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Items: 1 to 50 of 303

1.

Biased modulators of NMDA receptors control channel opening and ion selectivity.

Perszyk RE, Swanger SA, Shelley C, Khatri A, Fernandez-Cuervo G, Epplin MP, Zhang J, Le P, Bülow P, Garnier-Amblard E, Gangireddy PKR, Bassell GJ, Yuan H, Menaldino DS, Liotta DC, Liebeskind LS, Traynelis SF.

Nat Chem Biol. 2020 Feb;16(2):188-196. doi: 10.1038/s41589-019-0449-5. Epub 2020 Jan 20.

PMID:
31959964
2.

Small molecule and peptide-based CXCR4 modulators as therapeutic agents. A patent review for the period from 2010 to 2018.

Tahirovic YA, Pelly S, Jecs E, Miller EJ, Sharma SK, Liotta DC, Wilson LJ.

Expert Opin Ther Pat. 2020 Feb;30(2):87-101. doi: 10.1080/13543776.2020.1707186. Epub 2020 Jan 7.

PMID:
31854208
3.

Post-traumatic stress disorder and subthreshold post-traumatic stress disorder in recent male asylum seekers: An expected but overlooked "European" epidemic.

Sacchetti E, Garozzo A, Mussoni C, Liotta D, Novelli G, Tamussi E, Deste G, Vita A.

Stress Health. 2019 Nov 25. doi: 10.1002/smi.2910. [Epub ahead of print]

PMID:
31769207
4.

Genetic diversity of the JC polyomavirus (JCPyV) and mitochondrial DNA ancestry in Misiones, Argentina.

Sanabria DJ, Mojsiejczuk LN, Torres C, Meyer AG, Mbayed VA, Liotta DJ, Campos RH, Schurr TG, Badano I.

Infect Genet Evol. 2019 Nov;75:104011. doi: 10.1016/j.meegid.2019.104011. Epub 2019 Aug 22.

PMID:
31446138
5.

Twice upon a time: The progression of canine visceral leishmaniasis in an Argentinean city.

Lamattina D, Berrozpe PE, Casas N, Moya SL, Giuliani MG, Costa SA, Arrabal JP, Martínez MF, Rivero MR, Salas M, Humeres CA, Liotta DJ, Meichtry MB, Salomón OD.

PLoS One. 2019 Jul 5;14(7):e0219395. doi: 10.1371/journal.pone.0219395. eCollection 2019.

6.

Recent advances in the development of HBV capsid assembly modulators.

Nijampatnam B, Liotta DC.

Curr Opin Chem Biol. 2019 Jun;50:73-79. doi: 10.1016/j.cbpa.2019.02.009. Epub 2019 Apr 2. Review.

PMID:
30952041
7.

Di-aryl Sulfonamide Motif Adds π-Stacking Bulk in Negative Allosteric Modulators of the NMDA Receptor.

Summer SL, Kell SA, Zhu Z, Moore R, Liotta DC, Myers SJ, Koszalka GW, Traynelis SF, Menaldino DS.

ACS Med Chem Lett. 2019 Jan 4;10(3):248-254. doi: 10.1021/acsmedchemlett.8b00395. eCollection 2019 Mar 14.

PMID:
30891121
8.

Aryl Substituted Benzimidazolones as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors.

Pribut N, Basson AE, van Otterlo WAL, Liotta DC, Pelly SC.

ACS Med Chem Lett. 2019 Jan 17;10(2):196-202. doi: 10.1021/acsmedchemlett.8b00549. eCollection 2019 Feb 14.

PMID:
30783503
9.

Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors.

Regan MC, Zhu Z, Yuan H, Myers SJ, Menaldino DS, Tahirovic YA, Liotta DC, Traynelis SF, Furukawa H.

Nat Commun. 2019 Jan 18;10(1):321. doi: 10.1038/s41467-019-08291-1.

10.

Tetrahydroisoquinoline CXCR4 Antagonists Adopt a Hybrid Binding Mode within the Peptide Subpocket of the CXCR4 Receptor.

Katzman BM, Cox BD, Prosser AR, Alcaraz AA, Murat B, Héroux M, Tebben A, Zhang Y, Schroeder GM, Snyder JP, Wilson LJ, Liotta DC.

