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Spatiotemporal Expression of Three Secretoglobin Proteins, SCGB1A1, SCGB3A1, and SCGB3A2, in Mouse Airway Epithelia.

Naizhen X, Kido T, Yokoyama S, Linnoila RI, Kimura S.

J Histochem Cytochem. 2019 Jun;67(6):453-463. doi: 10.1369/0022155419829050. Epub 2019 Feb 15.


The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung.

Gazdar AF, Savage TK, Johnson JE, Berns A, Sage J, Linnoila RI, MacPherson D, McFadden DG, Farago A, Jacks T, Travis WD, Brambilla E.

J Thorac Oncol. 2015 Apr;10(4):553-64. doi: 10.1097/JTO.0000000000000459.


Musashi1 as a potential therapeutic target and diagnostic marker for lung cancer.

Wang XY, Yu H, Linnoila RI, Li L, Li D, Mo B, Okano H, Penalva LO, Glazer RI.

Oncotarget. 2013 May;4(5):739-50.


Achaete-scute complex homolog-1 promotes DNA repair in the lung carcinogenesis through matrix metalloproteinase-7 and O(6)-methylguanine-DNA methyltransferase.

Wang XY, Jensen-Taubman SM, Keefe KM, Yang D, Linnoila RI.

PLoS One. 2012;7(12):e52832. doi: 10.1371/journal.pone.0052832. Epub 2012 Dec 26.


Novel method for isolation of murine clara cell secretory protein-expressing cells with traces of stemness.

Wang XY, Keefe KM, Jensen-Taubman SM, Yang D, Yan K, Linnoila RI.

PLoS One. 2012;7(8):e43008. doi: 10.1371/journal.pone.0043008. Epub 2012 Aug 16.


Multidirectional differentiation of Achaete-Scute homologue-1-defined progenitors in lung development and injury repair.

Li Y, Linnoila RI.

Am J Respir Cell Mol Biol. 2012 Dec;47(6):768-75. doi: 10.1165/rcmb.2012-0027OC. Epub 2012 Aug 9.


Achaete-scute homologue-1 (ASH1) stimulates migration of lung cancer cells through Cdk5/p35 pathway.

Demelash A, Rudrabhatla P, Pant HC, Wang X, Amin ND, McWhite CD, Naizhen X, Linnoila RI.

Mol Biol Cell. 2012 Aug;23(15):2856-66. doi: 10.1091/mbc.E10-12-1010. Epub 2012 Jun 13.


Nicotine does not enhance tumorigenesis in mutant K-ras-driven mouse models of lung cancer.

Maier CR, Hollander MC, Hobbs EA, Dogan I, Linnoila RI, Dennis PA.

Cancer Prev Res (Phila). 2011 Nov;4(11):1743-51. doi: 10.1158/1940-6207.CAPR-11-0365. Epub 2011 Oct 25.


Insights into the achaete-scute homolog-1 gene (hASH1) in normal and neoplastic human lung.

Miki M, Ball DW, Linnoila RI.

Lung Cancer. 2012 Jan;75(1):58-65. doi: 10.1016/j.lungcan.2011.05.019.


Akt1 deletion prevents lung tumorigenesis by mutant K-ras.

Hollander MC, Maier CR, Hobbs EA, Ashmore AR, Linnoila RI, Dennis PA.

Oncogene. 2011 Apr 14;30(15):1812-21. doi: 10.1038/onc.2010.556. Epub 2011 Jan 17.


Inherited polymorphisms in the RNA-mediated interference machinery affect microRNA expression and lung cancer survival.

Rotunno M, Zhao Y, Bergen AW, Koshiol J, Burdette L, Rubagotti M, Linnoila RI, Marincola FM, Bertazzi PA, Pesatori AC, Caporaso NE, McShane LM, Wang E, Landi MT.

Br J Cancer. 2010 Dec 7;103(12):1870-4. doi: 10.1038/sj.bjc.6605976. Epub 2010 Nov 23.


Cediranib/AZD2171 inhibits bone and brain metastasis in a preclinical model of advanced prostate cancer.

Yin JJ, Zhang L, Munasinghe J, Linnoila RI, Kelly K.

Cancer Res. 2010 Nov 1;70(21):8662-73. doi: 10.1158/0008-5472.CAN-10-1435. Epub 2010 Oct 19.


From nicotine to breast cancer, implications of cholinergic receptor pathway.

Linnoila RI.

J Natl Cancer Inst. 2010 Sep 8;102(17):1298-9. doi: 10.1093/jnci/djq314. Epub 2010 Aug 23. No abstract available.


Musashi1 regulates breast tumor cell proliferation and is a prognostic indicator of poor survival.

Wang XY, Penalva LO, Yuan H, Linnoila RI, Lu J, Okano H, Glazer RI.

Mol Cancer. 2010 Aug 21;9:221. doi: 10.1186/1476-4598-9-221.


Achaete-scute homologue-1 tapers neuroendocrine cell differentiation in lungs after exposure to naphthalene.

