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Items: 1 to 50 of 78

1.

TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes.

LaRocca TJ, Mariani A, Watkins LR, Link CD.

Neurobiol Dis. 2019 Jun 21;132:104514. doi: 10.1016/j.nbd.2019.104514. [Epub ahead of print]

PMID:
31229690
2.

α-Sheet secondary structure in amyloid β-peptide drives aggregation and toxicity in Alzheimer's disease.

Shea D, Hsu CC, Bi TM, Paranjapye N, Childers MC, Cochran J, Tomberlin CP, Wang L, Paris D, Zonderman J, Varani G, Link CD, Mullan M, Daggett V.

Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):8895-8900. doi: 10.1073/pnas.1820585116. Epub 2019 Apr 19.

PMID:
31004062
3.

Heat shock in C. elegans induces downstream of gene transcription and accumulation of double-stranded RNA.

Melnick M, Gonzales P, Cabral J, Allen MA, Dowell RD, Link CD.

PLoS One. 2019 Apr 8;14(4):e0206715. doi: 10.1371/journal.pone.0206715. eCollection 2019.

4.

Neurodegeneration, Heterochromatin, and Double-Stranded RNA.

Saldi TK, Gonzales PK, LaRocca TJ, Link CD.

J Exp Neurosci. 2019 Feb 14;13:1179069519830697. doi: 10.1177/1179069519830697. eCollection 2019. Review.

5.

Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation.

Guerrero-Gómez D, Mora-Lorca JA, Sáenz-Narciso B, Naranjo-Galindo FJ, Muñoz-Lobato F, Parrado-Fernández C, Goikolea J, Cedazo-Minguez Á, Link CD, Neri C, Sequedo MD, Vázquez-Manrique RP, Fernández-Suárez E, Goder V, Pané R, Cabiscol E, Askjaer P, Cabello J, Miranda-Vizuete A.

Cell Death Differ. 2019 Sep;26(9):1545-1565. doi: 10.1038/s41418-018-0270-9. Epub 2019 Feb 15.

PMID:
30770874
6.

Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity.

Zhang YJ, Guo L, Gonzales PK, Gendron TF, Wu Y, Jansen-West K, O'Raw AD, Pickles SR, Prudencio M, Carlomagno Y, Gachechiladze MA, Ludwig C, Tian R, Chew J, DeTure M, Lin WL, Tong J, Daughrity LM, Yue M, Song Y, Andersen JW, Castanedes-Casey M, Kurti A, Datta A, Antognetti G, McCampbell A, Rademakers R, Oskarsson B, Dickson DW, Kampmann M, Ward ME, Fryer JD, Link CD, Shorter J, Petrucelli L.

Science. 2019 Feb 15;363(6428). pii: eaav2606. doi: 10.1126/science.aav2606.

7.

In vivo induction of membrane damage by β-amyloid peptide oligomers.

Julien C, Tomberlin C, Roberts CM, Akram A, Stein GH, Silverman MA, Link CD.

Acta Neuropathol Commun. 2018 Nov 29;6(1):131. doi: 10.1186/s40478-018-0634-x.

8.

The Caenorhabditis elegans Ortholog of TDP-43 Regulates the Chromatin Localization of the Heterochromatin Protein 1 Homolog HPL-2.

Saldi TK, Gonzales P, Garrido-Lecca A, Dostal V, Roberts CM, Petrucelli L, Link CD.

Mol Cell Biol. 2018 Jul 16;38(15). pii: e00668-17. doi: 10.1128/MCB.00668-17. Print 2018 Aug 1.

9.

Transcriptome analysis of genetically matched human induced pluripotent stem cells disomic or trisomic for chromosome 21.

Gonzales PK, Roberts CM, Fonte V, Jacobsen C, Stein GH, Link CD.

PLoS One. 2018 Mar 27;13(3):e0194581. doi: 10.1371/journal.pone.0194581. eCollection 2018.

