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Discovery of ubonodin, an antimicrobial lasso peptide active against members of the Burkholderia cepacia complex.

Cheung-Lee WL, Parry M, Zong C, Jaramillo Cartagena A, Darst S, Connell N, Russo R, Link AJ.

Chembiochem. 2019 Nov 25. doi: 10.1002/cbic.201900707. [Epub ahead of print]


Pandonodin: A Proteobacterial Lasso Peptide with an Exceptionally Long C-Terminal Tail.

Cheung-Lee WL, Cao L, Link AJ.

ACS Chem Biol. 2019 Dec 5. doi: 10.1021/acschembio.9b00676. [Epub ahead of print]


Genome mining for lasso peptides: past, present, and future.

Cheung-Lee WL, Link AJ.

J Ind Microbiol Biotechnol. 2019 Oct;46(9-10):1371-1379. doi: 10.1007/s10295-019-02197-z. Epub 2019 Jun 5.


Discovery and structure of the antimicrobial lasso peptide citrocin.

Cheung-Lee WL, Parry ME, Jaramillo Cartagena A, Darst SA, Link AJ.

J Biol Chem. 2019 Apr 26;294(17):6822-6830. doi: 10.1074/jbc.RA118.006494. Epub 2019 Mar 7.


Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin.

Braffman NR, Piscotta FJ, Hauver J, Campbell EA, Link AJ, Darst SA.

Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1273-1278. doi: 10.1073/pnas.1817352116. Epub 2019 Jan 9.


ParST is a widespread toxin-antitoxin module that targets nucleotide metabolism.

Piscotta FJ, Jeffrey PD, Link AJ.

Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):826-834. doi: 10.1073/pnas.1814633116. Epub 2018 Dec 31.


AS03-Adjuvanted H5N1 Avian Influenza Vaccine Modulates Early Innate Immune Signatures in Human Peripheral Blood Mononuclear Cells.

Howard LM, Goll JB, Jensen TL, Hoek KL, Prasad N, Gelber CE, Levy SE, Joyce S, Link AJ, Creech CB, Edwards KM.

J Infect Dis. 2019 May 5;219(11):1786-1798. doi: 10.1093/infdis/jiy721.


Heterologous and in Vitro Reconstitution of Fuscanodin, a Lasso Peptide from Thermobifida fusca.

Koos JD, Link AJ.

J Am Chem Soc. 2019 Jan 16;141(2):928-935. doi: 10.1021/jacs.8b10724. Epub 2018 Dec 27.


Critical Role for Saccharomyces cerevisiae Asc1p in Translational Initiation at Elevated Temperatures.

Gerbasi VR, Browne CM, Samir P, Shen B, Sun M, Hazelbaker DZ, Galassie AC, Frank J, Link AJ.

Proteomics. 2018 Dec;18(23):e1800208. doi: 10.1002/pmic.201800208. Epub 2018 Oct 23.


Identification of Changing Ribosome Protein Compositions using Mass Spectrometry.

Samir P, Browne CM, Rahul, Sun M, Shen B, Li W, Frank J, Link AJ.

Proteomics. 2018 Oct;18(20):e1800217. doi: 10.1002/pmic.201800217.


Cyclic and Lasso Peptides: Sequence Determination, Topology Analysis, and Rotaxane Formation.

Elashal HE, Cohen RD, Elashal HE, Zong C, Link AJ, Raj M.

Angew Chem Int Ed Engl. 2018 May 22;57(21):6150-6154. doi: 10.1002/anie.201801299. Epub 2018 Apr 27.


Albusnodin: an acetylated lasso peptide from Streptomyces albus.

Zong C, Cheung-Lee WL, Elashal HE, Raj M, Link AJ.

Chem Commun (Camb). 2018 Feb 1;54(11):1339-1342. doi: 10.1039/c7cc08620b.


Lasso Peptide Benenodin-1 Is a Thermally Actuated [1]Rotaxane Switch.

Zong C, Wu MJ, Qin JZ, Link AJ.