ACS Med Chem Lett. 2018 Nov 30;10(1):67-73. doi: 10.1021/acsmedchemlett.8b00441. eCollection 2019 Jan 10.

11.

Inhibition of breast cancer metastasis to the lungs with UBS109.

Shoji M, Qian WP, Nagaraju GP, Brat DJ, Pessolano D, Luzietti R, Chennamadhavuni S, Yamaguchi M, Yang L, Liotta DC.

Oncotarget. 2018 Nov 16;9(90):36102-36109. doi: 10.18632/oncotarget.26302. eCollection 2018 Nov 16.

12.

Development of a novel progesterone analog in the treatment of traumatic brain injury.

Sayeed I, Wali B, Guthrie DB, Saindane MT, Natchus MG, Liotta DC, Stein DG.

Neuropharmacology. 2019 Feb;145(Pt B):292-298. doi: 10.1016/j.neuropharm.2018.09.013. Epub 2018 Sep 14. Review.

PMID:
30222982
13.

The GluN2B-Glu413Gly NMDA receptor variant arising from a de novo GRIN2B mutation promotes ligand-unbinding and domain opening.

Wells G, Yuan H, McDaniel MJ, Kusumoto H, Snyder JP, Liotta DC, Traynelis SF.

Proteins. 2018 Dec;86(12):1265-1276. doi: 10.1002/prot.25595. Epub 2018 Oct 5.

14.

Design, Synthesis, and Pharmacological Evaluation of Second-Generation Tetrahydroisoquinoline-Based CXCR4 Antagonists with Favorable ADME Properties.

Nguyen HH, Kim MB, Wilson RJ, Butch CJ, Kuo KM, Miller EJ, Tahirovic YA, Jecs E, Truax VM, Wang T, Sum CS, Cvijic ME, Schroeder GM, Wilson LJ, Liotta DC.

J Med Chem. 2018 Aug 23;61(16):7168-7188. doi: 10.1021/acs.jmedchem.8b00450. Epub 2018 Aug 15.

PMID:
30052039
15.

A Machine Learning Approach for Predicting HIV Reverse Transcriptase Mutation Susceptibility of Biologically Active Compounds.

Kaiser TM, Burger PB, Butch CJ, Pelly SC, Liotta DC.

J Chem Inf Model. 2018 Aug 27;58(8):1544-1552. doi: 10.1021/acs.jcim.7b00475. Epub 2018 Jul 17.

PMID:
29953819
16.

A structurally derived model of subunit-dependent NMDA receptor function.

Gibb AJ, Ogden KK, McDaniel MJ, Vance KM, Kell SA, Butch C, Burger P, Liotta DC, Traynelis SF.

J Physiol. 2018 Sep;596(17):4057-4089. doi: 10.1113/JP276093. Epub 2018 Aug 1.

17.

Discovery of N-Alkyl Piperazine Side Chain Based CXCR4 Antagonists with Improved Drug-like Properties.

Tahirovic YA, Truax VM, Wilson RJ, Jecs E, Nguyen HH, Miller EJ, Kim MB, Kuo KM, Wang T, Sum CS, Cvijic ME, Schroeder GM, Wilson LJ, Liotta DC.

ACS Med Chem Lett. 2018 Apr 9;9(5):446-451. doi: 10.1021/acsmedchemlett.8b00030. eCollection 2018 May 10.

18.

Academic Drug Development: The DRIVE Model.

Liotta D, Painter G.

ACS Med Chem Lett. 2018 Apr 2;9(5):403-407. doi: 10.1021/acsmedchemlett.8b00124. eCollection 2018 May 10.

19.

An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups.

Perszyk R, Katzman BM, Kusumoto H, Kell SA, Epplin MP, Tahirovic YA, Moore RL, Menaldino D, Burger P, Liotta DC, Traynelis SF.

Elife. 2018 May 24;7. pii: e34711. doi: 10.7554/eLife.34711.

20.

Small molecule CXCR4 antagonists block the HIV-1 Nef/CXCR4 axis and selectively initiate the apoptotic program in breast cancer cells.

