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Cerebral lesion correlates of sympathetic cardiovascular activation in multiple sclerosis.

Winder K, Linker RA, Seifert F, Wang R, Lee DH, Engelhorn T, Dörfler A, Fröhlich K, Hilz M.

Hum Brain Mapp. 2019 Aug 12. doi: 10.1002/hbm.24759. [Epub ahead of print]


MAdCAM-1-Mediated Intestinal Lymphocyte Homing Is Critical for the Development of Active Experimental Autoimmune Encephalomyelitis.

Kuhbandner K, Hammer A, Haase S, Terbrack E, Hoffmann A, Schippers A, Wagner N, Hussain RZ, Miller-Little WA, Koh AY, Stoolman JS, Segal BM, Linker RA, Stüve O.

Front Immunol. 2019 Apr 26;10:903. doi: 10.3389/fimmu.2019.00903. eCollection 2019.


Association of Intrathecal Immunoglobulin G Synthesis With Disability Worsening in Multiple Sclerosis.

Gasperi C, Salmen A, Antony G, Bayas A, Heesen C, Kümpfel T, Linker RA, Paul F, Stangel M, Tackenberg B, Bergh FT, Warnke C, Weber F, Wiendl H, Wildemann B, Zettl UK, Ziemann U, Zipp F, Tumani H, Gold R, Hemmer B; German Competence Network of Multiple Sclerosis.

JAMA Neurol. 2019 Jul 1;76(7):841-849. doi: 10.1001/jamaneurol.2019.0905.


Potential of Sodium MRI as a Biomarker for Neurodegeneration and Neuroinflammation in Multiple Sclerosis.

Huhn K, Engelhorn T, Linker RA, Nagel AM.

Front Neurol. 2019 Feb 11;10:84. doi: 10.3389/fneur.2019.00084. eCollection 2019. Review.


Sodium in the microenvironment regulates immune responses and tissue homeostasis.

Müller DN, Wilck N, Haase S, Kleinewietfeld M, Linker RA.

Nat Rev Immunol. 2019 Apr;19(4):243-254. doi: 10.1038/s41577-018-0113-4. Review.


Brain MRI Lesions are Related to Bowel Incontinence in Multiple Sclerosis.

Fröhlich K, Linker RA, Engelhorn T, Dörfler A, Lee DH, Huhn K, Schwab S, Hilz MJ, Seifert F, Winder K.

J Neuroimaging. 2019 Mar;29(2):211-217. doi: 10.1111/jon.12589. Epub 2018 Dec 11.


Efficacy and safety of alemtuzumab versus fingolimod in RRMS after natalizumab cessation.

Pfeuffer S, Schmidt R, Straeten FA, Pul R, Kleinschnitz C, Wieshuber M, Lee DH, Linker RA, Doerck S, Straeten V, Windhagen S, Pawlitzki M, Aufenberg C, Lang M, Eienbroeker C, Tackenberg B, Limmroth V, Wildemann B, Haas J, Klotz L, Wiendl H, Ruck T, Meuth SG.

J Neurol. 2019 Jan;266(1):165-173. doi: 10.1007/s00415-018-9117-z. Epub 2018 Nov 16.


No evidence of disease activity status over 3 years in a real-world cohort of relapsing remitting MS patients in Germany.

Huhn K, Senger D, Utz KS, Schmidt M, Fröhlich K, Waschbisch A, Seifert F, Dörfler A, Lee DH, Linker RA.

Mult Scler Relat Disord. 2019 Jan;27:133-138. doi: 10.1016/j.msard.2018.10.020. Epub 2018 Oct 23.


Peripheral CD19+ B-cell counts and infusion intervals as a surrogate for long-term B-cell depleting therapy in multiple sclerosis and neuromyelitis optica/neuromyelitis optica spectrum disorders.

Ellrichmann G, Bolz J, Peschke M, Duscha A, Hellwig K, Lee DH, Linker RA, Gold R, Haghikia A.

J Neurol. 2019 Jan;266(1):57-67. doi: 10.1007/s00415-018-9092-4. Epub 2018 Oct 30.


Diagnostic value of the 2017 McDonald criteria in patients with a first demyelinating event suggestive of relapsing-remitting multiple sclerosis.

Lee DH, Peschke M, Utz KS, Linker RA.

Eur J Neurol. 2019 Mar;26(3):540-545. doi: 10.1111/ene.13853. Epub 2018 Dec 1.


Microscopic polyangiitis after alemtuzumab treatment in relapsing-remitting MS.