10.

RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome.

Van Treeck B, Protter DSW, Matheny T, Khong A, Link CD, Parker R.

Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2734-2739. doi: 10.1073/pnas.1800038115. Epub 2018 Feb 26.

11.

Sedimentation Velocity Analysis with Fluorescence Detection of Mutant Huntingtin Exon 1 Aggregation in Drosophila melanogaster and Caenorhabditis elegans.

Kim SA, D'Acunto VF, Kokona B, Hofmann J, Cunningham NR, Bistline EM, Garcia FJ, Akhtar NM, Hoffman SH, Doshi SH, Ulrich KM, Jones NM, Bonini NM, Roberts CM, Link CD, Laue TM, Fairman R.

Biochemistry. 2017 Sep 5;56(35):4676-4688. doi: 10.1021/acs.biochem.7b00518. Epub 2017 Aug 24.

12.

Repetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients.

Prudencio M, Gonzales PK, Cook CN, Gendron TF, Daughrity LM, Song Y, Ebbert MTW, van Blitterswijk M, Zhang YJ, Jansen-West K, Baker MC, DeTure M, Rademakers R, Boylan KB, Dickson DW, Petrucelli L, Link CD.

Hum Mol Genet. 2017 Sep 1;26(17):3421-3431. doi: 10.1093/hmg/ddx233.

13.

Caenorhabditis elegans as a model system to study post-translational modifications of human transthyretin.

Henze A, Homann T, Rohn I, Aschner M, Link CD, Kleuser B, Schweigert FJ, Schwerdtle T, Bornhorst J.

Sci Rep. 2016 Nov 21;6:37346. doi: 10.1038/srep37346.

14.

Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts.

Kramer NJ, Carlomagno Y, Zhang YJ, Almeida S, Cook CN, Gendron TF, Prudencio M, Van Blitterswijk M, Belzil V, Couthouis J, Paul JW 3rd, Goodman LD, Daughrity L, Chew J, Garrett A, Pregent L, Jansen-West K, Tabassian LJ, Rademakers R, Boylan K, Graff-Radford NR, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Boeve BF, Deng N, Feng Y, Cheng TH, Dickson DW, Cohen SN, Bonini NM, Link CD, Gao FB, Petrucelli L, Gitler AD.

Science. 2016 Aug 12;353(6300):708-12. doi: 10.1126/science.aaf7791.

15.

DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans.

Munkácsy E, Khan MH, Lane RK, Borror MB, Park JH, Bokov AF, Fisher AL, Link CD, Rea SL.

PLoS Genet. 2016 Jul 15;12(7):e1006133. doi: 10.1371/journal.pgen.1006133. eCollection 2016 Jul.

16.

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins.

Zhang YJ, Gendron TF, Grima JC, Sasaguri H, Jansen-West K, Xu YF, Katzman RB, Gass J, Murray ME, Shinohara M, Lin WL, Garrett A, Stankowski JN, Daughrity L, Tong J, Perkerson EA, Yue M, Chew J, Castanedes-Casey M, Kurti A, Wang ZS, Liesinger AM, Baker JD, Jiang J, Lagier-Tourenne C, Edbauer D, Cleveland DW, Rademakers R, Boylan KB, Bu G, Link CD, Dickey CA, Rothstein JD, Dickson DW, Fryer JD, Petrucelli L.

Nat Neurosci. 2016 May;19(5):668-677. doi: 10.1038/nn.4272. Epub 2016 Mar 21.

17.

Studying polyglutamine aggregation in Caenorhabditis elegans using an analytical ultracentrifuge equipped with fluorescence detection.

Kokona B, May CA, Cunningham NR, Richmond L, Jay Garcia F, Durante JC, Ulrich KM, Roberts CM, Link CD, Stafford WF, Laue TM, Fairman R.

