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Items: 45


A Study of Hypermethylated Circulating Tumor DNA as a Universal Colorectal Cancer Biomarker.

Garrigou S, Perkins G, Garlan F, Normand C, Didelot A, Le Corre D, Peyvandi S, Mulot C, Niarra R, Aucouturier P, Chatellier G, Nizard P, Perez-Toralla K, Zonta E, Charpy C, Pujals A, Barau C, Bouché O, Emile JF, Pezet D, Bibeau F, Hutchison JB, Link DR, Zaanan A, Laurent-Puig P, Sobhani I, Taly V.

Clin Chem. 2016 Aug;62(8):1129-39. doi: 10.1373/clinchem.2015.253609. Epub 2016 Jun 1.


Clinical relevance of KRAS-mutated subclones detected with picodroplet digital PCR in advanced colorectal cancer treated with anti-EGFR therapy.

Laurent-Puig P, Pekin D, Normand C, Kotsopoulos SK, Nizard P, Perez-Toralla K, Rowell R, Olson J, Srinivasan P, Le Corre D, Hor T, El Harrak Z, Li X, Link DR, Bouché O, Emile JF, Landi B, Boige V, Hutchison JB, Taly V.

Clin Cancer Res. 2015 Mar 1;21(5):1087-97. doi: 10.1158/1078-0432.CCR-14-0983. Epub 2014 Sep 23.


Determining lower limits of detection of digital PCR assays for cancer-related gene mutations.

Milbury CA, Zhong Q, Lin J, Williams M, Olson J, Link DR, Hutchison B.

Biomol Detect Quantif. 2014 Aug 20;1(1):8-22. eCollection 2014 Sep.


Multiplex picodroplet digital PCR to detect KRAS mutations in circulating DNA from the plasma of colorectal cancer patients.

Taly V, Pekin D, Benhaim L, Kotsopoulos SK, Le Corre D, Li X, Atochin I, Link DR, Griffiths AD, Pallier K, Blons H, Bouché O, Landi B, Hutchison JB, Laurent-Puig P.

Clin Chem. 2013 Dec;59(12):1722-31. doi: 10.1373/clinchem.2013.206359. Epub 2013 Aug 12.


Multiplex picoliter-droplet digital PCR for quantitative assessment of DNA integrity in clinical samples.

Didelot A, Kotsopoulos SK, Lupo A, Pekin D, Li X, Atochin I, Srinivasan P, Zhong Q, Olson J, Link DR, Laurent-Puig P, Blons H, Hutchison JB, Taly V.

Clin Chem. 2013 May;59(5):815-23. doi: 10.1373/clinchem.2012.193409. Epub 2013 Feb 12.


Accurate variant detection across non-amplified and whole genome amplified DNA using targeted next generation sequencing.

ElSharawy A, Warner J, Olson J, Forster M, Schilhabel MB, Link DR, Rose-John S, Schreiber S, Rosenstiel P, Brayer J, Franke A.

BMC Genomics. 2012 Sep 20;13:500. doi: 10.1186/1471-2164-13-500.


Dynamic regulation of HIV-1 mRNA populations analyzed by single-molecule enrichment and long-read sequencing.

Ocwieja KE, Sherrill-Mix S, Mukherjee R, Custers-Allen R, David P, Brown M, Wang S, Link DR, Olson J, Travers K, Schadt E, Bushman FD.

Nucleic Acids Res. 2012 Nov 1;40(20):10345-55. doi: 10.1093/nar/gks753. Epub 2012 Aug 25.


High-resolution dose-response screening using droplet-based microfluidics.

Miller OJ, El Harrak A, Mangeat T, Baret JC, Frenz L, El Debs B, Mayot E, Samuels ML, Rooney EK, Dieu P, Galvan M, Link DR, Griffiths AD.

Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):378-83. doi: 10.1073/pnas.1113324109. Epub 2011 Dec 27.


