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Items: 1 to 50 of 206

1.

Brain MRI Lesions are Related to Bowel Incontinence in Multiple Sclerosis.

Fröhlich K, Linker RA, Engelhorn T, Dörfler A, Lee DH, Huhn K, Schwab S, Hilz MJ, Seifert F, Winder K.

J Neuroimaging. 2018 Dec 11. doi: 10.1111/jon.12589. [Epub ahead of print]

PMID:
30537408
2.

Efficacy and safety of alemtuzumab versus fingolimod in RRMS after natalizumab cessation.

Pfeuffer S, Schmidt R, Straeten FA, Pul R, Kleinschnitz C, Wieshuber M, Lee DH, Linker RA, Doerck S, Straeten V, Windhagen S, Pawlitzki M, Aufenberg C, Lang M, Eienbroeker C, Tackenberg B, Limmroth V, Wildemann B, Haas J, Klotz L, Wiendl H, Ruck T, Meuth SG.

J Neurol. 2018 Nov 16. doi: 10.1007/s00415-018-9117-z. [Epub ahead of print]

PMID:
30446966
3.

No evidence of disease activity status over 3 years in a real-world cohort of relapsing remitting MS patients in Germany.

Huhn K, Senger D, Utz KS, Schmidt M, Fröhlich K, Waschbisch A, Seifert F, Dörfler A, Lee DH, Linker RA.

Mult Scler Relat Disord. 2018 Oct 23;27:133-138. doi: 10.1016/j.msard.2018.10.020. [Epub ahead of print]

PMID:
30384198
4.

Peripheral CD19+ B-cell counts and infusion intervals as a surrogate for long-term B-cell depleting therapy in multiple sclerosis and neuromyelitis optica/neuromyelitis optica spectrum disorders.

Ellrichmann G, Bolz J, Peschke M, Duscha A, Hellwig K, Lee DH, Linker RA, Gold R, Haghikia A.

J Neurol. 2018 Oct 30. doi: 10.1007/s00415-018-9092-4. [Epub ahead of print]

PMID:
30377816
5.

Diagnostic value of the 2017 McDonald criteria in patients with a first demyelinating event suggestive of relapsing-remitting multiple sclerosis.

Lee DH, Peschke M, Utz KS, Linker RA.

Eur J Neurol. 2018 Oct 26. doi: 10.1111/ene.13853. [Epub ahead of print]

PMID:
30362206
6.

Teaching Video NeuroImages: Facial myokymia and myorhythmia in anti-IgLON5 disease: The bitten lip.

Vetter E, Olmes DG, Linker R, Seifert F.

Neurology. 2018 Oct 23;91(17):e1659. doi: 10.1212/WNL.0000000000006388. No abstract available.

PMID:
30348862
7.

Apheresis therapies for NMOSD attacks: A retrospective study of 207 therapeutic interventions.

Kleiter I, Gahlen A, Borisow N, Fischer K, Wernecke KD, Hellwig K, Pache F, Ruprecht K, Havla J, Kümpfel T, Aktas O, Hartung HP, Ringelstein M, Geis C, Kleinschnitz C, Berthele A, Hemmer B, Angstwurm K, Stellmann JP, Schuster S, Stangel M, Lauda F, Tumani H, Mayer C, Krumbholz M, Zeltner L, Ziemann U, Linker R, Schwab M, Marziniak M, Then Bergh F, Hofstadt-van Oy U, Neuhaus O, Zettl UK, Faiss J, Wildemann B, Paul F, Jarius S, Trebst C; NEMOS (Neuromyelitis Optica Study Group).

Neurol Neuroimmunol Neuroinflamm. 2018 Sep 26;5(6):e504. doi: 10.1212/NXI.0000000000000504. eCollection 2018 Nov.

8.

Microscopic polyangiitis after alemtuzumab treatment in relapsing-remitting MS.

Sauer EM, Schliep S, Manger B, Lee DH, Linker RA.

Neurol Neuroimmunol Neuroinflamm. 2018 Aug 10;5(5):e488. doi: 10.1212/NXI.0000000000000488. eCollection 2018 Sep. No abstract available.

9.

Sexual Dysfunction Seems to Trigger Depression in Female Multiple Sclerosis Patients.

Hösl KM, Deutsch M, Wang R, Roy S, Winder K, Niklewski G, Lee DH, Linker RA, Hilz MJ.

Eur Neurol. 2018;80(1-2):34-41. doi: 10.1159/000492126. Epub 2018 Aug 31.

PMID:
30173209
10.