Protein Sci. 2016 Mar;25(3):605-17. doi: 10.1002/pro.2854. Epub 2015 Dec 21.

18.

Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS.

Prudencio M, Belzil VV, Batra R, Ross CA, Gendron TF, Pregent LJ, Murray ME, Overstreet KK, Piazza-Johnston AE, Desaro P, Bieniek KF, DeTure M, Lee WC, Biendarra SM, Davis MD, Baker MC, Perkerson RB, van Blitterswijk M, Stetler CT, Rademakers R, Link CD, Dickson DW, Boylan KB, Li H, Petrucelli L.

Nat Neurosci. 2015 Aug;18(8):1175-82. doi: 10.1038/nn.4065. Epub 2015 Jul 20.

19.

Identifying Aβ-specific pathogenic mechanisms using a nematode model of Alzheimer's disease.

Hassan WM, Dostal V, Huemann BN, Yerg JE, Link CD.

Neurobiol Aging. 2015 Feb;36(2):857-66. doi: 10.1016/j.neurobiolaging.2014.10.016. Epub 2014 Oct 16.

20.

TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA.

Saldi TK, Ash PE, Wilson G, Gonzales P, Garrido-Lecca A, Roberts CM, Dostal V, Gendron TF, Stein LD, Blumenthal T, Petrucelli L, Link CD.

EMBO J. 2014 Dec 17;33(24):2947-66. doi: 10.15252/embj.201488740. Epub 2014 Nov 12.

21.

A semi-automated motion-tracking analysis of locomotion speed in the C. elegans transgenics overexpressing beta-amyloid in neurons.

Machino K, Link CD, Wang S, Murakami H, Murakami S.

Front Genet. 2014 Jul 4;5:202. doi: 10.3389/fgene.2014.00202. eCollection 2014.

22.

Alzheimer's disease drug discovery: in vivo screening using Caenorhabditis elegans as a model for β-amyloid peptide-induced toxicity.

Lublin AL, Link CD.

Drug Discov Today Technol. 2013 Spring;10(1):e115-9. doi: 10.1016/j.ddtec.2012.02.002. Review.

PMID:
24050239
23.
24.

Protective role of DNJ-27/ERdj5 in Caenorhabditis elegans models of human neurodegenerative diseases.

Muñoz-Lobato F, Rodríguez-Palero MJ, Naranjo-Galindo FJ, Shephard F, Gaffney CJ, Szewczyk NJ, Hamamichi S, Caldwell KA, Caldwell GA, Link CD, Miranda-Vizuete A.

Antioxid Redox Signal. 2014 Jan 10;20(2):217-35. doi: 10.1089/ars.2012.5051. Epub 2013 Jul 3.

25.

Utility of an improved model of amyloid-beta (Aβ₁₋₄₂) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease.

McColl G, Roberts BR, Pukala TL, Kenche VB, Roberts CM, Link CD, Ryan TM, Masters CL, Barnham KJ, Bush AI, Cherny RA.

Mol Neurodegener. 2012 Nov 21;7:57. doi: 10.1186/1750-1326-7-57.

26.

Progranulin regulates neuronal outgrowth independent of sortilin.

Gass J, Lee WC, Cook C, Finch N, Stetler C, Jansen-West K, Lewis J, Link CD, Rademakers R, Nykjær A, Petrucelli L.

Mol Neurodegener. 2012 Jul 10;7:33. doi: 10.1186/1750-1326-7-33.

27.

Toxic role of K+ channel oxidation in mammalian brain.

Cotella D, Hernandez-Enriquez B, Wu X, Li R, Pan Z, Leveille J, Link CD, Oddo S, Sesti F.

J Neurosci. 2012 Mar 21;32(12):4133-44. doi: 10.1523/JNEUROSCI.6153-11.2012. Erratum in: J Neurosci. 2012 Jul 4;32(27):9449.

28.

Development. Cell death by glutamine repeats?