Detection of low prevalence somatic mutations in solid tumors with ultra-deep targeted sequencing.

Harismendy O, Schwab RB, Bao L, Olson J, Rozenzhak S, Kotsopoulos SK, Pond S, Crain B, Chee MS, Messer K, Link DR, Frazer KA.

Genome Biol. 2011 Dec 20;12(12):R124. doi: 10.1186/gb-2011-12-12-r124.


Application of microdroplet PCR for large-scale targeted bisulfite sequencing.

Komori HK, LaMere SA, Torkamani A, Hart GT, Kotsopoulos S, Warner J, Samuels ML, Olson J, Head SR, Ordoukhanian P, Lee PL, Link DR, Salomon DR.

Genome Res. 2011 Oct;21(10):1738-45. doi: 10.1101/gr.116863.110. Epub 2011 Jul 14.


Pipeline for large-scale microdroplet bisulfite PCR-based sequencing allows the tracking of hepitype evolution in tumors.

Herrmann A, Haake A, Ammerpohl O, Martin-Guerrero I, Szafranski K, Stemshorn K, Nothnagel M, Kotsopoulos SK, Richter J, Warner J, Olson J, Link DR, Schreiber S, Krawczak M, Platzer M, Nürnberg P, Siebert R, Hampe J.

PLoS One. 2011;6(7):e21332. doi: 10.1371/journal.pone.0021332. Epub 2011 Jul 5.


Quantitative and sensitive detection of rare mutations using droplet-based microfluidics.

Pekin D, Skhiri Y, Baret JC, Le Corre D, Mazutis L, Salem CB, Millot F, El Harrak A, Hutchison JB, Larson JW, Link DR, Laurent-Puig P, Griffiths AD, Taly V.

Lab Chip. 2011 Jul 7;11(13):2156-66. doi: 10.1039/c1lc20128j. Epub 2011 May 19.


Multiplex digital PCR: breaking the one target per color barrier of quantitative PCR.

Zhong Q, Bhattacharya S, Kotsopoulos S, Olson J, Taly V, Griffiths AD, Link DR, Larson JW.

Lab Chip. 2011 Jul 7;11(13):2167-74. doi: 10.1039/c1lc20126c. Epub 2011 May 17.


Microdroplet-based PCR enrichment for large-scale targeted sequencing.

Tewhey R, Warner JB, Nakano M, Libby B, Medkova M, David PH, Kotsopoulos SK, Samuels ML, Hutchison JB, Larson JW, Topol EJ, Weiner MP, Harismendy O, Olson J, Link DR, Frazer KA.

Nat Biotechnol. 2009 Nov;27(11):1025-31. doi: 10.1038/nbt.1583. Epub 2009 Nov 1. Erratum in: Nat Biotechnol. 2010 Feb;28(2):178.


Helical nanofilament phases.

Hough LE, Jung HT, Krüerke D, Heberling MS, Nakata M, Jones CD, Chen D, Link DR, Zasadzinski J, Heppke G, Rabe JP, Stocker W, Körblova E, Walba DM, Glaser MA, Clark NA.

Science. 2009 Jul 24;325(5939):456-60. doi: 10.1126/science.1170027.


Droplet microfluidic technology for single-cell high-throughput screening.

Brouzes E, Medkova M, Savenelli N, Marran D, Twardowski M, Hutchison JB, Rothberg JM, Link DR, Perrimon N, Samuels ML.

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14195-200. doi: 10.1073/pnas.0903542106. Epub 2009 Jul 15.


High-throughput quantitative polymerase chain reaction in picoliter droplets.

Kiss MM, Ortoleva-Donnelly L, Beer NR, Warner J, Bailey CG, Colston BW, Rothberg JM, Link DR, Leamon JH.

Anal Chem. 2008 Dec 1;80(23):8975-81.


Fluorescence-activated droplet sorting (FADS): efficient microfluidic cell sorting based on enzymatic activity.