Sauer EM, Schliep S, Manger B, Lee DH, Linker RA.

Neurol Neuroimmunol Neuroinflamm. 2018 Aug 10;5(5):e488. doi: 10.1212/NXI.0000000000000488. eCollection 2018 Sep. No abstract available.


Sexual Dysfunction Seems to Trigger Depression in Female Multiple Sclerosis Patients.

Hösl KM, Deutsch M, Wang R, Roy S, Winder K, Niklewski G, Lee DH, Linker RA, Hilz MJ.

Eur Neurol. 2018;80(1-2):34-41. doi: 10.1159/000492126. Epub 2018 Aug 31.


Lesion correlates of secondary paroxysmal dyskinesia in multiple sclerosis.

Fröhlich K, Winder K, Linker RA, Huhn K, Engelhorn T, Dörfler A, Lee DH, Schwab S, Seifert F.

J Neurol. 2018 Oct;265(10):2277-2283. doi: 10.1007/s00415-018-8989-2. Epub 2018 Jul 31.


Sodium chloride triggers Th17 mediated autoimmunity.

Haase S, Wilck N, Kleinewietfeld M, Müller DN, Linker RA.

J Neuroimmunol. 2019 Apr 15;329:9-13. doi: 10.1016/j.jneuroim.2018.06.016. Epub 2018 Jun 30. Review.


The NRF2 pathway as potential biomarker for dimethyl fumarate treatment in multiple sclerosis.

Hammer A, Waschbisch A, Kuhbandner K, Bayas A, Lee DH, Duscha A, Haghikia A, Gold R, Linker RA.

Ann Clin Transl Neurol. 2018 Apr 16;5(6):668-676. doi: 10.1002/acn3.553. eCollection 2018 Jun.


Alemtuzumab as rescue therapy in a cohort of 50 relapsing-remitting MS patients with breakthrough disease on fingolimod: a multi-center observational study.

Huhn K, Bayas A, Doerck S, Frank B, Gerbershagen K, Hellwig K, Kallmann B, Kleinschnitz C, Kleiter I, Lee DH, Limmroth V, Mäurer M, Meuth S, Rieckmann P, Ruck T, Gold R, Linker RA.

J Neurol. 2018 Jul;265(7):1521-1527. doi: 10.1007/s00415-018-8871-2. Epub 2018 Apr 25.


Impacts of microbiome metabolites on immune regulation and autoimmunity.

Haase S, Haghikia A, Wilck N, Müller DN, Linker RA.

Immunology. 2018 Jun;154(2):230-238. doi: 10.1111/imm.12933. Epub 2018 Apr 30. Review.


[Nutrition, microbiome and multiple sclerosis : Current knowledge from basic research and clinical practice].

Haghikia A, Linker RA.

Nervenarzt. 2018 Apr;89(4):463-471. doi: 10.1007/s00115-018-0497-1. German.


Treatment choices and neuropsychological symptoms of a large cohort of early MS.

von Bismarck O, Dankowski T, Ambrosius B, Hessler N, Antony G, Ziegler A, Hoshi MM, Aly L, Luessi F, Groppa S, Klotz L, Meuth SG, Tackenberg B, Stoppe M, Then Bergh F, Tumani H, Kümpfel T, Stangel M, Heesen C, Wildemann B, Paul F, Bayas A, Warnke C, Weber F, Linker RA, Ziemann U, Zettl UK, Zipp F, Wiendl H, Hemmer B, Gold R, Salmen A.

Neurol Neuroimmunol Neuroinflamm. 2018 Mar 1;5(3):e446. doi: 10.1212/NXI.0000000000000446. eCollection 2018 May.


CLIPPERS with longitudinally extensive transverse myelitis: Role of T versus B cells.

Olmes DG, Metz I, Lee DH, Rosenwald A, Doerfler A, Brück W, Linker RA.

J Neurol Sci. 2018 Feb 15;385:96-98. doi: 10.1016/j.jns.2017.12.021. Epub 2017 Dec 18. No abstract available.


Insular multiple sclerosis lesions are associated with erectile dysfunction.

Winder K, Linker RA, Seifert F, Deutsch M, Engelhorn T, Dörfler A, Lee DH, Hösl KM, Hilz MJ.

J Neurol. 2018 Apr;265(4):783-792. doi: 10.1007/s00415-018-8763-5. Epub 2018 Feb 1.


Western lifestyle and immunopathology of multiple sclerosis.

Matveeva O, Bogie JFJ, Hendriks JJA, Linker RA, Haghikia A, Kleinewietfeld M.

