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Items: 1 to 50 of 246

1.

The properties of α-synuclein secondary nuclei are dominated by the solution conditions rather than the seed fibril strain.

Peduzzo A, Linse S, Buell AK.

ACS Chem Neurosci. 2020 Feb 18. doi: 10.1021/acschemneuro.9b00594. [Epub ahead of print]

PMID:
32069013
2.

The catalytic nature of protein aggregation.

Dear AJ, Meisl G, Michaels TCT, Zimmermann MR, Linse S, Knowles TPJ.

J Chem Phys. 2020 Jan 31;152(4):045101. doi: 10.1063/1.5133635.

PMID:
32007046
3.
4.

Lipid Dynamics and Phase Transition within α-Synuclein Amyloid Fibrils.

Galvagnion C, Topgaard D, Makasewicz K, Buell AK, Linse S, Sparr E, Dobson CM.

J Phys Chem Lett. 2019 Dec 19;10(24):7872-7877. doi: 10.1021/acs.jpclett.9b03005. Epub 2019 Dec 6.

5.

Fibril Charge Affects α-Synuclein Hydrogel Rheological Properties.

Pogostin BH, Linse S, Olsson U.

Langmuir. 2019 Dec 17;35(50):16536-16544. doi: 10.1021/acs.langmuir.9b02516. Epub 2019 Dec 3.

PMID:
31724872
6.

Revealing Well-Defined Soluble States during Amyloid Fibril Formation by Multilinear Analysis of NMR Diffusion Data.

Jensen KS, Linse S, Nilsson M, Akke M, Malmendal A.

J Am Chem Soc. 2019 Nov 27;141(47):18649-18652. doi: 10.1021/jacs.9b07952. Epub 2019 Nov 12.

PMID:
31702142
7.

Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid.

Frankel R, Törnquist M, Meisl G, Hansson O, Andreasson U, Zetterberg H, Blennow K, Frohm B, Cedervall T, Knowles TPJ, Leiding T, Linse S.

Commun Biol. 2019 Oct 8;2:365. doi: 10.1038/s42003-019-0612-2. eCollection 2019.

8.

The Molecular Basis of Human IgG-Mediated Enhancement of C4b-Binding Protein Recruitment to Group A Streptococcus.

Ermert D, Laabei M, Weckel A, Mörgelin M, Lundqvist M, Björck L, Ram S, Linse S, Blom AM.

Front Immunol. 2019 Jun 4;10:1230. doi: 10.3389/fimmu.2019.01230. eCollection 2019.

9.

Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease.

Boza-Serrano A, Ruiz R, Sanchez-Varo R, García-Revilla J, Yang Y, Jimenez-Ferrer I, Paulus A, Wennström M, Vilalta A, Allendorf D, Davila JC, Stegmayr J, Jiménez S, Roca-Ceballos MA, Navarro-Garrido V, Swanberg M, Hsieh CL, Real LM, Englund E, Linse S, Leffler H, Nilsson UJ, Brown GC, Gutierrez A, Vitorica J, Venero JL, Deierborg T.

Acta Neuropathol. 2019 Aug;138(2):251-273. doi: 10.1007/s00401-019-02013-z. Epub 2019 Apr 20.

10.

Secondary nucleation and elongation occur at different sites on Alzheimer's amyloid-β aggregates.

Scheidt T, Łapińska U, Kumita JR, Whiten DR, Klenerman D, Wilson MR, Cohen SIA, Linse S, Vendruscolo M, Dobson CM, Knowles TPJ, Arosio P.

Sci Adv. 2019 Apr 17;5(4):eaau3112. doi: 10.1126/sciadv.aau3112. eCollection 2019 Apr.

11.

Lipid-protein interactions in amyloid formation.

Sparr E, Linse S.

Biochim Biophys Acta Proteins Proteom. 2019 May;1867(5):455-457. doi: 10.1016/j.bbapap.2019.03.006. No abstract available.

PMID:
30948160
12.

Charting a course for chemistry.

Aspuru-Guzik A, Baik MH, Balasubramanian S, Banerjee R, Bart S, Borduas-Dedekind N, Chang S, Chen P, Corminboeuf C, Coudert FX, Cronin L, Crudden C, Cuk T, Doyle AG, Fan C, Feng X, Freedman D, Furukawa S, Ghosh S, Glorius F, Jeffries-El M, Katsonis N, Li A, Linse SS, Marchesan S, Maulide N, Milo A, Narayan ARH, Naumov P, Nevado C, Nyokong T, Palacin R, Reid M, Robinson C, Robinson G, Sarpong R, Schindler C, Schlau-Cohen GS, Schmidt TW, Sessoli R, Shao-Horn Y, Sleiman H, Sutherland J, Taylor A, Tezcan A, Tortosa M, Walsh A, Watson AJB, Weckhuysen BM, Weiss E, Wilson D, Yam VW, Yang X, Ying JY, Yoon T, You SL, Zarbin AJG, Zhang H.

