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A Phase I Study of Alpha-1,3-Galactosyltransferase-Expressing Allogeneic Renal Cell Carcinoma Immunotherapy in Patients with Refractory Metastatic Renal Cell Carcinoma.

Hahn AW, Drake C, Denmeade SR, Zakharia Y, Maughan BL, Kennedy E, Link C Jr, Vahanian N, Hammers H, Agarwal N.

Oncologist. 2019 Sep 6. pii: theoncologist.2019-0599. doi: 10.1634/theoncologist.2019-0599. [Epub ahead of print]


Quality of Life and Decision Regret After Postoperative Radiation Therapy to the Prostatic Bed Region With or Without Elective Pelvic Nodal Radiation Therapy.

Link C, Honeck P, Lohr F, Bolenz C, Schaefer J, Bohrer M, Giordano FA, Wenz F, Buergy D.

Pract Radiat Oncol. 2019 Jun 27. pii: S1879-8500(19)30182-1. doi: 10.1016/j.prro.2019.06.011. [Epub ahead of print]


TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes.

LaRocca TJ, Mariani A, Watkins LR, Link CD.

Neurobiol Dis. 2019 Jun 21;132:104514. doi: 10.1016/j.nbd.2019.104514. [Epub ahead of print]


Bone Marrow Plasma Cells Modulate Local Myeloid-Lineage Differentiation via IL-10.

Meng L, Almeida LN, Clauder AK, Lindemann T, Luther J, Link C, Hofmann K, Kulkarni U, Wong DM, David JP, Manz RA.

Front Immunol. 2019 May 31;10:1183. doi: 10.3389/fimmu.2019.01183. eCollection 2019.


Postoperative elective pelvic nodal irradiation compared to prostate bed irradiation in locally advanced prostate cancer - a retrospective analysis of dose-escalated patients.

Link C, Honeck P, Makabe A, Giordano FA, Bolenz C, Schaefer J, Bohrer M, Lohr F, Wenz F, Buergy D.

Radiat Oncol. 2019 Jun 7;14(1):96. doi: 10.1186/s13014-019-1301-5.


Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation.

Lempp FA, Schlund F, Rieble L, Nussbaum L, Link C, Zhang Z, Ni Y, Urban S.

Nat Commun. 2019 May 22;10(1):2265. doi: 10.1038/s41467-019-10211-2.


α-Sheet secondary structure in amyloid β-peptide drives aggregation and toxicity in Alzheimer's disease.

Shea D, Hsu CC, Bi TM, Paranjapye N, Childers MC, Cochran J, Tomberlin CP, Wang L, Paris D, Zonderman J, Varani G, Link CD, Mullan M, Daggett V.

Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):8895-8900. doi: 10.1073/pnas.1820585116. Epub 2019 Apr 19.


Heat shock in C. elegans induces downstream of gene transcription and accumulation of double-stranded RNA.

Melnick M, Gonzales P, Cabral J, Allen MA, Dowell RD, Link CD.

PLoS One. 2019 Apr 8;14(4):e0206715. doi: 10.1371/journal.pone.0206715. eCollection 2019.


Neurodegeneration, Heterochromatin, and Double-Stranded RNA.

Saldi TK, Gonzales PK, LaRocca TJ, Link CD.

J Exp Neurosci. 2019 Feb 14;13:1179069519830697. doi: 10.1177/1179069519830697. eCollection 2019. Review.


Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation.

Guerrero-Gómez D, Mora-Lorca JA, Sáenz-Narciso B, Naranjo-Galindo FJ, Muñoz-Lobato F, Parrado-Fernández C, Goikolea J, Cedazo-Minguez Á, Link CD, Neri C, Sequedo MD, Vázquez-Manrique RP, Fernández-Suárez E, Goder V, Pané R, Cabiscol E, Askjaer P, Cabello J, Miranda-Vizuete A.

Cell Death Differ. 2019 Sep;26(9):1545-1565. doi: 10.1038/s41418-018-0270-9. Epub 2019 Feb 15.


Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity.

Zhang YJ, Guo L, Gonzales PK, Gendron TF, Wu Y, Jansen-West K, O'Raw AD, Pickles SR, Prudencio M, Carlomagno Y, Gachechiladze MA, Ludwig C, Tian R, Chew J, DeTure M, Lin WL, Tong J, Daughrity LM, Yue M, Song Y, Andersen JW, Castanedes-Casey M, Kurti A, Datta A, Antognetti G, McCampbell A, Rademakers R, Oskarsson B, Dickson DW, Kampmann M, Ward ME, Fryer JD, Link CD, Shorter J, Petrucelli L.