Link CD, Saldi TK.

Science. 2012 Feb 24;335(6071):926-7. doi: 10.1126/science.1219834. No abstract available.

PMID:
22362996
29.

The characterization of the Caenorhabditis elegans mitochondrial thioredoxin system uncovers an unexpected protective role of thioredoxin reductase 2 in β-amyloid peptide toxicity.

Cacho-Valadez B, Muñoz-Lobato F, Pedrajas JR, Cabello J, Fierro-González JC, Navas P, Swoboda P, Link CD, Miranda-Vizuete A.

Antioxid Redox Signal. 2012 Jun 15;16(12):1384-400. doi: 10.1089/ars.2011.4265. Epub 2012 Feb 15.

30.

A glycine zipper motif mediates the formation of toxic β-amyloid oligomers in vitro and in vivo.

Fonte V, Dostal V, Roberts CM, Gonzales P, Lacor PN, Velasco PT, Magrane J, Dingwell N, Fan EY, Silverman MA, Stein GH, Link CD.

Mol Neurodegener. 2011 Aug 23;6(1):61. doi: 10.1186/1750-1326-6-61. Erratum in: Mol Neurodegener. 2014;9:12. Lacor, Pascale [corrected to Lacor, Pascale N]; Velasco, Pauline T [added].

31.

Genetic dissection of late-life fertility in Caenorhabditis elegans.

Mendenhall AR, Wu D, Park SK, Cypser JR, Tedesco PM, Link CD, Phillips PC, Johnson TE.

J Gerontol A Biol Sci Med Sci. 2011 Aug;66(8):842-54. doi: 10.1093/gerona/glr089. Epub 2011 May 28.

32.

Caenorhabditis elegans Model for Initial Screening and Mechanistic Evaluation of Potential New Drugs for Aging and Alzheimer’s Disease.

Luo Y, Wu Y, Brown M, Link CD.

In: Buccafusco JJ, editor. Methods of Behavior Analysis in Neuroscience. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2009. Chapter 16.

33.

Assaying β-amyloid toxicity using a transgenic C. elegans model.

Dostal V, Link CD.

J Vis Exp. 2010 Oct 9;(44). pii: 2252. doi: 10.3791/2252.

34.

Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans.

McColl G, Rogers AN, Alavez S, Hubbard AE, Melov S, Link CD, Bush AI, Kapahi P, Lithgow GJ.

Cell Metab. 2010 Sep 8;12(3):260-72. doi: 10.1016/j.cmet.2010.08.004.

35.

Genetic mechanisms of coffee extract protection in a Caenorhabditis elegans model of β-amyloid peptide toxicity.

Dostal V, Roberts CM, Link CD.

Genetics. 2010 Nov;186(3):857-66. doi: 10.1534/genetics.110.120436. Epub 2010 Aug 30.

36.

Neurotoxic effects of TDP-43 overexpression in C. elegans.

Ash PE, Zhang YJ, Roberts CM, Saldi T, Hutter H, Buratti E, Petrucelli L, Link CD.

Hum Mol Genet. 2010 Aug 15;19(16):3206-18. doi: 10.1093/hmg/ddq230. Epub 2010 Jun 8.

37.

Behavioral phenotyping of a transgenic Caenorhabditis elegans expressing neuronal amyloid-beta.

Dosanjh LE, Brown MK, Rao G, Link CD, Luo Y.

J Alzheimers Dis. 2010;19(2):681-90. doi: 10.3233/JAD-2010-1267.

PMID:
20110612
38.

What have worm models told us about the mechanisms of neuronal dysfunction in human neurodegenerative diseases?

Teschendorf D, Link CD.

Mol Neurodegener. 2009 Sep 28;4:38. doi: 10.1186/1750-1326-4-38.

39.

Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans.

Park SK, Link CD, Johnson TE.

FASEB J. 2010 Feb;24(2):383-92. doi: 10.1096/fj.09-142984. Epub 2009 Sep 25.

