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MIR142 Loss-of-Function Mutations Derepress ASH1L to Increase HOXA Gene Expression and Promote Leukemogenesis.

Trissal MC, Wong TN, Yao JC, Ramaswamy R, Kuo I, Baty J, Sun Y, Jih G, Parikh N, Berrien-Elliott MM, Fehniger TA, Ley TJ, Maillard I, Reddy PR, Link DC.

Cancer Res. 2018 Jul 1;78(13):3510-3521. doi: 10.1158/0008-5472.CAN-17-3592. Epub 2018 May 3.


Finding the gap: An empirical study of the most effective shots in elite goalball.

Link D, Weber C.

PLoS One. 2018 Apr 26;13(4):e0196679. doi: 10.1371/journal.pone.0196679. eCollection 2018.


Subclones dominate at MDS progression following allogeneic hematopoietic cell transplant.

Jacoby MA, Duncavage EJ, Chang GS, Miller CA, Shao J, Elliott K, Robinson J, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Pusic I, Welch JS, Link DC, DiPersio JF, Westervelt P, Ley TJ, Graubert TA, Walter MJ.

JCI Insight. 2018 Mar 8;3(5). pii: 98962. doi: 10.1172/jci.insight.98962. [Epub ahead of print]


Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential.

Wong TN, Miller CA, Jotte MRM, Bagegni N, Baty JD, Schmidt AP, Cashen AF, Duncavage EJ, Helton NM, Fiala M, Fulton RS, Heath SE, Janke M, Luber K, Westervelt P, Vij R, DiPersio JF, Welch JS, Graubert TA, Walter MJ, Ley TJ, Link DC.

Nat Commun. 2018 Jan 31;9(1):455. doi: 10.1038/s41467-018-02858-0.


Expression profiling of snoRNAs in normal hematopoiesis and AML.

Warner WA, Spencer DH, Trissal M, White BS, Helton N, Ley TJ, Link DC.

Blood Adv. 2018 Jan 23;2(2):151-163. doi: 10.1182/bloodadvances.2017006668.


Human-like machines: Transparency and comprehensibility.

Patrzyk PM, Link D, Marewski JN.

Behav Brain Sci. 2017 Jan;40:e276. doi: 10.1017/S0140525X17000255.


Long-Term Effects of G-CSF Therapy in Cyclic Neutropenia.

Dale DC, Bolyard A, Marrero T, Makaryan V, Bonilla M, Link DC, Newburger P, Shimamura A, Boxer LA, Spiekerman C.

N Engl J Med. 2017 Dec 7;377(23):2290-2292. doi: 10.1056/NEJMc1709258. No abstract available.


Somatic mutations and clonal hematopoiesis in congenital neutropenia.

Xia J, Miller CA, Baty J, Ramesh A, Jotte MRM, Fulton RS, Vogel TP, Cooper MA, Walkovich KJ, Makaryan V, Bolyard AA, Dinauer MC, Wilson DB, Vlachos A, Myers KC, Rothbaum RJ, Bertuch AA, Dale DC, Shimamura A, Boxer LA, Link DC.

Blood. 2018 Jan 25;131(4):408-416. doi: 10.1182/blood-2017-08-801985. Epub 2017 Nov 1.


Automatic Measurement of Fetal Brain Development from Magnetic Resonance Imaging: New Reference Data.

Link D, Braginsky MB, Joskowicz L, Ben Sira L, Harel S, Many A, Tarrasch R, Malinger G, Artzi M, Kapoor C, Miller E, Ben Bashat D.

Fetal Diagn Ther. 2018;43(2):113-122. doi: 10.1159/000475548. Epub 2017 Sep 13.


Comprehensive discovery of noncoding RNAs in acute myeloid leukemia cell transcriptomes.