J Am Chem Soc. 2017 Aug 2;139(30):10403-10409. doi: 10.1021/jacs.7b04830. Epub 2017 Jul 24.


Proteomics show antigen presentation processes in human immune cells after AS03-H5N1 vaccination.

Galassie AC, Goll JB, Samir P, Jensen TL, Hoek KL, Howard LM, Allos TM, Niu X, Gordy LE, Creech CB, Hill H, Joyce S, Edwards KM, Link AJ.

Proteomics. 2017 Jun;17(12). doi: 10.1002/pmic.201600453.


Cell-Based Systems Biology Analysis of Human AS03-Adjuvanted H5N1 Avian Influenza Vaccine Responses: A Phase I Randomized Controlled Trial.

Howard LM, Hoek KL, Goll JB, Samir P, Galassie A, Allos TM, Niu X, Gordy LE, Creech CB, Prasad N, Jensen TL, Hill H, Levy SE, Joyce S, Link AJ, Edwards KM.

PLoS One. 2017 Jan 18;12(1):e0167488. doi: 10.1371/journal.pone.0167488. eCollection 2017.


Structure of the Lasso Peptide Isopeptidase Identifies a Topology for Processing Threaded Substrates.

Chekan JR, Koos JD, Zong C, Maksimov MO, Link AJ, Nair SK.

J Am Chem Soc. 2016 Dec 21;138(50):16452-16458. doi: 10.1021/jacs.6b10389. Epub 2016 Dec 7.


Self-Assembly of Catenanes from Lasso Peptides.

Allen CD, Link AJ.

J Am Chem Soc. 2016 Nov 2;138(43):14214-14217. Epub 2016 Oct 21.


Lasso Peptide Biosynthetic Protein LarB1 Binds Both Leader and Core Peptide Regions of the Precursor Protein LarA.

Cheung WL, Chen MY, Maksimov MO, Link AJ.

ACS Cent Sci. 2016 Oct 26;2(10):702-709. Epub 2016 Sep 29.


Thermal Unthreading of the Lasso Peptides Astexin-2 and Astexin-3.

Allen CD, Chen MY, Trick AY, Le DT, Ferguson AL, Link AJ.

ACS Chem Biol. 2016 Nov 18;11(11):3043-3051. Epub 2016 Sep 15.


Transition from Beam-Target to Thermonuclear Fusion in High-Current Deuterium Z-Pinch Simulations.

Offermann DT, Welch DR, Rose DV, Thoma C, Clark RE, Mostrom CB, Schmidt AE, Link AJ.

Phys Rev Lett. 2016 May 13;116(19):195001. doi: 10.1103/PhysRevLett.116.195001. Epub 2016 May 9.


Bioorthogonal Chemistry for the Isolation and Study of Newly Synthesized Histones and Their Modifications.

Arnaudo AM, Link AJ, Garcia BA.

ACS Chem Biol. 2016 Mar 18;11(3):782-91. doi: 10.1021/acschembio.5b00816. Epub 2016 Feb 10.


Viral infection causes a shift in the self peptide repertoire presented by human MHC class I molecules.

Spencer CT, Bezbradica JS, Ramos MG, Arico CD, Conant SB, Gilchuk P, Gray JJ, Zheng M, Niu X, Hildebrand W, Link AJ, Joyce S.

Proteomics Clin Appl. 2015 Dec;9(11-12):1035-52. doi: 10.1002/prca.201500106.


Focus on Immunology and Proteomics.

Link AJ.

Proteomics Clin Appl. 2015 Dec;9(11-12):965-6. doi: 10.1002/prca.201570063. No abstract available.


Elucidating the Specificity Determinants of the AtxE2 Lasso Peptide Isopeptidase.

Maksimov MO, Koos JD, Zong C, Lisko B, Link AJ.

J Biol Chem. 2015 Dec 25;290(52):30806-12. doi: 10.1074/jbc.M115.694083. Epub 2015 Nov 3.


Construction of Lasso Peptide Fusion Proteins.

Zong C, Maksimov MO, Link AJ.