Lesion correlates of secondary paroxysmal dyskinesia in multiple sclerosis.

Fröhlich K, Winder K, Linker RA, Huhn K, Engelhorn T, Dörfler A, Lee DH, Schwab S, Seifert F.

J Neurol. 2018 Oct;265(10):2277-2283. doi: 10.1007/s00415-018-8989-2. Epub 2018 Jul 31.

PMID:
30066284
11.

Sodium chloride triggers Th17 mediated autoimmunity.

Haase S, Wilck N, Kleinewietfeld M, Müller DN, Linker RA.

J Neuroimmunol. 2018 Jun 30. pii: S0165-5728(17)30512-X. doi: 10.1016/j.jneuroim.2018.06.016. [Epub ahead of print] Review.

PMID:
29983198
12.

The NRF2 pathway as potential biomarker for dimethyl fumarate treatment in multiple sclerosis.

Hammer A, Waschbisch A, Kuhbandner K, Bayas A, Lee DH, Duscha A, Haghikia A, Gold R, Linker RA.

Ann Clin Transl Neurol. 2018 Apr 16;5(6):668-676. doi: 10.1002/acn3.553. eCollection 2018 Jun.

13.

Alemtuzumab as rescue therapy in a cohort of 50 relapsing-remitting MS patients with breakthrough disease on fingolimod: a multi-center observational study.

Huhn K, Bayas A, Doerck S, Frank B, Gerbershagen K, Hellwig K, Kallmann B, Kleinschnitz C, Kleiter I, Lee DH, Limmroth V, Mäurer M, Meuth S, Rieckmann P, Ruck T, Gold R, Linker RA.

J Neurol. 2018 Jul;265(7):1521-1527. doi: 10.1007/s00415-018-8871-2. Epub 2018 Apr 25.

PMID:
29696498
14.

Impacts of microbiome metabolites on immune regulation and autoimmunity.

Haase S, Haghikia A, Wilck N, Müller DN, Linker RA.

Immunology. 2018 Jun;154(2):230-238. doi: 10.1111/imm.12933. Epub 2018 Apr 30. Review.

PMID:
29637999
15.

Association of smoking but not HLA-DRB1*15:01, APOE or body mass index with brain atrophy in early multiple sclerosis.

Graetz C, Gröger A, Luessi F, Salmen A, Zöller D, Schultz J, Siller N, Fleischer V, Bellenberg B, Berthele A, Biberacher V, Havla J, Hecker M, Hohlfeld R, Infante-Duarte C, Kirschke JS, Kümpfel T, Linker R, Paul F, Pfeuffer S, Sämann P, Toenges G, Weber F, Zettl UK, Jahn-Eimermacher A, Antony G, Groppa S, Wiendl H, Hemmer B, Mühlau M, Lukas C, Gold R, Lill CM, Zipp F.

Mult Scler. 2018 Mar 1:1352458518763541. doi: 10.1177/1352458518763541. [Epub ahead of print]

PMID:
29532745
16.

[Nutrition, microbiome and multiple sclerosis : Current knowledge from basic research and clinical practice].

Haghikia A, Linker RA.

Nervenarzt. 2018 Apr;89(4):463-471. doi: 10.1007/s00115-018-0497-1. German.

PMID:
29516151
17.

Treatment choices and neuropsychological symptoms of a large cohort of early MS.

von Bismarck O, Dankowski T, Ambrosius B, Hessler N, Antony G, Ziegler A, Hoshi MM, Aly L, Luessi F, Groppa S, Klotz L, Meuth SG, Tackenberg B, Stoppe M, Then Bergh F, Tumani H, Kümpfel T, Stangel M, Heesen C, Wildemann B, Paul F, Bayas A, Warnke C, Weber F, Linker RA, Ziemann U, Zettl UK, Zipp F, Wiendl H, Hemmer B, Gold R, Salmen A.

Neurol Neuroimmunol Neuroinflamm. 2018 Mar 1;5(3):e446. doi: 10.1212/NXI.0000000000000446. eCollection 2018 May.

18.

CLIPPERS with longitudinally extensive transverse myelitis: Role of T versus B cells.

Olmes DG, Metz I, Lee DH, Rosenwald A, Doerfler A, Brück W, Linker RA.

J Neurol Sci. 2018 Feb 15;385:96-98. doi: 10.1016/j.jns.2017.12.021. Epub 2017 Dec 18. No abstract available.

PMID:
29406923
19.

Insular multiple sclerosis lesions are associated with erectile dysfunction.