Ann N Y Acad Sci. 2018 Apr;1417(1):71-86. doi: 10.1111/nyas.13583. Epub 2018 Jan 27. Review.


Role of Nuclear Factor (Erythroid-Derived 2)-Like 2 Signaling for Effects of Fumaric Acid Esters on Dendritic Cells.

Hammer A, Waschbisch A, Knippertz I, Zinser E, Berg J, Jörg S, Kuhbandner K, David C, Pi J, Bayas A, Lee DH, Haghikia A, Gold R, Steinkasserer A, Linker RA.

Front Immunol. 2017 Dec 22;8:1922. doi: 10.3389/fimmu.2017.01922. eCollection 2017.


Dietary fatty acids and susceptibility to multiple sclerosis.

Haase S, Haghikia A, Gold R, Linker RA.

Mult Scler. 2018 Jan;24(1):12-16. doi: 10.1177/1352458517737372. Review.


Salt-responsive gut commensal modulates TH17 axis and disease.

Wilck N, Matus MG, Kearney SM, Olesen SW, Forslund K, Bartolomaeus H, Haase S, Mähler A, Balogh A, Markó L, Vvedenskaya O, Kleiner FH, Tsvetkov D, Klug L, Costea PI, Sunagawa S, Maier L, Rakova N, Schatz V, Neubert P, Frätzer C, Krannich A, Gollasch M, Grohme DA, Côrte-Real BF, Gerlach RG, Basic M, Typas A, Wu C, Titze JM, Jantsch J, Boschmann M, Dechend R, Kleinewietfeld M, Kempa S, Bork P, Linker RA, Alm EJ, Müller DN.

Nature. 2017 Nov 30;551(7682):585-589. doi: 10.1038/nature24628. Epub 2017 Nov 15.


Supratentorial lesions contribute to trigeminal neuralgia in multiple sclerosis.

Fröhlich K, Winder K, Linker RA, Engelhorn T, Dörfler A, Lee DH, Hilz MJ, Schwab S, Seifert F.

Cephalalgia. 2018 Jun;38(7):1326-1334. doi: 10.1177/0333102417737788. Epub 2017 Oct 17.


Impact of combined sodium chloride and saturated long-chain fatty acid challenge on the differentiation of T helper cells in neuroinflammation.

Hammer A, Schliep A, Jörg S, Haghikia A, Gold R, Kleinewietfeld M, Müller DN, Linker RA.

J Neuroinflammation. 2017 Sep 12;14(1):184. doi: 10.1186/s12974-017-0954-y.


23Na MRI reveals persistent sodium accumulation in tumefactive MS lesions.

Huhn K, Mennecke A, Linz P, Tschunko F, Kästle N, Nagel AM, Uder M, Dörfler A, Linker RA, Engelhorn T.

J Neurol Sci. 2017 Aug 15;379:163-166. doi: 10.1016/j.jns.2017.06.003. Epub 2017 Jun 7.


Testosterone Differentially Affects T Cells and Neurons in Murine and Human Models of Neuroinflammation and Neurodegeneration.

Massa MG, David C, Jörg S, Berg J, Gisevius B, Hirschberg S, Linker RA, Gold R, Haghikia A.

Am J Pathol. 2017 Jul;187(7):1613-1622. doi: 10.1016/j.ajpath.2017.03.006.


Immunotherapies in neuromyelitis optica spectrum disorder: efficacy and predictors of response.

Stellmann JP, Krumbholz M, Friede T, Gahlen A, Borisow N, Fischer K, Hellwig K, Pache F, Ruprecht K, Havla J, Kümpfel T, Aktas O, Hartung HP, Ringelstein M, Geis C, Kleinschnitz C, Berthele A, Hemmer B, Angstwurm K, Young KL, Schuster S, Stangel M, Lauda F, Tumani H, Mayer C, Zeltner L, Ziemann U, Linker RA, Schwab M, Marziniak M, Then Bergh F, Hofstadt-van Oy U, Neuhaus O, Zettl U, Faiss J, Wildemann B, Paul F, Jarius S, Trebst C, Kleiter I; NEMOS (Neuromyelitis Optica Study Group).

J Neurol Neurosurg Psychiatry. 2017 Aug;88(8):639-647. doi: 10.1136/jnnp-2017-315603. Epub 2017 Jun 1.


Fingolimod initiation in multiple sclerosis patients is associated with potential beneficial cardiovascular autonomic effects.

Hilz MJ, Wang R, de Rojas Leal C, Liu M, Canavese F, Roy S, Hösl KM, Winder K, Lee DH, Linker RA.