Jensen-Taubman S, Wang XY, Linnoila RI.

Toxicol Sci. 2010 Sep;117(1):238-48. doi: 10.1093/toxsci/kfq177. Epub 2010 Jun 16.


Secretoglobin 3A2/uteroglobin-related protein 1 is a novel marker for pulmonary carcinoma in mice and humans.

Kurotani R, Kumaki N, Naizhen X, Ward JM, Linnoila RI, Kimura S.

Lung Cancer. 2011 Jan;71(1):42-8. doi: 10.1016/j.lungcan.2010.04.001. Epub 2010 May 13.


Matrilysin-1 mediates bronchiolization of alveoli, a potential premalignant change in lung cancer.

Wang XY, Demelash A, Kim H, Jensen-Taubman S, Dakir el H, Ozbun L, Birrer MJ, Linnoila RI.

Am J Pathol. 2009 Aug;175(2):592-604. doi: 10.2353/ajpath.2009.080461. Epub 2009 Jul 16.


Associations between p53 overexpression and multiple measures of clinical outcome in high-risk, early stage or suboptimally-resected, advanced stage epithelial ovarian cancers A Gynecologic Oncology Group study.

Darcy KM, Brady WE, McBroom JW, Bell JG, Young RC, McGuire WP, Linnoila RI, Hendricks D, Bonome T, Farley JH; Gynecologic Oncology Group.

Gynecol Oncol. 2008 Dec;111(3):487-95. doi: 10.1016/j.ygyno.2008.08.020. Epub 2008 Oct 2.


Constitutive expression of human keratin 14 gene in mouse lung induces premalignant lesions and squamous differentiation.

Dakir EL H, Feigenbaum L, Linnoila RI.

Carcinogenesis. 2008 Dec;29(12):2377-84. doi: 10.1093/carcin/bgn190. Epub 2008 Aug 12.


Acute damage by naphthalene triggers expression of the neuroendocrine marker PGP9.5 in airway epithelial cells.

Poulsen TT, Naizhen X, Poulsen HS, Linnoila RI.

Toxicol Lett. 2008 Sep 26;181(2):67-74. doi: 10.1016/j.toxlet.2008.06.872. Epub 2008 Jul 17.


Strain-specific spontaneous and NNK-mediated tumorigenesis in Pten+/- mice.

Hollander MC, Balogh AR, Liwanag J, Han W, Linnoila RI, Anver MR, Dennis PA.

Neoplasia. 2008 Aug;10(8):866-72.


Targeted disruption of NeuroD, a proneural basic helix-loop-helix factor, impairs distal lung formation and neuroendocrine morphology in the neonatal lung.

Neptune ER, Podowski M, Calvi C, Cho JH, Garcia JG, Tuder R, Linnoila RI, Tsai MJ, Dietz HC.

J Biol Chem. 2008 Jul 25;283(30):21160-9. doi: 10.1074/jbc.M708692200. Epub 2008 Mar 13.


Achaete-scute homolog-1 linked to remodeling and preneoplasia of pulmonary epithelium.

Wang XY, Dakir el H, Naizhen X, Jensen-Taubman SM, DeMayo FJ, Linnoila RI.

Lab Invest. 2007 Jun;87(6):527-39.


BAC consensus conference, November 4-6, 2004: epidemiology, pathogenesis, and preclinical models.

Christiani DC, Pao W, DeMartini JC, Linnoila RI, Malkinson AM, Onn A, Politi KA, Sharp M, Wong KK.

J Thorac Oncol. 2006 Nov;1(9 Suppl):S2-7. Erratum in: J Thorac Oncol. 2007 Jan;2(1):11. Kim, Kwok [corrected to Wong, Kwok-Kin].


Identification of a highly effective rapamycin schedule that markedly reduces the size, multiplicity, and phenotypic progression of tobacco carcinogen-induced murine lung tumors.

Granville CA, Warfel N, Tsurutani J, Hollander MC, Robertson M, Fox SD, Veenstra TD, Issaq HJ, Linnoila RI, Dennis PA.

Clin Cancer Res. 2007 Apr 1;13(7):2281-9.


Functional facets of the pulmonary neuroendocrine system.

Linnoila RI.

Lab Invest. 2006 May;86(5):425-44. Review.


Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis.

Hollander MC, Philburn RT, Patterson AD, Velasco-Miguel S, Friedberg EC, Linnoila RI, Fornace AJ Jr.

Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13200-5. Epub 2005 Sep 2.


Mouse lung neuroendocrine carcinomas: distinct morphologies, same transcription factors.

Linnoila RI, Naizhen X, Meuwissen R, Berns A, DeMayo FJ.

Exp Lung Res. 2005 Jan-Feb;31(1):37-55.


Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium.

Daniely Y, Liao G, Dixon D, Linnoila RI, Lori A, Randell SH, Oren M, Jetten AM.

Am J Physiol Cell Physiol. 2004 Jul;287(1):C171-81.


Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium.