Science. 2019 Feb 15;363(6428). pii: eaav2606. doi: 10.1126/science.aav2606.


In vivo induction of membrane damage by β-amyloid peptide oligomers.

Julien C, Tomberlin C, Roberts CM, Akram A, Stein GH, Silverman MA, Link CD.

Acta Neuropathol Commun. 2018 Nov 29;6(1):131. doi: 10.1186/s40478-018-0634-x.


In Reply to Zarzar.

Meegan AH, Link C.

Acad Med. 2018 Sep;93(9):1266-1267. doi: 10.1097/ACM.0000000000002335. No abstract available.


Chilaiditi Syndrome: A Case Report Highlighting the Intermittent Nature of the Disease.

Kapania EM, Link C, Eberhardt JM.

Case Rep Med. 2018 Jun 21;2018:3515370. doi: 10.1155/2018/3515370. eCollection 2018.


Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors.

Nayak-Kapoor A, Hao Z, Sadek R, Dobbins R, Marshall L, Vahanian NN, Jay Ramsey W, Kennedy E, Mautino MR, Link CJ, Lin RS, Royer-Joo S, Liang X, Salphati L, Morrissey KM, Mahrus S, McCall B, Pirzkall A, Munn DH, Janik JE, Khleif SN.

J Immunother Cancer. 2018 Jun 20;6(1):61. doi: 10.1186/s40425-018-0351-9.


Validation of the Revised Pretransplant Assessment of Mortality Score in Patients with Acute Myelogenous Leukemia Undergoing Allogeneic Hematopoietic Stem Cell Transplantation.

Middeke JM, Kollinger F, Baldauf H, Stölzel F, Wermke M, von Bonin M, Sockel K, Link CS, Teipel R, Röllig C, Thiede C, Platzbecker U, Ehninger G, Bornhäuser M, Schetelig J.

Biol Blood Marrow Transplant. 2018 Sep;24(9):1947-1951. doi: 10.1016/j.bbmt.2018.05.021. Epub 2018 May 21.


The Caenorhabditis elegans Ortholog of TDP-43 Regulates the Chromatin Localization of the Heterochromatin Protein 1 Homolog HPL-2.

Saldi TK, Gonzales P, Garrido-Lecca A, Dostal V, Roberts CM, Petrucelli L, Link CD.

Mol Cell Biol. 2018 Jul 16;38(15). pii: e00668-17. doi: 10.1128/MCB.00668-17. Print 2018 Aug 1.


Transcriptome analysis of genetically matched human induced pluripotent stem cells disomic or trisomic for chromosome 21.

Gonzales PK, Roberts CM, Fonte V, Jacobsen C, Stein GH, Link CD.

PLoS One. 2018 Mar 27;13(3):e0194581. doi: 10.1371/journal.pone.0194581. eCollection 2018.


Anti-CD20 immunotherapy as a bridge to tolerance, after allogeneic stem cell transplantation for patients with chronic lymphocytic leukaemia: results of the CLLX4 trial.

Schetelig J, Link CS, Stuhler G, Wagner EM, Hänel M, Kobbe G, Böttcher S, Kreuzer KA, Middeke JM, Sockel K, Teipel R, von Bonin M, Stölzel F, Kramer M, Stilgenbauer S, Hallek M, Bornhäuser M; Deutsche CLL Studiengruppe and the German Cooperative Transplant Study Group.

Br J Haematol. 2019 Mar;184(5):833-836. doi: 10.1111/bjh.15181. Epub 2018 Mar 12. No abstract available.


RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome.

Van Treeck B, Protter DSW, Matheny T, Khong A, Link CD, Parker R.

Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2734-2739. doi: 10.1073/pnas.1800038115. Epub 2018 Feb 26.


Mass spectrometry-based identification of a naturally presented receptor tyrosine kinase-like orphan receptor 1-derived epitope recognized by CD8+ cytotoxic T cells.

Heidenreich F, Rücker-Braun E, Walz JS, Eugster A, Kühn D, Dietz S, Nelde A, Tunger A, Wehner R, Link CS, Middeke JM, Stölzel F, Tonn T, Stevanovic S, Rammensee HG, Bonifacio E, Bachmann M, Zeis M, Ehninger G, Bornhäuser M, Schetelig J, Schmitz M.

Haematologica. 2017 Nov;102(11):e460-e464. doi: 10.3324/haematol.2017.167312. Epub 2017 Aug 24. No abstract available.