40.

AIP-1 ameliorates beta-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model.

Hassan WM, Merin DA, Fonte V, Link CD.

Hum Mol Genet. 2009 Aug 1;18(15):2739-47. doi: 10.1093/hmg/ddp209. Epub 2009 May 3.

41.

Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity.

Zhang YJ, Xu YF, Cook C, Gendron TF, Roettges P, Link CD, Lin WL, Tong J, Castanedes-Casey M, Ash P, Gass J, Rangachari V, Buratti E, Baralle F, Golde TE, Dickson DW, Petrucelli L.

Proc Natl Acad Sci U S A. 2009 May 5;106(18):7607-12. doi: 10.1073/pnas.0900688106. Epub 2009 Apr 21.

42.

Exercise training prevents development of cardiac contractile dysfunction in hypertensive TG (mREN-2)27 rats.

Morris RT, Fine DM, Lees SJ, Booth FW, Link CD, Ferrario CM, Stump CS, Sowers JR.

J Am Soc Hypertens. 2007 Nov-Dec;1(6):393-9. doi: 10.1016/j.jash.2007.09.001.

43.

The beta amyloid peptide can act as a modular aggregation domain.

Link CD, Fonte V, Roberts CM, Hiester B, Silverman MA, Stein GH.

Neurobiol Dis. 2008 Dec;32(3):420-5. doi: 10.1016/j.nbd.2008.08.003. Epub 2008 Aug 22.

44.

Suppression of in vivo beta-amyloid peptide toxicity by overexpression of the HSP-16.2 small chaperone protein.

Fonte V, Kipp DR, Yerg J 3rd, Merin D, Forrestal M, Wagner E, Roberts CM, Link CD.

J Biol Chem. 2008 Jan 11;283(2):784-91. Epub 2007 Nov 9.

45.

Decreased insulin-receptor signaling promotes the autophagic degradation of beta-amyloid peptide in C. elegans.

Florez-McClure ML, Hohsfield LA, Fonte G, Bealor MT, Link CD.

Autophagy. 2007 Nov-Dec;3(6):569-80. Epub 2007 Jul 20. Erratum in: Autophagy. 2009 Jan 1;5(1):132-3.

PMID:
17675890
46.

Mineralocorticoid receptor blockade attenuates chronic overexpression of the renin-angiotensin-aldosterone system stimulation of reduced nicotinamide adenine dinucleotide phosphate oxidase and cardiac remodeling.

Stas S, Whaley-Connell A, Habibi J, Appesh L, Hayden MR, Karuparthi PR, Qazi M, Morris EM, Cooper SA, Link CD, Stump C, Hay M, Ferrario C, Sowers JR.

Endocrinology. 2007 Aug;148(8):3773-80. Epub 2007 May 10.

PMID:
17494996
47.

Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans.

Wu Y, Wu Z, Butko P, Christen Y, Lambert MP, Klein WL, Link CD, Luo Y.

J Neurosci. 2006 Dec 13;26(50):13102-13.

48.
49.

Oxidative stress and glomerular filtration barrier injury: role of the renin-angiotensin system in the Ren2 transgenic rat.

Whaley-Connell AT, Chowdhury NA, Hayden MR, Stump CS, Habibi J, Wiedmeyer CE, Gallagher PE, Tallant EA, Cooper SA, Link CD, Ferrario C, Sowers JR.

Am J Physiol Renal Physiol. 2006 Dec;291(6):F1308-14. Epub 2006 Jun 20.

50.

Conversion of green fluorescent protein into a toxic, aggregation-prone protein by C-terminal addition of a short peptide.

Link CD, Fonte V, Hiester B, Yerg J, Ferguson J, Csontos S, Silverman MA, Stein GH.

J Biol Chem. 2006 Jan 20;281(3):1808-16. Epub 2005 Oct 19.

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