol. 2015 Oct;81(19):6637-48. doi: 10.1128/AEM.00916-15. Epub 2015 Jul 17.

16.

A natural short pathway synthesizes roquefortine C but not meleagrin in three different Penicillium roqueforti strains.

Kosalková K, Domínguez-Santos R, Coton M, Coton E, García-Estrada C, Liras P, Martín JF.

Appl Microbiol Biotechnol. 2015 Sep;99(18):7601-12. doi: 10.1007/s00253-015-6676-0. Epub 2015 May 22.

PMID:
25998659
17.

Heterologous expression of Streptomyces clavuligerus ATCC 27064 cephamycin C gene cluster.

Martínez-Burgo Y, Álvarez-Álvarez R, Pérez-Redondo R, Liras P.

J Biotechnol. 2014 Sep 30;186:21-9. doi: 10.1016/j.jbiotec.2014.06.002. Epub 2014 Jun 26.

PMID:
24975573
18.

Transcriptomic analysis of Streptomyces clavuligerus ΔccaR::tsr: effects of the cephamycin C-clavulanic acid cluster regulator CcaR on global regulation.

Alvarez-Álvarez R, Rodríguez-García A, Santamarta I, Pérez-Redondo R, Prieto-Domínguez A, Martínez-Burgo Y, Liras P.

Microb Biotechnol. 2014 May;7(3):221-31. doi: 10.1111/1751-7915.12109. Epub 2014 Jan 22.

19.

Holomycin, a dithiolopyrrolone compound produced by Streptomyces clavuligerus.

Liras P.

Appl Microbiol Biotechnol. 2014 Feb;98(3):1023-30. doi: 10.1007/s00253-013-5410-z. Epub 2013 Dec 10. Review.

PMID:
24323287
20.

A 1.8-Mb-reduced Streptomyces clavuligerus genome: relevance for secondary metabolism and differentiation.

Álvarez-Álvarez R, Rodríguez-García A, Martínez-Burgo Y, Robles-Reglero V, Santamarta I, Pérez-Redondo R, Martín JF, Liras P.

Appl Microbiol Biotechnol. 2014 Mar;98(5):2183-95. doi: 10.1007/s00253-013-5382-z. Epub 2013 Dec 5.

PMID:
24305736
21.

Expression of the endogenous and heterologous clavulanic acid cluster in Streptomyces flavogriseus: why a silent cluster is sleeping.

Alvarez-Álvarez R, Martínez-Burgo Y, Pérez-Redondo R, Braña AF, Martín JF, Liras P.

Appl Microbiol Biotechnol. 2013 Nov;97(21):9451-63. doi: 10.1007/s00253-013-5148-7. Epub 2013 Aug 22.

PMID:
23974366
22.

Role of the cmcH-ccaR intergenic region and ccaR overexpression in cephamycin C biosynthesis in Streptomyces clavuligerus.

Kurt A, Álvarez-Álvarez R, Liras P, Özcengiz G.

Appl Microbiol Biotechnol. 2013 Jul;97(13):5869-80. doi: 10.1007/s00253-013-4721-4. Epub 2013 Jan 30.

PMID:
23361841
23.

Transcriptional analysis and proteomics of the holomycin gene cluster in overproducer mutants of Streptomyces clavuligerus.

Robles-Reglero V, Santamarta I, Álvarez-Álvarez R, Martín JF, Liras P.

J Biotechnol. 2013 Jan 10;163(1):69-76. doi: 10.1016/j.jbiotec.2012.09.017. Epub 2012 Nov 9.

PMID:
23147422
24.

Cascades and networks of regulatory genes that control antibiotic biosynthesis.

Martín JF, Liras P.

Subcell Biochem. 2012;64:115-38. doi: 10.1007/978-94-007-5055-5_6. Review.

PMID:
23080248
25.

ArgR of Streptomyces coelicolor is a versatile regulator.

Pérez-Redondo R, Rodríguez-García A, Botas A, Santamarta I, Martín JF, Liras P.

PLoS One. 2012;7(3):e32697. doi: 10.1371/journal.pone.0032697. Epub 2012 Mar 5.

26.

Characterization of DNA-binding sequences for CcaR in the cephamycin-clavulanic acid supercluster of Streptomyces clavuligerus.

Santamarta I, López-García MT, Kurt A, Nárdiz N, Alvarez-Álvarez R, Pérez-Redondo R, Martín JF, Liras P.

Mol Microbiol. 2011 Aug;81(4):968-81. doi: 10.1111/j.1365-2958.2011.07743.x. Epub 2011 Jul 20.

27.

A rhodanese-like protein is highly overrepresented in the mutant S. clavuligerus oppA2::aph: effect on holomycin and other secondary metabolites production.

Nárdiz N, Santamarta I, Lorenzana LM, Martín JF, Liras P.

Microb Biotechnol. 2011 Mar;4(2):216-25. doi: 10.1111/j.1751-7915.2010.00222.x. Epub 2010 Nov 2.

28.

Homologous expression of aspartokinase (ask) gene in Streptomyces clavuligerus and its hom-deleted mutant: effects on cephamycin C production.

Özcengiz G, Okay S, Ünsaldı E, Taşkın B, Liras P, Piret J.