Huang MB, Giesler KE, Katzman BM, Prosser AR, Truax V, Liotta DC, Wilson LJ, Bond VC.

Oncotarget. 2018 Feb 26;9(24):16996-17013. doi: 10.18632/oncotarget.24580. eCollection 2018 Mar 30.

21.

Synthesis of Novel Tetrahydroisoquinoline CXCR4 Antagonists with Rigidified Side-Chains.

Jecs E, Miller EJ, Wilson RJ, Nguyen HH, Tahirovic YA, Katzman BM, Truax VM, Kim MB, Kuo KM, Wang T, Sum CS, Cvijic ME, Schroeder GM, Wilson LJ, Liotta DC.

ACS Med Chem Lett. 2017 Dec 20;9(2):89-93. doi: 10.1021/acsmedchemlett.7b00406. eCollection 2018 Feb 8.

22.

Discovery of Tetrahydroisoquinoline-Containing CXCR4 Antagonists with Improved in Vitro ADMET Properties.

Miller EJ, Jecs E, Truax VM, Katzman BM, Tahirovic YA, Wilson RJ, Kuo KM, Kim MB, Nguyen HH, Saindane MT, Zhao H, Wang T, Sum CS, Cvijic ME, Schroeder GM, Wilson LJ, Liotta DC.

J Med Chem. 2018 Feb 8;61(3):946-979. doi: 10.1021/acs.jmedchem.7b01420. Epub 2018 Jan 30.

PMID:
29350534
23.

Synthesis and SAR of 1,2,3,4-Tetrahydroisoquinoline-Based CXCR4 Antagonists.

Wilson RJ, Jecs E, Miller EJ, Nguyen HH, Tahirovic YA, Truax VM, Kim MB, Kuo KM, Wang T, Sum CS, Cvijic ME, Paiva AA, Schroeder GM, Wilson LJ, Liotta DC.

ACS Med Chem Lett. 2017 Dec 8;9(1):17-22. doi: 10.1021/acsmedchemlett.7b00381. eCollection 2018 Jan 11.

24.

Mitochondrial DNA ancestry, HPV infection and the risk of cervical cancer in a multiethnic population of northeastern Argentina.

Badano I, Sanabria DJ, Totaro ME, Rubinstein S, Gili JA, Liotta DJ, Picconi MA, Campos RH, Schurr TG.

PLoS One. 2018 Jan 12;13(1):e0190966. doi: 10.1371/journal.pone.0190966. eCollection 2018.

25.

Assessment of the role of small mammals in the transmission cycle of tegumentary leishmaniasis and first report of natural infection with Leishmania braziliensis in two sigmodontines in northeastern Argentina.

Fernández MS, Fraschina J, Acardi S, Liotta DJ, Lestani E, Giuliani M, Busch M, Salomón OD.

Parasitol Res. 2018 Feb;117(2):405-412. doi: 10.1007/s00436-017-5714-5. Epub 2017 Dec 21.

PMID:
29264720
26.

The Bioactive Protein-Ligand Conformation of GluN2C-Selective Positive Allosteric Modulators Bound to the NMDA Receptor.

Kaiser TM, Kell SA, Kusumoto H, Shaulsky G, Bhattacharya S, Epplin MP, Strong KL, Miller EJ, Cox BD, Menaldino DS, Liotta DC, Traynelis SF, Burger PB.

Mol Pharmacol. 2018 Feb;93(2):141-156. doi: 10.1124/mol.117.110940. Epub 2017 Dec 14.

27.

A Novel Negative Allosteric Modulator Selective for GluN2C/2D-Containing NMDA Receptors Inhibits Synaptic Transmission in Hippocampal Interneurons.

Swanger SA, Vance KM, Acker TM, Zimmerman SS, DiRaddo JO, Myers SJ, Bundgaard C, Mosley CA, Summer SL, Menaldino DS, Jensen HS, Liotta DC, Traynelis SF.

ACS Chem Neurosci. 2018 Feb 21;9(2):306-319. doi: 10.1021/acschemneuro.7b00329. Epub 2017 Nov 2.

28.

The Structure-Activity Relationship of a Tetrahydroisoquinoline Class of N-Methyl-d-Aspartate Receptor Modulators that Potentiates GluN2B-Containing N-Methyl-d-Aspartate Receptors.

