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Items: 20

1.

PISD is a mitochondrial disease gene causing skeletal dysplasia, cataracts, and white matter changes.

Zhao T, Goedhart CM, Sam PN, Sabouny R, Lingrell S, Cornish AJ, Lamont RE, Bernier FP, Sinasac D, Parboosingh JS; Care4Rare Canada Consortium, Vance JE, Claypool SM, Innes AM, Shutt TE.

Life Sci Alliance. 2019 Mar 11;2(2). pii: e201900353. doi: 10.26508/lsa.201900353. Print 2019 Apr.

2.

A role for phosphatidylcholine and phosphatidylethanolamine in hepatic insulin signaling.

van der Veen JN, Lingrell S, McCloskey N, LeBlond ND, Galleguillos D, Zhao YY, Curtis JM, Sipione S, Fullerton MD, Vance DE, Jacobs RL.

FASEB J. 2019 Jan 7:fj201802117R. doi: 10.1096/fj.201802117R. [Epub ahead of print]

PMID:
30615497
3.

Vitamin E alleviates non-alcoholic fatty liver disease in phosphatidylethanolamine N-methyltransferase deficient mice.

Presa N, Clugston RD, Lingrell S, Kelly SE, Merrill AH Jr, Jana S, Kassiri Z, Gómez-Muñoz A, Vance DE, Jacobs RL, van der Veen JN.

Biochim Biophys Acta Mol Basis Dis. 2019 Jan;1865(1):14-25. doi: 10.1016/j.bbadis.2018.10.010. Epub 2018 Oct 6.

PMID:
30300671
4.

LACTB is a tumour suppressor that modulates lipid metabolism and cell state.

Keckesova Z, Donaher JL, De Cock J, Freinkman E, Lingrell S, Bachovchin DA, Bierie B, Tischler V, Noske A, Okondo MC, Reinhardt F, Thiru P, Golub TR, Vance JE, Weinberg RA.

Nature. 2017 Mar 30;543(7647):681-686. doi: 10.1038/nature21408. Epub 2017 Mar 22.

5.

Fenofibrate, but not ezetimibe, prevents fatty liver disease in mice lacking phosphatidylethanolamine N-methyltransferase.

van der Veen JN, Lingrell S, Gao X, Takawale A, Kassiri Z, Vance DE, Jacobs RL.

J Lipid Res. 2017 Apr;58(4):656-667. doi: 10.1194/jlr.M070631. Epub 2017 Feb 3.

6.

Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase-deficient mice.

van der Veen JN, Lingrell S, Gao X, Quiroga AD, Takawale A, Armstrong EA, Yager JY, Kassiri Z, Lehner R, Vance DE, Jacobs RL.

Am J Physiol Gastrointest Liver Physiol. 2016 Apr 1;310(7):G526-38. doi: 10.1152/ajpgi.00243.2015. Epub 2016 Jan 21.

7.

Lack of phosphatidylethanolamine N-methyltransferase in mice does not promote fatty acid oxidation in skeletal muscle.

Tasseva G, van der Veen JN, Lingrell S, Jacobs RL, Vance DE, Vance JE.

Biochim Biophys Acta. 2016 Feb;1861(2):119-129. doi: 10.1016/j.bbalip.2015.11.008. Epub 2015 Nov 18.

PMID:
26603903
8.

Vagus nerve contributes to the development of steatohepatitis and obesity in phosphatidylethanolamine N-methyltransferase deficient mice.

Gao X, van der Veen JN, Zhu L, Chaba T, Ordoñez M, Lingrell S, Koonen DP, Dyck JR, Gomez-Muñoz A, Vance DE, Jacobs RL.

J Hepatol. 2015 Apr;62(4):913-20. doi: 10.1016/j.jhep.2014.11.026. Epub 2014 Nov 27.

PMID:
25433161
9.

The concentration of phosphatidylethanolamine in mitochondria can modulate ATP production and glucose metabolism in mice.

van der Veen JN, Lingrell S, da Silva RP, Jacobs RL, Vance DE.

Diabetes. 2014 Aug;63(8):2620-30. doi: 10.2337/db13-0993. Epub 2014 Mar 27.

10.

The membrane lipid phosphatidylcholine is an unexpected source of triacylglycerol in the liver.

van der Veen JN, Lingrell S, Vance DE.

J Biol Chem. 2012 Jul 6;287(28):23418-26. doi: 10.1074/jbc.M112.381723. Epub 2012 May 18.

11.

Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase.

Krahmer N, Guo Y, Wilfling F, Hilger M, Lingrell S, Heger K, Newman HW, Schmidt-Supprian M, Vance DE, Mann M, Farese RV Jr, Walther TC.

Cell Metab. 2011 Oct 5;14(4):504-15. doi: 10.1016/j.cmet.2011.07.013.

12.

Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity.

Jacobs RL, Zhao Y, Koonen DP, Sletten T, Su B, Lingrell S, Cao G, Peake DA, Kuo MS, Proctor SD, Kennedy BP, Dyck JR, Vance DE.

J Biol Chem. 2010 Jul 16;285(29):22403-13. doi: 10.1074/jbc.M110.108514. Epub 2010 May 7.

13.

Impaired ganglioside metabolism in Huntington's disease and neuroprotective role of GM1.

Maglione V, Marchi P, Di Pardo A, Lingrell S, Horkey M, Tidmarsh E, Sipione S.

J Neurosci. 2010 Mar 17;30(11):4072-80. doi: 10.1523/JNEUROSCI.6348-09.2010.

14.

Hepatic CTP:phosphocholine cytidylyltransferase-alpha is a critical predictor of plasma high density lipoprotein and very low density lipoprotein.

Jacobs RL, Lingrell S, Zhao Y, Francis GA, Vance DE.

J Biol Chem. 2008 Jan 25;283(4):2147-55. Epub 2007 Nov 27.

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17.

Role of histone deacetylase in the expression of CTP:phosphocholine cytidylyltransferase alpha.

Banchio C, Lingrell S, Vance DE.

J Biol Chem. 2006 Apr 14;281(15):10010-5. Epub 2006 Feb 16.

18.

Localization-independent regulation of homocysteine secretion by phosphatidylethanolamine N-methyltransferase.

Shields DJ, Lingrell S, Agellon LB, Brosnan JT, Vance DE.

J Biol Chem. 2005 Jul 22;280(29):27339-44. Epub 2005 May 31.

20.

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