Ther Adv Neurol Disord. 2017 Apr;10(4):191-209. doi: 10.1177/1756285616682936. Epub 2017 Jan 6.


Nimodipine fosters remyelination in a mouse model of multiple sclerosis and induces microglia-specific apoptosis.

Schampel A, Volovitch O, Koeniger T, Scholz CJ, Jörg S, Linker RA, Wischmeyer E, Wunsch M, Hell JW, Ergün S, Kuerten S.

Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3295-E3304. doi: 10.1073/pnas.1620052114. Epub 2017 Apr 5.


Good outcome of brain stem progressive multifocal leukoencephalopathy in an immunosuppressed renal transplant patient: Importance of early detection and rapid immune reconstitution.

Sauer R, Gölitz P, Jacobi J, Schwab S, Linker RA, Lee DH.

J Neurol Sci. 2017 Apr 15;375:76-79. doi: 10.1016/j.jns.2017.01.046. Epub 2017 Jan 14.


Fingolimod effects in neuroinflammation: Regulation of astroglial glutamate transporters?

Lee DH, Seubert S, Huhn K, Brecht L, Rötger C, Waschbisch A, Schlachetzki J, Klausmeyer A, Melms A, Wiese S, Winkler J, Linker RA.

PLoS One. 2017 Mar 8;12(3):e0171552. doi: 10.1371/journal.pone.0171552. eCollection 2017.


FLAIRfusion Processing with Contrast Inversion : Improving Detection and Reading Time of New Cerebral MS Lesions.

Schmidt MA, Linker RA, Lang S, Lücking H, Engelhorn T, Kloska S, Uder M, Cavallaro A, Dörfler A, Dankerl P.

Clin Neuroradiol. 2018 Sep;28(3):367-376. doi: 10.1007/s00062-017-0567-y. Epub 2017 Mar 6.


Macrophages in neuroinflammation: role of the renin-angiotensin-system.

Hammer A, Stegbauer J, Linker RA.

Pflugers Arch. 2017 Apr;469(3-4):431-444. doi: 10.1007/s00424-017-1942-x. Epub 2017 Feb 11. Review.


Role of the receptor Mas in macrophage-mediated inflammation in vivo.

Hammer A, Yang G, Friedrich J, Kovacs A, Lee DH, Grave K, Jörg S, Alenina N, Grosch J, Winkler J, Gold R, Bader M, Manzel A, Rump LC, Müller DN, Linker RA, Stegbauer J.

Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):14109-14114. Epub 2016 Nov 21.


Retinal imaging and axonal degeneration in later onset multiple sclerosis.

Huhn K, Lämmer R, Zimmermann H, Lämmer A, Waschbisch A, Utz K, Gieß RM, Paul F, Linker RA, Lee DH.

J Neurol Sci. 2016 Nov 15;370:1-6. doi: 10.1016/j.jns.2016.09.009. Epub 2016 Sep 8.


Influence of female sex and fertile age on neuromyelitis optica spectrum disorders.

Borisow N, Kleiter I, Gahlen A, Fischer K, Wernecke KD, Pache F, Ruprecht K, Havla J, Krumbholz M, Kümpfel T, Aktas O, Ringelstein M, Geis C, Kleinschnitz C, Berthele A, Hemmer B, Angstwurm K, Weissert R, Stellmann JP, Schuster S, Stangel M, Lauda F, Tumani H, Mayer C, Zeltner L, Ziemann U, Linker RA, Schwab M, Marziniak M, Then Bergh F, Hofstadt-van Oy U, Neuhaus O, Winkelmann A, Marouf W, Rückriem L, Faiss J, Wildemann B, Paul F, Jarius S, Trebst C, Hellwig K; NEMOS (Neuromyelitis Optica Study Group).

Mult Scler. 2017 Jul;23(8):1092-1103. doi: 10.1177/1352458516671203. Epub 2016 Oct 6.


Immunotherapy Improves Cognitive Function in Secondary Progressive Multiple Sclerosis.

Kinner M, Hoepner R, Klotz P, Prehn C, Faissner S, Salmen A, Linker RA, Gold R, Chan A.

CNS Neurosci Ther. 2016 Dec;22(12):1019-1022. doi: 10.1111/cns.12652. Epub 2016 Oct 13. No abstract available.


Neprilysin is a Mediator of Alternative Renin-Angiotensin-System Activation in the Murine and Human Kidney.