Addition of αGal HyperAcute™ technology to recombinant avian influenza vaccines induces strong low-dose antibody responses.

Chen WA, Zhang J, Hall KM, Martin CB, Kisselev S, Dasen EJ, Vahanian NN, Link CJ, Martin BK.

PLoS One. 2017 Aug 7;12(8):e0182683. doi: 10.1371/journal.pone.0182683. eCollection 2017.


Sedimentation Velocity Analysis with Fluorescence Detection of Mutant Huntingtin Exon 1 Aggregation in Drosophila melanogaster and Caenorhabditis elegans.

Kim SA, D'Acunto VF, Kokona B, Hofmann J, Cunningham NR, Bistline EM, Garcia FJ, Akhtar NM, Hoffman SH, Doshi SH, Ulrich KM, Jones NM, Bonini NM, Roberts CM, Link CD, Laue TM, Fairman R.

Biochemistry. 2017 Sep 5;56(35):4676-4688. doi: 10.1021/acs.biochem.7b00518. Epub 2017 Aug 24.


Transgender and Gender Nonconforming Patient Experiences at a Family Medicine Clinic.

Hinrichs A, Link C, Seaquist L, Ehlinger P, Aldrin S, Pratt R.

Acad Med. 2018 Jan;93(1):76-81. doi: 10.1097/ACM.0000000000001837.


Effects of isoflavone-containing soya protein on ex vivo cholesterol efflux, vascular function and blood markers of CVD risk in adults with moderately elevated blood pressure: a dose-response randomised controlled trial.

Richter CK, Skulas-Ray AC, Fleming JA, Link CJ, Mukherjea R, Krul ES, Kris-Etherton PM.

Br J Nutr. 2017 May;117(10):1403-1413. doi: 10.1017/S000711451700143X.


Repetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients.

Prudencio M, Gonzales PK, Cook CN, Gendron TF, Daughrity LM, Song Y, Ebbert MTW, van Blitterswijk M, Zhang YJ, Jansen-West K, Baker MC, DeTure M, Rademakers R, Boylan KB, Dickson DW, Petrucelli L, Link CD.

Hum Mol Genet. 2017 Sep 1;26(17):3421-3431. doi: 10.1093/hmg/ddx233.


Safety and immunogenicity of the rVSV∆G-ZEBOV-GP Ebola virus vaccine candidate in healthy adults: a phase 1b randomised, multicentre, double-blind, placebo-controlled, dose-response study.

Heppner DG Jr, Kemp TL, Martin BK, Ramsey WJ, Nichols R, Dasen EJ, Link CJ, Das R, Xu ZJ, Sheldon EA, Nowak TA, Monath TP; V920-004 study team.

Lancet Infect Dis. 2017 Aug;17(8):854-866. doi: 10.1016/S1473-3099(17)30313-4. Epub 2017 Jun 9.


High-Frequency Spinal Cord Stimulation at 10 kHz for the Treatment of Chronic Neuropathic Pain After a II-III Degree Burn.

Steinbach K, Bettstetter H, Link C.

Pain Med. 2017 Sep 1;18(9):1826-1828. doi: 10.1093/pm/pnx012. No abstract available.


Assessment of the T cell receptor repertoire in long-term platelet donors by next generation sequencing.

Link CS, Hölig K, Rücker-Braun E, Lang K, Kuhn M, Eugster A, Klesse C, Schmiedgen M, Heidenreich F, Oelschlägel U, Dahl A, Bornhäuser M, Bonifacio E, Schetelig J.

Br J Haematol. 2018 May;181(3):389-391. doi: 10.1111/bjh.14576. Epub 2017 Mar 8. No abstract available.


Burst Spinal Cord Stimulation Increases Peripheral Antineuroinflammatory Interleukin 10 Levels in Failed Back Surgery Syndrome Patients With Predominant Back Pain.

Kinfe TM, Muhammad S, Link C, Roeske S, Chaudhry SR, Yearwood TL.

Neuromodulation. 2017 Jun;20(4):322-330. doi: 10.1111/ner.12586. Epub 2017 Feb 13.


Caenorhabditis elegans as a model system to study post-translational modifications of human transthyretin.

Henze A, Homann T, Rohn I, Aschner M, Link CD, Kleuser B, Schweigert FJ, Schwerdtle T, Bornhorst J.

Sci Rep. 2016 Nov 21;6:37346. doi: 10.1038/srep37346.


Generation of high-avidity, WT1-reactive CD8+ cytotoxic T cell clones with anti-leukemic activity by streptamer technology.