Bioeng Bugs. 2010 May-Jun;1(3):191-7. doi: 10.4161/bbug.1.3.11244. Epub 2010 Jan 11.

29.

Morphological differentiation and clavulanic acid formation are affected in a Streptomyces clavuligerus adpA-deleted mutant.

López-García MT, Santamarta I, Liras P.

Microbiology. 2010 Aug;156(Pt 8):2354-65. doi: 10.1099/mic.0.035956-0. Epub 2010 May 6.

PMID:
20447998
30.

Engineering of regulatory cascades and networks controlling antibiotic biosynthesis in Streptomyces.

Martín JF, Liras P.

Curr Opin Microbiol. 2010 Jun;13(3):263-73. doi: 10.1016/j.mib.2010.02.008. Epub 2010 Mar 19. Review.

PMID:
20303823
31.

The enigmatic lack of glucose utilization in Streptomyces clavuligerus is due to inefficient expression of the glucose permease gene.

Pérez-Redondo R, Santamarta I, Bovenberg R, Martín JF, Liras P.

Microbiology. 2010 May;156(Pt 5):1527-1537. doi: 10.1099/mic.0.035840-0. Epub 2010 Jan 28.

PMID:
20110297
32.

Chapter 16. Enzymology of beta-lactam compounds with cephem structure produced by actinomycete.

Liras P, Demain AL.

Methods Enzymol. 2009;458:401-29. doi: 10.1016/S0076-6879(09)04816-2.

PMID:
19374992
33.

Glycerol utilization gene cluster in Streptomyces clavuligerus.

Baños S, Pérez-Redondo R, Koekman B, Liras P.

Appl Environ Microbiol. 2009 May;75(9):2991-5. doi: 10.1128/AEM.00181-09. Epub 2009 Mar 13.

34.

Regulatory mechanisms controlling antibiotic production in Streptomyces clavuligerus.

Liras P, Gomez-Escribano JP, Santamarta I.

J Ind Microbiol Biotechnol. 2008 Jul;35(7):667-76. doi: 10.1007/s10295-008-0351-8. Epub 2008 Apr 30. Review.

PMID:
18446393
35.

Streptomyces clavuligerus relA-null mutants overproduce clavulanic acid and cephamycin C: negative regulation of secondary metabolism by (p)ppGpp.

Gomez-Escribano JP, Martín JF, Hesketh A, Bibb MJ, Liras P.

Microbiology. 2008 Mar;154(Pt 3):744-55. doi: 10.1099/mic.0.2007/011890-0.

PMID:
18310021
36.
38.

Characterization of a two-gene operon epeRA involved in multidrug resistance in Streptomyces clavuligerus.

Rodríguez-García A, Santamarta I, Pérez-Redondo R, Martín JF, Liras P.

Res Microbiol. 2006 Jul-Aug;157(6):559-68. Epub 2006 Feb 9.

PMID:
16797928
40.

Characterization of an hyperpigmenting mutant of Monascus purpureus IB1: identification of two novel pigment chemical structures.

Campoy S, Rumbero A, Martín JF, Liras P.

Appl Microbiol Biotechnol. 2006 Apr;70(4):488-96. Epub 2005 Sep 7.

PMID:
16151799
41.

Secretion systems for secondary metabolites: how producer cells send out messages of intercellular communication.

Martín JF, Casqueiro J, Liras P.

Curr Opin Microbiol. 2005 Jun;8(3):282-93. Review.

PMID:
15939351
42.

Different proteins bind to the butyrolactone receptor protein ARE sequence located upstream of the regulatory ccaR gene of Streptomyces clavuligerus.

Santamarta I, Pérez-Redondo R, Lorenzana LM, Martín JF, Liras P.

Mol Microbiol. 2005 May;56(3):824-35. Erratum in: Mol Microbiol. 2005 Aug;57(4):1175-6.

44.
45.
46.

Stable transformants of the azaphilone pigment-producing Monascus purpureus obtained by protoplast transformation and Agrobacterium-mediated DNA transfer.

Campoy S, Pérez F, Martín JF, Gutiérrez S, Liras P.

Curr Genet. 2003 Sep;43(6):447-52. Epub 2003 Jul 1.

PMID:
12838368
48.

CcaR is an autoregulatory protein that binds to the ccaR and cefD-cmcI promoters of the cephamycin C-clavulanic acid cluster in Streptomyces clavuligerus.

Santamarta I, Rodríguez-García A, Pérez-Redondo R, Martín JF, Liras P.

J Bacteriol. 2002 Jun;184(11):3106-13.

49.

The clavulanic acid biosynthetic cluster of Streptomyces clavuligerus: genetic organization of the region upstream of the car gene.

Mellado E, Lorenzana LM, Rodríguez-Sáiz M, Díez B, Liras P, Barredo JL.

Microbiology. 2002 May;148(Pt 5):1427-38.

PMID:
11988517
50.

Structure of the ask-asd operon and formation of aspartokinase subunits in the cephamycin producer 'Amycolatopsis lactamdurans'.

Hernándo-Rico V, Martín JF, Santamarta I, Liras P.

Microbiology. 2001 Jun;147(Pt 6):1547-55.

PMID:
11390685

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