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Items: 27


Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers.

Tokatlian T, Read BJ, Jones CA, Kulp DW, Menis S, Chang JYH, Steichen JM, Kumari S, Allen JD, Dane EL, Liguori A, Sangesland M, Lingwood D, Crispin M, Schief WR, Irvine DJ.

Science. 2019 Feb 8;363(6427):649-654. doi: 10.1126/science.aat9120. Epub 2018 Dec 20.


Correction: Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies.

Nandin IS, Fong C, Deantonio C, Torreno-Pina JA, Pecetta S, Maldonado P, Gasparrini F, Ordovas-Montanes J, Kazer SW, Kjaer S, Borley DW, Nair U, Coleman JA, Lingwood D, Shalek AK, Meffre E, Poignard P, Burton DR, Batista FD.

J Exp Med. 2017 Sep 4;214(9):2811. doi: 10.1084/jem.2017063307262017c. Epub 2017 Aug 21. No abstract available.


Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies.

Sanjuan Nandin I, Fong C, Deantonio C, Torreno-Pina JA, Pecetta S, Maldonado P, Gasparrini F, Ordovas-Montanes J, Kazer SW, Kjaer S, Borley DW, Nair U, Coleman JA, Lingwood D, Shalek AK, Meffre E, Poignard P, Burton DR, Batista FD.

J Exp Med. 2017 Jul 24. pii: jem.20170633. doi: 10.1084/jem.20170633. [Epub ahead of print] Erratum in: J Exp Med. 2017 Aug 21;:.


Reconstituted B cell receptor signaling reveals carbohydrate-dependent mode of activation.

Villar RF, Patel J, Weaver GC, Kanekiyo M, Wheatley AK, Yassine HM, Costello CE, Chandler KB, McTamney PM, Nabel GJ, McDermott AB, Mascola JR, Carr SA, Lingwood D.

Sci Rep. 2016 Oct 31;6:36298. doi: 10.1038/srep36298.


In vitro reconstitution of B cell receptor-antigen interactions to evaluate potential vaccine candidates.

Weaver GC, Villar RF, Kanekiyo M, Nabel GJ, Mascola JR, Lingwood D.

Nat Protoc. 2016 Feb;11(2):193-213. doi: 10.1038/nprot.2016.009. Epub 2016 Jan 7.


Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection.

Yassine HM, Boyington JC, McTamney PM, Wei CJ, Kanekiyo M, Kong WP, Gallagher JR, Wang L, Zhang Y, Joyce MG, Lingwood D, Moin SM, Andersen H, Okuno Y, Rao SS, Harris AK, Kwong PD, Mascola JR, Nabel GJ, Graham BS.

Nat Med. 2015 Sep;21(9):1065-70. doi: 10.1038/nm.3927. Epub 2015 Aug 24.


H5N1 Vaccine-Elicited Memory B Cells Are Genetically Constrained by the IGHV Locus in the Recognition of a Neutralizing Epitope in the Hemagglutinin Stem.

Wheatley AK, Whittle JR, Lingwood D, Kanekiyo M, Yassine HM, Ma SS, Narpala SR, Prabhakaran MS, Matus-Nicodemos RA, Bailer RT, Nabel GJ, Graham BS, Ledgerwood JE, Koup RA, McDermott AB.

J Immunol. 2015 Jul 15;195(2):602-10. doi: 10.4049/jimmunol.1402835. Epub 2015 Jun 15.


Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.

Zhou T, Lynch RM, Chen L, Acharya P, Wu X, Doria-Rose NA, Joyce MG, Lingwood D, Soto C, Bailer RT, Ernandes MJ, Kong R, Longo NS, Louder MK, McKee K, O'Dell S, Schmidt SD, Tran L, Yang Z, Druz A, Luongo TS, Moquin S, Srivatsan S, Yang Y, Zhang B, Zheng A, Pancera M, Kirys T, Georgiev IS, Gindin T, Peng HP, Yang AS; NISC Comparative Sequencing Program, Mullikin JC, Gray MD, Stamatatos L, Burton DR, Koff WC, Cohen MS, Haynes BF, Casazza JP, Connors M, Corti D, Lanzavecchia A, Sattentau QJ, Weiss RA, West AP Jr, Bjorkman PJ, Scheid JF, Nussenzweig MC, Shapiro L, Mascola JR, Kwong PD.

Cell. 2015 Jun 4;161(6):1280-92. doi: 10.1016/j.cell.2015.05.007. Epub 2015 May 21.


Lipocalin 2 as a membrane-reorganizing agent.

Lingwood D.

Sci Signal. 2014 Aug 12;7(338):pe19. doi: 10.1126/scisignal.2005563.


Flow cytometry reveals that H5N1 vaccination elicits cross-reactive stem-directed antibodies from multiple Ig heavy-chain lineages.