Domenig O, Manzel A, Grobe N, Königshausen E, Kaltenecker CC, Kovarik JJ, Stegbauer J, Gurley SB, van Oyen D, Antlanger M, Bader M, Motta-Santos D, Santos RA, Elased KM, Säemann MD, Linker RA, Poglitsch M.

Sci Rep. 2016 Sep 21;6:33678. doi: 10.1038/srep33678.


Expression of brain-derived neurotrophic factor in astrocytes - Beneficial effects of glatiramer acetate in the R6/2 and YAC128 mouse models of Huntington's disease.

Reick C, Ellrichmann G, Tsai T, Lee DH, Wiese S, Gold R, Saft C, Linker RA.

Exp Neurol. 2016 Nov;285(Pt A):12-23. doi: 10.1016/j.expneurol.2016.08.012. Epub 2016 Aug 29.


α-Synuclein deficiency promotes neuroinflammation by increasing Th1 cell-mediated immune responses.

Ettle B, Kuhbandner K, Jörg S, Hoffmann A, Winkler J, Linker RA.

J Neuroinflammation. 2016 Aug 26;13(1):201. doi: 10.1186/s12974-016-0694-4.


Environmental factors in autoimmune diseases and their role in multiple sclerosis.

Jörg S, Grohme DA, Erzler M, Binsfeld M, Haghikia A, Müller DN, Linker RA, Kleinewietfeld M.

Cell Mol Life Sci. 2016 Dec;73(24):4611-4622. Epub 2016 Aug 4. Review.


Neuroanatomic Correlates of Female Sexual Dysfunction in Multiple Sclerosis.

Winder K, Linker RA, Seifert F, Deutsch M, Engelhorn T, Dörfler A, Lee DH, Hösl KM, Hilz MJ.

Ann Neurol. 2016 Oct;80(4):490-8. doi: 10.1002/ana.24746. Epub 2016 Aug 19.


Dimethyl fumarate in multiple sclerosis: latest developments, evidence and place in therapy.

Linker RA, Haghikia A.

Ther Adv Chronic Dis. 2016 Jul;7(4):198-207. doi: 10.1177/2040622316653307. Epub 2016 Jun 10. Review.


Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation.

Andlauer TF, Buck D, Antony G, Bayas A, Bechmann L, Berthele A, Chan A, Gasperi C, Gold R, Graetz C, Haas J, Hecker M, Infante-Duarte C, Knop M, Kümpfel T, Limmroth V, Linker RA, Loleit V, Luessi F, Meuth SG, Mühlau M, Nischwitz S, Paul F, Pütz M, Ruck T, Salmen A, Stangel M, Stellmann JP, Stürner KH, Tackenberg B, Then Bergh F, Tumani H, Warnke C, Weber F, Wiendl H, Wildemann B, Zettl UK, Ziemann U, Zipp F, Arloth J, Weber P, Radivojkov-Blagojevic M, Scheinhardt MO, Dankowski T, Bettecken T, Lichtner P, Czamara D, Carrillo-Roa T, Binder EB, Berger K, Bertram L, Franke A, Gieger C, Herms S, Homuth G, Ising M, Jöckel KH, Kacprowski T, Kloiber S, Laudes M, Lieb W, Lill CM, Lucae S, Meitinger T, Moebus S, Müller-Nurasyid M, Nöthen MM, Petersmann A, Rawal R, Schminke U, Strauch K, Völzke H, Waldenberger M, Wellmann J, Porcu E, Mulas A, Pitzalis M, Sidore C, Zara I, Cucca F, Zoledziewska M, Ziegler A, Hemmer B, Müller-Myhsok B.

Sci Adv. 2016 Jun 17;2(6):e1501678. doi: 10.1126/sciadv.1501678. eCollection 2016 Jun.


Cognitive functions over the course of 1 year in multiple sclerosis patients treated with disease modifying therapies.

Utz KS, Lee DH, Lämmer A, Waschbisch A, Linker RA, Schenk T.

Ther Adv Neurol Disord. 2016 Jul;9(4):269-80. doi: 10.1177/1756285616643892. Epub 2016 Apr 18.


Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine.

Haghikia A, Jörg S, Duscha A, Berg J, Manzel A, Waschbisch A, Hammer A, Lee DH, May C, Wilck N, Balogh A, Ostermann AI, Schebb NH, Akkad DA, Grohme DA, Kleinewietfeld M, Kempa S, Thöne J, Demir S, Müller DN, Gold R, Linker RA.

Immunity. 2016 Apr 19;44(4):951-3. doi: 10.1016/j.immuni.2016.04.006. No abstract available.

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