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Items: 1 to 50 of 94

1.

Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease.

Del Re DP, Amgalan D, Linkermann A, Liu Q, Kitsis RN.

Physiol Rev. 2019 Oct 1;99(4):1765-1817. doi: 10.1152/physrev.00022.2018.

PMID:
31364924
2.

Mitochondria Permeability Transition versus Necroptosis in Oxalate-Induced AKI.

Mulay SR, Honarpisheh MM, Foresto-Neto O, Shi C, Desai J, Zhao ZB, Marschner JA, Popper B, Buhl EM, Boor P, Linkermann A, Liapis H, Bilyy R, Herrmann M, Romagnani P, Belevich I, Jokitalo E, Becker JU, Anders HJ.

J Am Soc Nephrol. 2019 Oct;30(10):1857-1869. doi: 10.1681/ASN.2018121218. Epub 2019 Jul 11.

PMID:
31296606
3.

Don't trick me twice!

Tonnus W, Belavgeni A, Xu Y, Linkermann A.

Kidney Int. 2019 Apr;95(4):736-738. doi: 10.1016/j.kint.2018.12.004.

PMID:
30904060
4.

HLA class II antibodies induce necrotic cell death in human endothelial cells via a lysosomal membrane permeabilization-mediated pathway.

Aljabri A, Vijayan V, Stankov M, Nikolin C, Figueiredo C, Blasczyk R, Becker JU, Linkermann A, Immenschuh S.

Cell Death Dis. 2019 Mar 8;10(3):235. doi: 10.1038/s41419-019-1319-5.

5.

Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation.

Li W, Feng G, Gauthier JM, Lokshina I, Higashikubo R, Evans S, Liu X, Hassan A, Tanaka S, Cicka M, Hsiao HM, Ruiz-Perez D, Bredemeyer A, Gross RW, Mann DL, Tyurina YY, Gelman AE, Kagan VE, Linkermann A, Lavine KJ, Kreisel D.

J Clin Invest. 2019 Feb 26;129(6):2293-2304. doi: 10.1172/JCI126428.

6.

The pathological features of regulated necrosis.

Tonnus W, Meyer C, Paliege A, Belavgeni A, von Mässenhausen A, Bornstein SR, Hugo C, Becker JU, Linkermann A.

J Pathol. 2019 Apr;247(5):697-707. doi: 10.1002/path.5248. Epub 2019 Feb 25. Review.

PMID:
30714148
7.

Ferroptosis as a target for protection against cardiomyopathy.

Fang X, Wang H, Han D, Xie E, Yang X, Wei J, Gu S, Gao F, Zhu N, Yin X, Cheng Q, Zhang P, Dai W, Chen J, Yang F, Yang HT, Linkermann A, Gu W, Min J, Wang F.

Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2672-2680. doi: 10.1073/pnas.1821022116. Epub 2019 Jan 28.

8.

Death and fire-the concept of necroinflammation.

Linkermann A.

Cell Death Differ. 2019 Jan;26(1):1-3. doi: 10.1038/s41418-018-0218-0. Epub 2018 Nov 23. No abstract available.

9.

TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation.

Lafont E, Draber P, Rieser E, Reichert M, Kupka S, de Miguel D, Draberova H, von Mässenhausen A, Bhamra A, Henderson S, Wojdyla K, Chalk A, Surinova S, Linkermann A, Walczak H.

Nat Cell Biol. 2018 Dec;20(12):1389-1399. doi: 10.1038/s41556-018-0229-6. Epub 2018 Nov 12.

10.

Stress-inducible-stem cells: a new view on endocrine, metabolic and mental disease?

Bornstein SR, Steenblock C, Chrousos GP, Schally AV, Beuschlein F, Kline G, Krone NP, Licinio J, Wong ML, Ullmann E, Ruiz-Babot G, Boehm BO, Behrens A, Brennand A, Santambrogio A, Berger I, Werdermann M, Sancho R, Linkermann A, Lenders JW, Eisenhofer G, Andoniadou CL.

Mol Psychiatry. 2019 Jan;24(1):2-9. doi: 10.1038/s41380-018-0244-9. Epub 2018 Sep 21. No abstract available.

11.

The clinical relevance of necroinflammation-highlighting the importance of acute kidney injury and the adrenal glands.

Tonnus W, Gembardt F, Latk M, Parmentier S, Hugo C, Bornstein SR, Linkermann A.

Cell Death Differ. 2019 Jan;26(1):68-82. doi: 10.1038/s41418-018-0193-5. Epub 2018 Sep 17.

PMID:
30224638
12.

Assessment of In Vivo Kidney Cell Death: Glomerular Injury.

Tonnus W, Al-Mekhlafi M, Gembardt F, Hugo C, Linkermann A.