Zhang J, Griffith M, Miller CA, Griffith OL, Spencer DH, Walker JR, Magrini V, McGrath SD, Ly A, Helton NM, Trissal M, Link DC, Dang HX, Larson DE, Kulkarni S, Cordes MG, Fronick CC, Fulton RS, Klco JM, Mardis ER, Ley TJ, Wilson RK, Maher CA.

Exp Hematol. 2017 Nov;55:19-33. doi: 10.1016/j.exphem.2017.07.008. Epub 2017 Jul 28.


Individual ball possession in soccer.

Link D, Hoernig M.

PLoS One. 2017 Jul 10;12(7):e0179953. doi: 10.1371/journal.pone.0179953. eCollection 2017.


miR-125b promotes leukemogenesis via VEGFA.

Wong TN, Link DC.

Blood. 2017 Mar 16;129(11):1409-1410. doi: 10.1182/blood-2017-01-761544. No abstract available.


N-cadherin Regulation of Bone Growth and Homeostasis Is Osteolineage Stage-Specific.

Fontana F, Hickman-Brecks CL, Salazar VS, Revollo L, Abou-Ezzi G, Grimston SK, Jeong SY, Watkins M, Fortunato M, Alippe Y, Link DC, Mbalaviele G, Civitelli R.

J Bone Miner Res. 2017 Jun;32(6):1332-1342. doi: 10.1002/jbmr.3112. Epub 2017 Mar 29.


CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.

Spencer DH, Russler-Germain DA, Ketkar S, Helton NM, Lamprecht TL, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Shinawi M, Westervelt P, Payton JE, Wartman LD, Welch JS, Wilson RK, Walter MJ, Link DC, DiPersio JF, Ley TJ.

Cell. 2017 Feb 23;168(5):801-816.e13. doi: 10.1016/j.cell.2017.01.021. Epub 2017 Feb 16.


Mutational landscape and response are conserved in peripheral blood of AML and MDS patients during decitabine therapy.

Duncavage EJ, Uy GL, Petti AA, Miller CA, Lee YS, Tandon B, Gao F, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Jacoby MA, Cashen AF, Wartman LD, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ, Welch JS.

Blood. 2017 Mar 9;129(10):1397-1401. doi: 10.1182/blood-2016-10-745273. Epub 2017 Jan 12. No abstract available.


Real Time Quantification of Dangerousity in Football Using Spatiotemporal Tracking Data.

Link D, Lang S, Seidenschwarz P.

PLoS One. 2016 Dec 30;11(12):e0168768. doi: 10.1371/journal.pone.0168768. eCollection 2016.


TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes.

Welch JS, Petti AA, Miller CA, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Baty JD, Duncavage EJ, Tandon B, Lee YS, Wartman LD, Uy GL, Ghobadi A, Tomasson MH, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Cashen AF, Schroeder MA, Jacoby MA, Heath SE, Luber K, Janke MR, Hantel A, Khan N, Sukhanova MJ, Knoebel RW, Stock W, Graubert TA, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ.

N Engl J Med. 2016 Nov 24;375(21):2023-2036. doi: 10.1056/NEJMoa1605949.


A topography of free kicks in soccer.

Link D, Kolbinger O, Weber H, Stöckl M.

J Sports Sci. 2016 Dec;34(24):2312-2320.


Dynamic changes in the clonal structure of MDS and AML in response to epigenetic therapy.

Uy GL, Duncavage EJ, Chang GS, Jacoby MA, Miller CA, Shao J, Heath S, Elliott K, Reineck T, Fulton RS, Fronick CC, O'Laughlin M, Ganel L, Abboud CN, Cashen AF, DiPersio JF, Wilson RK, Link DC, Welch JS, Ley TJ, Graubert TA, Westervelt P, Walter MJ.

Leukemia. 2017 Apr;31(4):872-881. doi: 10.1038/leu.2016.282. Epub 2016 Oct 14.


Combination of confocal principle and aperture stop separation improves suppression of crystalline lens fluorescence in an eye model.

Klemm M, Blum J, Link D, Hammer M, Haueisen J, Schweitzer D.