Nat Chem. 2019 Apr;11(4):286-294. doi: 10.1038/s41557-019-0236-7. No abstract available.

PMID:
30903035
13.

Reprint of "Ganglioside lipids accelerate α-synuclein amyloid formation".

Gaspar R, Pallbo J, Weininger U, Linse S, Sparr E.

Biochim Biophys Acta Proteins Proteom. 2019 May;1867(5):508-518. doi: 10.1016/j.bbapap.2019.02.003. Epub 2019 Mar 13.

14.

A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli.

Sanagavarapu K, Nüske E, Nasir I, Meisl G, Immink JN, Sormanni P, Vendruscolo M, Knowles TPJ, Malmendal A, Cabaleiro-Lago C, Linse S.

Sci Rep. 2019 Mar 6;9(1):3680. doi: 10.1038/s41598-019-39216-z.

15.

Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42.

Weiffert T, Meisl G, Flagmeier P, De S, Dunning CJR, Frohm B, Zetterberg H, Blennow K, Portelius E, Klenerman D, Dobson CM, Knowles TPJ, Linse S.

ACS Chem Neurosci. 2019 May 15;10(5):2374-2384. doi: 10.1021/acschemneuro.8b00676. Epub 2019 Mar 8.

PMID:
30793584
16.

Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes.

Limbocker R, Chia S, Ruggeri FS, Perni M, Cascella R, Heller GT, Meisl G, Mannini B, Habchi J, Michaels TCT, Challa PK, Ahn M, Casford ST, Fernando N, Xu CK, Kloss ND, Cohen SIA, Kumita JR, Cecchi C, Zasloff M, Linse S, Knowles TPJ, Chiti F, Vendruscolo M, Dobson CM.

Nat Commun. 2019 Jan 15;10(1):225. doi: 10.1038/s41467-018-07699-5.

17.

SAR by kinetics for drug discovery in protein misfolding diseases.

Chia S, Habchi J, Michaels TCT, Cohen SIA, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10245-10250. doi: 10.1073/pnas.1807884115. Epub 2018 Sep 26.

18.

Protein stabilization with retained function of monellin using a split GFP system.

Weiffert T, Linse S.

Sci Rep. 2018 Aug 24;8(1):12763. doi: 10.1038/s41598-018-31177-z.

19.

Ganglioside lipids accelerate α-synuclein amyloid formation.

Gaspar R, Pallbo J, Weininger U, Linse S, Sparr E.

Biochim Biophys Acta Proteins Proteom. 2018 Aug 2. pii: S1570-9639(18)30116-X. doi: 10.1016/j.bbapap.2018.07.004. [Epub ahead of print]

20.

Disaggregation of gold nanoparticles by Daphnia magna.

Mattsson K, Aguilar R, Torstensson O, Perry D, Bernfur K, Linse S, Hansson LA, Åkerfeldt KS, Cedervall T.

Nanotoxicology. 2018 Oct;12(8):885-900. doi: 10.1080/17435390.2018.1485982. Epub 2018 Jul 27.

PMID:
30053796
21.

Conserved S/T Residues of the Human Chaperone DNAJB6 Are Required for Effective Inhibition of Aβ42 Amyloid Fibril Formation.

Månsson C, van Cruchten RTP, Weininger U, Yang X, Cukalevski R, Arosio P, Dobson CM, Knowles T, Akke M, Linse S, Emanuelsson C.

Biochemistry. 2018 Aug 14;57(32):4891-4902. doi: 10.1021/acs.biochem.8b00353. Epub 2018 Jul 30.

PMID:
30024736
22.

Secondary nucleation in amyloid formation.

Törnquist M, Michaels TCT, Sanagavarapu K, Yang X, Meisl G, Cohen SIA, Knowles TPJ, Linse S.

Chem Commun (Camb). 2018 Aug 2;54(63):8667-8684. doi: 10.1039/c8cc02204f. Review.

PMID:
29978862
23.

Protein-protein interactions in AQP regulation - biophysical characterization of AQP0-CaM and AQP2-LIP5 complex formation.

Kreida S, Roche JV, Olsson C, Linse S, Törnroth-Horsefield S.