Methods Mol Biol. 2018;1857:145-151. doi: 10.1007/978-1-4939-8754-2_14.

PMID:
30136238
13.

Assessment of In Vivo Kidney Cell Death: Acute Kidney Injury.

Tonnus W, Al-Mekhlafi M, Hugo C, Linkermann A.

Methods Mol Biol. 2018;1857:135-144. doi: 10.1007/978-1-4939-8754-2_13.

PMID:
30136237
14.

Cell Death Pathways Drive Necroinflammation during Acute Kidney Injury.

von Mässenhausen A, Tonnus W, Linkermann A.

Nephron. 2018;140(2):144-147. doi: 10.1159/000490807. Epub 2018 Jun 29. Review.

15.

Regulated Cell Death Seen through the Lens of Islet Transplantation.

Bruni A, Bornstein S, Linkermann A, Shapiro AMJ.

Cell Transplant. 2018 Jun;27(6):890-901. doi: 10.1177/0963689718766323. Epub 2018 May 30. Review.

16.

Correction to: Phenytoin inhibits necroptosis.

von Mässenhausen A, Tonnus W, Himmerkus N, Parmentier S, Saleh D, Rodriguez D, Ousingsawat J, Ang RL, Weinberg JM, Sanz AB, Ortiz A, Zierleyn A, Becker JU, Baratte B, Desban N, Bach S, Schiessl IM, Nogusa S, Balachandran S, Anders HJ, Ting AT, Bleich M, Degterev A, Kunzelmann K, Bornstein SR, Green DR, Hugo C, Linkermann A.

Cell Death Dis. 2018 May 24;9(6):622. doi: 10.1038/s41419-018-0638-2.

17.

Ferroptosis-inducing agents compromise in vitro human islet viability and function.

Bruni A, Pepper AR, Pawlick RL, Gala-Lopez B, Gamble AF, Kin T, Seeberger K, Korbutt GS, Bornstein SR, Linkermann A, Shapiro AMJ.

Cell Death Dis. 2018 May 22;9(6):595. doi: 10.1038/s41419-018-0506-0.

18.

The protective role of macrophage migration inhibitory factor in acute kidney injury after cardiac surgery.

Stoppe C, Averdunk L, Goetzenich A, Soppert J, Marlier A, Kraemer S, Vieten J, Coburn M, Kowark A, Kim BS, Marx G, Rex S, Ochi A, Leng L, Moeckel G, Linkermann A, El Bounkari O, Zarbock A, Bernhagen J, Djudjaj S, Bucala R, Boor P.

Sci Transl Med. 2018 May 16;10(441). pii: eaan4886. doi: 10.1126/scitranslmed.aan4886.

PMID:
29769287
19.

TWEAK and RIPK1 mediate a second wave of cell death during AKI.

Martin-Sanchez D, Fontecha-Barriuso M, Carrasco S, Sanchez-Niño MD, Mässenhausen AV, Linkermann A, Cannata-Ortiz P, Ruiz-Ortega M, Egido J, Ortiz A, Sanz AB.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4182-4187. doi: 10.1073/pnas.1716578115. Epub 2018 Mar 27. Erratum in: Proc Natl Acad Sci U S A. 2018 May 7;:.

20.

The enhanced susceptibility of ADAM-17 hypomorphic mice to DSS-induced colitis is not ameliorated by loss of RIPK3, revealing an unexpected function of ADAM-17 in necroptosis.

Fuchslocher Chico J, Falk-Paulsen M, Luzius A, Saggau C, Ruder B, Bolik J, Schmidt-Arras D, Linkermann A, Becker C, Rosenstiel P, Rose-John S, Adam D.

Oncotarget. 2018 Feb 5;9(16):12941-12958. doi: 10.18632/oncotarget.24410. eCollection 2018 Feb 27.

21.

Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis.

Gaschler MM, Hu F, Feng H, Linkermann A, Min W, Stockwell BR.

ACS Chem Biol. 2018 Apr 20;13(4):1013-1020. doi: 10.1021/acschembio.8b00199. Epub 2018 Mar 13.

22.

We AIM2 Inflame.

Linkermann A, Parmentier SP, Hugo C.

J Am Soc Nephrol. 2018 Apr;29(4):1077-1079. doi: 10.1681/ASN.2018020116. Epub 2018 Mar 6. No abstract available.

23.

Phenytoin inhibits necroptosis.

von Mässenhausen A, Tonnus W, Himmerkus N, Parmentier S, Saleh D, Rodriguez D, Ousingsawat J, Ang RL, Weinberg JM, Sanz AB, Ortiz A, Zierleyn A, Becker JU, Baratte B, Desban N, Bach S, Schiessl IM, Nogusa S, Balachandran S, Anders HJ, Ting AT, Bleich M, Degterev A, Kunzelmann K, Bornstein SR, Green DR, Hugo C, Linkermann A.