Biomed Opt Express. 2016 Aug 1;7(9):3198-3210. eCollection 2016 Sep 1.


The use of vanishing spray reduces the extent of rule violations in soccer.

Kolbinger O, Link D.

Springerplus. 2016 Sep 15;5(1):1572. doi: 10.1186/s40064-016-3274-2. eCollection 2016.


Concise Review: The Malignant Hematopoietic Stem Cell Niche.

Yao JC, Link DC.

Stem Cells. 2017 Jan;35(1):3-8. doi: 10.1002/stem.2487. Epub 2016 Sep 23. Review.


Eleven Tips for Successfully Handling Additional Documentation Requests.

Macon J, Link D.

Home Healthc Now. 2016 Sep;34(8):462. doi: 10.1097/NHH.0000000000000430. No abstract available.


Marrow Adipose Tissue Expansion Coincides with Insulin Resistance in MAGP1-Deficient Mice.

Walji TA, Turecamo SE, Sanchez AC, Anthony BA, Abou-Ezzi G, Scheller EL, Link DC, Mecham RP, Craft CS.

Front Endocrinol (Lausanne). 2016 Jun 30;7:87. doi: 10.3389/fendo.2016.00087. eCollection 2016.


'CHIP'ping away at clonal hematopoiesis.

Link DC, Walter MJ.

Leukemia. 2016 Aug;30(8):1633-5. doi: 10.1038/leu.2016.130. Epub 2016 Jun 17. No abstract available.


Seasonal Pacing - Match Importance Affects Activity in Professional Soccer.

Link D, de Lorenzo MF.

PLoS One. 2016 Jun 9;11(6):e0157127. doi: 10.1371/journal.pone.0157127. eCollection 2016.


A Study of Hypermethylated Circulating Tumor DNA as a Universal Colorectal Cancer Biomarker.

Garrigou S, Perkins G, Garlan F, Normand C, Didelot A, Le Corre D, Peyvandi S, Mulot C, Niarra R, Aucouturier P, Chatellier G, Nizard P, Perez-Toralla K, Zonta E, Charpy C, Pujals A, Barau C, Bouché O, Emile JF, Pezet D, Bibeau F, Hutchison JB, Link DR, Zaanan A, Laurent-Puig P, Sobhani I, Taly V.

Clin Chem. 2016 Aug;62(8):1129-39. doi: 10.1373/clinchem.2015.253609. Epub 2016 Jun 1.


Targeting of Mesenchymal Stromal Cells by Cre-Recombinase Transgenes Commonly Used to Target Osteoblast Lineage Cells.

Zhang J, Link DC.

J Bone Miner Res. 2016 Nov;31(11):2001-2007. doi: 10.1002/jbmr.2877. Epub 2016 Jun 14.


Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia.

Griffith M, Griffith OL, Krysiak K, Skidmore ZL, Christopher MJ, Klco JM, Ramu A, Lamprecht TL, Wagner AH, Campbell KM, Lesurf R, Hundal J, Zhang J, Spies NC, Ainscough BJ, Larson DE, Heath SE, Fronick C, O'Laughlin S, Fulton RS, Magrini V, McGrath S, Smith SM, Miller CA, Maher CA, Payton JE, Walker JR, Eldred JM, Walter MJ, Link DC, Graubert TA, Westervelt P, Kulkarni S, DiPersio JF, Mardis ER, Wilson RK, Ley TJ.

Exp Hematol. 2016 Jul;44(7):603-13. doi: 10.1016/j.exphem.2016.04.011. Epub 2016 May 13.


Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML.

Wong TN, Miller CA, Klco JM, Petti A, Demeter R, Helton NM, Li T, Fulton RS, Heath SE, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Welch JS, Graubert TA, Wilson RK, Ley TJ, Link DC.

Blood. 2016 Feb 18;127(7):893-7. doi: 10.1182/blood-2015-10-677021. Epub 2015 Dec 2.


Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia.

Churpek JE, Pyrtel K, Kanchi KL, Shao J, Koboldt D, Miller CA, Shen D, Fulton R, O'Laughlin M, Fronick C, Pusic I, Uy GL, Braunstein EM, Levis M, Ross J, Elliott K, Heath S, Jiang A, Westervelt P, DiPersio JF, Link DC, Walter MJ, Welch J, Wilson R, Ley TJ, Godley LA, Graubert TA.

Blood. 2015 Nov 26;126(22):2484-90. doi: 10.1182/blood-2015-04-641100. Epub 2015 Oct 22.


The hematopoietic stem cell niche in homeostasis and disease.

Calvi LM, Link DC.

Blood. 2015 Nov 26;126(22):2443-51. doi: 10.1182/blood-2015-07-533588. Epub 2015 Oct 14. Review.


Targeting bone marrow lymphoid niches in acute lymphoblastic leukemia.

Uy GL, Hsu YM, Schmidt AP, Stock W, Fletcher TR, Trinkaus KM, Westervelt P, DiPersio JF, Link DC.

Leuk Res. 2015 Dec;39(12):1437-42. doi: 10.1016/j.leukres.2015.09.020. Epub 2015 Oct 1.


Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia.

Klco JM, Miller CA, Griffith M, Petti A, Spencer DH, Ketkar-Kulkarni S, Wartman LD, Christopher M, Lamprecht TL, Helton NM, Duncavage EJ, Payton JE, Baty J, Heath SE, Griffith OL, Shen D, Hundal J, Chang GS, Fulton R, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Larson DE, Kulkarni S, Ozenberger BA, Welch JS, Walter MJ, Graubert TA, Westervelt P, Radich JP, Link DC, Mardis ER, DiPersio JF, Wilson RK, Ley TJ.

JAMA. 2015 Aug 25;314(8):811-22. doi: 10.1001/jama.2015.9643.


Management of mixed arterial venous lower extremity ulceration: A review.

Hedayati N, Carson JG, Chi YW, Link D.

Vasc Med. 2015 Oct;20(5):479-86. doi: 10.1177/1358863X15594683. Epub 2015 Jul 23. Review.


Chronic kidney disease: New paradigms in diagnosis and management.

Link DK.

JAAPA. 2015 Jul;28(7):23-8. doi: 10.1097/01.JAA.0000466586.10595.2e.


The Suicide Prevention, Depression Awareness, and Clinical Engagement Program for Faculty and Residents at the University of California, Davis Health System.

Haskins J, Carson JG, Chang CH, Kirshnit C, Link DP, Navarra L, Scher LM, Sciolla AF, Uppington J, Yellowlees P.

Acad Psychiatry. 2016 Feb;40(1):23-9. doi: 10.1007/s40596-015-0359-0. Epub 2015 Jun 11.


Effect of Ambient Temperature on Pacing in Soccer Depends on Skill Level.

Link D, Weber H.

J Strength Cond Res. 2017 Jul;31(7):1766-1770. doi: 10.1519/JSC.0000000000001013.


Acute ether lipid deficiency affects neutrophil biology in mice.

Lodhi IJ, Link DC, Semenkovich CF.

Cell Metab. 2015 May 5;21(5):652-3. doi: 10.1016/j.cmet.2015.04.018. No abstract available.


A planned care approach and patient registry to improve adherence to clinical guidelines for the diagnosis and management of attention-deficit/hyperactivity disorder.

Geltman PL, Fried LE, Arsenault LN, Knowles AM, Link DA, Goldstein JN, Perrin JM, Hacker KA.

Acad Pediatr. 2015 May-Jun;15(3):289-96. doi: 10.1016/j.acap.2014.12.002.


Society for Vascular Surgery and American Venous Forum Guidelines on the management of venous leg ulcers: the point of view of the International Union of Phlebology.