Winder K, Linker RA, Seifert F, Deutsch M, Engelhorn T, Dörfler A, Lee DH, Hösl KM, Hilz MJ.

J Neurol. 2018 Apr;265(4):783-792. doi: 10.1007/s00415-018-8763-5. Epub 2018 Feb 1.

PMID:
29392463
20.

Western lifestyle and immunopathology of multiple sclerosis.

Matveeva O, Bogie JFJ, Hendriks JJA, Linker RA, Haghikia A, Kleinewietfeld M.

Ann N Y Acad Sci. 2018 Apr;1417(1):71-86. doi: 10.1111/nyas.13583. Epub 2018 Jan 27. Review.

21.

Role of Nuclear Factor (Erythroid-Derived 2)-Like 2 Signaling for Effects of Fumaric Acid Esters on Dendritic Cells.

Hammer A, Waschbisch A, Knippertz I, Zinser E, Berg J, Jörg S, Kuhbandner K, David C, Pi J, Bayas A, Lee DH, Haghikia A, Gold R, Steinkasserer A, Linker RA.

Front Immunol. 2017 Dec 22;8:1922. doi: 10.3389/fimmu.2017.01922. eCollection 2017.

22.

Dietary fatty acids and susceptibility to multiple sclerosis.

Haase S, Haghikia A, Gold R, Linker RA.

Mult Scler. 2018 Jan;24(1):12-16. doi: 10.1177/1352458517737372.

PMID:
29307296
23.

Salt-responsive gut commensal modulates TH17 axis and disease.

Wilck N, Matus MG, Kearney SM, Olesen SW, Forslund K, Bartolomaeus H, Haase S, Mähler A, Balogh A, Markó L, Vvedenskaya O, Kleiner FH, Tsvetkov D, Klug L, Costea PI, Sunagawa S, Maier L, Rakova N, Schatz V, Neubert P, Frätzer C, Krannich A, Gollasch M, Grohme DA, Côrte-Real BF, Gerlach RG, Basic M, Typas A, Wu C, Titze JM, Jantsch J, Boschmann M, Dechend R, Kleinewietfeld M, Kempa S, Bork P, Linker RA, Alm EJ, Müller DN.

Nature. 2017 Nov 30;551(7682):585-589. doi: 10.1038/nature24628. Epub 2017 Nov 15.

24.

What's new in multiple sclerosis spasticity research? Poster session highlights.

Linker R.

Neurodegener Dis Manag. 2017 Nov;7(6s):51-53. doi: 10.2217/nmt-2017-0043.

PMID:
29143588
25.

Foreword.

Linker R.

Neurodegener Dis Manag. 2017 Nov;7(6s):1-2. doi: 10.2217/nmt-2017-0032. No abstract available.

PMID:
29143587
26.

Break-out session highlights.

Myhr KM, Mäurer M, Ginés MM, Esposito F, Linker R.

Neurodegener Dis Manag. 2017 Nov;7(6s):45-49. doi: 10.2217/nmt-2017-0042.

PMID:
29143586
27.

Supratentorial lesions contribute to trigeminal neuralgia in multiple sclerosis.

Fröhlich K, Winder K, Linker RA, Engelhorn T, Dörfler A, Lee DH, Hilz MJ, Schwab S, Seifert F.

Cephalalgia. 2018 Jun;38(7):1326-1334. doi: 10.1177/0333102417737788. Epub 2017 Oct 17.

PMID:
29041817
28.

Impact of combined sodium chloride and saturated long-chain fatty acid challenge on the differentiation of T helper cells in neuroinflammation.

Hammer A, Schliep A, Jörg S, Haghikia A, Gold R, Kleinewietfeld M, Müller DN, Linker RA.

J Neuroinflammation. 2017 Sep 12;14(1):184. doi: 10.1186/s12974-017-0954-y.

29.

23Na MRI reveals persistent sodium accumulation in tumefactive MS lesions.

Huhn K, Mennecke A, Linz P, Tschunko F, Kästle N, Nagel AM, Uder M, Dörfler A, Linker RA, Engelhorn T.

J Neurol Sci. 2017 Aug 15;379:163-166. doi: 10.1016/j.jns.2017.06.003. Epub 2017 Jun 7.

PMID:
28716233
30.

Testosterone Differentially Affects T Cells and Neurons in Murine and Human Models of Neuroinflammation and Neurodegeneration.

Massa MG, David C, Jörg S, Berg J, Gisevius B, Hirschberg S, Linker RA, Gold R, Haghikia A.

