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Items: 13

1.

In vitro-In vivo extrapolation of key transporter activity at the blood-brain barrier.

Trapa PE, Troutman MD, Lau TY, Wager TT, Maurer TS, Patel NC, West MA, Umland JP, Carlo AA, Feng B, Liras JL.

Drug Metab Dispos. 2019 Jan 25. pii: dmd.118.083279. doi: 10.1124/dmd.118.083279. [Epub ahead of print]

2.

Discovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1.

Humphrey JM, Movsesian M, Am Ende CW, Becker SL, Chappie TA, Jenkinson S, Liras JL, Liras S, Orozco C, Pandit J, Vajdos FF, Vandeput F, Yang E, Menniti FS.

J Med Chem. 2018 May 24;61(10):4635-4640. doi: 10.1021/acs.jmedchem.8b00374. Epub 2018 May 10.

PMID:
29718668
3.

Insights From an Integrated Physiologically Based Pharmacokinetic Model for Brain Penetration.

Trapa PE, Belova E, Liras JL, Scott DO, Steyn SJ.

J Pharm Sci. 2016 Feb;105(2):965-971. doi: 10.1016/j.xphs.2015.12.005.

PMID:
26869440
4.

Strategies to minimize CNS toxicity: in vitro high-throughput assays and computational modeling.

Wager TT, Liras JL, Mente S, Trapa P.

Expert Opin Drug Metab Toxicol. 2012 May;8(5):531-42. doi: 10.1517/17425255.2012.677028. Epub 2012 Mar 29. Review.

PMID:
22458547
5.

Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections.

Magee TV, Ripp SL, Li B, Buzon RA, Chupak L, Dougherty TJ, Finegan SM, Girard D, Hagen AE, Falcone MJ, Farley KA, Granskog K, Hardink JR, Huband MD, Kamicker BJ, Kaneko T, Knickerbocker MJ, Liras JL, Marra A, Medina I, Nguyen TT, Noe MC, Obach RS, O'Donnell JP, Penzien JB, Reilly UD, Schafer JR, Shen Y, Stone GG, Strelevitz TJ, Sun J, Tait-Kamradt A, Vaz AD, Whipple DA, Widlicka DW, Wishka DG, Wolkowski JP, Flanagan ME.

J Med Chem. 2009 Dec 10;52(23):7446-57. doi: 10.1021/jm900729s.

PMID:
19775168
6.

Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13.

Freeman-Cook KD, Reiter LA, Noe MC, Antipas AS, Danley DE, Datta K, Downs JT, Eisenbeis S, Eskra JD, Garmene DJ, Greer EM, Griffiths RJ, Guzman R, Hardink JR, Janat F, Jones CS, Martinelli GJ, Mitchell PG, Laird ER, Liras JL, Lopresti-Morrow LL, Pandit J, Reilly UD, Robertson D, Vaughn-Bowser ML, Wolf-Gouviea LA, Yocum SA.

Bioorg Med Chem Lett. 2007 Dec 1;17(23):6529-34. Epub 2007 Sep 29.

PMID:
17935984
7.

Potent, selective pyrimidinetrione-based inhibitors of MMP-13.

Reiter LA, Freeman-Cook KD, Jones CS, Martinelli GJ, Antipas AS, Berliner MA, Datta K, Downs JT, Eskra JD, Forman MD, Greer EM, Guzman R, Hardink JR, Janat F, Keene NF, Laird ER, Liras JL, Lopresti-Morrow LL, Mitchell PG, Pandit J, Robertson D, Sperger D, Vaughn-Bowser ML, Waller DM, Yocum SA.

Bioorg Med Chem Lett. 2006 Nov 15;16(22):5822-6. Epub 2006 Aug 30.

PMID:
16942871
8.

Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction.

Ripp SL, Mills JB, Fahmi OA, Trevena KA, Liras JL, Maurer TS, de Morais SM.

Drug Metab Dispos. 2006 Oct;34(10):1742-8. Epub 2006 Jul 12.

PMID:
16837568
9.

Discovery of 3-OH-3-methylpipecolic hydroxamates: potent orally active inhibitors of aggrecanase and MMP-13.

Noe MC, Natarajan V, Snow SL, Wolf-Gouveia LA, Mitchell PG, Lopresti-Morrow L, Reeves LM, Yocum SA, Otterness I, Bliven MA, Carty TJ, Barberia JT, Sweeney FJ, Liras JL, Vaughn M.

Bioorg Med Chem Lett. 2005 Jul 15;15(14):3385-8.

PMID:
15953722
10.

Discovery of 3,3-dimethyl-5-hydroxypipecolic hydroxamate-based inhibitors of aggrecanase and MMP-13.

Noe MC, Natarajan V, Snow SL, Mitchell PG, Lopresti-Morrow L, Reeves LM, Yocum SA, Carty TJ, Barberia JA, Sweeney FJ, Liras JL, Vaughn M, Hardink JR, Hawkins JM, Tokar C.

Bioorg Med Chem Lett. 2005 Jun 2;15(11):2808-11.

PMID:
15911259
11.

Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14.

Blagg JA, Noe MC, Wolf-Gouveia LA, Reiter LA, Laird ER, Chang SP, Danley DE, Downs JT, Elliott NC, Eskra JD, Griffiths RJ, Hardink JR, Haugeto AI, Jones CS, Liras JL, Lopresti-Morrow LL, Mitchell PG, Pandit J, Robinson RP, Subramanyam C, Vaughn-Bowser ML, Yocum SA.

Bioorg Med Chem Lett. 2005 Apr 1;15(7):1807-10.

PMID:
15780611
12.

3-Hydroxy-4-arylsulfonyltetrahydropyranyl-3-hydroxamic acids are novel inhibitors of MMP-13 and aggrecanase.

Noe MC, Snow SL, Wolf-Gouveia LA, Mitchell PG, Lopresti-Morrow L, Reeves LM, Yocum SA, Liras JL, Vaughn M.

Bioorg Med Chem Lett. 2004 Sep 20;14(18):4727-30.

PMID:
15324896
13.

Solid and Solution Phase Organic Syntheses of Oligomeric Thioureas.

Smith J, Liras JL, Schneider SE, Anslyn EV.

J Org Chem. 1996 Dec 13;61(25):8811-8818.

PMID:
11667859

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