Mosti G, De Maeseneer M, Cavezzi A, Parsi K, Morrison N, Nelzen O, Rabe E, Partsch H, Caggiati A, Simka M, Obermayer A, Malouf M, Flour M, Maleti O, Perrin M, Reina L, Kalodiki E, Mannello F, Rerkasem K, Cornu-Thenard A, Chi YW, Soloviy M, Bottini O, Mendyk N, Tessari L, Varghese R, Etcheverry R, Pannier F, Lugli M, Carvallo Lantz AJ, Zamboni P, Zuolo M, Godoy MF, Godoy JM, Link DP, Junger M, Scuderi A.

Int Angiol. 2015 Jun;34(3):202-18. Epub 2015 Apr 21. No abstract available.


Granulocyte colony-stimulating factor reprograms bone marrow stromal cells to actively suppress B lymphopoiesis in mice.

Day RB, Bhattacharya D, Nagasawa T, Link DC.

Blood. 2015 May 14;125(20):3114-7. doi: 10.1182/blood-2015-02-629444. Epub 2015 Mar 26.


MicroRNA-223 regulates granulopoiesis but is not required for HSC maintenance in mice.

Trissal MC, DeMoya RA, Schmidt AP, Link DC.

PLoS One. 2015 Mar 20;10(3):e0119304. doi: 10.1371/journal.pone.0119304. eCollection 2015.


PTEN regulates natural killer cell trafficking in vivo.

Leong JW, Schneider SE, Sullivan RP, Parikh BA, Anthony BA, Singh A, Jewell BA, Schappe T, Wagner JA, Link DC, Yokoyama WM, Fehniger TA.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E700-9. doi: 10.1073/pnas.1413886112. Epub 2015 Feb 2.


Quantifying ultra-rare pre-leukemic clones via targeted error-corrected sequencing.

Young AL, Wong TN, Hughes AE, Heath SE, Ley TJ, Link DC, Druley TE.

Leukemia. 2015 Jul;29(7):1608-11. doi: 10.1038/leu.2015.17. Epub 2015 Feb 3. No abstract available.


Phantom materials mimicking the optical properties in the near infrared range for non-invasive fetal pulse oximetry.

Ley S, Stadthalter M, Link D, Laqua D, Husar P.

Conf Proc IEEE Eng Med Biol Soc. 2014;2014:1432-5. doi: 10.1109/EMBC.2014.6943869.


Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability.

Lodhi IJ, Wei X, Yin L, Feng C, Adak S, Abou-Ezzi G, Hsu FF, Link DC, Semenkovich CF.

Cell Metab. 2015 Jan 6;21(1):51-64. doi: 10.1016/j.cmet.2014.12.002.


Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia.

Wong TN, Ramsingh G, Young AL, Miller CA, Touma W, Welch JS, Lamprecht TL, Shen D, Hundal J, Fulton RS, Heath S, Baty JD, Klco JM, Ding L, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Graubert TA, Ley TJ, Druley T, Link DC, Wilson RK.

Nature. 2015 Feb 26;518(7540):552-555. doi: 10.1038/nature13968. Epub 2014 Dec 8.


Osteoclasts are dispensable for hematopoietic progenitor mobilization by granulocyte colony-stimulating factor in mice.

Rao M, Supakorndej T, Schmidt AP, Link DC.

Exp Hematol. 2015 Feb;43(2):110-4.e1-2. doi: 10.1016/j.exphem.2014.10.012. Epub 2014 Nov 1.


The diversity of mutations and clinical outcomes for ELANE-associated neutropenia.

Makaryan V, Zeidler C, Bolyard AA, Skokowa J, Rodger E, Kelley ML, Boxer LA, Bonilla MA, Newburger PE, Shimamura A, Zhu B, Rosenberg PS, Link DC, Welte K, Dale DC.

Curr Opin Hematol. 2015 Jan;22(1):3-11. doi: 10.1097/MOH.0000000000000105. Review.

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