Tunger A, Wehner R, von Bonin M, Kühn D, Heidenreich F, Matko S, Nauerth M, Rücker-Braun E, Dietz S, Link CS, Eugster A, Odendahl M, Busch DH, Tonn T, Bonifacio E, Germeroth L, Schetelig J, Bachmann MP, Bornhäuser M, Schmitz M.

Leuk Lymphoma. 2017 May;58(5):1246-1249. doi: 10.1080/10428194.2016.1233538. Epub 2016 Nov 16. No abstract available.


Long-term follow-up of patients with relapsed or refractory non-Hodgkin's lymphoma receiving allogeneic stem cell transplantation.

Link CS, Mies F, Scheele J, Kramer M, Schetelig J, Ordemann R, Hänel M, Bornhäuser M, Ehninger G, Kroschinsky F.

Bone Marrow Transplant. 2016 Nov;51(11):1527-1529. doi: 10.1038/bmt.2016.165. Epub 2016 Jun 13. No abstract available.


Longitudinal analyses of leukemia-associated antigen-specific CD8+ T cells in patients after allogeneic stem cell transplantation.

Rücker-Braun E, Link CS, Schmiedgen M, Tunger A, Vizjak P, Teipel R, Wehner R, Kühn D, Fuchs YF, Oelschlägel U, Germeroth L, Schmitz M, Bornhäuser M, Schetelig J, Heidenreich F.

Exp Hematol. 2016 Nov;44(11):1024-1033.e1. doi: 10.1016/j.exphem.2016.07.008. Epub 2016 Jul 26.


Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts.

Kramer NJ, Carlomagno Y, Zhang YJ, Almeida S, Cook CN, Gendron TF, Prudencio M, Van Blitterswijk M, Belzil V, Couthouis J, Paul JW 3rd, Goodman LD, Daughrity L, Chew J, Garrett A, Pregent L, Jansen-West K, Tabassian LJ, Rademakers R, Boylan K, Graff-Radford NR, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Boeve BF, Deng N, Feng Y, Cheng TH, Dickson DW, Cohen SN, Bonini NM, Link CD, Gao FB, Petrucelli L, Gitler AD.

Science. 2016 Aug 12;353(6300):708-12. doi: 10.1126/science.aaf7791.


In Vivo Expansion of Endogenous Regulatory T Cell Populations Induces Long-Term Suppression of Contact Hypersensitivity.

El Beidaq A, Link CW, Hofmann K, Frehse B, Hartmann K, Bieber K, Martin SF, Ludwig RJ, Manz RA.

J Immunol. 2016 Sep 1;197(5):1567-76. doi: 10.4049/jimmunol.1600508. Epub 2016 Jul 20.


DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans.

Munkácsy E, Khan MH, Lane RK, Borror MB, Park JH, Bokov AF, Fisher AL, Link CD, Rea SL.

PLoS Genet. 2016 Jul 15;12(7):e1006133. doi: 10.1371/journal.pgen.1006133. eCollection 2016 Jul.


A phase I study of indoximod in patients with advanced malignancies.

Soliman HH, Minton SE, Han HS, Ismail-Khan R, Neuger A, Khambati F, Noyes D, Lush R, Chiappori AA, Roberts JD, Link C, Vahanian NN, Mautino M, Streicher H, Sullivan DM, Antonia SJ.

Oncotarget. 2016 Apr 19;7(16):22928-38. doi: 10.18632/oncotarget.8216.


C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins.

Zhang YJ, Gendron TF, Grima JC, Sasaguri H, Jansen-West K, Xu YF, Katzman RB, Gass J, Murray ME, Shinohara M, Lin WL, Garrett A, Stankowski JN, Daughrity L, Tong J, Perkerson EA, Yue M, Chew J, Castanedes-Casey M, Kurti A, Wang ZS, Liesinger AM, Baker JD, Jiang J, Lagier-Tourenne C, Edbauer D, Cleveland DW, Rademakers R, Boylan KB, Bu G, Link CD, Dickey CA, Rothstein JD, Dickson DW, Fryer JD, Petrucelli L.

Nat Neurosci. 2016 May;19(5):668-677. doi: 10.1038/nn.4272. Epub 2016 Mar 21.


Abundant cytomegalovirus (CMV) reactive clonotypes in the CD8(+) T cell receptor alpha repertoire following allogeneic transplantation.

Link CS, Eugster A, Heidenreich F, Rücker-Braun E, Schmiedgen M, Oelschlägel U, Kühn D, Dietz S, Fuchs Y, Dahl A, Domingues AM, Klesse C, Schmitz M, Ehninger G, Bornhäuser M, Schetelig J, Bonifacio E.

