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Items: 1 to 50 of 94

1.

Contribution of the eighth transmembrane segment to the function of the CFTR chloride channel pore.

Negoda A, Hogan MS, Cowley EA, Linsdell P.

Cell Mol Life Sci. 2019 Jun;76(12):2411-2423. doi: 10.1007/s00018-019-03043-2. Epub 2019 Feb 13.

PMID:
30758641
2.

Cystic fibrosis transmembrane conductance regulator (CFTR): Making an ion channel out of an active transporter structure.

Linsdell P.

Channels (Austin). 2018;12(1):284-290. doi: 10.1080/19336950.2018.1502585. Review.

PMID:
30152709
3.

Functional organization of cytoplasmic portals controlling access to the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel pore.

Li MS, Cowley EA, El Hiani Y, Linsdell P.

J Biol Chem. 2018 Apr 13;293(15):5649-5658. doi: 10.1074/jbc.RA117.001373. Epub 2018 Feb 23.

4.

Conformational change of the extracellular parts of the CFTR protein during channel gating.

Negoda A, Cowley EA, El Hiani Y, Linsdell P.

Cell Mol Life Sci. 2018 Aug;75(16):3027-3038. doi: 10.1007/s00018-018-2777-0. Epub 2018 Feb 14.

PMID:
29441426
5.

Contribution of a leucine residue in the first transmembrane segment to the selectivity filter region in the CFTR chloride channel.

Negoda A, El Hiani Y, Cowley EA, Linsdell P.

Biochim Biophys Acta Biomembr. 2017 May;1859(5):1049-1058. doi: 10.1016/j.bbamem.2017.02.014. Epub 2017 Feb 22.

6.

Architecture and functional properties of the CFTR channel pore.

Linsdell P.

Cell Mol Life Sci. 2017 Jan;74(1):67-83. doi: 10.1007/s00018-016-2389-5. Epub 2016 Oct 3. Review.

PMID:
27699452
7.

Structural Changes Fundamental to Gating of the Cystic Fibrosis Transmembrane Conductance Regulator Anion Channel Pore.

Linsdell P.

Adv Exp Med Biol. 2017;925:13-32. doi: 10.1007/5584_2016_33. Review.

PMID:
27311317
8.

Anion conductance selectivity mechanism of the CFTR chloride channel.

Linsdell P.

Biochim Biophys Acta. 2016 Apr;1858(4):740-7. doi: 10.1016/j.bbamem.2016.01.009. Epub 2016 Jan 15.

9.

Cytoplasmic pathway followed by chloride ions to enter the CFTR channel pore.

El Hiani Y, Negoda A, Linsdell P.

Cell Mol Life Sci. 2016 May;73(9):1917-25. doi: 10.1007/s00018-015-2113-x. Epub 2015 Dec 13.

PMID:
26659082
10.

Metal bridges to probe membrane ion channel structure and function.

Linsdell P.

Biomol Concepts. 2015 Jun;6(3):191-203. doi: 10.1515/bmc-2015-0013. Review.

PMID:
26103632
11.

Functional Architecture of the Cytoplasmic Entrance to the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore.

El Hiani Y, Linsdell P.

J Biol Chem. 2015 Jun 19;290(25):15855-65. doi: 10.1074/jbc.M115.656181. Epub 2015 May 5.

12.

Interactions between permeant and blocking anions inside the CFTR chloride channel pore.

Linsdell P.

Biochim Biophys Acta. 2015 Jul;1848(7):1573-90. doi: 10.1016/j.bbamem.2015.04.004. Epub 2015 Apr 17.

13.

Location of a permeant anion binding site in the cystic fibrosis transmembrane conductance regulator chloride channel pore.

Rubaiy HN, Linsdell P.

J Physiol Sci. 2015 May;65(3):233-41. doi: 10.1007/s12576-015-0359-6. Epub 2015 Feb 12.

PMID:
25673337
14.

Conformational changes opening and closing the CFTR chloride channel: insights from cysteine scanning mutagenesis.

El Hiani Y, Linsdell P.

Biochem Cell Biol. 2014 Dec;92(6):481-8. doi: 10.1139/bcb-2014-0038. Epub 2014 Sep 12. Review.

PMID:
25367045
15.

The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor.

Broadbent SD, Ramjeesingh M, Bear CE, Argent BE, Linsdell P, Gray MA.