Whittle JR, Wheatley AK, Wu L, Lingwood D, Kanekiyo M, Ma SS, Narpala SR, Yassine HM, Frank GM, Yewdell JW, Ledgerwood JE, Wei CJ, McDermott AB, Graham BS, Koup RA, Nabel GJ.

J Virol. 2014 Apr;88(8):4047-57. doi: 10.1128/JVI.03422-13. Epub 2014 Feb 5.


Structural and genetic basis for development of broadly neutralizing influenza antibodies.

Lingwood D, McTamney PM, Yassine HM, Whittle JR, Guo X, Boyington JC, Wei CJ, Nabel GJ.

Nature. 2012 Sep 27;489(7417):566-70. doi: 10.1038/nature11371. Epub 2012 Aug 29.


Molecular convergence of bacterial and eukaryotic surface order.

Kaiser HJ, Surma MA, Mayer F, Levental I, Grzybek M, Klemm RW, Da Cruz S, Meisinger C, Müller V, Simons K, Lingwood D.

J Biol Chem. 2011 Nov 25;286(47):40631-7. doi: 10.1074/jbc.M111.276444. Epub 2011 Sep 30.


Lateral sorting in model membranes by cholesterol-mediated hydrophobic matching.

Kaiser HJ, Orłowski A, Róg T, Nyholm TK, Chai W, Feizi T, Lingwood D, Vattulainen I, Simons K.

Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16628-33. doi: 10.1073/pnas.1103742108. Epub 2011 Sep 19.


Cholesterol modulates glycolipid conformation and receptor activity.

Lingwood D, Binnington B, Róg T, Vattulainen I, Grzybek M, Coskun U, Lingwood CA, Simons K.

Nat Chem Biol. 2011 May;7(5):260-2. doi: 10.1038/nchembio.551. Epub 2011 Apr 3.


Palmitoylation regulates raft affinity for the majority of integral raft proteins.

Levental I, Lingwood D, Grzybek M, Coskun U, Simons K.

Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22050-4. doi: 10.1073/pnas.1016184107. Epub 2010 Dec 3.


Lipid rafts as a membrane-organizing principle.

Lingwood D, Simons K.

Science. 2010 Jan 1;327(5961):46-50. doi: 10.1126/science.1174621. Review.


Order of lipid phases in model and plasma membranes.

Kaiser HJ, Lingwood D, Levental I, Sampaio JL, Kalvodova L, Rajendran L, Simons K.

Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16645-50. doi: 10.1073/pnas.0908987106. Epub 2009 Sep 15.


Lipid rafts as functional heterogeneity in cell membranes.

Lingwood D, Kaiser HJ, Levental I, Simons K.

Biochem Soc Trans. 2009 Oct;37(Pt 5):955-60. doi: 10.1042/BST0370955. Review.


Morphological homeostasis by autophagy.

Lingwood D, Schuck S, Ferguson C, Gerl M, Simons K.

Autophagy. 2009 Oct;5(7):1039-40. Epub 2009 Oct 19.


Generation of cubic membranes by controlled homotypic interaction of membrane proteins in the endoplasmic reticulum.

Lingwood D, Schuck S, Ferguson C, Gerl MJ, Simons K.

J Biol Chem. 2009 May 1;284(18):12041-8. doi: 10.1074/jbc.M900220200. Epub 2009 Mar 3.


Plasma membranes are poised for activation of raft phase coalescence at physiological temperature.

Lingwood D, Ries J, Schwille P, Simons K.

Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10005-10. doi: 10.1073/pnas.0804374105. Epub 2008 Jul 9.


Detergent resistance as a tool in membrane research.

Lingwood D, Simons K.

Nat Protoc. 2007;2(9):2159-65.


Decoupling the Na+-K+-ATPase in vivo: a possible new role in the gills of freshwater fishes.

Lingwood D, Harauz G, Ballantyne JS.

Comp Biochem Physiol A Mol Integr Physiol. 2006 Aug;144(4):451-7. Epub 2006 May 24. Review.


Alkaline phosphatase-immunoglobulin conjugate binds to lipids in vitro, independent of antibody selectivity.

Lingwood D, Ballantyne JS.

J Immunol Methods. 2006 Apr 20;311(1-2):174-7. Epub 2006 Feb 28.


Regulation of fish gill Na(+)-K(+)-ATPase by selective sulfatide-enriched raft partitioning during seawater adaptation.

Lingwood D, Harauz G, Ballantyne JS.

J Biol Chem. 2005 Nov 4;280(44):36545-50. Epub 2005 Aug 11.


Sulfatide and Na+-K+-ATPase: a salinity-sensitive relationship in the gill basolateral membrane of rainbow trout.

Lingwood D, Fisher LJ, Callahan JW, Ballantyne JS.

J Membr Biol. 2004 Sep 15;201(2):77-84.


Effect of globotriaosyl ceramide fatty acid alpha-hydroxylation on the binding by verotoxin 1 and verotoxin 2.

Binnington B, Lingwood D, Nutikka A, Lingwood CA.

Neurochem Res. 2002 Aug;27(7-8):807-13.


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