ACS Chem Biol. 2016 Jan 15;11(1):61-8. doi: 10.1021/acschembio.5b00745. Epub 2015 Oct 29.


Leisure Functioning and Offender Rehabilitation.

Link AJ, Williams DJ.

Int J Offender Ther Comp Criminol. 2017 Feb;61(2):150-170. doi: 10.1177/0306624X15600695. Epub 2016 Jul 28.


l2 Multiple Kernel Fuzzy SVM-Based Data Fusion for Improving Peptide Identification.

Jian L, Xia Z, Niu X, Liang X, Samir P, Link AJ.

IEEE/ACM Trans Comput Biol Bioinform. 2016 Jul-Aug;13(4):804-9. doi: 10.1109/TCBB.2015.2480084. Epub 2015 Sep 18.


Environmental Interactions and Epistasis Are Revealed in the Proteomic Responses to Complex Stimuli.

Samir P, Rahul, Slaughter JC, Link AJ.

PLoS One. 2015 Aug 6;10(8):e0134099. doi: 10.1371/journal.pone.0134099. eCollection 2015.


Biosynthesis: Leading the way to RiPPs.

Link AJ.

Nat Chem Biol. 2015 Aug;11(8):551-2. doi: 10.1038/nchembio.1862. No abstract available.


Proteomic contributions to our understanding of vaccine and immune responses.

Galassie AC, Link AJ.

Proteomics Clin Appl. 2015 Dec;9(11-12):972-89. doi: 10.1002/prca.201500054. Epub 2015 Sep 10. Review.


Mapping the binding interface of ERK and transcriptional repressor Capicua using photocrosslinking.

Futran AS, Kyin S, Shvartsman SY, Link AJ.

Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8590-5. doi: 10.1073/pnas.1501373112. Epub 2015 Jun 29.


A cell-based systems biology assessment of human blood to monitor immune responses after influenza vaccination.

Hoek KL, Samir P, Howard LM, Niu X, Prasad N, Galassie A, Liu Q, Allos TM, Floyd KA, Guo Y, Shyr Y, Levy SE, Joyce S, Edwards KM, Link AJ.

PLoS One. 2015 Feb 23;10(2):e0118528. doi: 10.1371/journal.pone.0118528. eCollection 2015. Erratum in: PLoS One. 2015;10(3):e0122550.


Expanding the chemical diversity of lasso peptide MccJ25 with genetically encoded noncanonical amino acids.

Piscotta FJ, Tharp JM, Liu WR, Link AJ.

Chem Commun (Camb). 2015;51(2):409-12. doi: 10.1039/c4cc07778d. Epub 2014 Nov 18.


Analysis of protein composition using multidimensional chromatography and mass spectrometry.

Link AJ, Washburn MP.

Curr Protoc Protein Sci. 2014 Nov 3;78:23.1.1-23.1.25. doi: 10.1002/0471140864.ps2301s78. Review.


Peptide identification based on fuzzy classification and clustering.

Liang X, Xia Z, Niu X, Link AJ, Pang L, Wu FX, Zhang H.

Proteome Sci. 2013 Nov 7;11(Suppl 1):S10. doi: 10.1186/1477-5956-11-S1-S10. Epub 2013 Nov 7.


ERK as a model for systems biology of enzyme kinetics in cells.

Futran AS, Link AJ, Seger R, Shvartsman SY.

Curr Biol. 2013 Nov 4;23(21):R972-9. doi: 10.1016/j.cub.2013.09.033. Review.


Prospecting genomes for lasso peptides.

Maksimov MO, Link AJ.

J Ind Microbiol Biotechnol. 2014 Feb;41(2):333-44. doi: 10.1007/s10295-013-1357-4. Epub 2013 Oct 19. Review.


Discovery and characterization of an isopeptidase that linearizes lasso peptides.

Maksimov MO, Link AJ.

J Am Chem Soc. 2013 Aug 14;135(32):12038-47. doi: 10.1021/ja4054256. Epub 2013 Jul 31.


