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Items: 1 to 50 of 74

1.

Dysregulation of Rac or Rho elicits death of motor neurons and activation of these GTPases is altered in the G93A mutant hSOD1 mouse model of amyotrophic lateral sclerosis.

Stankiewicz TR, Pena C, Bouchard RJ, Linseman DA.

Neurobiol Dis. 2020 Mar;136:104743. doi: 10.1016/j.nbd.2020.104743. Epub 2020 Jan 10.

2.

Glutathione precursors shield the brain from trauma.

Koza L, Linseman DA.

Neural Regen Res. 2019 Oct;14(10):1701-1702. doi: 10.4103/1673-5374.257520. No abstract available.

3.

Neuroprotection Comparison of Rosmarinic Acid and Carnosic Acid in Primary Cultures of Cerebellar Granule Neurons.

Taram F, Ignowski E, Duval N, Linseman DA.

Molecules. 2018 Nov 13;23(11). pii: E2956. doi: 10.3390/molecules23112956.

4.

The cysteine-rich whey protein supplement, Immunocal®, preserves brain glutathione and improves cognitive, motor, and histopathological indices of traumatic brain injury in a mouse model of controlled cortical impact.

Ignowski E, Winter AN, Duval N, Fleming H, Wallace T, Manning E, Koza L, Huber K, Serkova NJ, Linseman DA.

Free Radic Biol Med. 2018 Aug 20;124:328-341. doi: 10.1016/j.freeradbiomed.2018.06.026. Epub 2018 Jun 27.

5.

The Bcl-2 Homology-3 Domain (BH3)-Only Proteins, Bid, DP5/Hrk, and BNip3L, Are Upregulated in Reactive Astrocytes of End-Stage Mutant SOD1 Mouse Spinal Cord.

Duval N, Sumner WA, Andrianakos AG, Gray JJ, Bouchard RJ, Wilkins HM, Linseman DA.

Front Cell Neurosci. 2018 Jan 30;12:15. doi: 10.3389/fncel.2018.00015. eCollection 2018.

6.

Procyanidin B2 Protects Neurons from Oxidative, Nitrosative, and Excitotoxic Stress.

Sutcliffe TC, Winter AN, Punessen NC, Linseman DA.

Antioxidants (Basel). 2017 Oct 13;6(4). pii: E77. doi: 10.3390/antiox6040077.

7.

A Cystine-Rich Whey Supplement (Immunocal®) Provides Neuroprotection from Diverse Oxidative Stress-Inducing Agents In Vitro by Preserving Cellular Glutathione.

Winter AN, Ross EK, Daliparthi V, Sumner WA, Kirchhof DM, Manning E, Wilkins HM, Linseman DA.

Oxid Med Cell Longev. 2017;2017:3103272. doi: 10.1155/2017/3103272. Epub 2017 Aug 15.

8.

Comparison of the Neuroprotective and Anti-Inflammatory Effects of the Anthocyanin Metabolites, Protocatechuic Acid and 4-Hydroxybenzoic Acid.

Winter AN, Brenner MC, Punessen N, Snodgrass M, Byars C, Arora Y, Linseman DA.

Oxid Med Cell Longev. 2017;2017:6297080. doi: 10.1155/2017/6297080. Epub 2017 Jun 27.

9.

An anthocyanin-enriched extract from strawberries delays disease onset and extends survival in the hSOD1G93A mouse model of amyotrophic lateral sclerosis.

Winter AN, Ross EK, Wilkins HM, Stankiewicz TR, Wallace T, Miller K, Linseman DA.

Nutr Neurosci. 2018 Jul;21(6):414-426. doi: 10.1080/1028415X.2017.1297023. Epub 2017 Mar 9.

PMID:
28276271
10.

Chemical basis for the disparate neuroprotective effects of the anthocyanins, callistephin and kuromanin, against nitrosative stress.

Winter AN, Ross EK, Khatter S, Miller K, Linseman DA.

Free Radic Biol Med. 2017 Feb;103:23-34. doi: 10.1016/j.freeradbiomed.2016.12.012. Epub 2016 Dec 13.

PMID:
27986528
11.

Neuroprotection comparison of chlorogenic acid and its metabolites against mechanistically distinct cell death-inducing agents in cultured cerebellar granule neurons.

Taram F, Winter AN, Linseman DA.

