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Items: 1 to 50 of 517


Sensing intracellular calcium ions using a manganese-based MRI contrast agent.

Barandov A, Bartelle BB, Williamson CG, Loucks ES, Lippard SJ, Jasanoff A.

Nat Commun. 2019 Feb 22;10(1):897. doi: 10.1038/s41467-019-08558-7.


DNA Intercalation Facilitates Efficient DNA-Targeted Covalent Binding of Phenanthriplatin.

Almaqwashi AA, Zhou W, Naufer MN, Riddell IA, Yilmaz ÖH, Lippard SJ, Williams MC.

J Am Chem Soc. 2019 Jan 30;141(4):1537-1545. doi: 10.1021/jacs.8b10252. Epub 2019 Jan 17.


A Sensitive, Nonradioactive Assay for Zn(II) Uptake into Metazoan Cells.

Richardson CER, Nolan EM, Shoulders MD, Lippard SJ.

Biochemistry. 2018 Dec 18;57(50):6807-6815. doi: 10.1021/acs.biochem.8b01043. Epub 2018 Dec 5.


Superiority of SpiroZin2 Versus FluoZin-3 for monitoring vesicular Zn2+ allows tracking of lysosomal Zn2+ pools.

Han Y, Goldberg JM, Lippard SJ, Palmer AE.

Sci Rep. 2018 Oct 9;8(1):15034. doi: 10.1038/s41598-018-33102-w.


Glutathione-Scavenging Poly(disulfide amide) Nanoparticles for the Effective Delivery of Pt(IV) Prodrugs and Reversal of Cisplatin Resistance.

Ling X, Chen X, Riddell IA, Tao W, Wang J, Hollett G, Lippard SJ, Farokhzad OC, Shi J, Wu J.

Nano Lett. 2018 Jul 11;18(7):4618-4625. doi: 10.1021/acs.nanolett.8b01924. Epub 2018 Jun 19.


Interaction of the New Monofunctional Anticancer Agent Phenanthriplatin With Transporters for Organic Cations.

Hucke A, Park GY, Bauer OB, Beyer G, Köppen C, Zeeh D, Wehe CA, Sperling M, Schröter R, Kantauskaitè M, Hagos Y, Karst U, Lippard SJ, Ciarimboli G.

Front Chem. 2018 May 25;6:180. doi: 10.3389/fchem.2018.00180. eCollection 2018.


Speciation of Phenanthriplatin and Its Analogs in the Core of Tobacco Mosaic Virus.

Vernekar AA, Berger G, Czapar AE, Veliz FA, Wang DI, Steinmetz NF, Lippard SJ.

J Am Chem Soc. 2018 Mar 28;140(12):4279-4287. doi: 10.1021/jacs.7b12697. Epub 2018 Mar 19.


New Tools Uncover New Functions for Mobile Zinc in the Brain.

Goldberg JM, Lippard SJ.

Biochemistry. 2018 Jul 10;57(27):3991-3992. doi: 10.1021/acs.biochem.8b00108. Epub 2018 Mar 19. No abstract available.


The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex trans-[Pt(NH3)2(phenanthridine)Cl]NO3.

Zhou W, Almeqdadi M, Xifaras ME, Riddell IA, Yilmaz ÖH, Lippard SJ.

Chem Commun (Camb). 2018 Mar 13;54(22):2788-2791. doi: 10.1039/c8cc00393a.


Photoactivatable Sensors for Detecting Mobile Zinc.

Goldberg JM, Wang F, Sessler CD, Vogler NW, Zhang DY, Loucks WH, Tzounopoulos T, Lippard SJ.

J Am Chem Soc. 2018 Feb 14;140(6):2020-2023. doi: 10.1021/jacs.7b12766. Epub 2018 Jan 31.


A Method for Selective Depletion of Zn(II) Ions from Complex Biological Media and Evaluation of Cellular Consequences of Zn(II) Deficiency.

Richardson CER, Cunden LS, Butty VL, Nolan EM, Lippard SJ, Shoulders MD.

J Am Chem Soc. 2018 Feb 21;140(7):2413-2416. doi: 10.1021/jacs.7b12897. Epub 2018 Feb 12.


Anticancer activity of osmium(VI) nitrido complexes in patient-derived glioblastoma initiating cells and in vivo mouse models.