Faraday Discuss. 2018 Sep 28;209(0):35-54. doi: 10.1039/c8fd00065d.

PMID:
29972182
24.

Simplifying G Protein-Coupled Receptor Isolation with a Calcium-Dependent Fragment Complementation Affinity System.

Mhurchú NN, Zoubak L, McGauran G, Linse S, Yeliseev A, O'Connell DJ.

Biochemistry. 2018 Jul 31;57(30):4383-4390. doi: 10.1021/acs.biochem.8b00469. Epub 2018 Jul 17.

PMID:
29956929
25.

On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations.

Yang X, Meisl G, Frohm B, Thulin E, Knowles TPJ, Linse S.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E5849-E5858. doi: 10.1073/pnas.1803539115. Epub 2018 Jun 12.

26.

Kinetic Analysis of Amyloid Formation.

Meisl G, Michaels TCT, Linse S, Knowles TPJ.

Methods Mol Biol. 2018;1779:181-196. doi: 10.1007/978-1-4939-7816-8_12.

PMID:
29886534
27.

Cyanylated Cysteine Reports Site-Specific Changes at Protein-Protein-Binding Interfaces Without Perturbation.

Dalton SR, Vienneau AR, Burstein SR, Xu RJ, Linse S, Londergan CH.

Biochemistry. 2018 Jul 3;57(26):3702-3712. doi: 10.1021/acs.biochem.8b00283. Epub 2018 Jun 5.

28.

Production and Use of Recombinant Aβ for Aggregation Studies.

O'Malley TT, Linse S, Walsh DM.

Methods Mol Biol. 2018;1777:307-320. doi: 10.1007/978-1-4939-7811-3_19.

29.

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes.

Habchi J, Chia S, Galvagnion C, Michaels TCT, Bellaiche MMJ, Ruggeri FS, Sanguanini M, Idini I, Kumita JR, Sparr E, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M.

Nat Chem. 2018 Jun;10(6):673-683. doi: 10.1038/s41557-018-0031-x. Epub 2018 May 7.

PMID:
29736006
30.

Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide.

Cohen SIA, Cukalevski R, Michaels TCT, Šarić A, Törnquist M, Vendruscolo M, Dobson CM, Buell AK, Knowles TPJ, Linse S.

Nat Chem. 2018 May;10(5):523-531. doi: 10.1038/s41557-018-0023-x. Epub 2018 Mar 26.

31.

Conformational Ensembles of Calmodulin Revealed by Nonperturbing Site-Specific Vibrational Probe Groups.

Kelly KL, Dalton SR, Wai RB, Ramchandani K, Xu RJ, Linse S, Londergan CH.

J Phys Chem A. 2018 Mar 22;122(11):2947-2955. doi: 10.1021/acs.jpca.8b00475. Epub 2018 Mar 9.

32.

Aggregate Size Dependence of Amyloid Adsorption onto Charged Interfaces.

Tesei G, Hellstrand E, Sanagavarapu K, Linse S, Sparr E, Vácha R, Lund M.

Langmuir. 2018 Jan 30;34(4):1266-1273. doi: 10.1021/acs.langmuir.7b03155. Epub 2018 Jan 17.

33.

Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification.

Gaspar R, Meisl G, Buell AK, Young L, Kaminski CF, Knowles TPJ, Sparr E, Linse S.

Q Rev Biophys. 2017 Jan;50:e6. doi: 10.1017/S0033583516000172.

PMID:
29233218
34.

On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products.

Saar KL, Zhang Y, Müller T, Kumar CP, Devenish S, Lynn A, Łapińska U, Yang X, Linse S, Knowles TPJ.

Lab Chip. 2017 Dec 19;18(1):162-170. doi: 10.1039/c7lc00797c.

PMID:
29192926
35.

Scaling behaviour and rate-determining steps in filamentous self-assembly.

Meisl G, Rajah L, Cohen SAI, Pfammatter M, Šarić A, Hellstrand E, Buell AK, Aguzzi A, Linse S, Vendruscolo M, Dobson CM, Knowles TPJ.

Chem Sci. 2017 Oct 1;8(10):7087-7097. doi: 10.1039/c7sc01965c. Epub 2017 Aug 31.

36.

Proton-Assisted Recoupling (PAR) in Peptides and Proteins.

Donovan KJ, Jain SK, Silvers R, Linse S, Griffin RG.

J Phys Chem B. 2017 Dec 7;121(48):10804-10817. doi: 10.1021/acs.jpcb.7b08934. Epub 2017 Nov 27.

PMID:
29043804
37.

Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants.