Cell Death Dis. 2018 Mar 2;9(3):359. doi: 10.1038/s41419-018-0394-3. Erratum in: Cell Death Dis. 2018 May 24;9(6):622.

24.

Origin and Consequences of Necroinflammation.

Sarhan M, Land WG, Tonnus W, Hugo CP, Linkermann A.

Physiol Rev. 2018 Apr 1;98(2):727-780. doi: 10.1152/physrev.00041.2016. Review.

25.

Cell death-based approaches in treatment of the urinary tract-associated diseases: a fight for survival in the killing fields.

Martin-Sanchez D, Fontecha-Barriuso M, Sanchez-Niño MD, Ramos AM, Cabello R, Gonzalez-Enguita C, Linkermann A, Sanz AB, Ortiz A.

Cell Death Dis. 2018 Jan 25;9(2):118. doi: 10.1038/s41419-017-0043-2. Review.

26.

Immunological consequences of kidney cell death.

Sarhan M, von Mässenhausen A, Hugo C, Oberbauer R, Linkermann A.

Cell Death Dis. 2018 Jan 25;9(2):114. doi: 10.1038/s41419-017-0057-9. Review.

27.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

28.

Necroptosis controls NET generation and mediates complement activation, endothelial damage, and autoimmune vasculitis.

Schreiber A, Rousselle A, Becker JU, von Mässenhausen A, Linkermann A, Kettritz R.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9618-E9625. doi: 10.1073/pnas.1708247114. Epub 2017 Oct 24.

29.

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.

Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascón S, Hatzios SK, Kagan VE, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat GC, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti FM, Torti SV, Toyokuni S, Woerpel KA, Zhang DD.

Cell. 2017 Oct 5;171(2):273-285. doi: 10.1016/j.cell.2017.09.021. Review.

30.

Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury.

Martens S, Jeong M, Tonnus W, Feldmann F, Hofmans S, Goossens V, Takahashi N, Bräsen JH, Lee EW, Van der Veken P, Joossens J, Augustyns K, Fulda S, Linkermann A, Song J, Vandenabeele P.

Cell Death Dis. 2017 Jun 29;8(6):e2904. doi: 10.1038/cddis.2017.298.

31.

Die later with ESCRT!

Tonnus W, Gembardt F, Hugo C, Linkermann A.

Oncotarget. 2017 Jun 27;8(26):41790-41791. doi: 10.18632/oncotarget.17903. No abstract available.

32.

Heavy metal suicide.

Linkermann A, Stockwell B, Vanden Berghe T.

Am J Physiol Renal Physiol. 2017 Oct 1;313(4):F959-F960. doi: 10.1152/ajprenal.00273.2017. Epub 2017 May 31. No abstract available.

33.

The in vivo evidence for regulated necrosis.

Tonnus W, Linkermann A.

Immunol Rev. 2017 May;277(1):128-149. doi: 10.1111/imr.12551. Review.

PMID:
28462528
34.

P2X1, P2X4, and P2X7 Receptor Knock Out Mice Expose Differential Outcome of Sepsis Induced by α-Haemolysin Producing Escherichia coli.

Greve AS, Skals M, Fagerberg SK, Tonnus W, Ellermann-Eriksen S, Evans RJ, Linkermann A, Praetorius HA.

Front Cell Infect Microbiol. 2017 Apr 6;7:113. doi: 10.3389/fcimb.2017.00113. eCollection 2017.

35.

ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences.

Gong YN, Guy C, Olauson H, Becker JU, Yang M, Fitzgerald P, Linkermann A, Green DR.

Cell. 2017 Apr 6;169(2):286-300.e16. doi: 10.1016/j.cell.2017.03.020.

36.

Role of CCL20 mediated immune cell recruitment in NF-κB mediated TRAIL resistance of pancreatic cancer.

Geismann C, Grohmann F, Dreher A, Häsler R, Rosenstiel P, Legler K, Hauser C, Egberts JH, Sipos B, Schreiber S, Linkermann A, Hassan Z, Schneider G, Schäfer H, Arlt A.

Biochim Biophys Acta Mol Cell Res. 2017 May;1864(5):782-796. doi: 10.1016/j.bbamcr.2017.02.005. Epub 2017 Feb 8.

37.

Back to the roots of regulated necrosis.

Todorov V, Linkermann A.

J Cell Biol. 2017 Feb;216(2):303-304. doi: 10.1083/jcb.201612078. Epub 2017 Jan 20.

38.

Gimme a complex! Resident mononuclear phagocytes in the kidney as monitors of circulating antigens and immune complexes.

Tonnus W, Hugo C, Linkermann A.

Kidney Int. 2017 Feb;91(2):267-269. doi: 10.1016/j.kint.2016.10.029.