Am J Pathol. 2017 Jul;187(7):1613-1622. doi: 10.1016/j.ajpath.2017.03.006.

PMID:
28634006
31.

Immunotherapies in neuromyelitis optica spectrum disorder: efficacy and predictors of response.

Stellmann JP, Krumbholz M, Friede T, Gahlen A, Borisow N, Fischer K, Hellwig K, Pache F, Ruprecht K, Havla J, Kümpfel T, Aktas O, Hartung HP, Ringelstein M, Geis C, Kleinschnitz C, Berthele A, Hemmer B, Angstwurm K, Young KL, Schuster S, Stangel M, Lauda F, Tumani H, Mayer C, Zeltner L, Ziemann U, Linker RA, Schwab M, Marziniak M, Then Bergh F, Hofstadt-van Oy U, Neuhaus O, Zettl U, Faiss J, Wildemann B, Paul F, Jarius S, Trebst C, Kleiter I; NEMOS (Neuromyelitis Optica Study Group).

J Neurol Neurosurg Psychiatry. 2017 Aug;88(8):639-647. doi: 10.1136/jnnp-2017-315603. Epub 2017 Jun 1.

32.

Fingolimod initiation in multiple sclerosis patients is associated with potential beneficial cardiovascular autonomic effects.

Hilz MJ, Wang R, de Rojas Leal C, Liu M, Canavese F, Roy S, Hösl KM, Winder K, Lee DH, Linker RA.

Ther Adv Neurol Disord. 2017 Apr;10(4):191-209. doi: 10.1177/1756285616682936. Epub 2017 Jan 6.

33.

Nimodipine fosters remyelination in a mouse model of multiple sclerosis and induces microglia-specific apoptosis.

Schampel A, Volovitch O, Koeniger T, Scholz CJ, Jörg S, Linker RA, Wischmeyer E, Wunsch M, Hell JW, Ergün S, Kuerten S.

Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3295-E3304. doi: 10.1073/pnas.1620052114. Epub 2017 Apr 5.

34.

Good outcome of brain stem progressive multifocal leukoencephalopathy in an immunosuppressed renal transplant patient: Importance of early detection and rapid immune reconstitution.

Sauer R, Gölitz P, Jacobi J, Schwab S, Linker RA, Lee DH.

J Neurol Sci. 2017 Apr 15;375:76-79. doi: 10.1016/j.jns.2017.01.046. Epub 2017 Jan 14.

PMID:
28320193
35.

Fingolimod effects in neuroinflammation: Regulation of astroglial glutamate transporters?

Lee DH, Seubert S, Huhn K, Brecht L, Rötger C, Waschbisch A, Schlachetzki J, Klausmeyer A, Melms A, Wiese S, Winkler J, Linker RA.

PLoS One. 2017 Mar 8;12(3):e0171552. doi: 10.1371/journal.pone.0171552. eCollection 2017.

36.

FLAIRfusion Processing with Contrast Inversion : Improving Detection and Reading Time of New Cerebral MS Lesions.

Schmidt MA, Linker RA, Lang S, Lücking H, Engelhorn T, Kloska S, Uder M, Cavallaro A, Dörfler A, Dankerl P.

Clin Neuroradiol. 2018 Sep;28(3):367-376. doi: 10.1007/s00062-017-0567-y. Epub 2017 Mar 6.

PMID:
28265679
37.

Macrophages in neuroinflammation: role of the renin-angiotensin-system.

Hammer A, Stegbauer J, Linker RA.

Pflugers Arch. 2017 Apr;469(3-4):431-444. doi: 10.1007/s00424-017-1942-x. Epub 2017 Feb 11. Review.

PMID:
28190090
38.

Role of the receptor Mas in macrophage-mediated inflammation in vivo.

Hammer A, Yang G, Friedrich J, Kovacs A, Lee DH, Grave K, Jörg S, Alenina N, Grosch J, Winkler J, Gold R, Bader M, Manzel A, Rump LC, Müller DN, Linker RA, Stegbauer J.

Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):14109-14114. Epub 2016 Nov 21.

39.

Direct Estimation of Local pH Change at Infection Sites of Fungi in Potato Tubers.

Tardi-Ovadia R, Linker R, Tsror Lahkim L.

Phytopathology. 2017 Jan;107(1):132-137. Epub 2016 Nov 7.

40.

Retinal imaging and axonal degeneration in later onset multiple sclerosis.

Huhn K, Lämmer R, Zimmermann H, Lämmer A, Waschbisch A, Utz K, Gieß RM, Paul F, Linker RA, Lee DH.