Strong KL, Epplin MP, Bacsa J, Butch CJ, Burger PB, Menaldino DS, Traynelis SF, Liotta DC.

J Med Chem. 2017 Jul 13;60(13):5556-5585. doi: 10.1021/acs.jmedchem.7b00239. Epub 2017 Jun 26.

29.

Leishmania infantum DNA detected in phlebotomine species from Puerto Iguazú City, Misiones province, Argentina.

Moya SL, Giuliani MG, Santini MS, Quintana MG, Salomón OD, Liotta DJ.

Acta Trop. 2017 Aug;172:122-124. doi: 10.1016/j.actatropica.2017.05.004. Epub 2017 May 2.

PMID:
28476601
30.

The Ecstasy and Agony of Assay Interference Compounds.

Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM Jr, Schepartz A, Wang S.

ACS Med Chem Lett. 2017 Feb 28;8(4):379-382. doi: 10.1021/acsmedchemlett.7b00056. eCollection 2017 Apr 13. No abstract available.

31.

Correction to Reduction Sensitive Lipid Conjugates of Tenofovir: Synthesis, Stability, and Antiviral Activity.

Giesler KE, Marengo J, Liotta DC.

J Med Chem. 2017 Apr 27;60(8):3531. doi: 10.1021/acs.jmedchem.7b00537. Epub 2017 Apr 17. No abstract available.

PMID:
28413877
32.

The Ecstasy and Agony of Assay Interference Compounds.

Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM Jr, Schepartz A, Wang S.

ACS Cent Sci. 2017 Mar 22;3(3):143-147. doi: 10.1021/acscentsci.7b00069. Epub 2017 Feb 28. No abstract available.

33.

Identification of Non-Nucleoside Inhibitors of the Respiratory Syncytial Virus Polymerase Complex.

Jiménez-Somarribas A, Mao S, Yoon JJ, Weisshaar M, Cox RM, Marengo JR, Mitchell DG, Morehouse ZP, Yan D, Solis I, Liotta DC, Natchus MG, Plemper RK.

J Med Chem. 2017 Mar 23;60(6):2305-2325. doi: 10.1021/acs.jmedchem.6b01568. Epub 2017 Mar 13.

34.

The Ecstasy and Agony of Assay Interference Compounds.

Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM Jr, Schepartz A, Wang S.

J Med Chem. 2017 Mar 23;60(6):2165-2168. doi: 10.1021/acs.jmedchem.7b00229. Epub 2017 Feb 28. No abstract available.

PMID:
28244745
35.

The Ecstasy and Agony of Assay Interference Compounds.

Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM Jr, Schepartz A, Wang S.

J Chem Inf Model. 2017 Mar 27;57(3):387-390. doi: 10.1021/acs.jcim.7b00105. Epub 2017 Feb 28. No abstract available.

PMID:
28244743
36.

The Ecstasy and Agony of Assay Interference Compounds.

Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM Jr, Schepartz A, Wang S.

Biochemistry. 2017 Mar 14;56(10):1363-1366. doi: 10.1021/acs.biochem.7b00110. Epub 2017 Feb 28. No abstract available.

PMID:
28244742
37.

The Ecstasy and Agony of Assay Interference Compounds.

Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM Jr, Schepartz A, Wang S.

ACS Chem Neurosci. 2017 Mar 15;8(3):420-423. doi: 10.1021/acschemneuro.7b00064. Epub 2017 Feb 28. No abstract available.

PMID:
28244737
38.

The Ecstasy and Agony of Assay Interference Compounds.

Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM Jr, Schepartz A, Wang S.

ACS Chem Biol. 2017 Mar 17;12(3):575-578. doi: 10.1021/acschembio.7b00119. Epub 2017 Feb 28. No abstract available.

PMID:
28244728
39.

The Ecstasy and Agony of Assay Interference Compounds.

Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM Jr, Schepartz A, Wang S.

ACS Infect Dis. 2017 Apr 14;3(4):259-262. doi: 10.1021/acsinfecdis.7b00023. Epub 2017 Feb 28. No abstract available.

PMID:
28244723
40.