Berger G, Grauwet K, Zhang H, Hussey AM, Nowicki MO, Wang DI, Chiocca EA, Lawler SE, Lippard SJ.

Cancer Lett. 2018 Mar 1;416:138-148. doi: 10.1016/j.canlet.2017.11.041. Epub 2017 Dec 13.


Challenges and Opportunities in Brain Bioinorganic Chemistry.

Goldberg JM, Lippard SJ.

Acc Chem Res. 2017 Mar 21;50(3):577-579. doi: 10.1021/acs.accounts.6b00561.


Tuning the Diiron Core Geometry in Carboxylate-Bridged Macrocyclic Model Complexes Affects Their Redox Properties and Supports Oxidation Chemistry.

Wang F, Becker S, Minier MA, Loas A, Jackson MN, Lippard SJ.

Inorg Chem. 2017 Sep 18;56(18):11050-11058. doi: 10.1021/acs.inorgchem.7b01418. Epub 2017 Sep 5.


CF2H, a Hydrogen Bond Donor.

Sessler CD, Rahm M, Becker S, Goldberg JM, Wang F, Lippard SJ.

J Am Chem Soc. 2017 Jul 12;139(27):9325-9332. doi: 10.1021/jacs.7b04457. Epub 2017 Jun 27.


A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress.

Bruno PM, Liu Y, Park GY, Murai J, Koch CE, Eisen TJ, Pritchard JR, Pommier Y, Lippard SJ, Hemann MT.

Nat Med. 2017 Apr;23(4):461-471. doi: 10.1038/nm.4291. Epub 2017 Feb 27.


Metalloneurochemistry and the Pierian Spring: 'Shallow Draughts Intoxicate the Brain'.

Goldberg JM, Loas A, Lippard SJ.

Isr J Chem. 2016 Oct;56(9-10):791-802. doi: 10.1002/ijch.201600034. Epub 2016 Jul 29.


Repair shielding of platinum-DNA lesions in testicular germ cell tumors by high-mobility group box protein 4 imparts cisplatin hypersensitivity.

Awuah SG, Riddell IA, Lippard SJ.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):950-955. doi: 10.1073/pnas.1615327114. Epub 2017 Jan 17.


Mobile zinc increases rapidly in the retina after optic nerve injury and regulates ganglion cell survival and optic nerve regeneration.

Li Y, Andereggen L, Yuki K, Omura K, Yin Y, Gilbert HY, Erdogan B, Asdourian MS, Shrock C, de Lima S, Apfel UP, Zhuo Y, Hershfinkel M, Lippard SJ, Rosenberg PA, Benowitz L.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E209-E218. doi: 10.1073/pnas.1616811114. Epub 2017 Jan 3.


Roger Y. Tsien (1952-2016).

Lippard SJ.

Science. 2016 Oct 7;354(6308):41. No abstract available.


Mechanistic Studies of the Anticancer Activity of An Octahedral Hexanuclear Pt(II) Cage.

Zheng YR, Suntharalingam K, Bruno PM, Lin W, Wang W, Hemann MT, Lippard SJ.

Inorganica Chim Acta. 2016 Oct 1;452:125-129. Epub 2016 Mar 25.


Phenanthriplatin Acts As a Covalent Poison of Topoisomerase II Cleavage Complexes.

Riddell IA, Agama K, Park GY, Pommier Y, Lippard SJ.

ACS Chem Biol. 2016 Nov 18;11(11):2996-3001. Epub 2016 Oct 6.


Chemical Approach to Positional Isomers of Glucose-Platinum Conjugates Reveals Specific Cancer Targeting through Glucose-Transporter-Mediated Uptake in Vitro and in Vivo.

Patra M, Awuah SG, Lippard SJ.

J Am Chem Soc. 2016 Sep 28;138(38):12541-51. doi: 10.1021/jacs.6b06937. Epub 2016 Sep 16.


Nucleotide Binding Preference of the Monofunctional Platinum Anticancer-Agent Phenanthriplatin.

Riddell IA, Johnstone TC, Park GY, Lippard SJ.

Chemistry. 2016 May 23;22(22):7574-81. doi: 10.1002/chem.201600236. Epub 2016 Apr 25.


Membrane-Permeable Mn(III) Complexes for Molecular Magnetic Resonance Imaging of Intracellular Targets.

Barandov A, Bartelle BB, Gonzalez BA, White WL, Lippard SJ, Jasanoff A.