Brain Res. 2016 Oct 1;1648(Pt A):69-80. doi: 10.1016/j.brainres.2016.07.028. Epub 2016 Jul 18.

PMID:
27444557
12.

Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades.

Stankiewicz TR, Ramaswami SA, Bouchard RJ, Aktories K, Linseman DA.

J Biol Chem. 2015 Apr 10;290(15):9363-76. doi: 10.1074/jbc.M114.575217. Epub 2015 Feb 9.

13.

Mitochondrial lysates induce inflammation and Alzheimer's disease-relevant changes in microglial and neuronal cells.

Wilkins HM, Carl SM, Weber SG, Ramanujan SA, Festoff BW, Linseman DA, Swerdlow RH.

J Alzheimers Dis. 2015;45(1):305-18. doi: 10.3233/JAD-142334.

14.

C-terminal binding proteins: central players in development and disease.

Stankiewicz TR, Gray JJ, Winter AN, Linseman DA.

Biomol Concepts. 2014 Dec;5(6):489-511. doi: 10.1515/bmc-2014-0027. Review.

PMID:
25429601
15.

Rho family GTPases: key players in neuronal development, neuronal survival, and neurodegeneration.

Stankiewicz TR, Linseman DA.

Front Cell Neurosci. 2014 Oct 7;8:314. doi: 10.3389/fncel.2014.00314. eCollection 2014. Review.

16.

Monitoring of single vesicle cytochrome-c release illuminates BAK as a novel target of Aβ oligomers.

Linseman DA.

Biophys J. 2014 Oct 7;107(7):1491-2. doi: 10.1016/j.bpj.2014.08.012. No abstract available.

17.

Stable over-expression of the 2-oxoglutarate carrier enhances neuronal cell resistance to oxidative stress via Bcl-2-dependent mitochondrial GSH transport.

Wilkins HM, Brock S, Gray JJ, Linseman DA.

J Neurochem. 2014 Jul;130(1):75-86. doi: 10.1111/jnc.12709. Epub 2014 Apr 2.

18.

A Cystine-Rich Whey Supplement (Immunocal(®)) Delays Disease Onset and Prevents Spinal Cord Glutathione Depletion in the hSOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis.

Ross EK, Winter AN, Wilkins HM, Sumner WA, Duval N, Patterson D, Linseman DA.

Antioxidants (Basel). 2014 Dec 12;3(4):843-65. doi: 10.3390/antiox3040843.

19.

C-terminal binding proteins are essential pro-survival factors that undergo caspase-dependent downregulation during neuronal apoptosis.

Stankiewicz TR, Schroeder EK, Kelsey NA, Bouchard RJ, Linseman DA.

Mol Cell Neurosci. 2013 Sep;56:322-332. doi: 10.1016/j.mcn.2013.07.004. Epub 2013 Jul 13.

20.

Mitochondrial glutathione transport is a key determinant of neuronal susceptibility to oxidative and nitrosative stress.

Wilkins HM, Kirchhof D, Manning E, Joseph JW, Linseman DA.

J Biol Chem. 2013 Feb 15;288(7):5091-101. doi: 10.1074/jbc.M112.405738. Epub 2013 Jan 2.

21.

N-terminal cleavage of the mitochondrial fusion GTPase OPA1 occurs via a caspase-independent mechanism in cerebellar granule neurons exposed to oxidative or nitrosative stress.

Gray JJ, Zommer AE, Bouchard RJ, Duval N, Blackstone C, Linseman DA.

Brain Res. 2013 Feb 4;1494:28-43. doi: 10.1016/j.brainres.2012.12.001. Epub 2012 Dec 7.

22.

Therapeutic antioxidants for neurodegenerative disease.

Linseman DA.

Recent Pat CNS Drug Discov. 2012 Dec;7(3):183. No abstract available.

PMID:
22857712
23.

Immunocal® and preservation of glutathione as a novel neuroprotective strategy for degenerative disorders of the nervous system.

Ross EK, Gray JJ, Winter AN, Linseman DA.

Recent Pat CNS Drug Discov. 2012 Dec;7(3):230-5. Review.

PMID:
22742422
24.

Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by inhibition of Rac GTPase activity.

Stankiewicz TR, Loucks FA, Schroeder EK, Nevalainen MT, Tyler KL, Aktories K, Bouchard RJ, Linseman DA.

J Biol Chem. 2012 May 11;287(20):16835-48. doi: 10.1074/jbc.M111.302166. Epub 2012 Feb 29.