J Neurol Sci. 2016 Nov 15;370:1-6. doi: 10.1016/j.jns.2016.09.009. Epub 2016 Sep 8.

PMID:
27772735
41.

Influence of female sex and fertile age on neuromyelitis optica spectrum disorders.

Borisow N, Kleiter I, Gahlen A, Fischer K, Wernecke KD, Pache F, Ruprecht K, Havla J, Krumbholz M, Kümpfel T, Aktas O, Ringelstein M, Geis C, Kleinschnitz C, Berthele A, Hemmer B, Angstwurm K, Weissert R, Stellmann JP, Schuster S, Stangel M, Lauda F, Tumani H, Mayer C, Zeltner L, Ziemann U, Linker RA, Schwab M, Marziniak M, Then Bergh F, Hofstadt-van Oy U, Neuhaus O, Winkelmann A, Marouf W, Rückriem L, Faiss J, Wildemann B, Paul F, Jarius S, Trebst C, Hellwig K; NEMOS (Neuromyelitis Optica Study Group).

Mult Scler. 2017 Jul;23(8):1092-1103. doi: 10.1177/1352458516671203. Epub 2016 Oct 6.

PMID:
27758954
42.

Immunotherapy Improves Cognitive Function in Secondary Progressive Multiple Sclerosis.

Kinner M, Hoepner R, Klotz P, Prehn C, Faissner S, Salmen A, Linker RA, Gold R, Chan A.

CNS Neurosci Ther. 2016 Dec;22(12):1019-1022. doi: 10.1111/cns.12652. Epub 2016 Oct 13. No abstract available.

PMID:
27739247
43.

Neprilysin is a Mediator of Alternative Renin-Angiotensin-System Activation in the Murine and Human Kidney.

Domenig O, Manzel A, Grobe N, Königshausen E, Kaltenecker CC, Kovarik JJ, Stegbauer J, Gurley SB, van Oyen D, Antlanger M, Bader M, Motta-Santos D, Santos RA, Elased KM, Säemann MD, Linker RA, Poglitsch M.

Sci Rep. 2016 Sep 21;6:33678. doi: 10.1038/srep33678.

45.

Expression of brain-derived neurotrophic factor in astrocytes - Beneficial effects of glatiramer acetate in the R6/2 and YAC128 mouse models of Huntington's disease.

Reick C, Ellrichmann G, Tsai T, Lee DH, Wiese S, Gold R, Saft C, Linker RA.

Exp Neurol. 2016 Nov;285(Pt A):12-23. doi: 10.1016/j.expneurol.2016.08.012. Epub 2016 Aug 29.

PMID:
27587303
46.

α-Synuclein deficiency promotes neuroinflammation by increasing Th1 cell-mediated immune responses.

Ettle B, Kuhbandner K, Jörg S, Hoffmann A, Winkler J, Linker RA.

J Neuroinflammation. 2016 Aug 26;13(1):201. doi: 10.1186/s12974-016-0694-4.

47.

Environmental factors in autoimmune diseases and their role in multiple sclerosis.

Jörg S, Grohme DA, Erzler M, Binsfeld M, Haghikia A, Müller DN, Linker RA, Kleinewietfeld M.

Cell Mol Life Sci. 2016 Dec;73(24):4611-4622. Epub 2016 Aug 4. Review.

48.

Neuroanatomic Correlates of Female Sexual Dysfunction in Multiple Sclerosis.

Winder K, Linker RA, Seifert F, Deutsch M, Engelhorn T, Dörfler A, Lee DH, Hösl KM, Hilz MJ.

Ann Neurol. 2016 Oct;80(4):490-8. doi: 10.1002/ana.24746. Epub 2016 Aug 19.

PMID:
27464008
49.

Dimethyl fumarate in multiple sclerosis: latest developments, evidence and place in therapy.

Linker RA, Haghikia A.

Ther Adv Chronic Dis. 2016 Jul;7(4):198-207. doi: 10.1177/2040622316653307. Epub 2016 Jun 10. Review.

50.

Design of TRUST, a non-interventional, multicenter, 3-year prospective study investigating an integrated patient management approach in patients with relapsing-remitting multiple sclerosis treated with natalizumab.

Ziemssen T, Gass A, Wuerfel J, Bayas A, Tackenberg B, Limmroth V, Linker R, Mäurer M, Haas J, Stangel M, Meergans M, Harlin O, Hartung HP.

BMC Neurol. 2016 Jul 12;16:98. doi: 10.1186/s12883-016-0625-0.

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