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Items: 30


A Biological Signature for Breast Ductal Carcinoma In Situ to Predict Radiotherapy Benefit and Assess Recurrence Risk.

Bremer T, Whitworth PW, Patel R, Savala J, Barry T, Lyle S, Leesman G, Linke SP, Jirström K, Zhou W, Amini RM, Wärnberg F.

Clin Cancer Res. 2018 Dec 1;24(23):5895-5901. doi: 10.1158/1078-0432.CCR-18-0842. Epub 2018 Jul 27.


Image analysis algorithms for immunohistochemical assessment of cell death events and fibrosis in tissue sections.

Krajewska M, Smith LH, Rong J, Huang X, Hyer ML, Zeps N, Iacopetta B, Linke SP, Olson AH, Reed JC, Krajewski S.

J Histochem Cytochem. 2009 Jul;57(7):649-63. doi: 10.1369/jhc.2009.952812. Epub 2009 Mar 16.


Prognostic marker profile to assess risk in stage I-III hormone receptor-positive breast cancer patients.

Bremer TM, Jacquemier J, Charafe-Jauffret E, Viens P, Birnbaum D, Linke SP.

Int J Cancer. 2009 Feb 15;124(4):896-904. doi: 10.1002/ijc.24001.


A multimarker model to predict outcome in tamoxifen-treated breast cancer patients.

Linke SP, Bremer TM, Herold CD, Sauter G, Diamond C.

Clin Cancer Res. 2006 Feb 15;12(4):1175-83.


BLM helicase facilitates Mus81 endonuclease activity in human cells.

Zhang R, Sengupta S, Yang Q, Linke SP, Yanaihara N, Bradsher J, Blais V, McGowan CH, Harris CC.

Cancer Res. 2005 Apr 1;65(7):2526-31.


Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest.

Sengupta S, Robles AI, Linke SP, Sinogeeva NI, Zhang R, Pedeux R, Ward IM, Celeste A, Nussenzweig A, Chen J, Halazonetis TD, Harris CC.

J Cell Biol. 2004 Sep 13;166(6):801-13.


The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase.

Yang Q, Zhang R, Wang XW, Linke SP, Sengupta S, Hickson ID, Pedrazzi G, Perrera C, Stagljar I, Littman SJ, Modrich P, Harris CC.

Oncogene. 2004 May 6;23(21):3749-56.


Involvement of Crm1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles.

Forgues M, Difilippantonio MJ, Linke SP, Ried T, Nagashima K, Feden J, Valerie K, Fukasawa K, Wang XW.

Mol Cell Biol. 2003 Aug;23(15):5282-92.


p53 interacts with hRAD51 and hRAD54, and directly modulates homologous recombination.

Linke SP, Sengupta S, Khabie N, Jeffries BA, Buchhop S, Miska S, Henning W, Pedeux R, Wang XW, Hofseth LJ, Yang Q, Garfield SH, Stürzbecher HW, Harris CC.

Cancer Res. 2003 May 15;63(10):2596-605.


Human malignant glioma cell lines are sensitive to low radiation doses.

Beauchesne PD, Bertrand S, Branche R, Linke SP, Revel R, Dore JF, Pedeux RM.

Int J Cancer. 2003 May 20;105(1):33-40.


UV-C-induced DNA damage leads to p53-dependent nuclear trafficking of PML.

Seker H, Rubbi C, Linke SP, Bowman ED, Garfield S, Hansen L, Borden KL, Milner J, Harris CC.

Oncogene. 2003 Mar 20;22(11):1620-8.


BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination.

Sengupta S, Linke SP, Pedeux R, Yang Q, Farnsworth J, Garfield SH, Valerie K, Shay JW, Ellis NA, Wasylyk B, Harris CC.

EMBO J. 2003 Mar 3;22(5):1210-22.


Nitric oxide-induced cellular stress and p53 activation in chronic inflammation.