25.

Overexpression of amyloid-β protein precursor induces mitochondrial oxidative stress and activates the intrinsic apoptotic cascade.

Bartley MG, Marquardt K, Kirchhof D, Wilkins HM, Patterson D, Linseman DA.

J Alzheimers Dis. 2012;28(4):855-68. doi: 10.3233/JAD-2011-111172.

26.

Bcl-2 is a novel interacting partner for the 2-oxoglutarate carrier and a key regulator of mitochondrial glutathione.

Wilkins HM, Marquardt K, Lash LH, Linseman DA.

Free Radic Biol Med. 2012 Jan 15;52(2):410-9. doi: 10.1016/j.freeradbiomed.2011.10.495. Epub 2011 Nov 9.

27.

Nutraceutical antioxidants as novel neuroprotective agents.

Kelsey NA, Wilkins HM, Linseman DA.

Molecules. 2010 Nov 3;15(11):7792-814. doi: 10.3390/molecules15117792. Review.

28.

Calpain plays a central role in 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity in cerebellar granule neurons.

Harbison RA, Ryan KR, Wilkins HM, Schroeder EK, Loucks FA, Bouchard RJ, Linseman DA.

Neurotox Res. 2011 Apr;19(3):374-88. doi: 10.1007/s12640-010-9172-4. Epub 2010 Mar 24.

PMID:
20333497
29.

Caspases indirectly regulate cleavage of the mitochondrial fusion GTPase OPA1 in neurons undergoing apoptosis.

Loucks FA, Schroeder EK, Zommer AE, Hilger S, Kelsey NA, Bouchard RJ, Blackstone C, Brewster JL, Linseman DA.

Brain Res. 2009 Jan 23;1250:63-74. doi: 10.1016/j.brainres.2008.10.081. Epub 2008 Nov 18.

30.

Green tea epigallocatechin 3-gallate accumulates in mitochondria and displays a selective antiapoptotic effect against inducers of mitochondrial oxidative stress in neurons.

Schroeder EK, Kelsey NA, Doyle J, Breed E, Bouchard RJ, Loucks FA, Harbison RA, Linseman DA.

Antioxid Redox Signal. 2009 Mar;11(3):469-80. doi: 10.1089/ARS.2008.2215.

PMID:
18754708
31.

Targeting oxidative stress for neuroprotection.

Linseman DA.

Antioxid Redox Signal. 2009 Mar;11(3):421-4. doi: 10.1089/ARS.2008.2236. No abstract available.

PMID:
18715147
32.

Diverse roles of Rho family GTPases in neuronal development, survival, and death.

Linseman DA, Loucks FA.

Front Biosci. 2008 Jan 1;13:657-76. Review.

PMID:
17981578
33.

Glutathione binding to the Bcl-2 homology-3 domain groove: a molecular basis for Bcl-2 antioxidant function at mitochondria.

Zimmermann AK, Loucks FA, Schroeder EK, Bouchard RJ, Tyler KL, Linseman DA.

J Biol Chem. 2007 Oct 5;282(40):29296-304. Epub 2007 Aug 9.

34.

Adhesion-related kinase induction of migration requires phosphatidylinositol-3-kinase and ras stimulation of rac activity in immortalized gonadotropin-releasing hormone neuronal cells.

Nielsen-Preiss SM, Allen MP, Xu M, Linseman DA, Pawlowski JE, Bouchard RJ, Varnum BC, Heidenreich KA, Wierman ME.

Endocrinology. 2007 Jun;148(6):2806-14. Epub 2007 Mar 1.

PMID:
17332061
35.

Endoplasmic reticulum stress and trophic factor withdrawal activate distinct signaling cascades that induce glycogen synthase kinase-3 beta and a caspase-9-dependent apoptosis in cerebellar granule neurons.

Brewster JL, Linseman DA, Bouchard RJ, Loucks FA, Precht TA, Esch EA, Heidenreich KA.

Mol Cell Neurosci. 2006 Jul;32(3):242-53. Epub 2006 Jun 9.

PMID:
16765055
37.

Proteasome inhibition elicits a biphasic effect on neuronal apoptosis via differential regulation of pro-survival and pro-apoptotic transcription factors.

Butts BD, Hudson HR, Linseman DA, Le SS, Ryan KR, Bouchard RJ, Heidenreich KA.

