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Items: 1 to 50 of 109

1.

27nt-RNAs guide histone variant deposition via 'RNA-induced DNA replication interference' and thus transmit parental genome partitioning in Stylonychia.

Postberg J, Jönsson F, Weil PP, Bulic A, Juranek SA, Lipps HJ.

Epigenetics Chromatin. 2018 Jun 12;11(1):31. doi: 10.1186/s13072-018-0201-5.

2.

S/MAR Element Facilitates Episomal Long-Term Persistence of Adeno-Associated Virus Vector Genomes in Proliferating Cells.

Hagedorn C, Schnödt-Fuchs M, Boehme P, Abdelrazik H, Lipps HJ, Büning H.

Hum Gene Ther. 2017 Dec;28(12):1169-1179. doi: 10.1089/hum.2017.025. Epub 2017 Jun 29.

PMID:
28665147
3.

Genome-wide profiling of S/MAR-based replicon contact sites.

Hagedorn C, Gogol-Döring A, Schreiber S, Epplen JT, Lipps HJ.

Nucleic Acids Res. 2017 Jul 27;45(13):7841-7854. doi: 10.1093/nar/gkx522.

4.

RNA-template dependent de novo telomere addition.

Fuhrmann G, Jönsson F, Weil PP, Postberg J, Lipps HJ.

RNA Biol. 2016 Aug 2;13(8):733-9. doi: 10.1080/15476286.2015.1134414. Epub 2016 Jan 19.

5.

G-quadruplexes and their regulatory roles in biology.

Rhodes D, Lipps HJ.

Nucleic Acids Res. 2015 Oct 15;43(18):8627-37. doi: 10.1093/nar/gkv862. Epub 2015 Sep 8. Review.

6.

The draft assembly of the radically organized Stylonychia lemnae macronuclear genome.

Aeschlimann SH, Jönsson F, Postberg J, Stover NA, Petera RL, Lipps HJ, Nowacki M, Swart EC.

Genome Biol Evol. 2014 Jun 20;6(7):1707-23. doi: 10.1093/gbe/evu139.

7.

Differential expression of histone H3 genes and selective association of the variant H3.7 with a specific sequence class in Stylonychia macronuclear development.

Forcob S, Bulic A, Jönsson F, Lipps HJ, Postberg J.

Epigenetics Chromatin. 2014 Feb 7;7(1):4. doi: 10.1186/1756-8935-7-4.

8.

S/MAR sequence confers long-term mitotic stability on non-integrating lentiviral vector episomes without selection.

Verghese SC, Goloviznina NA, Skinner AM, Lipps HJ, Kurre P.

Nucleic Acids Res. 2014 Apr;42(7):e53. doi: 10.1093/nar/gku082. Epub 2014 Jan 27.

9.

Viral hybrid-vectors for delivery of autonomous replicons.

Zhang W, Hagedorn C, Schulz E, Lipps HJ, Ehrhardt A.

Curr Gene Ther. 2014 Feb;14(1):10-23. Review.

PMID:
24365145
10.

Genomic cis-acting Sequences Improve Expression and Establishment of a Nonviral Vector.

Hagedorn C, Antoniou MN, Lipps HJ.

Mol Ther Nucleic Acids. 2013 Sep 3;2:e118. doi: 10.1038/mtna.2013.47.

11.

RNA-dependent genome processing during nuclear differentiation: the model systems of stichotrichous ciliates.

Fuhrmann G, Swart E, Nowacki M, Lipps HJ.

Epigenomics. 2013 Apr;5(2):229-36. doi: 10.2217/epi.13.15.

PMID:
23566098
12.

A Novel Adenoviral Hybrid-vector System Carrying a Plasmid Replicon for Safe and Efficient Cell and Gene Therapeutic Applications.

Voigtlander R, Haase R, Mück-Hausl M, Zhang W, Boehme P, Lipps HJ, Schulz E, Baiker A, Ehrhardt A.

Mol Ther Nucleic Acids. 2013 Apr 2;2:e83. doi: 10.1038/mtna.2013.11.

13.

A permissive chromatin structure is adopted prior to site-specific DNA demethylation of developmentally expressed genes involved in macronuclear differentiation.

Bulic A, Postberg J, Fischer A, Jönsson F, Reuter G, Lipps HJ.

Epigenetics Chromatin. 2013 Mar 5;6(1):5. doi: 10.1186/1756-8935-6-5.

14.

In vivo studies on non-viral transdifferentiation of liver cells towards pancreatic β cells.

Cim A, Sawyer GJ, Zhang X, Su H, Collins L, Jones P, Antoniou M, Reynes JP, Lipps HJ, Fabre JW.

J Endocrinol. 2012 Sep;214(3):277-88. Epub 2012 Jun 8.

PMID:
22685335
15.

Copy number variations of 11 macronuclear chromosomes and their gene expression in Oxytricha trifallax.

Xu K, Doak TG, Lipps HJ, Wang J, Swart EC, Chang WJ.

Gene. 2012 Aug 15;505(1):75-80. doi: 10.1016/j.gene.2012.05.045. Epub 2012 Jun 2.