Clin Exp Immunol. 2016 Jun;184(3):389-402. doi: 10.1111/cei.12770. Epub 2016 Mar 8.


A Comprehensive Review of Novel Drug-Disease Models in Diabetes Drug Development.

Gaitonde P, Garhyan P, Link C, Chien JY, Trame MN, Schmidt S.

Clin Pharmacokinet. 2016 Jul;55(7):769-788. doi: 10.1007/s40262-015-0359-y. Review.


Algenpantucel-L immunotherapy in pancreatic adenocarcinoma.

Coveler AL, Rossi GR, Vahanian NN, Link C, Chiorean EG.

Immunotherapy. 2016 Feb;8(2):117-25. doi: 10.2217/imt.15.113. Epub 2016 Jan 20. Review.


High Frequency (10 kHz) or Burst Spinal Cord Stimulation in Failed Back Surgery Syndrome Patients With Predominant Back Pain: Preliminary Data From a Prospective Observational Study.

Kinfe TM, Pintea B, Link C, Roeske S, Güresir E, Güresir Á, Vatter H.

Neuromodulation. 2016 Apr;19(3):268-75. doi: 10.1111/ner.12379. Epub 2016 Jan 13.


Durable responses to ibrutinib in patients with relapsed CLL after allogeneic stem cell transplantation.

Link CS, Teipel R, Heidenreich F, Rücker-Braun E, Schmiedgen M, Reinhardt J, Oelschlägel U, von Bonin M, Middeke JM, Muetherig A, Trautmann-Grill K, Platzbecker U, Bornhäuser M, Schetelig J.

Bone Marrow Transplant. 2016 Jun;51(6):793-8. doi: 10.1038/bmt.2015.339. Epub 2016 Jan 11.


Studying polyglutamine aggregation in Caenorhabditis elegans using an analytical ultracentrifuge equipped with fluorescence detection.

Kokona B, May CA, Cunningham NR, Richmond L, Jay Garcia F, Durante JC, Ulrich KM, Roberts CM, Link CD, Stafford WF, Laue TM, Fairman R.

Protein Sci. 2016 Mar;25(3):605-17. doi: 10.1002/pro.2854. Epub 2015 Dec 21.


Pancreatic cancer: Update on immunotherapies and algenpantucel-L.

McCormick KA, Coveler AL, Rossi GR, Vahanian NN, Link C, Chiorean EG.

Hum Vaccin Immunother. 2016 Mar 3;12(3):563-75. doi: 10.1080/21645515.2015.1093264. Review.


Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS.

Prudencio M, Belzil VV, Batra R, Ross CA, Gendron TF, Pregent LJ, Murray ME, Overstreet KK, Piazza-Johnston AE, Desaro P, Bieniek KF, DeTure M, Lee WC, Biendarra SM, Davis MD, Baker MC, Perkerson RB, van Blitterswijk M, Stetler CT, Rademakers R, Link CD, Dickson DW, Boylan KB, Li H, Petrucelli L.

Nat Neurosci. 2015 Aug;18(8):1175-82. doi: 10.1038/nn.4065. Epub 2015 Jul 20.


The Relationship Between Parent Trait Anxiety and Parent-reported Pain, Solicitous Behaviors, and Quality of Life Impairment in Children With Cancer.

Link CJ, Fortier MA.

J Pediatr Hematol Oncol. 2016 Jan;38(1):58-62. doi: 10.1097/MPH.0000000000000376.


A Recombinant Vesicular Stomatitis Virus Ebola Vaccine.

Regules JA, Beigel JH, Paolino KM, Voell J, Castellano AR, Hu Z, Muñoz P, Moon JE, Ruck RC, Bennett JW, Twomey PS, Gutiérrez RL, Remich SA, Hack HR, Wisniewski ML, Josleyn MD, Kwilas SA, Van Deusen N, Mbaya OT, Zhou Y, Stanley DA, Jing W, Smith KS, Shi M, Ledgerwood JE, Graham BS, Sullivan NJ, Jagodzinski LL, Peel SA, Alimonti JB, Hooper JW, Silvera PM, Martin BK, Monath TP, Ramsey WJ, Link CJ, Lane HC, Michael NL, Davey RT Jr, Thomas SJ; rVSVΔG-ZEBOV-GP Study Group.

N Engl J Med. 2017 Jan 26;376(4):330-341. doi: 10.1056/NEJMoa1414216. Epub 2015 Apr 1.

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