Hofseth LJ, Saito S, Hussain SP, Espey MG, Miranda KM, Araki Y, Jhappan C, Higashimoto Y, He P, Linke SP, Quezado MM, Zurer I, Rotter V, Wink DA, Appella E, Harris CC.

Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):143-8. Epub 2002 Dec 23.


The p53 network in lung carcinogenesis.

Robles AI, Linke SP, Harris CC.

Oncogene. 2002 Oct 7;21(45):6898-907. Review.


The processing of Holliday junctions by BLM and WRN helicases is regulated by p53.

Yang Q, Zhang R, Wang XW, Spillare EA, Linke SP, Subramanian D, Griffith JD, Li JL, Hickson ID, Shen JC, Loeb LA, Mazur SJ, Appella E, Brosh RM Jr, Karmakar P, Bohr VA, Harris CC.

J Biol Chem. 2002 Aug 30;277(35):31980-7. Epub 2002 Jun 21.


DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53.

Nagashima M, Shiseki M, Miura K, Hagiwara K, Linke SP, Pedeux R, Wang XW, Yokota J, Riabowol K, Harris CC.

Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9671-6. Epub 2001 Jul 31.


Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis.

Xu X, Qiao W, Linke SP, Cao L, Li WM, Furth PA, Harris CC, Deng CX.

Nat Genet. 2001 Jul;28(3):266-71.


Functional interaction of p53 and BLM DNA helicase in apoptosis.

Wang XW, Tseng A, Ellis NA, Spillare EA, Linke SP, Robles AI, Seker H, Yang Q, Hu P, Beresten S, Bemmels NA, Garfield S, Harris CC.

J Biol Chem. 2001 Aug 31;276(35):32948-55. Epub 2001 Jun 8.


Identification of a functional domain in a GADD45-mediated G2/M checkpoint.

Yang Q, Manicone A, Coursen JD, Linke SP, Nagashima M, Forgues M, Wang XW.

J Biol Chem. 2000 Nov 24;275(47):36892-8.


Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells.

Xu X, Weaver Z, Linke SP, Li C, Gotay J, Wang XW, Harris CC, Ried T, Deng CX.

Mol Cell. 1999 Mar;3(3):389-95.


Cancer. Has the smart bomb been defused?

Linke SP.

Nature. 1998 Sep 3;395(6697):13, 15. No abstract available.


p53-mediated accumulation of hypophosphorylated pRb after the G1 restriction point fails to halt cell cycle progression.

Linke SP, Harris MP, Neugebauer SE, Clarkin KC, Shepard HM, Maneval DC, Wahl GM.

Oncogene. 1997 Jul 17;15(3):337-45.


p53 mediates permanent arrest over multiple cell cycles in response to gamma-irradiation.

Linke SP, Clarkin KC, Wahl GM.

Cancer Res. 1997 Mar 15;57(6):1171-9.


DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function.

Di Leonardo A, Khan SH, Linke SP, Greco V, Seidita G, Wahl GM.

Cancer Res. 1997 Mar 15;57(6):1013-9.


Maintaining genetic stability through TP53 mediated checkpoint control.

Wahl GM, Linke SP, Paulson TG, Huang LC.

Cancer Surv. 1997;29:183-219. Review.


The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.

Jones SN, Sands AT, Hancock AR, Vogel H, Donehower LA, Linke SP, Wahl GM, Bradley A.

Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14106-11.


A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

Linke SP, Clarkin KC, Di Leonardo A, Tsou A, Wahl GM.

Genes Dev. 1996 Apr 15;10(8):934-47.


Genetic instability as a consequence of inappropriate entry into and progression through S-phase.

Almasan A, Linke SP, Paulson TG, Huang LC, Wahl GM.

Cancer Metastasis Rev. 1995 Mar;14(1):59-73. Review.


Cell cycle regulation of gene amplification.

Di Leonardo A, Linke SP, Yin Y, Wahl GM.

Cold Spring Harb Symp Quant Biol. 1993;58:655-67. No abstract available.


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