PMID:
22669045
16.

Handling S/MAR vectors.

Hagedorn C, Baiker A, Postberg J, Ehrhardt A, Lipps HJ.

Cold Spring Harb Protoc. 2012 Jun 1;2012(6):657-63. doi: 10.1101/pdb.top068262.

PMID:
22661441
17.

Rescue of S/MAR-containing nonviral episomal expression vectors.

Hagedorn C, Baiker A, Postberg J, Ehrhardt A, Lipps HJ.

Cold Spring Harb Protoc. 2012 Jun 1;2012(6):709-11. doi: 10.1101/pdb.prot069518.

PMID:
22661432
18.

A colony-forming assay for determining the establishment efficiency of S/MAR-containing nonviral episomal expression vectors.

Hagedorn C, Baiker A, Postberg J, Ehrhardt A, Lipps HJ.

Cold Spring Harb Protoc. 2012 Jun 1;2012(6):706-8. doi: 10.1101/pdb.prot069500.

PMID:
22661431
19.

A telomerase-associated RecQ protein-like helicase resolves telomeric G-quadruplex structures during replication.

Postberg J, Tsytlonok M, Sparvoli D, Rhodes D, Lipps HJ.

Gene. 2012 Apr 15;497(2):147-54. doi: 10.1016/j.gene.2012.01.068. Epub 2012 Feb 2.

20.

[Lifelong healing via gene transfer - reality or utopia? Stable versus transient gene transfer].

Lipps HJ, Hammerschmidt W, Ehrhardt A.

Pharm Unserer Zeit. 2011 May;40(3):240-6. doi: 10.1002/pauz.201100419. Review. German. No abstract available.

PMID:
21698613
21.

Scaffold/matrix attached region-based nonviral episomal vectors.

Hagedorn C, Wong SP, Harbottle R, Lipps HJ.

Hum Gene Ther. 2011 Aug;22(8):915-23. doi: 10.1089/hum.2011.084. Epub 2011 Jul 27.

PMID:
21644838
22.

RNA-dependent control of gene amplification.

Heyse G, Jönsson F, Chang WJ, Lipps HJ.

Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22134-9. doi: 10.1073/pnas.1009284107. Epub 2010 Oct 25.

23.

Evolutionary origin of the cell nucleus and its functional architecture.

Postberg J, Lipps HJ, Cremer T.

Essays Biochem. 2010 Sep 20;48(1):1-24. doi: 10.1042/bse0480001. Review.

PMID:
20822483
24.

The evolutionary history of histone H3 suggests a deep eukaryotic root of chromatin modifying mechanisms.

Postberg J, Forcob S, Chang WJ, Lipps HJ.

BMC Evol Biol. 2010 Aug 25;10:259. doi: 10.1186/1471-2148-10-259.

25.

Controlled removal of a nonviral episomal vector from transfected cells.

Rupprecht S, Hagedorn C, Seruggia D, Magnusson T, Wagner E, Ogris M, Lipps HJ.

Gene. 2010 Oct 15;466(1-2):36-42. doi: 10.1016/j.gene.2010.07.001. Epub 2010 Jul 16.

PMID:
20621169
26.

The epigenetic regulation of autonomous replicons.

Hagedorn C, Lipps HJ, Rupprecht S.

Biomol Concepts. 2010 May 1;1(1):17-30. doi: 10.1515/bmc.2010.009.

PMID:
25961982
27.

pEPito: a significantly improved non-viral episomal expression vector for mammalian cells.

Haase R, Argyros O, Wong SP, Harbottle RP, Lipps HJ, Ogris M, Magnusson T, Vizoso Pinto MG, Haas J, Baiker A.

BMC Biotechnol. 2010 Mar 15;10:20. doi: 10.1186/1472-6750-10-20.

28.

Probing telomeric G-quadruplex DNA structures in cells with in vitro generated single-chain antibody fragments.

Schaffitzel C, Postberg J, Paeschke K, Lipps HJ.

Methods Mol Biol. 2010;608:159-81. doi: 10.1007/978-1-59745-363-9_11.

PMID:
20012422
29.

Histone modifications are specifically relocated during gene activation and nuclear differentiation.

Heyse KS, Weber SE, Lipps HJ.

BMC Genomics. 2009 Nov 24;10:554. doi: 10.1186/1471-2164-10-554.

30.

G-quadruplex structures: in vivo evidence and function.

Lipps HJ, Rhodes D.

Trends Cell Biol. 2009 Aug;19(8):414-22. doi: 10.1016/j.tcb.2009.05.002. Epub 2009 Jul 7. Review.

PMID:
19589679
31.

Cell cycle dependent histone dynamics of an episomal non-viral vector.

Rupprecht S, Lipps HJ.

Gene. 2009 Jun 15;439(1-2):95-101. doi: 10.1016/j.gene.2009.03.010. Epub 2009 Mar 21.

PMID:
19306916
32.

The unusual way to make a genetically active nucleus.

Jönsson F, Postberg J, Lipps HJ.

DNA Cell Biol. 2009 Feb;28(2):71-8. doi: 10.1089/dna.2008.0806. Review.