Next-Generation Reduction Sensitive Lipid Conjugates of Tenofovir: Antiviral Activity and Mechanism of Release.

Giesler KE, Liotta DC.

J Med Chem. 2016 Nov 23;59(22):10244-10252. Epub 2016 Nov 2.

41.

GluN2D-Containing N-methyl-d-Aspartate Receptors Mediate Synaptic Transmission in Hippocampal Interneurons and Regulate Interneuron Activity.

Perszyk RE, DiRaddo JO, Strong KL, Low CM, Ogden KK, Khatri A, Vargish GA, Pelkey KA, Tricoire L, Liotta DC, Smith Y, McBain CJ, Traynelis SF.

Mol Pharmacol. 2016 Dec;90(6):689-702. Epub 2016 Sep 13.

42.

CCR5 receptor antagonists in preclinical to phase II clinical development for treatment of HIV.

Kim MB, Giesler KE, Tahirovic YA, Truax VM, Liotta DC, Wilson LJ.

Expert Opin Investig Drugs. 2016 Dec;25(12):1377-1392. Review.

43.

[Retrospective eco-epidemiology as a tool for the surveillance of leishmaniasis in Misiones, Argentina, 1920-2014].

Salomón OD, Mastrángelo AV, Santini MS, Liotta DJ, Yadón ZE.

Rev Panam Salud Publica. 2016 Aug;40(1):29-39. Spanish.

PMID:
27706386
44.

Discovery and Development of the Anti-Human Immunodeficiency Virus Drug, Emtricitabine (Emtriva, FTC).

Liotta DC, Painter GR.

Acc Chem Res. 2016;49(10):2091-2098. Epub 2016 Oct 5.

45.

Innovations in Medicinal Chemistry.

Liotta D.

ACS Med Chem Lett. 2016 Jul 14;7(7):656-7. doi: 10.1021/acsmedchemlett.6b00250. eCollection 2016 Jul 14. No abstract available.

46.

Reduction Sensitive Lipid Conjugates of Tenofovir: Synthesis, Stability, and Antiviral Activity.

Giesler KE, Marengo J, Liotta DC.

J Med Chem. 2016 Aug 11;59(15):7097-110. doi: 10.1021/acs.jmedchem.6b00428. Epub 2016 Jul 22. Erratum in: J Med Chem. 2017 Apr 27;60(8):3531.

47.

In Vitro Metabolic Stability and in Vivo Biodistribution of 3-Methyl-4-furoxancarbaldehyde Using PET Imaging in Rats.

Pippin AB, Mohd Arshad ZH, Voll RJ, Nye JA, Ghassabian S, Williams CM, Mancini A, Liotta DC, Smith MT, Goodman MM.

ACS Med Chem Lett. 2016 Mar 30;7(6):563-7. doi: 10.1021/acsmedchemlett.5b00410. eCollection 2016 Jun 9.

48.

Molecular epidemiology of hepatitis B virus in Misiones, Argentina.

Mojsiejczuk LN, Torres C, Sevic I, Badano I, Malan R, Flichman DM, Liotta DJ, Campos RH.

Infect Genet Evol. 2016 Oct;44:34-42. doi: 10.1016/j.meegid.2016.06.032. Epub 2016 Jun 16.

PMID:
27321439
49.

Evaluating the neurotherapeutic potential of a water-soluble progesterone analog after traumatic brain injury in rats.

Wali B, Sayeed I, Guthrie DB, Natchus MG, Turan N, Liotta DC, Stein DG.

Neuropharmacology. 2016 Oct;109:148-158. doi: 10.1016/j.neuropharm.2016.05.017. Epub 2016 Jun 4.

PMID:
27267687
50.

Discovery of a Fluorinated Enigmol Analog with Enhanced in Vivo Pharmacokinetic and Anti-Tumor Properties.

Miller EJ, Mays SG, Baillie MT, Howard RB, Culver DG, Saindane M, Pruett ST, Holt JJ, Menaldino DS, Evers TJ, Reddy GP, Arrendale RF, Natchus MG, Petros JA, Liotta DC.

ACS Med Chem Lett. 2016 Mar 21;7(5):537-42. doi: 10.1021/acsmedchemlett.6b00113. eCollection 2016 May 12.

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