Nikitin AY, Alcaraz A, Anver MR, Bronson RT, Cardiff RD, Dixon D, Fraire AE, Gabrielson EW, Gunning WT, Haines DC, Kaufman MH, Linnoila RI, Maronpot RR, Rabson AS, Reddick RL, Rehm S, Rozengurt N, Schuller HM, Shmidt EN, Travis WD, Ward JM, Jacks T.

Cancer Res. 2004 Apr 1;64(7):2307-16. Review. Erratum in: Cancer Res. 2004 May 15;64(10):3725.


Randomized, double-blind, placebo-controlled phase IIb trial of the cyclooxygenase inhibitor ketorolac as an oral rinse in oropharyngeal leukoplakia.

Mulshine JL, Atkinson JC, Greer RO, Papadimitrakopoulou VA, Van Waes C, Rudy S, Martin JW, Steinberg SM, Liewehr DJ, Avis I, Linnoila RI, Hewitt S, Lippman SM, Frye R, Cavanaugh PF Jr.

Clin Cancer Res. 2004 Mar 1;10(5):1565-73.


Prospective study of the airways and pulmonary parenchyma of patients at risk for a second lung cancer.

Means-Markwell M, Linnoila RI, Williams J, Jänne PA, Kaye F, O'Neil K, Johnson BE.

Clin Cancer Res. 2003 Dec 1;9(16 Pt 1):5915-21.


Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model.

Meuwissen R, Linn SC, Linnoila RI, Zevenhoven J, Mooi WJ, Berns A.

Cancer Cell. 2003 Sep;4(3):181-9.


Transforming growth factor-beta 1 and its receptors in human lung cancer and mouse lung carcinogenesis.

Kang Y, Prentice MA, Mariano JM, Davarya S, Linnoila RI, Moody TW, Wakefield LM, Jakowlew SB.

Exp Lung Res. 2000 Dec;26(8):685-707.


Morphometric analysis of CC10-hASH1 transgenic mouse lung: a model for bronchiolization of alveoli and neuroendocrine carcinoma.

Linnoila RI, Sahu A, Miki M, Ball DW, DeMayo FJ.

Exp Lung Res. 2000 Dec;26(8):595-615.


The role of CC10 in pulmonary carcinogenesis: from a marker to tumor suppression.

Linnoila RI, Szabo E, DeMayo F, Witschi H, Sabourin C, Malkinson A.

Ann N Y Acad Sci. 2000;923:249-67. Review.


Genetic changes in contralateral bronchioloalveolar carcinomas of the lung.

Shin SW, Breathnach OS, Linnoila RI, Williams J, Gillespie JW, Kelley MJ, Johnson BE.

Oncology. 2001;60(1):81-7.


Attenuation of pulmonary neuroendocrine differentiation in mice lacking Clara cell secretory protein.

Castro CM, Yang Y, Zhang Z, Linnoila RI.

Lab Invest. 2000 Oct;80(10):1533-40.


Constitutive achaete-scute homologue-1 promotes airway dysplasia and lung neuroendocrine tumors in transgenic mice.

Linnoila RI, Zhao B, DeMayo JL, Nelkin BD, Baylin SB, DeMayo FJ, Ball DW.

Cancer Res. 2000 Aug 1;60(15):4005-9.


Clinical features of patients with stage IIIB and IV bronchioloalveolar carcinoma of the lung.

Breathnach OS, Ishibe N, Williams J, Linnoila RI, Caporaso N, Johnson BE.

Cancer. 1999 Oct 1;86(7):1165-73.


MUC1 is a novel marker for the type II pneumocyte lineage during lung carcinogenesis.

Jarrard JA, Linnoila RI, Lee H, Steinberg SM, Witschi H, Szabo E.

Cancer Res. 1998 Dec 1;58(23):5582-9.


Overexpression of CC10 modifies neoplastic potential in lung cancer cells.

Szabo E, Goheer A, Witschi H, Linnoila RI.

Cell Growth Differ. 1998 Jun;9(6):475-85.


Specific primer design and exonuclease III treatment for the reduction of nonspecific staining in direct in situ PCR.

Sagawa M, Jones JE, Saito Y, Fujimura S, Linnoila RI.

Cell Vis. 1998 Jan-Feb;5(1):20-3.


K-ras point mutation occurs in the early stage of carcinogenesis in lung cancer.

Sagawa M, Saito Y, Fujimura S, Linnoila RI.

Br J Cancer. 1998 Mar;77(5):720-3.


Bronchiolization of the alveoli in lung cancer: pathology, patterns of differentiation and oncogene expression.

Jensen-Taubman SM, Steinberg SM, Linnoila RI.

Int J Cancer. 1998 Feb 9;75(4):489-96.


Detection of K-ras point mutation by in situ PCR in cell suspensions: comparison of the indirect and direct methods.

Sagawa M, Jones JE, Ebina M, Jensen S, Linnoila RI.

Lung Cancer. 1997 Jul;17(2-3):181-95.


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