J Am Chem Soc. 2016 May 4;138(17):5483-6. doi: 10.1021/jacs.5b13337. Epub 2016 Apr 22.


Tobacco Mosaic Virus Delivery of Phenanthriplatin for Cancer therapy.

Czapar AE, Zheng YR, Riddell IA, Shukla S, Awuah SG, Lippard SJ, Steinmetz NF.

ACS Nano. 2016 Apr 26;10(4):4119-26. doi: 10.1021/acsnano.5b07360. Epub 2016 Mar 28.


Addition to "Achieving Reversible Sensing of Nitroxyl by Tuning the Ligand Environment of Azamacrocyclic Copper(II) Complexes".

Kim S, Minier MA, Loas A, Becker S, Wang F, Lippard SJ.

J Am Chem Soc. 2016 Mar 30;138(12):4268. doi: 10.1021/jacs.6b01932. Epub 2016 Mar 15. No abstract available.


Correction to "A Pt(IV) Pro-drug Preferentially Targets Indoleamine-2,3-dioxygenase, Providing Enhanced Ovarian Cancer Immuno-Chemotherapy".

Awuah SG, Zheng YR, Bruno PM, Hemann MT, Lippard SJ.

J Am Chem Soc. 2016 Mar 9;138(9):3250. doi: 10.1021/jacs.6b01316. Epub 2016 Feb 26. No abstract available.


Reaction-Based Probes for Imaging Mobile Zinc in Live Cells and Tissues.

Zastrow ML, Radford RJ, Chyan W, Anderson CT, Zhang DY, Loas A, Tzounopoulos T, Lippard SJ.

ACS Sens. 2016 Jan 22;1(1):32-39. Epub 2015 Sep 23.


The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs.

Johnstone TC, Suntharalingam K, Lippard SJ.

Chem Rev. 2016 Mar 9;116(5):3436-86. doi: 10.1021/acs.chemrev.5b00597. Epub 2016 Feb 11. Review.


Achieving Reversible Sensing of Nitroxyl by Tuning the Ligand Environment of Azamacrocyclic Copper(II) Complexes.

Kim S, Minier MA, Loas A, Becker S, Wang F, Lippard SJ.

J Am Chem Soc. 2016 Feb 17;138(6):1804-7. doi: 10.1021/jacs.5b12825. Epub 2016 Feb 8. Erratum in: J Am Chem Soc. 2016 Mar 30;138(12):4268.


A Potent Glucose-Platinum Conjugate Exploits Glucose Transporters and Preferentially Accumulates in Cancer Cells.

Patra M, Johnstone TC, Suntharalingam K, Lippard SJ.

Angew Chem Int Ed Engl. 2016 Feb 12;55(7):2550-4. doi: 10.1002/anie.201510551. Epub 2016 Jan 8.


AMPA receptor inhibition by synaptically released zinc.

Kalappa BI, Anderson CT, Goldberg JM, Lippard SJ, Tzounopoulos T.

Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15749-54. doi: 10.1073/pnas.1512296112. Epub 2015 Dec 8.


A Pt(IV) Pro-drug Preferentially Targets Indoleamine-2,3-dioxygenase, Providing Enhanced Ovarian Cancer Immuno-Chemotherapy.

Awuah SG, Zheng YR, Bruno PM, Hemann MT, Lippard SJ.

J Am Chem Soc. 2015 Dec 2;137(47):14854-7. doi: 10.1021/jacs.5b10182. Epub 2015 Nov 18. Erratum in: J Am Chem Soc. 2016 Mar 9;138(9):3250.


Metal-based optical probes for live cell imaging of nitroxyl (HNO).

Rivera-Fuentes P, Lippard SJ.

Acc Chem Res. 2015 Nov 17;48(11):2927-34. doi: 10.1021/acs.accounts.5b00388. Epub 2015 Nov 9.


Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug.

Miller MA, Zheng YR, Gadde S, Pfirschke C, Zope H, Engblom C, Kohler RH, Iwamoto Y, Yang KS, Askevold B, Kolishetti N, Pittet M, Lippard SJ, Farokhzad OC, Weissleder R.

Nat Commun. 2015 Oct 27;6:8692. doi: 10.1038/ncomms9692.


Solving 21st Century Problems in Biological Inorganic Chemistry Using Synthetic Models.

Karlin KD, Lippard SJ, Valentine JS, Burrows CJ.