Baret JC, Miller OJ, Taly V, Ryckelynck M, El-Harrak A, Frenz L, Rick C, Samuels ML, Hutchison JB, Agresti JJ, Link DR, Weitz DA, Griffiths AD.

Lab Chip. 2009 Jul 7;9(13):1850-8. doi: 10.1039/b902504a. Epub 2009 Apr 23.


Detection and analysis of low-abundance cell-surface biomarkers using enzymatic amplification in microfluidic droplets.

Joensson HN, Samuels ML, Brouzes ER, Medkova M, Uhlén M, Link DR, Andersson-Svahn H.

Angew Chem Int Ed Engl. 2009;48(14):2518-21. doi: 10.1002/anie.200804326.


Novel defect structures in nematic liquid crystal shells.

Fernández-Nieves A, Vitelli V, Utada AS, Link DR, Márquez M, Nelson DR, Weitz DA.

Phys Rev Lett. 2007 Oct 12;99(15):157801. Epub 2007 Oct 9.


Control and measurement of the phase behavior of aqueous solutions using microfluidics.

Shim JU, Cristobal G, Link DR, Thorsen T, Jia Y, Piattelli K, Fraden S.

J Am Chem Soc. 2007 Jul 18;129(28):8825-35. Epub 2007 Jun 20.


Topological changes in bipolar nematic droplets under flow.

Fernández-Nieves A, Link DR, Márquez M, Weitz DA.

Phys Rev Lett. 2007 Feb 23;98(8):087801. Epub 2007 Feb 21.


Using Microfluidics to Decouple Nucleation and Growth of Protein Crystals.

Shim JU, Cristobal G, Link DR, Thorsen T, Fraden S.

Cryst Growth Des. 2007;7(11):2192-2194.


Bifurcation of droplet flows within capillaries.

Jousse F, Farr R, Link DR, Fuerstman MJ, Garstecki P.

Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Sep;74(3 Pt 2):036311. Epub 2006 Sep 29.


Microfluidic assembly of homogeneous and Janus colloid-filled hydrogel granules.

Shepherd RF, Conrad JC, Rhodes SK, Link DR, Marquez M, Weitz DA, Lewis JA.

Langmuir. 2006 Oct 10;22(21):8618-22.


Overview: methods and applications for droplet compartmentalization of biology.

Leamon JH, Link DR, Egholm M, Rothberg JM.

Nat Methods. 2006 Jul;3(7):541-3.


Electric control of droplets in microfluidic devices.

Link DR, Grasland-Mongrain E, Duri A, Sarrazin F, Cheng Z, Cristobal G, Marquez M, Weitz DA.

Angew Chem Int Ed Engl. 2006 Apr 10;45(16):2556-60. No abstract available.


Generation of polymerosomes from double-emulsions.

Lorenceau E, Utada AS, Link DR, Cristobal G, Joanicot M, Weitz DA.

Langmuir. 2005 Sep 27;21(20):9183-6.


Monodisperse double emulsions generated from a microcapillary device.

Utada AS, Lorenceau E, Link DR, Kaplan PD, Stone HA, Weitz DA.

Science. 2005 Apr 22;308(5721):537-41.


Effect of high spontaneous polarization on defect structures and orientational dynamics of tilted chiral smectic freely suspended films.

Link DR, Chattham N, Maclennan JE, Clark NA.

Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Feb;71(2 Pt 1):021704. Epub 2005 Feb 10.


Electric-field-induced transition between the polarization-modulated and ferroelectric smectic- C(S) P(F)* liquid crystalline states studied using microbeam x-ray diffraction.

Nakata M, Link DR, Takanishi Y, Takahasi Y, Thisayukta J, Niwano H, Coleman DA, Watanabe J, Iida A, Clark NA, Takezoe H.

Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Jan;71(1 Pt 1):011705. Epub 2005 Jan 31.


Electro-optics of bipolar nematic liquid crystal droplets.

Fernández-Nieves A, Link DR, Rudhardt D, Weitz DA.