Pflugers Arch. 2015 Aug;467(8):1783-94. doi: 10.1007/s00424-014-1618-8. Epub 2014 Oct 4.

16.

Interaction between 2 extracellular loops influences the activity of the cystic fibrosis transmembrane conductance regulator chloride channel.

Broadbent SD, Wang W, Linsdell P.

Biochem Cell Biol. 2014 Oct;92(5):390-6. doi: 10.1139/bcb-2014-0066. Epub 2014 Aug 20.

PMID:
25253636
17.

Metal bridges illuminate transmembrane domain movements during gating of the cystic fibrosis transmembrane conductance regulator chloride channel.

El Hiani Y, Linsdell P.

J Biol Chem. 2014 Oct 10;289(41):28149-59. doi: 10.1074/jbc.M114.593103. Epub 2014 Aug 20.

18.

State-dependent blocker interactions with the CFTR chloride channel: implications for gating the pore.

Linsdell P.

Pflugers Arch. 2014 Dec;466(12):2243-55. doi: 10.1007/s00424-014-1501-7. Epub 2014 Mar 28.

PMID:
24671572
19.
20.

Functional architecture of the CFTR chloride channel.

Linsdell P.

Mol Membr Biol. 2014 Feb;31(1):1-16. doi: 10.3109/09687688.2013.868055. Epub 2013 Dec 17. Review.

PMID:
24341413
21.

Relative contribution of different transmembrane segments to the CFTR chloride channel pore.

Wang W, El Hiani Y, Rubaiy HN, Linsdell P.

Pflugers Arch. 2014 Mar;466(3):477-90. doi: 10.1007/s00424-013-1317-x. Epub 2013 Aug 20.

PMID:
23955087
22.

Tuning of CFTR chloride channel function by location of positive charges within the pore.

El Hiani Y, Linsdell P.

Biophys J. 2012 Oct 17;103(8):1719-26. doi: 10.1016/j.bpj.2012.09.020. Epub 2012 Oct 16.

23.
24.

Pseudohalide anions reveal a novel extracellular site for potentiators to increase CFTR function.

Li MS, Cowley EA, Linsdell P.

Br J Pharmacol. 2012 Nov;167(5):1062-75. doi: 10.1111/j.1476-5381.2012.02041.x.

25.
26.

Alternating access to the transmembrane domain of the ATP-binding cassette protein cystic fibrosis transmembrane conductance regulator (ABCC7).

Wang W, Linsdell P.

J Biol Chem. 2012 Mar 23;287(13):10156-65. doi: 10.1074/jbc.M112.342972. Epub 2012 Feb 1.

27.

Conformational change opening the CFTR chloride channel pore coupled to ATP-dependent gating.

Wang W, Linsdell P.

Biochim Biophys Acta. 2012 Mar;1818(3):851-60. doi: 10.1016/j.bbamem.2011.12.025. Epub 2012 Jan 2.

28.

Functional differences in pore properties between wild-type and cysteine-less forms of the CFTR chloride channel.

Holstead RG, Li MS, Linsdell P.

J Membr Biol. 2011 Oct;243(1-3):15-23. doi: 10.1007/s00232-011-9388-0. Epub 2011 Jul 28.

PMID:
21796426
29.

Functional arrangement of the 12th transmembrane region in the CFTR chloride channel pore based on functional investigation of a cysteine-less CFTR variant.

Qian F, El Hiani Y, Linsdell P.

Pflugers Arch. 2011 Oct;462(4):559-71. doi: 10.1007/s00424-011-0998-2. Epub 2011 Jul 28.

PMID:
21796338
30.

Alignment of transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore.

Wang W, El Hiani Y, Linsdell P.

J Gen Physiol. 2011 Aug;138(2):165-78. doi: 10.1085/jgp.201110605. Epub 2011 Jul 11.

31.

Regulation of CFTR chloride channel macroscopic conductance by extracellular bicarbonate.

Li MS, Holstead RG, Wang W, Linsdell P.

Am J Physiol Cell Physiol. 2011 Jan;300(1):C65-74. doi: 10.1152/ajpcell.00290.2010. Epub 2010 Oct 6.

32.
33.

Regulation of conductance by the number of fixed positive charges in the intracellular vestibule of the CFTR chloride channel pore.

Zhou JJ, Li MS, Qi J, Linsdell P.