Acc Chem Res. 2015 Oct 20;48(10):2659-60. doi: 10.1021/acs.accounts.5b00447. No abstract available.


(19)F NMR study of ligand dynamics in carboxylate-bridged diiron(II) complexes supported by a macrocyclic ligand.

Minier MA, Lippard SJ.

Dalton Trans. 2015 Nov 7;44(41):18111-21. doi: 10.1039/c5dt02138c. Epub 2015 Sep 29.


Coupling Oxygen Consumption with Hydrocarbon Oxidation in Bacterial Multicomponent Monooxygenases.

Wang W, Liang AD, Lippard SJ.

Acc Chem Res. 2015 Sep 15;48(9):2632-9. doi: 10.1021/acs.accounts.5b00312. Epub 2015 Aug 21.


Single Turnover Reveals Oxygenated Intermediates in Toluene/o-Xylene Monooxygenase in the Presence of the Native Redox Partners.

Liang AD, Lippard SJ.

J Am Chem Soc. 2015 Aug 26;137(33):10520-3. doi: 10.1021/jacs.5b07055. Epub 2015 Aug 12.


Singlet-Triplet Gaps of Cobalt Nitrosyls: Insights from Tropocoronand Complexes.

Hopmann KH, Conradie J, Tangen E, Tonzetich ZJ, Lippard SJ, Ghosh A.

Inorg Chem. 2015 Aug 3;54(15):7362-7. doi: 10.1021/acs.inorgchem.5b00901. Epub 2015 Jul 23.


Solid-phase synthesis provides a modular, lysine-based platform for fluorescent discrimination of nitroxyl and biological thiols.

Loas A, Radford RJ, Deliz Liang A, Lippard SJ.

Chem Sci. 2015 Jul 15;6(7):4131-4140. doi: 10.1039/c5sc00880h. Epub 2015 May 19.


Modulation of extrasynaptic NMDA receptors by synaptic and tonic zinc.

Anderson CT, Radford RJ, Zastrow ML, Zhang DY, Apfel UP, Lippard SJ, Tzounopoulos T.

Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2705-14. doi: 10.1073/pnas.1503348112. Epub 2015 May 6.


A Far-Red Emitting Probe for Unambiguous Detection of Mobile Zinc in Acidic Vesicles and Deep Tissue.

Rivera-Fuentes P, Wrobel AT, Zastrow ML, Khan M, Georgiou J, Luyben TT, Roder JC, Okamoto K, Lippard SJ.

Chem Sci. 2015;6(3):1944-1948.


Tonic zinc inhibits spontaneous firing in dorsal cochlear nucleus principal neurons by enhancing glycinergic neurotransmission.

Perez-Rosello T, Anderson CT, Ling C, Lippard SJ, Tzounopoulos T.

Neurobiol Dis. 2015 Sep;81:14-9. doi: 10.1016/j.nbd.2015.03.012. Epub 2015 Mar 18.


Methane monooxygenase: functionalizing methane at iron and copper.

Sazinsky MH, Lippard SJ.

Met Ions Life Sci. 2015;15:205-56. doi: 10.1007/978-3-319-12415-5_6. Review.


Necroptosis-inducing rhenium(V) oxo complexes.

Suntharalingam K, Awuah SG, Bruno PM, Johnstone TC, Wang F, Lin W, Zheng YR, Page JE, Hemann MT, Lippard SJ.

J Am Chem Soc. 2015 Mar 4;137(8):2967-74. doi: 10.1021/ja511978y. Epub 2015 Feb 20.


Third row transition metals for the treatment of cancer.

Johnstone TC, Suntharalingam K, Lippard SJ.

Philos Trans A Math Phys Eng Sci. 2015 Mar 13;373(2037). pii: 20140185. doi: 10.1098/rsta.2014.0185. Review.


Encapsulation of Pt(IV) Prodrugs within a Pt(II) Cage for Drug Delivery.

Zheng YR, Suntharalingam K, Johnstone TC, Lippard SJ.

Chem Sci. 2015 Feb 1;6(2):1189-1193.


Synthesis and characterization of mononuclear, pseudotetrahedral cobalt(III) compounds.

Kozhukh J, Minier MA, Lippard SJ.

Inorg Chem. 2015 Jan 20;54(2):418-24. doi: 10.1021/ic5009279. Epub 2014 Dec 22.

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