Mol Cell Neurosci. 2005 Oct;30(2):279-89.

PMID:
16112871
38.

Inhibition of Rac GTPase triggers a c-Jun- and Bim-dependent mitochondrial apoptotic cascade in cerebellar granule neurons.

Le SS, Loucks FA, Udo H, Richardson-Burns S, Phelps RA, Bouchard RJ, Barth H, Aktories K, Tyler KL, Kandel ER, Heidenreich KA, Linseman DA.

J Neurochem. 2005 Aug;94(4):1025-39.

39.

Distinct mechanisms of neuronal apoptosis are triggered by antagonism of Bcl-2/Bcl-x(L) versus induction of the BH3-only protein Bim.

Zimmermann AK, Loucks FA, Le SS, Butts BD, Florez-McClure ML, Bouchard RJ, Heidenreich KA, Linseman DA.

J Neurochem. 2005 Jul;94(1):22-36.

40.

The permeability transition pore triggers Bax translocation to mitochondria during neuronal apoptosis.

Precht TA, Phelps RA, Linseman DA, Butts BD, Le SS, Laessig TA, Bouchard RJ, Heidenreich KA.

Cell Death Differ. 2005 Mar;12(3):255-65.

41.

Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis.

Linseman DA, Butts BD, Precht TA, Phelps RA, Le SS, Laessig TA, Bouchard RJ, Florez-McClure ML, Heidenreich KA.

J Neurosci. 2004 Nov 3;24(44):9993-10002.

42.

The p75 neurotrophin receptor can induce autophagy and death of cerebellar Purkinje neurons.

Florez-McClure ML, Linseman DA, Chu CT, Barker PA, Bouchard RJ, Le SS, Laessig TA, Heidenreich KA.

J Neurosci. 2004 May 12;24(19):4498-509.

43.

Myocyte enhancer factor-2 transcription factors in neuronal differentiation and survival.

Heidenreich KA, Linseman DA.

Mol Neurobiol. 2004 Apr;29(2):155-66. Review.

PMID:
15126683
44.

Molecular mechanisms of gonadotropin-releasing hormone neuronal migration.

Wierman ME, Pawlowski JE, Allen MP, Xu M, Linseman DA, Nielsen-Preiss S.

Trends Endocrinol Metab. 2004 Apr;15(3):96-102. Review.

PMID:
15046737
45.

Insulin-like growth factor-I suppresses degradation of the pro-survival transcription factor myocyte enhancer factor 2D (MEF2D) during neuronal apoptosis.

Butts BD, Linseman DA, Le SS, Laessig TA, Heidenreich KA.

Horm Metab Res. 2003 Nov-Dec;35(11-12):763-70.

PMID:
14710356
46.

The pesticide rotenone induces caspase-3-mediated apoptosis in ventral mesencephalic dopaminergic neurons.

Ahmadi FA, Linseman DA, Grammatopoulos TN, Jones SM, Bouchard RJ, Freed CR, Heidenreich KA, Zawada WM.

J Neurochem. 2003 Nov;87(4):914-21.

47.

Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca(2+) //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survival.

Linseman DA, Bartley CM, Le SS, Laessig TA, Bouchard RJ, Meintzer MK, Li M, Heidenreich KA.

J Biol Chem. 2003 Oct 17;278(42):41472-81. Epub 2003 Aug 1.

48.

A myocyte enhancer factor 2D (MEF2D) kinase activated during neuronal apoptosis is a novel target inhibited by lithium.

Linseman DA, Cornejo BJ, Le SS, Meintzer MK, Laessig TA, Bouchard RJ, Heidenreich KA.

J Neurochem. 2003 Jun;85(6):1488-99.

49.

Insulin-like growth factor-I blocks Bcl-2 interacting mediator of cell death (Bim) induction and intrinsic death signaling in cerebellar granule neurons.

Linseman DA, Phelps RA, Bouchard RJ, Le SS, Laessig TA, McClure ML, Heidenreich KA.

J Neurosci. 2002 Nov 1;22(21):9287-97.

50.

Adhesion-related kinase repression of gonadotropin-releasing hormone gene expression requires Rac activation of the extracellular signal-regulated kinase pathway.

Allen MP, Xu M, Linseman DA, Pawlowski JE, Bokoch GM, Heidenreich KA, Wierman ME.

J Biol Chem. 2002 Oct 11;277(41):38133-40. Epub 2002 Jul 22.

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