Phys Rev Lett. 2004 Mar 12;92(10):105503. Epub 2004 Mar 12.


Geometrically mediated breakup of drops in microfluidic devices.

Link DR, Anna SL, Weitz DA, Stone HA.

Phys Rev Lett. 2004 Feb 6;92(5):054503. Epub 2004 Feb 6.


Polarization-modulated smectic liquid crystal phases.

Coleman DA, Fernsler J, Chattham N, Nakata M, Takanishi Y, Körblova E, Link DR, Shao RF, Jang WG, Maclennan JE, Mondainn-Monval O, Boyer C, Weissflog W, Pelzl G, Chien LC, Zasadzinski J, Watanabe J, Walba DM, Takezoe H, Clark NA.

Science. 2003 Aug 29;301(5637):1204-11.


Nonplanar structure of molecular tilt planes in the surface layers of smectic-A free-standing liquid crystal films.

Han XF, Olson DA, Cady A, Link DR, Clark NA, Huang CC.

Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Oct;66(4 Pt 1):040701. Epub 2002 Oct 21.


Flexoelectric polarization in hybrid nematic films.

Link DR, Nakata M, Takanishi Y, Ishikawa K, Takezoe H.

Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Jan;65(1 Pt 1):010701. Epub 2001 Dec 5.


Patterns in hybrid nematic liquid-crystal films: topography and topology.

Link DR, Nakata M, Takanishi Y, Ishikawa K, Takezoe H.

Phys Rev Lett. 2001 Nov 5;87(19):195507. Epub 2001 Oct 23.


Holes and disclinations in hybrid nematic liquid crystal films.

Nakata M, Link DR, Takanishi Y, Ishikawa K, Takezoe H.

Phys Rev E Stat Nonlin Soft Matter Phys. 2001 Aug;64(2 Pt 1):021709. Epub 2001 Jul 26.


Unusual thickness-dependent thermal behavior and anticlinic coupling in chiral smectic free-standing liquid-crystal films.

Chao CY, Lo CR, Wu PJ, Liu YH, Link DR, Maclennan JE, Clark NA, Veum M, Huang CC, Ho JT.

Phys Rev Lett. 2001 Apr 30;86(18):4048-51.


Ferroelectric phases in a chiral bent-core smectic liquid crystal: dielectric and optical second-harmonic generation measurements

Gorecka E, Pociecha D, Araoka F, Link DR, Nakata M, Thisayukta J, Takanishi Y, Ishikawa K, Watanabe J, Takezoe H.

Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 2000 Oct;62(4 Pt A):R4524-7.


Bilayer-by-bilayer antiferroelectric ordering in freely suspended films of an achiral polymer-monomer liquid crystal mixture

Link DR, Clark NA, Ostrovskii BI, Soto Bustamante EA.

Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 2000 Jan;61(1):R37-40.


Ring-pattern dynamics in smectic-C* and smectic-C*A freely suspended liquid crystal films.

Link DR, Radzihovsky L, Natale G, Maclennan JE, Clark NA, Walsh M, Keast SS, Neubert ME.

Phys Rev Lett. 2000 Jun 19;84(25):5772-5.


A ferroelectric liquid crystal conglomerate composed of racemic molecules

Walba DM, Korblova E, Shao R, Maclennan JE, Link DR, Glaser MA, Clark NA.

Science. 2000 Jun 23;288(5474):2181-4.


Spontaneous formation of macroscopic chiral domains in a fluid smectic phase of achiral molecules

Link DR, Natale G, Shao R, Maclennan JE, Clark NA, Korblova E, Walba DM.

Science. 1997 Dec 12;278(5345):1924-7.


Simultaneous Observation of Electric Field Coupling to Longitudinal and Transverse Ferroelectricity in a Chiral Liquid Crystal.

Link DR, Maclennan JE, Clark NA.

Phys Rev Lett. 1996 Sep 9;77(11):2237-2240. No abstract available.


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