Discovering naturally processed antigenic determinants that confer protective T cell immunity.

Gilchuk P, Spencer CT, Conant SB, Hill T, Gray JJ, Niu X, Zheng M, Erickson JJ, Boyd KL, McAfee KJ, Oseroff C, Hadrup SR, Bennink JR, Hildebrand W, Edwards KM, Crowe JE Jr, Williams JV, Buus S, Sette A, Schumacher TN, Link AJ, Joyce S.

J Clin Invest. 2013 May;123(5):1976-87. doi: 10.1172/JCI67388. Epub 2013 Apr 1.


A novel algorithm for validating peptide identification from a shotgun proteomics search engine.

Jian L, Niu X, Xia Z, Samir P, Sumanasekera C, Mu Z, Jennings JL, Hoek KL, Allos T, Howard LM, Edwards KM, Weil PA, Link AJ.

J Proteome Res. 2013 Mar 1;12(3):1108-19. doi: 10.1021/pr300631t. Epub 2013 Feb 12.


Sculpting MHC class II-restricted self and non-self peptidome by the class I Ag-processing machinery and its impact on Th-cell responses.

Spencer CT, Dragovic SM, Conant SB, Gray JJ, Zheng M, Samir P, Niu X, Moutaftsi M, Van Kaer L, Sette A, Link AJ, Joyce S.

Eur J Immunol. 2013 May;43(5):1162-72. doi: 10.1002/eji.201243087. Epub 2013 Mar 5.


The yeast eukaryotic translation initiation factor 2B translation initiation complex interacts with the fatty acid synthesis enzyme YBR159W and endoplasmic reticulum membranes.

Browne CM, Samir P, Fites JS, Villarreal SA, Link AJ.

Mol Cell Biol. 2013 Mar;33(5):1041-56. doi: 10.1128/MCB.00811-12. Epub 2012 Dec 21.


Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.

Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA.

Nat Prod Rep. 2013 Jan;30(1):108-60. doi: 10.1039/c2np20085f. Review.


Precursor-centric genome-mining approach for lasso peptide discovery.

Maksimov MO, Pelczer I, Link AJ.

Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15223-8. Epub 2012 Sep 4.


A new associate editor for Proteomics.

Dunn MJ, Link AJ.

Proteomics. 2012 Aug;12(14):2237. doi: 10.1002/pmic.201270094. No abstract available.


Using light to covalently immobilize and pattern nanoparticles onto surfaces.

Park EJ, Wagenaar T, Zhang S, Link AJ, Prud'homme RK, Koberstein JT, Turro NJ.

Langmuir. 2012 Jul 24;28(29):10934-41. doi: 10.1021/la302113k. Epub 2012 Jul 13.


Synthesis and evaluation of clickable block copolymers for targeted nanoparticle drug delivery.

Zhang S, Chan KH, Prud'homme RK, Link AJ.

Mol Pharm. 2012 Aug 6;9(8):2228-36. doi: 10.1021/mp3000748. Epub 2012 Jul 12.


The sodium channel accessory subunit Navβ1 regulates neuronal excitability through modulation of repolarizing voltage-gated K⁺ channels.

Marionneau C, Carrasquillo Y, Norris AJ, Townsend RR, Isom LL, Link AJ, Nerbonne JM.

J Neurosci. 2012 Apr 25;32(17):5716-27. doi: 10.1523/JNEUROSCI.6450-11.2012.


A comparison of two strategies for affinity maturation of a BH3 peptide toward pro-survival Bcl-2 proteins.

Zhang S, Long A, Link AJ.

ACS Synth Biol. 2012 Mar 16;1(3):89-98. doi: 10.1021/sb200002m. Epub 2011 Oct 7.


The role of a conserved threonine residue in the leader peptide of lasso peptide precursors.

Pan SJ, Rajniak J, Maksimov MO, Link AJ.

Chem Commun (Camb). 2012 Feb 11;48(13):1880-2. doi: 10.1039/c2cc17211a. Epub 2012 Jan 5.


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