Meisl G, Yang X, Dobson CM, Linse S, Knowles TPJ.

Chem Sci. 2017 Jun 1;8(6):4352-4362. doi: 10.1039/c7sc00215g. Epub 2017 Apr 26.

38.

Brain damage and behavioural disorders in fish induced by plastic nanoparticles delivered through the food chain.

Mattsson K, Johnson EV, Malmendal A, Linse S, Hansson LA, Cedervall T.

Sci Rep. 2017 Sep 13;7(1):11452. doi: 10.1038/s41598-017-10813-0.

39.

Monomer-dependent secondary nucleation in amyloid formation.

Linse S.

Biophys Rev. 2017 Aug;9(4):329-338. doi: 10.1007/s12551-017-0289-z. Epub 2017 Aug 15. Review.

40.

Aggregation and Fibril Structure of AβM01-42 and Aβ1-42.

Silvers R, Colvin MT, Frederick KK, Jacavone AC, Lindquist S, Linse S, Griffin RG.

Biochemistry. 2017 Sep 12;56(36):4850-4859. doi: 10.1021/acs.biochem.7b00729. Epub 2017 Aug 30.

PMID:
28792214
41.

Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates.

Chia S, Flagmeier P, Habchi J, Lattanzi V, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):8005-8010. doi: 10.1073/pnas.1700239114. Epub 2017 Jul 11.

42.

Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method.

Aprile FA, Sormanni P, Perni M, Arosio P, Linse S, Knowles TPJ, Dobson CM, Vendruscolo M.

Sci Adv. 2017 Jun 21;3(6):e1700488. doi: 10.1126/sciadv.1700488. eCollection 2017 Jun.

43.

Cu/Zn Superoxide Dismutase Forms Amyloid Fibrils under Near-Physiological Quiescent Conditions: The Roles of Disulfide Bonds and Effects of Denaturant.

Khan MAI, Respondek M, Kjellström S, Deep S, Linse S, Akke M.

ACS Chem Neurosci. 2017 Sep 20;8(9):2019-2026. doi: 10.1021/acschemneuro.7b00162. Epub 2017 Jun 20.

44.

Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication.

Munke A, Persson J, Weiffert T, De Genst E, Meisl G, Arosio P, Carnerup A, Dobson CM, Vendruscolo M, Knowles TPJ, Linse S.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):6444-6449. doi: 10.1073/pnas.1700407114. Epub 2017 Jun 5.

45.

3D MAS NMR Experiment Utilizing Through-Space 15N-15N Correlations.

Donovan KJ, Silvers R, Linse S, Griffin RG.

J Am Chem Soc. 2017 May 17;139(19):6518-6521. doi: 10.1021/jacs.7b01159. Epub 2017 May 3.

PMID:
28447786
46.

Acceleration of α-synuclein aggregation.

Gaspar R, Meisl G, Buell AK, Young L, Kaminski CF, Knowles TPJ, Sparr E, Linse S.

Amyloid. 2017 Mar;24(sup1):20-21. doi: 10.1080/13506129.2017.1292904. No abstract available.

PMID:
28434341
47.

The nanoparticle protein corona formed in human blood or human blood fractions.

Lundqvist M, Augustsson C, Lilja M, Lundkvist K, Dahlbäck B, Linse S, Cedervall T.

PLoS One. 2017 Apr 17;12(4):e0175871. doi: 10.1371/journal.pone.0175871. eCollection 2017.

48.

Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease.

Habchi J, Chia S, Limbocker R, Mannini B, Ahn M, Perni M, Hansson O, Arosio P, Kumita JR, Challa PK, Cohen SI, Linse S, Dobson CM, Knowles TP, Vendruscolo M.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E200-E208. doi: 10.1073/pnas.1615613114. Epub 2016 Dec 23.

49.

Calcium Binding and Disulfide Bonds Regulate the Stability of Secretagogin towards Thermal and Urea Denaturation.

Sanagavarapu K, Weiffert T, Ní Mhurchú N, O'Connell D, Linse S.

PLoS One. 2016 Nov 3;11(11):e0165709. doi: 10.1371/journal.pone.0165709. eCollection 2016.

50.

Cerebrospinal fluid-induced retardation of amyloid β aggregation correlates with Alzheimer's disease and the APOE ε4 allele.

Padayachee ER, Zetterberg H, Portelius E, Borén J, Molinuevo JL, Andreasen N, Cukalevski R, Linse S, Blennow K, Andreasson U.

Brain Res. 2016 Nov 15;1651:11-16. doi: 10.1016/j.brainres.2016.09.022. Epub 2016 Sep 23.

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