PMID:
19196049
33.

Spatial and temporal plasticity of chromatin during programmed DNA-reorganization in Stylonychia macronuclear development.

Postberg J, Heyse K, Cremer M, Cremer T, Lipps HJ.

Epigenetics Chromatin. 2008 Oct 27;1(1):3. doi: 10.1186/1756-8935-1-3.

34.

Episomal vectors for gene therapy.

Ehrhardt A, Haase R, Schepers A, Deutsch MJ, Lipps HJ, Baiker A.

Curr Gene Ther. 2008 Jun;8(3):147-61. Review.

PMID:
18537590
35.

The pathway to detangle a scrambled gene.

Möllenbeck M, Zhou Y, Cavalcanti AR, Jönsson F, Higgins BP, Chang WJ, Juranek S, Doak TG, Rozenberg G, Lipps HJ, Landweber LF.

PLoS One. 2008 Jun 4;3(6):e2330. doi: 10.1371/journal.pone.0002330.

36.

Cell cycle-dependent regulation of telomere tethering in the nucleus.

Paeschke K, Juranek S, Rhodes D, Lipps HJ.

Chromosome Res. 2008;16(5):721-8. doi: 10.1007/s10577-008-1222-x. Epub 2008 May 29.

PMID:
18506590
37.

Telomerase recruitment by the telomere end binding protein-beta facilitates G-quadruplex DNA unfolding in ciliates.

Paeschke K, Juranek S, Simonsson T, Hempel A, Rhodes D, Lipps HJ.

Nat Struct Mol Biol. 2008 Jun;15(6):598-604. doi: 10.1038/nsmb.1422. Epub 2008 May 18.

PMID:
18488043
38.

Long-term suppression of hepatitis B virus replication by short hairpin RNA expression using the scaffold/matrix attachment region-based replicating vector system pEPI-1.

Jenke AC, Wilhelm AD, Orth V, Lipps HJ, Protzer U, Wirth S.

Antimicrob Agents Chemother. 2008 Jul;52(7):2355-9. doi: 10.1128/AAC.00067-08. Epub 2008 May 12.

39.

Establishment and mitotic stability of an extra-chromosomal mammalian replicon.

Stehle IM, Postberg J, Rupprecht S, Cremer T, Jackson DA, Lipps HJ.

BMC Cell Biol. 2007 Aug 6;8:33.

40.

New insights into the macronuclear development in ciliates.

Juranek SA, Lipps HJ.

Int Rev Cytol. 2007;262:219-51. Review.

PMID:
17631190
41.

Genetically modified pigs produced with a nonviral episomal vector.

Manzini S, Vargiolu A, Stehle IM, Bacci ML, Cerrito MG, Giovannoni R, Zannoni A, Bianco MR, Forni M, Donini P, Papa M, Lipps HJ, Lavitrano M.

Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17672-7. Epub 2006 Nov 13.

42.

Designing nonviral vectors for efficient gene transfer and long-term gene expression.

Jackson DA, Juranek S, Lipps HJ.

Mol Ther. 2006 Nov;14(5):613-26. Epub 2006 Jun 19. Review.

43.

Interconversion of germline-limited and somatic DNA in a scrambled gene.

Möllenbeck M, Cavalcanti AR, Jönsson F, Lipps HJ, Landweber LF.

J Mol Evol. 2006 Jul;63(1):69-73. Epub 2006 Jun 3.

PMID:
16755354
44.
45.

snRNA and heterochromatin formation are involved in DNA excision during macronuclear development in stichotrichous ciliates.

Juranek SA, Rupprecht S, Postberg J, Lipps HJ.

Eukaryot Cell. 2005 Nov;4(11):1934-41. Erratum in: Eukaryot Cell. 2008 Sep;7(9):1616.

46.

A microarray analysis of developmentally regulated genes during macronuclear differentiation in the stichotrichous ciliate Stylonychia lemnae.

Paschka AG, Horejschi V, Jönsson F, Lindecke A, Weier G, Kaltschmidt C, Lipps HJ.

Gene. 2005 Oct 10;359:81-90.

PMID:
16150557
47.

Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo.

Paeschke K, Simonsson T, Postberg J, Rhodes D, Lipps HJ.

Nat Struct Mol Biol. 2005 Oct;12(10):847-54. Epub 2005 Sep 4.

PMID:
16142245
48.

Exploiting nuclear duality of ciliates to analyse topological requirements for DNA replication and transcription.

Postberg J, Alexandrova O, Cremer T, Lipps HJ.

J Cell Sci. 2005 Sep 1;118(Pt 17):3973-83.

49.

The nonviral episomal replicating vector pEPI-1 allows long-term inhibition of bcr-abl expression by shRNA.

Jenke AC, Eisenberger T, Baiker A, Stehle IM, Wirth S, Lipps HJ.

Hum Gene Ther. 2005 Apr;16(4):533-9.

PMID:
15871685
50.

Towards safe, non-viral therapeutic gene expression in humans.

Glover DJ, Lipps HJ, Jans DA.

Nat Rev Genet. 2005 Apr;6(4):299-310. Review.

PMID:
15761468

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