PMID:
28087004
39.

Corrigendum: Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells.

Martinez J, Cunha LD, Park S, Yang M, Lu Q, Orchard R, Li QZ, Yan M, Janke L, Guy C, Linkermann A, Virgin HW, Green DR.

Nature. 2016 Nov 3;539(7627):124. doi: 10.1038/nature19837. Epub 2016 Sep 28. No abstract available.

PMID:
27680703
40.

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis.

Günther C, He GW, Kremer AE, Murphy JM, Petrie EJ, Amann K, Vandenabeele P, Linkermann A, Poremba C, Schleicher U, Dewitz C, Krautwald S, Neurath MF, Becker C, Wirtz S.

J Clin Invest. 2016 Nov 1;126(11):4346-4360. doi: 10.1172/JCI87545. Epub 2016 Oct 17.

41.

Welcome to the Jungle: The Kidney during Sepsis.

Schulte K, Linkermann A.

Am J Respir Crit Care Med. 2016 Sep 15;194(6):649-50. doi: 10.1164/rccm.201603-0550ED. No abstract available.

PMID:
27628072
42.

Ca2+ signals, cell membrane disintegration, and activation of TMEM16F during necroptosis.

Ousingsawat J, Cabrita I, Wanitchakool P, Sirianant L, Krautwald S, Linkermann A, Schreiber R, Kunzelmann K.

Cell Mol Life Sci. 2017 Jan;74(1):173-181. doi: 10.1007/s00018-016-2338-3. Epub 2016 Aug 17.

PMID:
27535660
43.

DAMP-Induced Allograft and Tumor Rejection: The Circle Is Closing.

Land WG, Agostinis P, Gasser S, Garg AD, Linkermann A.

Am J Transplant. 2016 Dec;16(12):3322-3337. doi: 10.1111/ajt.14012. Epub 2016 Sep 21. Review.

44.

Transplantation and Damage-Associated Molecular Patterns (DAMPs).

Land WG, Agostinis P, Gasser S, Garg AD, Linkermann A.

Am J Transplant. 2016 Dec;16(12):3338-3361. doi: 10.1111/ajt.13963. Epub 2016 Aug 24. Review.

45.

Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid-Induced AKI.

Martin-Sanchez D, Ruiz-Andres O, Poveda J, Carrasco S, Cannata-Ortiz P, Sanchez-Niño MD, Ruiz Ortega M, Egido J, Linkermann A, Ortiz A, Sanz AB.

J Am Soc Nephrol. 2017 Jan;28(1):218-229. doi: 10.1681/ASN.2015121376. Epub 2016 Jun 27.

46.

An Overview of Pathways of Regulated Necrosis in Acute Kidney Injury.

Kers J, Leemans JC, Linkermann A.

Semin Nephrol. 2016 May;36(3):139-52. doi: 10.1016/j.semnephrol.2016.03.002. Review.

PMID:
27339380
47.

Introduction: Toward an Anti-Cell Death Therapy for Kidney Transplantation and Kidney Diseases.

Linkermann A.

Semin Nephrol. 2016 May;36(3):137-8. doi: 10.1016/j.semnephrol.2016.03.001. No abstract available.

PMID:
27339379
48.

The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance.

Gautheron J, Vucur M, Schneider AT, Severi I, Roderburg C, Roy S, Bartneck M, Schrammen P, Diaz MB, Ehling J, Gremse F, Heymann F, Koppe C, Lammers T, Kiessling F, Van Best N, Pabst O, Courtois G, Linkermann A, Krautwald S, Neumann UP, Tacke F, Trautwein C, Green DR, Longerich T, Frey N, Luedde M, Bluher M, Herzig S, Heikenwalder M, Luedde T.

Nat Commun. 2016 Jun 21;7:11869. doi: 10.1038/ncomms11869.

49.

Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells.

Martinez J, Cunha LD, Park S, Yang M, Lu Q, Orchard R, Li QZ, Yan M, Janke L, Guy C, Linkermann A, Virgin HW, Green DR.

Nature. 2016 May 5;533(7601):115-9. doi: 10.1038/nature17950. Epub 2016 Apr 20. Erratum in: Nature. 2016 Nov 3;539(7627):124.

50.

Excess sphingomyelin disturbs ATG9A trafficking and autophagosome closure.

Corcelle-Termeau E, Vindeløv SD, Hämälistö S, Mograbi B, Keldsbo A, Bräsen JH, Favaro E, Adam D, Szyniarowski P, Hofman P, Krautwald S, Farkas T, Petersen NH, Rohde M, Linkermann A, Jäättelä M.

Autophagy. 2016 May 3;12(5):833-49. doi: 10.1080/15548627.2016.1159378. Epub 2016 Apr 12.

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