J Gen Physiol. 2010 Mar;135(3):229-45. doi: 10.1085/jgp.200910327. Epub 2010 Feb 8.

34.

The intermediate conductance Ca2+-activated K+ channel inhibitor TRAM-34 stimulates proliferation of breast cancer cells via activation of oestrogen receptors.

Roy JW, Cowley EA, Blay J, Linsdell P.

Br J Pharmacol. 2010 Feb 1;159(3):650-8. doi: 10.1111/j.1476-5381.2009.00557.x. Epub 2009 Dec 24.

35.

Cysteine-independent inhibition of the CFTR chloride channel by the cysteine-reactive reagent sodium (2-sulphonatoethyl) methanethiosulphonate.

Li MS, Demsey AF, Qi J, Linsdell P.

Br J Pharmacol. 2009 Jul;157(6):1065-71. doi: 10.1111/j.1476-5381.2009.00258.x. Epub 2009 May 19.

36.

Evidence that extracellular anions interact with a site outside the CFTR chloride channel pore to modify channel properties.

Zhou JJ, Linsdell P.

Can J Physiol Pharmacol. 2009 May;87(5):387-95. doi: 10.1139/y09-023.

PMID:
19448737
37.

Novel residues lining the CFTR chloride channel pore identified by functional modification of introduced cysteines.

Fatehi M, Linsdell P.

J Membr Biol. 2009 Apr;228(3):151-64. doi: 10.1007/s00232-009-9167-3. Epub 2009 Apr 19.

PMID:
19381710
38.

Regulation of wild-type and mutant KCNQ1/KCNE1 channels by tyrosine kinase.

Missan S, Qi J, Crack J, McDonald TF, Linsdell P.

Pflugers Arch. 2009 Jul;458(3):471-80. doi: 10.1007/s00424-008-0634-y. Epub 2009 Jan 13.

PMID:
19139916
39.

Mechanism of direct bicarbonate transport by the CFTR anion channel.

Tang L, Fatehi M, Linsdell P.

J Cyst Fibros. 2009 Mar;8(2):115-21. doi: 10.1016/j.jcf.2008.10.004. Epub 2008 Nov 18.

40.

Pharmacological separation of hEAG and hERG K+ channel function in the human mammary carcinoma cell line MCF-7.

Roy J, Vantol B, Cowley EA, Blay J, Linsdell P.

Oncol Rep. 2008 Jun;19(6):1511-6.

PMID:
18497958
41.

Identification of positive charges situated at the outer mouth of the CFTR chloride channel pore.

Zhou JJ, Fatehi M, Linsdell P.

Pflugers Arch. 2008 Nov;457(2):351-60. doi: 10.1007/s00424-008-0521-6. Epub 2008 May 1.

PMID:
18449561
42.

State-dependent access of anions to the cystic fibrosis transmembrane conductance regulator chloride channel pore.

Fatehi M, Linsdell P.

J Biol Chem. 2008 Mar 7;283(10):6102-9. doi: 10.1074/jbc.M707736200. Epub 2007 Dec 31.

43.

Involvement of tyrosine kinase in the hyposmotic stimulation of I Ks in guinea-pig ventricular myocytes.

Missan S, Linsdell P, McDonald TF.

Pflugers Arch. 2008 Jun;456(3):489-500. Epub 2007 Dec 21.

PMID:
18097684
44.
45.

Contribution of KCNQ1 to the regulatory volume decrease in the human mammary epithelial cell line MCF-7.

vanTol BL, Missan S, Crack J, Moser S, Baldridge WH, Linsdell P, Cowley EA.

Am J Physiol Cell Physiol. 2007 Sep;293(3):C1010-9. Epub 2007 Jun 27.

46.

Molecular mechanism of arachidonic acid inhibition of the CFTR chloride channel.

Zhou JJ, Linsdell P.

Eur J Pharmacol. 2007 Jun 1;563(1-3):88-91. Epub 2007 Mar 3.

PMID:
17397825
47.
48.
49.

Exposure to sodium butyrate leads to functional downregulation of calcium-activated potassium channels in human airway epithelial cells.

Roy J, Denovan-Wright EM, Linsdell P, Cowley EA.

Pflugers Arch. 2006 Nov;453(2):167-76. Epub 2006 Sep 19.

PMID:
17047984
50.

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